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Dementia & Neuropsychologia

Print version ISSN 1980-5764

Dement. neuropsychol. vol.8 no.2 São Paulo June 2014

http://dx.doi.org/10.1590/S1980-57642014DN82000009 

ORIGINAL ARTICLES

A systematic review and meta-analysis of the diagnostic accuracy of the Phototest for cognitive impairment and dementia

REVISÃO SISTEMÁTICA E META-ANÁLISE DA ACURÁCIA DIAGNÓSTICA DO PHOTOTEST EM COMPROMETIMENTO COGNITIVO E DEMÊNCIA

Cristóbal Carnero-Pardo1  2 

Samuel Lopez-Alcalde1  2 

Ricardo Francisco Allegri3 

María Julieta Russo3 

1Cognitive Behavioral Neurology Unit, Service of Neurology, Hospital Universitario Virgen de las Nieves, Granada, Spain.

2FIDYAN Neurocenter, Granada, España.

3Department of Cognitive Neurology, Instituto de Investigaciones Neurológicas Raúl Carrea (FLENI), Buenos Aires, Argentina.

Abstract

The recently developed Phototest is a simple, easy and very brief test for detecting cognitive impairment or dementia.

Objective:

To evaluate the diagnostic accuracy of the Phototest for detecting cognitive impairment or dementia.

Methods:

We used a manually created database to search for studies evaluating the Phototest diagnostic yield and performed an initial meta-analysis to determine sensitivity (Sn) and specificity (Sp) of diagnostic parameters. We also performed a second meta-analysis of individual participant data.

Results:

In total, 6 studies were included in the meta-analysis. For dementia, Sn was 0.85 (95% CI, 0.82-0.88) and Sp 0.87 (95% CI, 0.85-0.99); for cognitive impairment, Sn was 0.80 (95% CI, 0.77-0.92) and Sp 0.88 (95% CI, 0.86-0.90). In the individual data meta-analysis, 1565 subjects were included, where best cut-off points for dementia and for cognitive impairment were 26/27 (Sn=0.89 (95% CI 0.85-0.91), Sp=0.84 (95% CI, 0.82-0.91)) and 28/29 (Sn=0.79 (95% CI, 0.76-0.81), Sp=0.88 (95% CI, 0.86-0.90)), respectively.

Conclusion:

Phototest has good diagnostic accuracy for dementia and cognitive impairment. It is brief, simple and can be used in illiterate persons. This makes it suitable for use in primary care settings and/or in subjects with low educational level.

Key words meta-analysis; screening; detection; cognitive impairment; phototest; dementia

RESUMO

Phototest é um teste simples, fácil e muito rápido para detecção de comprometimento cognitivo e demência recentemente desenvolvido.

Objetivo:

Avaliar a acurácia diagnostica do Phototest para detecção de comprometimento cognitivo e demência.

Métodos:

Nós usamos um banco de dados manualmente criado para estudos que avaliassem a capacidade diagnóstica do Phototest e realizamos uma meta-análise para determinar a sensibilidade (Sn) e especificidade (Ep) dos parâmetros diagnósticos. Nós também realizamos uma segunda meta-análise dos dados individuais dos participantes.

Resultados:

Um total de seis estudos foram incluídos na meta-análise. Para demência a Sn foi 0.85 (95% CI, 0,82-0,88) e Ep 0,87 (95% CI, 0,85-0,99); para comprometimento cognitivo a Sn foi 0,80 (95% CI, 0,77-0,92) e Sp 0,88 (95% CI, 0,86-0,90). Na meta-análise de dados individuais, 1565 foram incluídos, os melhores escores de corte para demência e para comprometimento cognitivo foram 26/27 (Sn=0,89 (95% CI 0,85-0,91), Ep=0,84 (95% CI, 0,82-0,91)) e 28/29 (Sn=0,79 (95% CI, 0,76-0,81), Ep=0,88 (95% CI, 0,86-0,90)), respectivamente.

Conclusão:

Photest tem boa acurácia diagnostica para demência e comprometimento cognitivo. É breve, simples e pode ser usado em pessoas analfabetas. Tornando-o apropriado para o uso em cuidados primários e/ou sujeitos com baixo nível educacional.

Palavras-chave meta-análise; rastreio; detecção; comprometimento cogntivo; phototest; demência

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Full text available only in PDF format.

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Received: March 20, 2014; Accepted: May 30, 2014

Cristóbal Carnero Pardo. Service of Neurology, Hospital Universitario Virgen de las Nieves. Avenida de Madrid s/n -18014 - Granada Spain. E-mail: ccarnero@neurocenter.es

Disclosure: The authors report no conflicts of interest.

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