Acessibilidade / Reportar erro

Action/Verb processing: Debates in neuroimaging and the contribution of studies in patients with Parkinson's disease

Processamento de verbos de ação: debates sobre neuroimagem e contribuição de estudos em pacientes com doença de Parkinson

ABSTRACT

The objective of the current review was to verify whether studies investigating lexical-semantic difficulties in patients with Parkinson's disease (PD) support the Embodied Cognition model. Under this framework, it is predicted that patients with PD will have more difficulties in the semantic processing of action concepts (action verbs) than of motionless objects. We also verified how and whether these studies are following current debates of Neuroscience, particularly the debate between the Lexical and the Embodied Cognition models. Recent neuroimaging studies on the neural basis of the semantics of verbs were presented, as well as others that focused on the neural processing of verbs in PD. We concluded that few studies suitably verified the Embodied Cognition theory in the context of PD, especially using neuroimaging techniques. These limitations show there is much to investigate on the semantic difficulties with action verbs in these patients, where it is particularly important to control for psycholinguistic variables and the inherent semantic characteristics of verbs in future studies.

Key words:
Parkinson's disease; language disorders; semantics

RESUMO

O objetivo deste trabalho foi verificar se estudos sobre dificuldades léxico-semânticas de pacientes com doença de Parkinson (DP) confirmam o modelo da Cognição Incorporada. Este propõe que pacientes com DP terão mais dificuldade no processamento semântico de conceitos de ações (verbos de ação) do que de objetos estáticos. Também verificamos se estes estudos seguem os debates atuais da Neurociência, e especialmente o debate entre o Modelo Lexical e a Cognição Incorporada. Estudos recentes sobre as bases neurais da semântica de verbos coletados através de neuroimagem foram descritos e após, foram apresentados aqueles que focalizaram o processamento neural de verbos em pacientes com DP. Concluímos que ainda existem poucos estudos que verificaram adequadamente a teoria da Cognição Incorporada no contexto da DP, especialmente utilizando neuroimagem. Estas limitações mostram que ainda existe muito para ser investigado sobre dificuldades semânticas de verbos nestes pacientes, principalmente controlando variáveis psicolinguísticas e características semânticas inerentes dos verbos.

Palavras-chave:
doença de Parkinson; distúrbios de linguagem; semântica

Texto completo disponível apenas em PDF.

Full text available only in PDF format.

References

  • 1
    Vinson DP, Druks J, Barber H, Cappa S. Nouns and verbs in the brain:A review of behavioural, electrophysiological, neuropsycho logical and imaging studies. Neurosci Biobehav R 2011;35:407-426.
  • 2
    Shapiro L. Embodied Cognition: New problems of Phiosophy. Rout ledge, New York, 2011.
  • 3
    Pulvermüller F., Härley M, Hummel F. Walking or Talking?: Behavioral and Neurophysiological correlations of action verb processing. Brain Lang 2001;78:143-168.
  • 4
    Crepaldi D, Berlingeri M, Paulesu E, Luzzatti C. A place for nouns and a place for verbs? A critical review of neurocognitive data on grammatical-class effects. Brain Lang2011;116:33-49.
  • 5
    Barber HA, Kousta ST, Otten LJ, Vigliocco G. Event-related potentials to event-related words: Grammatical class and semantic attributes in the representation of knowledge. Brain Res 2010;1332:65-74.
  • 6
    Lu A, Liu J, Zhang JX. Event-related potentials reveal early activation of body part representations in action concept comprehension. Neurosci Lett 2012;511:74-78.
  • 7
    Maguire MJ, Magnon G, Ogiela DA, Egbert R, Sides L. The N300 ERP component reveals developmental changes in object and action identi fication. Dev Cogn Neurosci 2013;5:1-9.
  • 8
    Pulvermüller F, Mohr B, Schleichert H. Semantic or lexico-syntactic fac tors: what determines word-class specific activity in the human brain?. Neurosci Lett1999;275:81-84.
  • 9
    Boulenger V, Roy AC, Paulignan Y, Deprez V, Jeannerod M, Nazir TA. Cross-talk between language processes and overt motor behavior in the first 200 msec of processing. J Cognitive Neurosci 2006;18:1607-1615.
  • 10
    Tonietto L, Villavicencio A, Siqueira M, Sperb TM, Parente, MAMP. A especificidade semântica como fator determinante na aquisição de ver bos. Psico 2008;39:343-351.
  • 11
    Kim M, Thompson, CK. Verb deficits in Alzheimer's disease and agram matism: implications for lexical organization. Brain Lang2004;88:1-20.
  • 12
    Moseley, R. L., Pulvermüller, F., & Shtyrov, Y. (2013). Sensorimotor se mantics on the spot: brain activity dissociates between conceptual cat egories within 150 ms. Sci Rep 2013;3:1928.
  • 13
    Klepp A, Weissler H, Niccolai V, Terhalle A, Geisler H, Schnitzler A, Bier mann-Ruben K. Neuromagnetic hand and foot motor sources recruited during action verb processing. Brain Lang2014;128:41-52.
  • 14
    Hauk O, Johnsrude I, Pulvermüller F. Somatotopic representation of action words in human motor and premotor cortex. Neuron 2004;41: 301-307.
  • 15
    Tettamanti Herrera E, Rodriguéz-Ferreiro J, Cuetos, F. The effect of mo tion content in action naming by Parkinson's disease patients. Cortex 2012;48:900-904.
  • 16
    Bak TH, Crawford LM, Hearn VC, Mathuranath PS, Hodges JH. Sub cortical dementia revisited: similarities and differences in cognitive function between Progressive Supranuclear Palsy (PSP), Corticobasal Degeneration (CBD) and Multiple System Atrophy (MSA). Neurocase 2005,11:268-273.
  • 17
    Rüschemeyer S.-A, Brass M, Friederici AD Comprehending prehend ing: Neural correlates of processing verbs with motor stems. J Cognitive Neurosci2007, 19, 855-865.
  • 18
    Tettamanti M, Buccino G, Saccuman MC, et al. Listening to action-related sentences activates fronto-parietal motor circuits. J Cognitive Neurosci2005;17:273-281.
  • 19
    Kemmerer D, Gonzalez-Castillo J, Talavage T, Patterson S, Wiley C. Neuroanatomical distribution of five semantic components of verbs: Evidence from fMRI. Brain Lang2008;107:16-43.
  • 20
    Bedny M, Caramazza A, Grosman E, Pascual-Leone A, Saxe R. Con cepts are more than percepts: the case of action verbs. J Neurosci 2008;28:11347-11353.
  • 21
    Bedny M, Caramazza A, Pascual-Leone A, Saxe R. Typical neural representations of action verbs develop without vision. Cereb Cortex2012;22:286-293.
  • 22
    Mahon BZ, Schwarzbach J, Caramazza A. The representation of tools in left parietal cortex is independent of visual experience. Psychol Sci 2010;21:764-771.
  • 23
    Sitnikova T, Holcomb PJ, Kiyonaga KA, Kuperberg GR. Two Neuro cognitive Mechanisms of Semantic Integration during the Comprehen sion of Visual Real-world Events. J Cognitive Neurosci2008;20:2037- 2057.
  • 24
    Burton, MW, Krebs-Noble D, Gullapalli RP, Berndt RS . Functional neu roimaging of grammatical class: Ambiguous and unambiguous nouns and verbs. Cognitive Neuropsych 2009, 26:148-171.
  • 25
    Repetto C, Colombo B, Cipresso P, Riva G. The effects of rTMS over the primary motor cortex: The link between action and language. Neu ropsychologia 2013;5:8-13.
  • 26
    Innocenti A, De Stefani E, Sestito M, Gentilucci M. Understanding of action-related and abstract verbs in comparison: a behavioral and TMS study. Cognitive processing 2014;15:85-92.
  • 27
    Papeo L, Lingnau A, Agosta S, Pascual-Leone A, Battelli L, Caramazza, A. The Origin of Word-related Motor Activity. Cereb Cortex2014 [Epub ahead of print].
  • 28
    Watson CE, Cardillo ER, Ianni GR, Chatterjee A. Action concepts in the brain: an activation likelihood estimation meta-analysis. J Cognitive Neurosci2013;25:1191-1205.
  • 29
    Bak TH, Hodges JR The effects of motor neuron disease on language: Further evidence. Brain Lang2004, 89:354-361.
  • 30
    Bak T, Yancopoulou D, Nestor PJ, et al. Clinical, imaging and patho logical correlates of a hereditary deficit in verb and action. Brain 2006; 129:321-332.
  • 31
    Goetz CG. Charcot and Parkinson's Disease. In: Factor SA, Weiner WJ (Edited by) Parkinson's Disease: Diagnosis and clinical management. New York: Demos Medical Publishing, 2008. cap.3, p.21-32.
  • 32
    Kemmerer D, Miller L, MacPherson MK, Huber J, Tranel D. An Inves tigation of semantic similarity judgments about action and non-actions verbs in Parkinson's disease: Implications for the embodied cognition framework. Front Human Neurosci 2013;7:1-19.
  • 33
    Cardona JF, Gershanik O, Gelormini-Lezana C, et al. Action-verb pro cessing in Parkinsons disease: new pathways for motor-language cou pling. Brain Struct Funct 2013;218:1355-1373.
  • 34
    Cotelli M, Borroni B, Manenti R, et al. Action and object naming in Par kinson's disease without dementia. Eur J Neurol 2007;14:632-637.
  • 35
    Silveri MC, Ciccarelli N, Baldonero E, et al. Effects of stimulation of sub thalamic nucleus on naming and reading nouns and verbs in Parkin son's disease. Neuropsychologia 2012;50:1980-1989.
  • 36
    Mahon BZ, Caramazza A. A critical look at the Embodied Cognition Hypothesis and a new proposal for grounding conceptual content. J Physiol-Paris 2008;102:59-70.
  • 37
    Péran P, Nemmi F, Méligne D, et al. Effect of levodopa in both verbal and motor representation of action in Parkinson's disease: A fMRI study. Brain Lang2013;125:324-329.
  • 38
    Péran P, Cardebat D, Cherunbini A, et al. Object naming and action-verb generation in Parkinson's disease: A fMRI study. Cortex2009;45: 960-971.
  • 39
    Herrera E, Cuetos F. Semantic disturbance for verbs in Parkinson's disease patients off medication. Journal of Neurolinguist 2013;26: 737-744.
  • 40
    Fernandino L, Conant LL, Binder JR, et al. Where is the action? Action-sentence processing in Parkinson's disease. Neuropsychologia2013; 51:1510-1517.
  • 41
    Boulenger V, Mechtouff L, Thobois S, Broussolle E, Jeannerod M, Nazir TA. Word processing in Parkinson's disease is impaired for action verbs but not for concrete nouns. Neuropsychologia2008;46:743-756.
  • 42
    Ibáñez A, Cardona JF, Santos YV, et al. Motor-language coupling: direct evidence from early Parkinson's disease and intracranial cortical record ings. Cortex2013;49:968-984.
  • 43
    Fernandino L, Conant LL, Binder JR, et al. Parkinson's disease disrupts both automatic and controlled processing of action verbs. Brain Lang2013;127:65-74.
  • 44
    Herrera E, Rodríguez-Ferreiro J, Cuetos F. The effect of motion con tent in action naming by Parkinson's disease patients. Cortex2012;48: 900-904.
  • 45
    Mätzig S, Druks J, Masterson J, Vigliocco G. Noun and verb differences in picture naming: past studies and new evidence. Cortex2009;45: 738-758.
  • 46
    Van Dam WO, Rueschemeyer S-A, Bekkering H . How specifically are action verbs represented in the neural motor system: An fMRI study. NeuroImage 2010;53:1318-1325.
  • 47
    Letter MD, Borsel JV, Santes, P . An electrophysiological investigation of the effects of levodopa in semantic comprehension of actions words in Parkinson's disease. J Neurolinguist 2012;25:95-103.
  • 48
    Crescentini C, Mondolo F, Biasutti E, Shallice T. Supervisory and routine processes in noun and verb generation in nondemented patientes with Parkinson's disease. Neuropsychologia2008;46:434-447.
  • 49
    Herrera E, Cuetos F, Ribacoba R. Verbal fluency in Parkinson's disease patients on/off dopamine medication. Neuropsychologia2012;50: 3636-3640.
  • 50
    Bertella L, Albani G, Greco E, et al. Noun verb dissociation in Parkin son's disease. Brain Cogn 2002;48:277-280.
  • 51
    Péran P, Rascol O, Démonet JF, et al. Deficit of verb generation in nondemented patients with Parkinson's disease. Mov Disord 2003;18: 150-156.
  • 52
    Castner JE, Chenery HJ, et al. Effects of subthalamic deep brain stimula tion on noun/verb generation and selection from competing alternatives in Parkinson's disease. J Neurol Neurosurg Psychiatr 2008;79:700-705.
  • 53
    Rodríguez-Ferreiro J, Menéndez M, Ribacoba R, Cuetos F. Action naming is impaired in Parkinson's disease patients. Neuropsychologia2009;47:3271-3274.

Publication Dates

  • Publication in this collection
    Jan-Mar 2014

History

  • Received
    10 Dec 2013
  • Accepted
    10 Feb 2014
Academia Brasileira de Neurologia, Departamento de Neurologia Cognitiva e Envelhecimento R. Vergueiro, 1353 sl.1404 - Ed. Top Towers Offices, Torre Norte, São Paulo, SP, Brazil, CEP 04101-000, Tel.: +55 11 5084-9463 | +55 11 5083-3876 - São Paulo - SP - Brazil
E-mail: revistadementia@abneuro.org.br | demneuropsy@uol.com.br