SciELO - Scientific Electronic Library Online

vol.13 issue3Subjective memory complaint and its relationship with cognitive changes and physical vulnerability of community-dwelling older adultsFranz Nissl (1860-1919), noted neuropsychiatrist and neuropathologist, staining the neuron, but not limiting it author indexsubject indexarticles search
Home Pagealphabetic serial listing  

Services on Demand




Related links


Dementia & Neuropsychologia

Print version ISSN 1980-5764On-line version ISSN 1980-5764

Dement. neuropsychol. vol.13 no.3 São Paulo July/Sept. 2019  Epub Sep 23, 2019 

Neuroimaging Through Clinical Cases

[18F]FDG-PET in a case of right temporal lobe variant of frontotemporal dementia


Marcelo Houat de Brito1

Thiago Bezerra Moraes Teixeira1 

Poliana Fonseca Zampieri2 

Artur Martins Coutinho2 

Sonia Maria Dozzi Brucki1 

1Hospital das Clínicas, University of São Paulo School of Medicine, Department of Neurology, São Paulo, SP, Brazil.

2Hospital das Clínicas, University of Sao Paulo School of Medicine, Nuclear Medicine Center, Department of Radiology, São Paulo, SP, Brazil.

Key words: positron-emission tomography; fluorodeoxyglucose F18; frontotemporal dementia

Palavras-chave: tomografia por emissão de pósitrons; fluordeoxiglicose F18; demência frontotemporal

A 61-year-old woman presented with a 4-year history of slowly progressive amnestic and topographical disorientation symptoms, followed by an early onset of apathy, hyperorality, ritualistic behaviors, prosopagnosia, and phonagnosia. Due to diagnostic uncertainty between Frontotemporal Dementia (FTD) and Alzheimer's Disease (AD) pathology, CSF biomarker analysis and brain [18F]FDG-PET were ordered. The first proved negative for AD profile, and the latter demonstrated marked hypometabolism in the right temporal and frontal lobes, areas that also had asymmetric atrophy on brain MRI. These findings, together with the clinical picture, were compatible with the hypothesis of a right temporal lobe variant of FTD.1,2

Figure Upper row - A1, A2: [18F]FDG-PET transaxial images showing prominent hypometabolism in the right temporal lobe and, to a lesser degree, in the right frontal and parietal lobes, particularly orbitofrontal areas. B - transaxial T2 FLAIR MRI image showing selective right temporal atrophy. Lower row - C1: a 3D-SSP reconstruction (inferior view) showing prominent hypometabolism in the right temporal lobe and right orbitofrontal cortex. C2 - 3D-SSP projection of comparison with a group of healthy age-matched individuals. Red areas indicate areas of lower metabolism than expected 423x423mm (72 x 72 DPI). 

This study was conducted at Hospital das Clínicas, University of Sao Paulo School of Medicine, São Paulo, SP, Brazil.


1 Foster NL, Heidebrink JL, Clark CM, et al. FDG-PET improves accuracy in distinguishing frontotemporal dementia and Alzheimer's disease. Brain 2007;130(Pt 10):2616-35. [ Links ]

2 Seeley WW, Bauer AM, Miller BL, et al. The natural history of temporal variant frontotemporal dementia. Neurology 2005;64:1384-90. [ Links ]

Received: March 27, 2019; Accepted: June 13, 2019

Marcelo Houat de Brito. Divisão de Clínica Neurológica do Hospital das Clínicas da FMUSP / Secretaria da Neurologia, Instituto Central - Av.Dr. Enéas de Carvalho Aguiar, 255 / 5º andar, sala 5084 - Cerqueira César - 05403-900 São Paulo SP - Brazil. E-mail:

Disclosure: The authors report no conflicts of interest.

Author contributions. All authors contributed significantly and approved, the content of this manuscript.

Creative Commons License This is an Open Access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.