Prevalence of frontotemporal dementia in community-based studies in Latin America: A systematic review

Custodio, Nilton; Herrera-Perez, Eder; Lira, David; Montesinos, Rosa; Bendezu, Liliana

doi:10.1590/S1980-57642013DN70100005

ABSTRACT

Latin America (LA) is experiencing a rise in the elderly population and a consequent increase in geriatric problems such as dementia. There are few epidemiological studies assessing the magnitude of dementia and dementia subtypes in LA.

Objective:

To identify published community-based studies on the prevalence of FTD in LA countries.

Methods:

A database search for door-to-door studies on FTD prevalence in LA was performed. The search was carried out on Medline, Embase, and LILACS databases for research conducted between 1994 and 2012. The main inclusion criteria were: use of any internationally accepted diagnostic criteria and investigation of community samples.

Results:

Four hundred and ninety two articles were found, of which 26 were initially pre-selected by title or abstract review. Five studies from 3 different countries were included. The FTD prevalence rates in community-dwelling elderly were 1.2 (Venezuela), 1.3 (Peru) and 1.7-1.8 (Brazil) per thousand persons, depending on age group.

Conclusion:

The FTD prevalence in LA studies showed values mid-way between those observed in western and in oriental populations. Despite the magnitude of this problem, epidemiological information on FTD remains scarce in LA.

Key words:
prevalence; frontotemporal lobar degeneration; frontotemporal dementia; primary progressive nonfluent aphasia

RESUMO

A América Latina (AL) está experimentando um aumento na população de idosos e um consequente aumento nos problemas geriátricos, como demência. Existem poucos estudos epidemiológicos avaliando a magnitude de demência e demência subtipos na AL

Objetivo:

Identificar publicações baseadas em estudos sobre a prevalência da FTD em países da AL.

Métodos:

A pesquisa realizada foi por estudos de prevalência de FTD em comunidade na AL. A pesquisa foi realizada em Med-line, Embase, e LILACS no período entre 1994 e 2012. Os principais critérios de inclusão foram: utilização de quaisquer critérios internacionalmente aceitos de diagnóstico e investigação de amostras em comunidade.

Resultados:

Quatrocentos e noventa e dois artigos foram encontrados, dos quais 26 foram inicialmente pré-selecionados pelo título ou fiscalização do abstract . Cinco estudos de 3 países diferentes foram incluídos. As taxas de prevalência na comunidade em idosos com FTD eram 1,2 (Venezuela), 1,3 (Peru) e 1,7-1,8 (Brasil) por mil pessoas, dependendo da faixa etária.

Conclusão:

A prevalência FTD em estudos da AL, apresentaram valores intermediários entre os observados em populações ocidentais e orientais. Apesar da magnitude do problema, informações epidemiológicas sobre FTD permanecem escassas em AL.

Palavras-chave:
prevalência; degeneração lobar frontotemporal; demência frontotemporal; afasia progressiva primária não fluente

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REFERENCES

Centro Latinoamericano y Caribeño de Demografía. Los adultos mayores en América Latina y el Caribe: datos e indicadores. Santiago, Chile; 2002.
Ferri CP, Prince M, Brayne C, et al. Global prevalence of dementia: a Delphi consensus study. Lancet 2005;366:2112-2117.
Prince M, Jackson J. Alzheimer's disease international world alzheimer report 2009. Alzheimer's Disease International; 2009.
Prince M. Methodological issues for population-based research into dementia in developing countries. A position paper from the 10/66 Dementia Research Group. Int J Geriatr Psychiatry 2000;15:21-30.
Nitrini R, Bottino CMC, Albala C, et al. Prevalence of dementia in Latin America: a collaborative study of population-based cohorts. Int Psychogeriatr 2009;21:622-630.
Ren RJ, Huang Y, Xu G, et al. History, Present, and Progress of Frontotemporal Dementia in China: A Systematic Review. Int J Alzheimers Dis 2012;2012:587215.
Rabinovici GD, Miller BL. Frontotemporal lobar degeneration: epidemiology, pathophysiology, diagnosis and management. CNS Drugs 2010; 24:375-398.
Hodges JR, Miller B. The classification, genetics and neuropathology of frontotemporal dementia. Introduction to the special topic papers: Part I. Neurocase 2001;7:31-35.
McKhann GM, Albert MS, Grossman M, Miller B, Dickson D, Trojanowski JQ. Clinical and pathological diagnosis of frontotemporal dementia: report of the Work Group on Frontotemporal Dementia and Pick's Disease. Arch Neurol 2001;58:1803-1809.
Neary D, Snowden JS, Gustafson L, et al. Frontotemporal lobar degeneration: a consensus on clinical diagnostic criteria. Neurology 1998; 51:1546-1554.
Ratnavalli E, Brayne C, Dawson K, Hodges JR. The prevalence of frontotemporal dementia. Neurology2002;58:1615-1621.
Van Swieten JC, Rosso SM. Epidemiological aspects of frontotemporal dementia. Handb Clin Neurol 2008;89:331-341.
Bernardi L, Frangipane F, Smirne N, et al. Epidemiology and genetics of frontotemporal dementia: a door-to-door survey in Southern Italy. Neurobiol Aging 2012;33:2948.e1-2948.e10.
Clinical and neuropathological criteria for frontotemporal dementia. The Lund and Manchester Groups. J Neurol Neurosurg Psychiatry 1994; 57:416-418.
Rabinovici GD, Rascovsky K, Miller BL. Frontotemporal lobar degeneration: clinical and pathologic overview. Handb Clin Neurol2008;89:343-364.
Neary D, Snowden JS, Gustafson L, et al. Frontotemporal lobar degeneration: a consensus on clinical diagnostic criteria. Neurology1998;51: 1546-1554.
Kertesz A, McMonagle P, Blair M, Davidson W, Munoz DG. The evolution and pathology of frontotemporal dementia. Brain 2005;128:1996-2005.
Gorno-Tempini ML, Hillis AE, Weintraub S, et al. Classification of primary progressive aphasia and its variants. Neurology2011;76:1006-1014.
Leyton CE, Hodges JR. Frontotemporal dementias: Recent advances and current controversies. Ann Indian Acad Neurol 2010;13(Suppl 2):S74-S80.
Kirshner HS. Frontotemporal dementia and primary progressive aphasia: an update. Curr Neurol Neurosci Rep 2010;10:504-511.
Andreasen N, Blennow K, Sjödin C, Winblad B, Svärdsudd K. Prevalence and incidence of clinically diagnosed memory impairments in a geographically defined general population in Sweden. The Piteå Dementia Project. Neuroepidemiology 1999;18:144-155.
Knopman DS, Roberts RO. Estimating the number of persons with frontotemporal lobar degeneration in the US population. J Mol Neurosc 2011;45:330-335.
Borroni B, Alberici A, Grassi M, et al. Is frontotemporal lobar degeneration a rare disorder? Evidence from a preliminary study in Brescia county, Italy. J Alzheimers Dis 2010;19:111-116.
Gilberti N, Turla M, Alberici A, et al. Prevalence of frontotemporal lobar degeneration in an isolated population: the Vallecamonica study. Neurol Sci 2012;33:899-904.
Rosso SM, Donker Kaat L, Baks T, et al. Frontotemporal dementia in The Netherlands: patient characteristics and prevalence estimates from a population-based study. Brain2003;126:2016-2022.
Ikejima C, Yasuno F, Mizukami K, Sasaki M, Tanimukai S, Asada T. Prevalence and causes of early-onset dementia in Japan: a population-based study. Stroke 2009;40:2709-2714.
Harvey RJ, Skelton-Robinson M, Rossor MN. The prevalence and causes of dementia in people under the age of 65 years. J Neurol Neurosurg Psychiatry2003;74:1206-1209.
Gascón-Bayarri J, Reñé R, Del Barrio JL, et al. Prevalence of dementia subtypes in El Prat de Llobregat, Catalonia, Spain: the PRATICON study. Neuroepidemiology 2007;28:224-234.
Gislason TB, Sjögren M, Larsson L, Skoog I. The prevalence of frontal variant frontotemporal dementia and the frontal lobe syndrome in a population based sample of 85 year olds. J Neurol Neurosurg Psychiatry 2003;74:867-871.
Stevens T, Livingston G, Kitchen G, Manela M, Walker Z, Katona C. Islington study of dementia subtypes in the community. Br J Psychiatry 2002;180:270-276.
Wada-Isoe K, Uemura Y, Suto Y, et al. Prevalence of dementia in the rural island town of Ama-cho, Japan. Neuroepidemiology2009;32: 101-106.
Yamada T, Hattori H, Miura A, Tanabe M, Yamori Y. Prevalence of Alzheimer's disease, vascular dementia and dementia with Lewy bodies in a Japanese population. Psychiatry Clin Neurosci 2001;55:21-25.
Ferran J, Wilson K, Doran M, et al. The Early Onset Dementias: a study of clinical characteristics and service use. Int J Geriatr Psychiatry1996;11:863-869.
Herrera E Jr, Caramelli P, Silveira ASB, Nitrini R. Epidemiologic survey of dementia in a community-dwelling Brazilian population. Alzheimer Dis Assoc Disord 2002;16:103-108.
Maestre GE, Pino-Ramírez G, Molero AE, et al. The Maracaibo Aging Study: population and methodological issues. Neuroepidemiology2002;21:194-201.
Molero AE, Pino-Ramírez G, Maestre GE. High prevalence of dementia in a Caribbean population. Neuroepidemiology2007;29:107-112.
Lopes MA. Estudo epidemiológico de prevalência de demência em Ribeirão Preto; Epidemiological survey of prevalence of dementia in Ribeirão Preto. Universidade de Paulo. Faculdade de Medicina. Departamento de Psiquiatria; 2006. http://www.teses.usp.br/teses/disponiveis/5/5142/tde-18042007-110300/pt-br.php
» http://www.teses.usp.br/teses/disponiveis/5/5142/tde-18042007-110300/pt-br.php
Custodio N, García A, Montesinos R, Escobar J, Bendezú L. Prevalencia de demencia en una población urbana de Lima-Perú: estudio puerta a puerta. An fac Med 2008;69:233-238.
Yamada T, Hattori H, Miura A, Tanabe M, Yamori Y. Prevalence of Alzheimer's disease, vascular dementia and dementia with Lewy bodies in a Japanese population. Psychiatry Clin Neurosci2001;55:21-25.

Publication Dates

Publication in this collection
Jan-Mar 2013

History

Received
10 Dec 2012
Accepted
13 Feb 2013

This is an open-access article distributed under the terms of the Creative Commons Attribution License

[1] Centro Latinoamericano y Caribeño de Demografía. Los adultos mayores en América Latina y el Caribe: datos e indicadores. Santiago, Chile; 2002.

[2] Ferri CP, Prince M, Brayne C, et al. Global prevalence of dementia: a Delphi consensus study. Lancet 2005;366:2112-2117.

[3] Prince M, Jackson J. Alzheimer's disease international world alzheimer report 2009. Alzheimer's Disease International; 2009.

[4] Prince M. Methodological issues for population-based research into dementia in developing countries. A position paper from the 10/66 Dementia Research Group. Int J Geriatr Psychiatry 2000;15:21-30.

[5] Nitrini R, Bottino CMC, Albala C, et al. Prevalence of dementia in Latin America: a collaborative study of population-based cohorts. Int Psychogeriatr 2009;21:622-630.

[6] Ren RJ, Huang Y, Xu G, et al. History, Present, and Progress of Frontotemporal Dementia in China: A Systematic Review. Int J Alzheimers Dis 2012;2012:587215.

[7] Rabinovici GD, Miller BL. Frontotemporal lobar degeneration: epidemiology, pathophysiology, diagnosis and management. CNS Drugs 2010; 24:375-398.

[8] Hodges JR, Miller B. The classification, genetics and neuropathology of frontotemporal dementia. Introduction to the special topic papers: Part I. Neurocase 2001;7:31-35.

[9] McKhann GM, Albert MS, Grossman M, Miller B, Dickson D, Trojanowski JQ. Clinical and pathological diagnosis of frontotemporal dementia: report of the Work Group on Frontotemporal Dementia and Pick's Disease. Arch Neurol 2001;58:1803-1809.

[10] Neary D, Snowden JS, Gustafson L, et al. Frontotemporal lobar degeneration: a consensus on clinical diagnostic criteria. Neurology 1998; 51:1546-1554.

[11] Ratnavalli E, Brayne C, Dawson K, Hodges JR. The prevalence of frontotemporal dementia. Neurology2002;58:1615-1621.

[12] Van Swieten JC, Rosso SM. Epidemiological aspects of frontotemporal dementia. Handb Clin Neurol 2008;89:331-341.

[13] Bernardi L, Frangipane F, Smirne N, et al. Epidemiology and genetics of frontotemporal dementia: a door-to-door survey in Southern Italy. Neurobiol Aging 2012;33:2948.e1-2948.e10.

[14] Clinical and neuropathological criteria for frontotemporal dementia. The Lund and Manchester Groups. J Neurol Neurosurg Psychiatry 1994; 57:416-418.

[15] Rabinovici GD, Rascovsky K, Miller BL. Frontotemporal lobar degeneration: clinical and pathologic overview. Handb Clin Neurol2008;89:343-364.

[16] Neary D, Snowden JS, Gustafson L, et al. Frontotemporal lobar degeneration: a consensus on clinical diagnostic criteria. Neurology1998;51: 1546-1554.

[17] Kertesz A, McMonagle P, Blair M, Davidson W, Munoz DG. The evolution and pathology of frontotemporal dementia. Brain 2005;128:1996-2005.

[18] Gorno-Tempini ML, Hillis AE, Weintraub S, et al. Classification of primary progressive aphasia and its variants. Neurology2011;76:1006-1014.

[19] Leyton CE, Hodges JR. Frontotemporal dementias: Recent advances and current controversies. Ann Indian Acad Neurol 2010;13(Suppl 2):S74-S80.

[20] Kirshner HS. Frontotemporal dementia and primary progressive aphasia: an update. Curr Neurol Neurosci Rep 2010;10:504-511.

[21] Andreasen N, Blennow K, Sjödin C, Winblad B, Svärdsudd K. Prevalence and incidence of clinically diagnosed memory impairments in a geographically defined general population in Sweden. The Piteå Dementia Project. Neuroepidemiology 1999;18:144-155.

[22] Knopman DS, Roberts RO. Estimating the number of persons with frontotemporal lobar degeneration in the US population. J Mol Neurosc 2011;45:330-335.

[23] Borroni B, Alberici A, Grassi M, et al. Is frontotemporal lobar degeneration a rare disorder? Evidence from a preliminary study in Brescia county, Italy. J Alzheimers Dis 2010;19:111-116.

[24] Gilberti N, Turla M, Alberici A, et al. Prevalence of frontotemporal lobar degeneration in an isolated population: the Vallecamonica study. Neurol Sci 2012;33:899-904.

[25] Rosso SM, Donker Kaat L, Baks T, et al. Frontotemporal dementia in The Netherlands: patient characteristics and prevalence estimates from a population-based study. Brain2003;126:2016-2022.

[26] Ikejima C, Yasuno F, Mizukami K, Sasaki M, Tanimukai S, Asada T. Prevalence and causes of early-onset dementia in Japan: a population-based study. Stroke 2009;40:2709-2714.

[27] Harvey RJ, Skelton-Robinson M, Rossor MN. The prevalence and causes of dementia in people under the age of 65 years. J Neurol Neurosurg Psychiatry2003;74:1206-1209.

[28] Gascón-Bayarri J, Reñé R, Del Barrio JL, et al. Prevalence of dementia subtypes in El Prat de Llobregat, Catalonia, Spain: the PRATICON study. Neuroepidemiology 2007;28:224-234.

[29] Gislason TB, Sjögren M, Larsson L, Skoog I. The prevalence of frontal variant frontotemporal dementia and the frontal lobe syndrome in a population based sample of 85 year olds. J Neurol Neurosurg Psychiatry 2003;74:867-871.

[30] Stevens T, Livingston G, Kitchen G, Manela M, Walker Z, Katona C. Islington study of dementia subtypes in the community. Br J Psychiatry 2002;180:270-276.

[31] Wada-Isoe K, Uemura Y, Suto Y, et al. Prevalence of dementia in the rural island town of Ama-cho, Japan. Neuroepidemiology2009;32: 101-106.

[32] Yamada T, Hattori H, Miura A, Tanabe M, Yamori Y. Prevalence of Alzheimer's disease, vascular dementia and dementia with Lewy bodies in a Japanese population. Psychiatry Clin Neurosci 2001;55:21-25.

[33] Ferran J, Wilson K, Doran M, et al. The Early Onset Dementias: a study of clinical characteristics and service use. Int J Geriatr Psychiatry1996;11:863-869.

[34] Herrera E Jr, Caramelli P, Silveira ASB, Nitrini R. Epidemiologic survey of dementia in a community-dwelling Brazilian population. Alzheimer Dis Assoc Disord 2002;16:103-108.

[35] Maestre GE, Pino-Ramírez G, Molero AE, et al. The Maracaibo Aging Study: population and methodological issues. Neuroepidemiology2002;21:194-201.

[36] Molero AE, Pino-Ramírez G, Maestre GE. High prevalence of dementia in a Caribbean population. Neuroepidemiology2007;29:107-112.

[37] Lopes MA. Estudo epidemiológico de prevalência de demência em Ribeirão Preto; Epidemiological survey of prevalence of dementia in Ribeirão Preto. Universidade de Paulo. Faculdade de Medicina. Departamento de Psiquiatria; 2006. http://www.teses.usp.br/teses/disponiveis/5/5142/tde-18042007-110300/pt-br.php
» http://www.teses.usp.br/teses/disponiveis/5/5142/tde-18042007-110300/pt-br.php

[38] Custodio N, García A, Montesinos R, Escobar J, Bendezú L. Prevalencia de demencia en una población urbana de Lima-Perú: estudio puerta a puerta. An fac Med 2008;69:233-238.

[39] Yamada T, Hattori H, Miura A, Tanabe M, Yamori Y. Prevalence of Alzheimer's disease, vascular dementia and dementia with Lewy bodies in a Japanese population. Psychiatry Clin Neurosci2001;55:21-25.

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