Scrotal reconstruction after Fournier’s gangrene

ABSTRACT

Introduction:

Fournier’s gangrene is a polybacterial infection, usually caused by anaerobic and aerobic bacteria, characterized by scrotal and perineal necrotizing fasciitis. Its treatment is based on surgical intervention by excision of the necrotic area and early antibiotic therapy. There are several strategies to reconstruct the defect resulting from debridement, and it should be noted that tissue losses greater than 50% are usually reconstructed with flaps.

Methods:

Retrospective analysis of the series of cases of scrotal reconstruction after Fournier’s gangrene performed by the authors throughout 2020, totaling eight patients.

Results:

The most used flap was thigh fasciocutaneous flap, which presented a partial necrosis rate of 14.29%, without total necrosis. In one of the cases, it was possible to reconstruct a spongy urethra with gracilis muscle without fistulization, preventing the patient from undergoing a definitive urethrostomy. As for complications, the occurrence of minor complications that required simple revision procedures was common. The prevalence of 75% of diabetes mellitus in our series is highlighted, which may have negatively interfered with the healing process.

Conclusion:

Scrotal reconstruction with flaps is important to accelerate wound healing from Fournier gangrene debridement and to maintain the pouch aspect necessary for testicular thermoregulation. Our primary option was thigh fasciocutaneous flap, which proved to be safe. And minor complications were frequent in this series, without compromising the final result.

Keywords:
Fournier gangrene; Fasciitis; Fasciitis, necrotizing; Scrotum; Reconstructive surgical procedures

RESUMO

Introdução:

Gangrena de Fournier é uma infecção polibacteriana, geralmente causada por bactérias anaeróbias e aeróbias, sendo caracterizada por fasciite necrosante escrotal e perineal. Seu tratamento é embasado em intervenção cirúrgica com excisão da área necrótica e antibioticoterapia precoces. Diversas são as estratégias de reconstrução do defeito resultante do desbridamento, devendo ser salientado que perdas teciduais maiores do que 50% costumam ser reconstruídas com retalhos.

Métodos:

Análise retrospectiva da série de casos de reconstrução escrotal após gangrena de Fournier procedidos pelos autores ao longo de 2020, totalizando oito pacientes.

Resultados:

O retalho mais utilizado foi o fasciocutâneo de coxa, que apresentou taxa de necrose parcial de 14,29%, sem necrose total. Em um dos casos foi possível reconstruir uma uretra esponjosa com músculo grácil sem fistulização, evitando que o paciente fosse submetido a uma uretrostomia definitiva. Quanto às complicações, foi comum a ocorrência de intercorrências menores que necessitaram de procedimentos revisionais simples. Destaca-se a prevalência de 75% de diabetes mellitus em nossa casuística, o que pode ter interferido negativamente no processo cicatricial.

Conclusão:

A reconstrução escrotal com retalhos é importante para acelerar a cicatrização da ferida proveniente do desbridamento de gangrena de Fournier e para manter o aspecto de bolsa necessário para a termorregulação do testículo. Nossa opção primária foi o retalho fasciocutâneo de coxa, que se mostrou seguro. Pequenas intercorrências foram frequentes nesta série, sem comprometimento do resultado final.

Descritores:
Gangrena de Fournier; Fasciite; Fasciite necrosante; Escroto; Procedimentos cirúrgicos reconstrutivos

INTRODUCTION

Fournier’s gangrene (Figure 1) is a term that was first described in 1883 by Alfred Fournier to designate necrotizing fasciitis that affects the scrotum and perineum. It has a polybacterial etiology, usually caused by anaerobic and aerobic bacteria¹. It is an infection of rapid progression, with a high potential for severity (high rates of morbidity and mortality), being more common in males². Its risk factors are diabetes mellitus, alcoholism, obesity, local trauma, perianal and perineal infections, and surgical procedures in the region¹. The treatment is based on surgical intervention with early excision of the necrotic area and antibiotic therapy, which may require reapproaches with the expansion of the debrided area².

Figure 1
Aspect of a scrotum affected by Fournier’s gangrene. Areas of induration, hyperemia, and wound drainage with fetid purulent secretion are common.

There are several strategies for reconstructing the bloody area resulting from debridement. Small wounds with tissue loss of up to 50% of the scrotum can generally be treated with secondary intention healing, primary synthesis and skin grafting. Larger losses are usually treated using skin, fasciocutaneous or myocutaneous flaps².

In this article, the authors’ reconstructive strategies after the debridement of eight patients with Fournier’s gangrene will be analyzed, with the fasciocutaneous thigh flap as the first option.

OBJECTIVE

To evaluate the outcome of scrotal reconstructions performed by the authors after debridement of Fournier’s gangrene and whether there are any complicating factors such as comorbidities and/or alteration of laboratory tests.

METHODS

The authors performed a retrospective analysis of the series of cases of scrotal reconstruction after Fournier’s gangrene throughout 2020 (Table 1). In all cases, one or both testicles were exposed. Medical records, photo files, albumin, and complete blood count tests were accessed immediately before the reconstructive surgical stage.

Table 1
Table with the data of each patient reconstructed after debridement of Fournier’s gangrene, including age, preoperative exams, comorbidities, the operative technique used, its complications and if any revision or secondary procedure was necessary.

Patient	Age	GL	Hb	CRP	Comorbidities	Technique	Complications	Revision
W.R.G.	46	10100	9.3	129.82	SAH	Bilateral fasciocutaneous thigh flaps	Dehiscence	Two z-plasties, resection of excess skin
S.H.M.F.	47	2786	7.46	35.8	DM	Unilateral thigh fasciocutaneous flap	No complications	None
G.M.A.	60	11540	10.65	42.5	SAH, DM, CAD	Gracilis myocutaneous flap	Partial skin island necrosis	Debridement
R.A.P.	46	4312	10.03	2.6	Alcoholism	Unilateral thigh fasciocutaneous flap	Epidermolysis	None
R.L.A.	74	12800	9.28	149.8	SAH, MD	Primary closure	Dehiscence	None
J.B.L.	48	6100	10.6	122	DM	Unilateral thigh fasciocutaneous flap	Partial necrosis	Debridement and edge reapproximation
A.F.S	51	6940	9.8	30.7	SAH, MD	Unilateral thigh fasciocutaneous flap thigh	Epidermolysis	Debridement and edge reapproximation
R.D.G.F.	48	6140	11.9	6.3	SAH, DM, asthma	Unilateral thigh fasciocutaneous flap	Dehiscence	None

GL=WBC total (WBC/microL); Hb=hemoglobin (g/dL); CRP=C-reactive protein (mg/L); SAH=systemic arterial hypertension); DM=diabetes mellitus; CAD=coronary artery disease

The total number of patients was eight, and the primary surgical option was the fasciocutaneous thigh flap, which was used on six occasions. The two exceptions were due to a urethral injury or inadequate clinical conditions for a larger reconstruction.

RESULTS

The authors’ first option for making the neoscrotum after debridement of Fournier’s gangrene was the unilateral thigh fasciocutaneous flap (Figures 2 to 5). Using two flaps from both thighs was reserved for a patient with a more extensive open wound (Figures 6 to 10). There was no case of total necrosis. One of the seven flaps performed evolved with partial necrosis, which is equivalent to a rate of vascular damage of 14.29%.

Figure 2
Unilateral fasciocutaneous thigh flap.

Figure 3
Marking of a unilateral thigh fasciocutaneous flap. Note that this patient’s thigh has a reduced circumference.

Figure 4
Photo showing the superomedial pedicle of the flap marked in Figure 3. It is possible to identify the following muscles in the dissection (from posterior to anterior region): adductor magnus, gracilis, vastus medialis, adductor longus and sartorius.

Figure 5
Due to the reduced thickness of this patient’s thigh, as seen in Figure 4, it was decided to perform skin grafting on the thigh to reduce tension during closure. The donor area was the skin already removed from the scrotum in the same surgical procedure.

Figure 6
Marking fasciocutaneous thigh flaps to cover an extensive scrotal wound after debridement of Fournier’s gangrene.

Figure 7
Dissection of fasciocutaneous thigh flaps whose markings are shown in Figure 6.

Figure 8
Transposition of the distal regions of the flaps shown in Figures 6 and 7 to the perineum. When bilateral fasciocutaneous flaps are used, they are sutured in the midline, mimicking the scrotal raphe.

Figure 9
Immediate postoperative appearance of the perineal region after scrotal reconstruction with fasciocutaneous flaps from the thighs, whose surgical steps are shown in Figures 6, 7 and 8. Note that partial skin grafting was also performed on the penis.

Figure 10
Aspect of the perineal region of the patient in Figures 6, 7, 8 and 9 one year after its reconstruction. With little more than six months, a small intervention was performed for resectioning excess skin near the glans and two zetaplasties at the base of the penis to improve aesthetics.

Another flap used in the series was the gracilis myocutaneous flap due to a urethral injury (Figures 11 to 14). There was an evolution to partial suffering of the island of skin, but the muscle tissue remained viable, making it possible to remove the urethral indwelling bladder probe and obtain a good urinary stream.

Figure 11
Patient with a large anterior urethral defect after debridement of Fournier’s gangrene. Programmed reconstruction of the urethral and bloody scrotal area in conjunction with Urology, and it was possible to observe the marking of the gracilis myocutaneous flap on the left thigh.

Figure 12
Closure of the spongy urethra defect with jugal mucosa graft on the posterior wall, lateral relaxation incisions and anterior primary synthesis. The Urology team performed this surgical step.

Figure 13
Photo showing the dominant pedicle of the gracilis muscle, originating from a branch of the deep femoral artery. Note that the muscle is already covering the reconstructed urethra to increase blood supply and decrease the chance of urinary fistula.

Figure 14
Immediate postoperative appearance of the perineal region after reconstruction with a gracilis myocutaneous flap. This patient evolved with partial necrosis of the skin island and underwent sequential debridement. After the indwelling urinary catheter was removed, there was spontaneous diuresis, with no evidence of urinary fistula one year after surgery.

And in one of the patients, we opted for the primary synthesis of the wound edges post-Fournier because he was elderly, hypertensive, diabetic, malnourished and with significant anemia, which made reconstruction using flaps unfeasible.

In addition to the two already mentioned partial necroses, five cases had minor complications: three dehiscences and two epidermolysis. As a result, four of the eight patients underwent simple revision procedures: three debridements, two of which also had the edges reapproximated, and one improvement in the aesthetic appearance through resection of excess skin and two zetaplasties.

It should be noted that the average time between the initial debridement and the reconstructive stage was 29 days. The average age of the eight patients was 52 years and six months.

As for comorbidities, the most frequent were diabetes mellitus and arterial hypertension, with respective prevalences of 75% and 62.50%. Asthma, coronary artery disease and alcoholism were also reported in 1/8 of the cases, which corresponds to a prevalence of 12.50% for each of these disorders. Regarding the preoperative revisions of the reconstructions, the averages of global leukocytes, hemoglobin and C-reactive protein were, respectively: 7590 leukocytes/microL, 9.88g/dL and 64.94mg/L.

DISCUSSION

The fasciocutaneous flap of the thigh was our main reconstructive choice because it has a reliable vascular supply with a good range of rotation, thin skin, does not leave exposed scars, is easy to perform technically, and because it preserves the musculature. On the other hand, color incompatibility, low skin sensitivity¹, and possibly inadequate thickness have been described in very obese patients.

The initial step in its marking is to draw a line from the pubic tubercle to the medial condyle of the tibia, which is the insertion site of the “pars anserina.” The vascular pedicle is then preserved in the superomedial region, and the flap length is determined according to the amount of tissue required to perform the transposition.

In most cases, using only one flap was preferred because the scrotal defects were smaller and to shorten the surgical time. The disadvantages of the unilateral flap are mentioned: the lack of mimicry of the median raphe and the greater chance of the tip suffering with the increase in the length X width ratio. Two of the five cases of unilateral thigh fasciocutaneous flap presented distal epidermolysis, while one evolved with partial necrosis. Probably something that contributed to this necrosis was the patient’s disrespect for postoperative rest.

A possible technical refinement of the thigh fasciocutaneous flap is using only one perforator of the medial circumflex femoral artery¹,². Other flaps that repair a scrotal defect are superficial circumflex iliac artery perforator flap³, free or pedicled greater omentum flap⁴,⁵, bilateral gracilis muscle flap⁶,⁷, anterolateral thigh flap⁸, inguinal flap (McGregor’s)⁹ and associated flaps to the use of expander¹⁰.

The main disadvantages of some of these techniques, which prevented them from being our choices, are high morbidity from laparotomy or laparoscopy and the possibility of inguinal hernia with the use of a great omentum flap, need for a skin graft for the omentum techniques and the bilateral gracilis muscle flap; possibility of tissue expander extrusion when it is positioned close to a contaminated wound.

Rarely, there is urethral involvement due to Fournier’s gangrene, given that the vascular supply of the urethra is different compared to the skin, subcutaneous tissue and fascia¹. As muscle flaps increase oxygen tension and, consequently, reduce the chance of urinary fistulization, we preferred the gracilis myocutaneous flap in cases in which urethral reconstruction was necessary. This muscle is Mathes and Nahai type II, with the main vascular contribution being the medial femoral circumflex artery, which is located approximately 6-10 cm from the pubic tubercle¹.

A jugal mucosal graft was also used on the posterior wall of the injured spongy urethra. The skin island of the myocutaneous flap was used to close the scrotal wound but evolved with partial necrosis and subsequent need for debridement. Perhaps an option with less probability of intercurrences would be the gracilis muscle flap associated with a partial skin graft instead of the gracilis myocutaneous flap. The balance was extremely positive since the chances of a definitive urethrostomy were not small.

In the case we primarily repaired the scrotal wound, the initial choice was early dehospitalization and postponement of reconstruction in better clinical conditions. However, the patient’s social context did not allow this strategy. This highlights the difficulty and complexity of managing surgical reconstructions in public health, where a vulnerable population is more frequent than in private services. We believe that this is a determining factor for surgical outcomes.

Other factors that may have had an unfavorable impact on the patients’ evolution are 1) High prevalence of comorbidities, especially diabetes mellitus; 2) Maintenance of an inflammatory state at the time of reconstruction, as evidenced by the C-reactive protein value; 3) Presence of anemia.

It is noteworthy that, concerning simpler reconstructive options, healing by secondary intention takes time and results in a poor aesthetic appearance⁶; while skin grafting promotes a desirable thin coverage, its fixation in the perineal region is difficult. In addition, the graft can adhere to the testicles and cause contractures that hinder the cremasteric reflex necessary for the testicles not to be affected by external conditions¹⁰. So, although there is no consensus on the best surgical option, flaps accelerate the healing process and maintain the aspect of the scrotum necessary for thermoregulation of the testicle².

CONCLUSION

Scrotal reconstruction with flaps is important to accelerate wound healing from Fournier’s gangrene debridement and to maintain the pouch appearance necessary for testicular thermoregulation. Our primary option was the thigh fasciocutaneous flap, which proved safe, with a partial necrosis rate of 14.29% and without total necrosis. It was also possible to reconstruct a spongy urethra with gracilis muscle without fistulization, preventing the patient from undergoing a definitive urethrostomy. As for complications, the occurrence of minor intercurrences that require simple revision procedures is common. This may result from important associated comorbidities and patients’ clinical conditions during reconstructive plastic surgery.

REFERÊNCIAS

• ¹
  Coskunfirat OK, Uslu A, Cinpolat A, Bektas G. Superiority of medial circumflex femoral artery perforator flap in scrotal reconstruction. Ann Plast Surg. 2011;67(5):526-30.
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  Mello DF, Helene Júnior A. Scrotal reconstruction with superomedial fasciocutaneous thigh flap. Rev Col Bras Cir. 2018;45(1):e1389.
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  Banks DW, O’Brien 3rd DP, Amerson JR, Hester Jr TR. Gracilis musculocutaneous flap scrotal reconstruction after Fournier gangrene. Urology. 1986;28(4):275-6.
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  Yu P, Sanger JR, Matloub HS, Gosain A, Larson D. Anterolateral thigh fasciocutaneous flap island flaps in perineoscrotal reconstruction. Plast Reconstr Surg. 2002;109(2):610-6. Discussion 617-8.
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  Ghahestani SM, Hekmati P, Karimi S. A new technique of scrotoplasty following total scrotal destruction by raised rotated perineal flaps with de epithelialized borders. Urol J. 2019;16(2):221-3.
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  Atik B, Tan O, Ceylan K, Etlik O, Demir C. Reconstruction of wide scrotal defect using superthin groin flap. Urology. 2006;68(2):419-22.

Publication Dates

• Publication in this collection
  30 Jan 2023
• Date of issue
  Oct-Dec 2022

History

• Received
  25 Nov 2021
• Accepted
  11 July 2022