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Journal of Coloproctology (Rio de Janeiro)

Print version ISSN 2237-9363

J. Coloproctol. (Rio J.) vol.32 no.1 Rio de Janeiro Jan./Mar. 2012

http://dx.doi.org/10.1590/S2237-93632012000100008 

ORIGINAL ARTICLE

 

Anal fistula: results of surgical treatment in a consecutive series of patients

 

 

Paulo Gonçalves de OliveiraI; João Batista de SousaII; Romulo Medeiros de AlmeidaIII; Isabel Ferreira Saenger WurmbauerIV; Antônio Carlos Nóbrega dos SantosIV; José Guilherme FilhoIV

IAssociate Professor of Surgical Clinic of the Medical School of the University of Brasilia (Universidade de Brasília - UnB); Head of the Coloproctology Department of the University Hospital at UnB - Brasília (DF), Brazil
IIAssociate Professor of Surgical Clinic of the Medical School of UnB - Brasília (DF), Brazil
IIIAssociate Professor of Surgical Clinic of the Medical School of UnB - Brasília (DF), Brazil
IVAssistent Physicians of Coloproctology Department of the University Hospital at UnB - Brasília (DF), Brazil

Correspondence to

 

 


ABSTRACT

OBJECTIVES: To evaluate the results of surgical treatment of patients with anal fistulas in a consecutive series of patients.
METHODS: A retrospective analytical study of a consecutive series of cases prospectively collected. The sample comprised 210 patients who underwent surgery; demographic data, signs and symptoms, intraoperative classification of the fistulas and healing time were analyzed.
RESULTS: The median age was 38 years and 69.0% of the patients were male. The most frequent symptom was perianal orifice with purulent drainage. The fistulas were classified as transsphincteric in 60.9% and the most used operative treatment was the marsupialization of fistulotomy, in 84.2% of cases. Complete healing occurred in all patients between 2 and 16 weeks. One hundred and seventy-eight patients, 84.8% of the patients who underwent surgery, were evaluated at least one year after surgery and recurrence occurred in 6.4% of cases.
CONCLUSIONS: There was male prevalence (2.2/1), and most fistulas were transsphincteric. The marsupialization of fistulotomy was the most used operative treatment, and it presented acceptable low rates of morbidity and recurrence of 6.4%.

Keywords: fistula; rectal fistula; surgery; classification; surgical treatment, operative.


RESUMO

OBJETIVOS: Avaliar os resultados do tratamento cirúrgico de pacientes portadores de fístulas anais em uma série consecutiva de pacientes.
MÉTODOS: Estudo analítico, retrospectivo, de uma série consecutiva de casos que foram coletados de forma prospectiva. A casuística englobou 210 pacientes operados, tendo sido analisados os dados demográficos, os sinais e sintomas, a classificação transoperatória das fístulas e o tempo até a cicatrização completa.
RESULTADOS: A mediana de idade foi de 38 anos e 69,0% dos pacientes eram homens. O sintoma mais frequente foi a drenagem de secreção purulenta por orifício perianal. As fístulas foram classificadas como transesfincterianas em 60,9%, e o tratamento operatório mais empregado foi a fistulotomia com marsupialização do trajeto fistuloso, em 84,2% dos casos. A cicatrização completa ocorreu em todos os pacientes entre 2 e 16 semanas. Cento e setenta e oito pacientes, 84,8% dos pacientes operados, foram avaliados com, pelo menos, um ano de pós-operatório e a recidiva ocorreu em 6,4% dos casos.
CONCLUSÕES: Houve prevalência do gênero masculino (2,2/1) com a maioria das fístulas transesfincterianas. A fistulotomia com marsupialização foi o tratamento operatório mais empregado e apresentou baixos índices de morbidade, com recidiva de 6,4%.

Palavras-chave: fístula; fístula retal; cirurgia; classificação; procedimentos cirúrgicos.


 

 

INTRODUCTION

Fistula is an anomalous pathway that communicates two epithelized surfaces; in case of anal fistulas, it connects the anorectal region to the skin. The internal orifice of the pathway is mostly located in the anal canal, and the external orifice is in the perianal skin, thus characterizing a chronic suppurative condition1,2.

It is a relatively common disease, with high prevalence and an important proportion among the conditions treated by the coloproctologist. It usually affects men in their 40s and male predominance estimated in most published series is of approximately 2:11-5.

Anal fistula is almost always a consequence of an anorectal abscess that was drained. While the abscess represents the acute phase of the disease, fistula represents the chronic phase. Following anorectal abscess drainage, the fistulous pathway may persist in about 1/3 of cases6-8.

The perianal abscess is mostly derived from an infection in the anal glands. However, many other conditions may cause abscess and fistulas, such as inflammatory bowel disease, fungal infection, mycobacterial infection, neoplasm and trauma1,2,7.

Considering the origin of the disease, anal fistulas may be classified as: specific or secondary to pathological process, such as Crohn's disease, ulcerative rectocolitis, tuberculosis, trauma, and other morbid conditions; and nonspecific or secondary to infection of the anal glands2,7-9.

After the abscess drainage, there may be formation of anal fistula, which will require surgical treatment in most cases6-10.

 

OBJECTIVE

To assess the demographic profile, signs, symptoms, intraoperative classification and the results of anal fistula surgery in a consecutive series of patients.

 

PATIENTS AND METHODS

Patients with anal fistulas who underwent surgery in the Coloproctology Department of the University Hospital at University of Brasilia, from January 1991 to December 2004, had their identification, anamnesis, physical and coloproctological exams, surgery report and outpatient follow-up data collected on a prospective basis. Then, these case report forms were assessed and represent the sample for this study.

Demographic data, disease-related symptoms, time elapsed between the onset of symptoms and treatment, fistulas classification according to intraoperative assessment, surgical technique, healing time and recurrent disease, abscess or incontinence in the postoperative follow-up were collected.

The preoperative diagnosis assessment was performed by a complete proctological exam in all cases and complemented by video-colonoscopy in case of suspected bowel inflammatory disease or that indicated colon assessment due to associated symptoms or tracking of neoplasm. A magnetic resonance was performed in two patients with fistulas that were considered complex.

 

RESULTS

Two hundred and ten case report forms of patients who underwent surgery between January 1991 and December 2004 were assessed. Median age was 38 years (12 to 78 years-old), being 62.8% of patients in their 30s and 40s. The predominant gender was male (69.0%), in a ratio of 2.2:1.

The most frequent symptom was the perianal orifice with purulent drainage (91.9%), followed by perianal tumorigenicity (80.0%) and pain (41.9%). The association of purulent secretion drainage with tumor and pain was referred by 38.1% of patients.

The median length between the onset of symptoms and surgical treatment was of 12 months (2 weeks to 30 years).

During the surgery, the surgeon tried to classify the fistulas according to possible sphincter impairment according to Parks11 classification. In 172 cases (81.9%), the classification could be performed safely, being the transsphincteric fistulas the most prevalent ones (Table 1).

 

 

Thirty-one (18.0%) patients presented complex fistula, including 20 with high transsphincteric, 6 with suprasphincteric and, 5 with extrasphincteric fistula. Out of the 20 high transsphincteric fistula, 6 presented horseshoe extension with deep involvement of postanal space.

The fistula origin was considered to be cryptoglandular in 91.9% of the patients, but anorectal trauma-fistulas were also observed in the orificial proctologic surgery, vaginal delivery and congenital origin (Table 2).

 

 

Previous surgical treatment was performed in 11 patients (5.2%) in other departments.

The most performed surgical treatment was the marsupialization with fistulotomy of the surgical wound (84.2%). For cases with major involvement of the sphincteric system, surgical treatment was mostly performed in two parts, and the loose seton was used in the first part, followed by fistulotomy, occasionally with the marsupialization of surgical wound in the second part in 9.5% of patients (Table 3).

 

 

In most patients, the internal orifice was identified by stylet exploration and, in other cases, by injecting coloring substances through the external orifice. The nuclear magnetic resonance was not available in the initial sampling period, but it was useful in the assessment of a patient with posterior horseshoe transsphincteric fistula following two disease relapses and in another patient to identify disease extension, contributing to the surgical approach and the success of the treatment.

Considering the minimum time of outpatient follow-up in one year, 178 (84.7%) patients were accompanied. To calculate healing time, a patient with an adverse result of approximately 28 months was withdrawn. To other patients, healing time ranged from 2 to 16 weeks, with a median of 5 weeks. Healing was complete in up to 4 weeks in 44.3% of patients and in up to 8 weeks in 78.0%.

Eleven patients were relapsed, i.e., 5.2% of patients who underwent surgery (11/210) or 6.2% of patients followed for at least one year (11/178). Out of these 11 patients, 10 underwent another fistulotomy, and the problem was resolved for 8 of them. One patient presented anal abscess in the postoperative which was resolved with simple drainage.

Six (3.3%) patients experienced fecal incontinence during follow-up and three underwent sphincteric repair with significant improvement of incontinence symptoms. Overall, the complication rate was 7.5%.

There were no deaths in the analyzed sample.

 

DISCUSSION

Clinical aspects identified in the analysis of this series of patients are similar to the ones described by other authors. The disease was predominant among men and affected mainly people in their 30s and 40s. The perianal inflammatory tumor, with purulent drainage and pain, also appeared as the most frequent symptoms, similar to other series3,9,12-14.

In preoperative investigation, the full proctological exam is crucial. Complementing it with colonoscopy is mandatory in case of suspected inflammatory disease, doubts about the diagnosis and in those patients indicated to be tracked for neoplasm. Other complementary methods for assessment have been employed, such as nuclear magnetic resonance and anorectal ultrasound in order to contribute to the planning of surgical technique7,8,15,16.

In the current study, the predominance of transsphincteric fistulas has been observed; although different from the ones mentioned by Parks, Gordon and Hardcastle11, whose model is used to classify the fistulas, they were also found by other authors as described in Table 410-13.

Fistulas presenting higher sphincteric involvement, called complex fistulas, represent a challenge to the surgeon. Among the several modalities employed for the surgical treatment, seton and mucous advance are highlighted. In the current series, seton was used in 9.5% of patients, similar data found by other authors6,7,10,13,17,18.

Most patients with anal fistula may be treated surgically; however, more conservative conducts have been raised, but still presenting high rates of recurrence. Sealing fibrin or injections of buffer solution, for instance, present low rates of incontinence, but high relapse rates19-21.

The postoperative sphincteric function, in the current study, has only been considered by patients' report, either spontaneously or by questioning, during the follow-up. By being a subjective assessment, this strategy may underestimate the occurrence of such complication. This is a frightening complication because it causes major discomfort to the patient, although its occurrence in the current series has been low [six patients (3.3%)], only three patients were successfully treated and the other three experienced permanent sequels9,10,14,22.

Up to one year, the surgical follow-up showed loss in about 15.3% of patients; however, postoperative complication rates must be underestimated. There are reports that the relapsed rates increase along with the follow-up time, evolving from 4% in two years to 6.3% in three years6,7,10.

Relapse and incontinency rates in the current study, 6.2 and 3.3%, respectively, were similar to those in other literature series (Table 5)3,10-13.

 

 

Surgeries to treat anal fistula are safe, there were no deaths associated to the procedure and only one abscess since an early postoperative complication has occurred.

Most of non-complicated anal fistula healed in 12 weeks, as the median healing period of this series was 6.3 weeks, similar to the results observed in other studies3,10,14.

The absence of standardized and internationally known classification, besides technical variation in the employment of surgical treatment, makes it difficult to compare series and, therefore, it is also difficult to establish acceptable rates of relapse and complications.

 

CONCLUSION

The assessment of this consecutive series of patients revealed disease prevalence in males aged around 30s and 40s, being transsphincteric fistula the most frequent one, with relapse and incontinence rates of 6.2 and 3.3%, respectively.

 

REFERENCES

1. Parks AG. Pathogenesis and treatment of fistula-in-ano. Br Med J 1961;1(5224):463-9.         [ Links ]

2. Parés D. Pathogenesis and treatment of fistula in ano. Br J Surg 2011;98(1):2-3.         [ Links ]

3. Mazier WP. The treatment and care of anal fistulas: a study of 1,000 patients. Dis Colon Rectum 1971;14(2):134-44.         [ Links ]

4. Sainio P. Fistula-in-ano in a defined population. Incidence and epidemiological aspects. Ann Chir Gynaecol 1984;73(4):219-24.         [ Links ]

5. Prudente ACL, Torres Neto JR, Santiago RR, Mariano DR, Vieira Filho MC. Cirurgias proctológicas em 3 anos de serviço de coloproctologia: série histórica. Rev Bras Coloproct 2009;29(1):71-7.         [ Links ]

6. Nelson R. Anorectal abscess fistula: what do we know? Surg Clin North Am 2002;82:1139-51.         [ Links ]

7. Whiteford MH, Kilkenny J 3rd, Hyman N, Buie WD, Cohen J, Orsay C, Dunn G, Perry WB, Ellis CN, Rakinic J, Gregorcyk S, Shellito P, Nelson R, Tjandra JJ, Newstead G, The Standards Practice Task Force, The American Society of Colon and Rectal Surgeons. Practice parameters for the treatment of perianal abscess and fistula-in-ano (revised). Dis Colon Rectum 2005;48:1337-42.         [ Links ]

8. Rizzo JA, Naig AL, Johnson EK. Anorectal abscess and fistula-in-ano: evidence-based management. Surg Clin North Am 2010;90(1):45-68.         [ Links ]

9. Jacob TJ, Perakath B, Keighley MR. Surgical intervention for anorectal fistula. Cochrane Database Syst Rev 2010;12(5):CD006319.         [ Links ]

10. Seow-Choen F, Phillips RK. Insights gained from the management of problematical anal fistulae at St. Mark's Hospital, 1984-88. Br J Surg 1991;78(5):539-41.         [ Links ]

11. Parks AG, Gordon PH, Hardcastle JD. A classification of fistula-in-ano. Br J Surg 1976;63(1):1-12.         [ Links ]

12. Marks CG, Ritchie JK. Anal fistulas at St. Mark's Hospital. Br J Surg 1977;64(2):84-91.         [ Links ]

13. Vasilevsky CA, Gordon PH. Results of treatment of fistula-in-ano. Dis Colon Rectum 1985;28(4):225-31.         [ Links ]

14. Malouf AJ, Buchanan GN, Carapeti EA, Rao S, Guy RJ, Westcott E, et al. A prospective audit of fistula-in-ano at St. Mark's hospital. Colorectal Dis 2002;4(1):13-9.         [ Links ]

15. Halligan S, Buchanan G. MR imaging of fistula-in-ano. Eur J Radiol 2003; 47(2):98-107.         [ Links ]

16. Murad-Regadas SM, Regadas FS, Rodrigues LV, Fernandes GO, Buchen G, Kenmoti VT, et al. Anatomic characteristics of anal fistula on three-dimensional anorectal ultrasonography. Dis Colon Rectum 2011;54(4):460-6.         [ Links ]

17. Ho YH, Tan M, Leong AF, Seow-Choen F. Marsupialization of fistulotomy wounds improves healing: a randomized controlled trial. Br J Surg 1998;85(1):105-7.         [ Links ]

18. Buchanan GN, Owen HA, Torkington J, Lunniss PJ, Nicholls RJ, Cohen CR. Long-term outcome following loose-seton technique for external sphincter preservation in complex anal fistula. Br J Surg 2004;91(4):476-80.         [ Links ]

19. Pandini, LC. Tract length predicts successful closure with anal fistula plug in cryptoglandular fistulas. Rev Bras Coloproct. 2010;30(3):378-9.         [ Links ]

20. Lopes-Paulo F. O emprego da cola de fibrina no tratamento das fístulas anais. Rev Bras Coloproct 2006;26(1):86-8.         [ Links ]

21. Cirocchi R, Farinella E, La Mura F, Cattorini L, Rossetti B, Milani D, et al. Fibrin glue in the treatment of anal fistula: a systematic review. Ann Surg Innov Res 2009;3:12.         [ Links ]

22. Steckert JS, Sartor MC, Miranda EF, Rocha JG, Martins JF, Wollmann MCFAS, et al. Análise das complicações tardias em operações anorretais: experiência de um serviço de referência em coloproctologia. Rev Bras Coloproct 2010;30(3):305-17.         [ Links ]

 

 

Correspondence to:
Paulo Gonçalves de Oliveira
Área de Clínica Cirúrgica da Faculdade de Medicina da Universidade de Brasília
Campus Universitário Darcy Ribeiro, Asa Norte
CEP: 70910-900 - Brasília (DF), Brazil
E-mail: pgofmunb@unb.br

Submitted on: 09/26/2011
Approved on: 11/25/2011
Financing source: none.
Conflict of interest: nothing to declare.

 

 

Study carried out at the Coloproctology Department of the University Hospital at the Medical School of the University of Brasilia (UnB) - Brasília (DF), Brazil.