Comparison of tranexamic acid and stapling line reinforcement in laparoscopic sleeve gastrectomy in postoperative bleeding outcomes

Brito, Roger Moura de; Oliveira, Caio Marcio Barros de; Moura, Ed Carlos Rey; Campelo, Giuliano Peixoto; Lima, Roclides Castro de; Servin, Elizabeth Teixeira Noguera; Gomes, Lyvia Maria Rodrigues de Sousa; Fe, Ciro Sousa de Moura; Oliveira, Eduardo José Silva Gomes de; Leal, Plínio da Cunha

doi:10.1016/j.bjane.2022.10.006

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Brazilian Journal of Anesthesiology

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LETTER TO THE EDITOR • para Braz. J. Anesthesiol. 73 (3) • May-Jun 2023 • https://doi.org/10.1016/j.bjane.2022.10.006 copy

Comparison of tranexamic acid and stapling line reinforcement in laparoscopic sleeve gastrectomy in postoperative bleeding outcomes

Authorship SCIMAGO INSTITUTIONS RANKINGS

Dear Editor,

Laparoscopic Sleeve Gastrectomy (LSG) is a type of bariatric surgery considered safe and technically simpler to perform than gastric bypass. One risk of this technique is bleeding in the staple line, with an incidence of up to 10%.¹1 Chakravartty S, Sarma DR, Chang A, Patel AG. Staple Line Bleeding in Sleeve Gastrectomy – a Simple and Cost-Effective Solution. ObesSurg. 2016;26:1422–8., ²2 Choi YY, Bae J, Hur KY, Choi D, Kim YJ. Reinforcing the Staple Line During Laparoscopic Sleeve Gastrectomy: Does It Have Advantages? A Meta-analysis. ObesSurg. 2012;22:1206–13.

The option of using Tranexamic Acid (TXA) as an auxiliary method to reduce bleeding is a possibility and has the advantages of low cost and fast execution.¹1 Chakravartty S, Sarma DR, Chang A, Patel AG. Staple Line Bleeding in Sleeve Gastrectomy – a Simple and Cost-Effective Solution. ObesSurg. 2016;26:1422–8. A dose of 1g has been suggested to produce a reduction in bleeding that is not improved by giving higher doses and is likely to be sufficient for most adults.³3 Hunt BJ. The current place of tranexamic acid in the management of bleeding. Anaesthesia. 2015;70:50–e18., ⁴4 Ker K, Prieto-Merino D, Roberts I. Systematic review, meta-analysis and meta-regression of the effect of tranexamic acid on surgical blood loss. Br J Surg. 2013;100:1271–9.

Due to the small number of studies on the use of TXA and the controversial results in Staple line Reinforcement (SR) techniques in bariatric surgeries, the authors decided to compare the efficacy of SR and the use of TXA in the reduction of complications of the LSG technique.

The study was a prospective, comparative, double-blind, non-randomized clinical trial, approved by the institutional Research Ethics Committee (CAAE 95198518.9.0000.5085/Number 4.058.659) and registered in the Brazilian Registry of Clinical Trials (REBEC RBR-4w39gz). Patients aged 18 to 65 years, American Society of Anesthesiologists (ASA) physical status II or III, who underwent LSG from January 2019 to June 2020 were included in the study.

The selected patients either received venous tranexamic acid (1g) at anesthesia induction (TXA Group), no intervention (Control Group – CG), or received Staple line Reinforcement (SR group) without TXA. Perioperative care protocols were the same for all groups.

To help minimize potential bias induced due to non-randomization, the researchers who collected the data and measured the outcomes did not know which group each patient belonged to. The sample size calculation was an estimated n of 90, with a confidence level of 95% and a margin of error of 5%.

Clinical and surgical data were collected. Data from laboratory tests were also collected at the time anesthesia was administered and 24 h postoperatively. Intraoperative bleeding was evaluated by the number of hemostatic interventions performed to control the bleeding points in the staple line. Estimated intraoperative bleeding was assessed by weighing the gauze and the volume of blood found in the suction pump reservoir at the end of the operation. Postoperative bleeding was evaluated in patients who underwent reoperations, and a comparative quantitative evaluation was performed of the hematological data obtained by laboratory tests at the time anesthesia was administered and 24 h postoperatively (Table 1).

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Table 1
Comparation between groups.

The following were used: chi-square test for categorical variables, ANOVA for parametrical numerical variables, and Kruskal-Wallis for nonparametric variables. Post hoc analysis was performed with the Bonferroni test. Statistical significance was set at p < 0.05.

A total of 89 patients were included: 31 in the Control Group (CG), 30 in the Tranexamic Acid Group (GTXA), and 28 in the Staple line Reinforcement Group (GSR). The clinical characteristics of the patients were similar among the groups. Moreover, there was no difference in the duration of surgery and anesthesia (Table 1).

Although a significant reduction in the surgical time was observed in another study for patients who used TXA,¹1 Chakravartty S, Sarma DR, Chang A, Patel AG. Staple Line Bleeding in Sleeve Gastrectomy – a Simple and Cost-Effective Solution. ObesSurg. 2016;26:1422–8. in this clinical trial, this factor was not statistically relevant. In a retrospective review,⁵5 Sepúlveda M, Astorga C, Hermosilla JP, Alamo M. Staple line reinforcement in laparoscopic sleeve gastrectomy: experience in 1023 consecutive cases. Obes Surg. 2017;27:1474–80. a significant increase in the surgical time of patients who received SR intervention was verified, as well as the necessity of having this method performed by trained professionals to avoid complications resulting from this procedure⁵5 Sepúlveda M, Astorga C, Hermosilla JP, Alamo M. Staple line reinforcement in laparoscopic sleeve gastrectomy: experience in 1023 consecutive cases. Obes Surg. 2017;27:1474–80. (Table 1).

The hemodynamic variables and hematological data were similar among the groups before surgery. Regarding the parameters for bleeding assessment, bleeding volume was greater in the CG (median 80 mL; 30-300) than in the GTXA (median 50 mL; 20–110) p = 0.013, but there was no difference concerning the weight of the gauze and the number of interventions applied to control bleeding (sutures and clips) among the three groups. In the postoperative period, GTXA patients were observed to have a higher hemoglobin value (p = 0.023), higher hematocrit (p < 0.001), greater prothrombin activity (p = 0.004), and lower INR value (p = 0.013) than the control group. The GSR also had a higher hematocrit value (p < 0.001) and prothrombin activity (p = 0.004) than the CG. A similar result was shown in the study performed by Chakravartty et al.,³3 Hunt BJ. The current place of tranexamic acid in the management of bleeding. Anaesthesia. 2015;70:50–e18. which also applied this approach for bariatric surgeries (Table 1).

In the CG group, one patient developed a large hematoma of the abdominal wall that did not require intervention, and another patient required surgical intervention for intra-abdominal bleeding on the first postoperative day, with 300 mL of blood being aspirated.

Four patients in the CG group had to remain hospitalized for 3 days. Thus, the time of hospitalization was longer in the CG (median 2; 2–3) than in the GTXA (median 2; 2–2), and in the GSR (median 2; 2–2) (p = 0.019).

The length of hospital stay of patients undergoing bariatric surgeries may vary among institutions using different discharge protocols. Although there already are strategies and protocols to reduce the length of hospital stay, such as ERAS, additional methods for avoiding complications that increase the length of hospital stay are continuously being investigated. Considering that bleeding is a complication commonly reported by studies that investigated the surgical complications of bariatric surgery and had the largest impact on hospital stay, the possibility of improving patient outcomes by intervening in this problem becomes even greater.

Despite the risk of thromboembolic events, the safety of this approach was demonstrated by the absence of throm-boembolic events and adverse events in this study, and the patients were monitored for at least 6 months after surgery. This result was similar to the few studies that used TXA in the context of bariatric surgeries, including Chakravartty et al.,¹1 Chakravartty S, Sarma DR, Chang A, Patel AG. Staple Line Bleeding in Sleeve Gastrectomy – a Simple and Cost-Effective Solution. ObesSurg. 2016;26:1422–8. who used tranexamic acid in the preoperative period of LSG.

Despite the limitations, the use of tranexamic acid was statistically relevant in reducing intraoperative bleeding volume, presenting less postoperative complications, which led to a reduction in the length of hospital stay. Thus, tranexamic acid can be an important alternative for preventing bleeding in the stapling line of patients undergoing LSG.

Ethical approval statement

Institutional Research Ethics Committee (CAAE 95198518. 9.0000.5085/Number 4.058.659) and registered in the Brazilian Registry of Clinical Trials (REBEC RBR-4w39gz).

All procedures performed in the study involving human participants were in accordance with the ethical standards of the institutional and/or national research committee and with the 1964 Helsinki declaration and its later amendments or comparable ethical standards.
Informed consent statement

Informed consent was obtained from all individual participants included in the study.

References

¹
Chakravartty S, Sarma DR, Chang A, Patel AG. Staple Line Bleeding in Sleeve Gastrectomy – a Simple and Cost-Effective Solution. ObesSurg. 2016;26:1422–8.
²
Choi YY, Bae J, Hur KY, Choi D, Kim YJ. Reinforcing the Staple Line During Laparoscopic Sleeve Gastrectomy: Does It Have Advantages? A Meta-analysis. ObesSurg. 2012;22:1206–13.
³
Hunt BJ. The current place of tranexamic acid in the management of bleeding. Anaesthesia. 2015;70:50–e18.
⁴
Ker K, Prieto-Merino D, Roberts I. Systematic review, meta-analysis and meta-regression of the effect of tranexamic acid on surgical blood loss. Br J Surg. 2013;100:1271–9.
⁵
Sepúlveda M, Astorga C, Hermosilla JP, Alamo M. Staple line reinforcement in laparoscopic sleeve gastrectomy: experience in 1023 consecutive cases. Obes Surg. 2017;27:1474–80.

Publication Dates

Publication in this collection
21 Apr 2023
Date of issue
May-Jun 2023

History

Received
24 Jan 2022
Accepted
31 Oct 2022

This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial No Derivative License, which permits unrestricted non-commercial use, distribution, and reproduction in any medium provided the original work is properly cited and the work is not changed in any way.

Variables	Group			p-value
Variables	Group Control	Group TXA	Group SR	p-value
Clinical characteristics of patients
Age
Med (Min–Max)	37 (24–59)	36 (19–62)	36 (19–64)	0.672^a a Kruskal-Wallis;
Gender
Female	26 (83.9%)	19 (63.3%)	22 (78.6%)	0.158^b b Chi-Square;
Male	5 (16.1%)	11 (36.7%)	6 (21.4%)
Diabetes Mellitus
Yes	7 (22.6%)	7 (23.3%)	7 (25%)	0.976^b b Chi-Square;
No	24 (77.4%)	23 (76.7%)	21 (75%)
Hypertension
Yes	10 (32.3%)	10 (33.3%)	8 (28.6%)	0.920^b b Chi-Square;
No	21 (67.7%)	20 (66.7%)	20 (71.4%)
Previous Surgeries
Yes	19 (61.3%)	18 (60%)	12 (42.9%)	0.291^b b Chi-Square;
No	12 (38.7%)	12 (40%)	16 (57.1%)
Weight (kg)	96.5 ± 10.9	103.9 ± 15.1	99.4 ± 9.4	0.062^c c ANOVA; For statistical significance the value of p < 0.05 was considered; Equal over-written letters indicate statistical difference in the inter-group post hoc analysis.
Height (cm)	160.5 ± 8.6	164.4 ± 7.9	161.7 ± 5.8	0.116^c c ANOVA; For statistical significance the value of p < 0.05 was considered; Equal over-written letters indicate statistical difference in the inter-group post hoc analysis.
BMI	37.3 (33.6–41.9)	38.1 (32.4-50.3)	38 (33.5-43.4)	0.475^a a Kruskal-Wallis;
Length of surgery (minutes)	92 ± 18	85 ± 17	86 ± 19	0.329^c c ANOVA; For statistical significance the value of p < 0.05 was considered; Equal over-written letters indicate statistical difference in the inter-group post hoc analysis.
Length of anesthesia (minutes)	140 ± 22	128 ± 23	133 ± 28	0.197^c c ANOVA; For statistical significance the value of p < 0.05 was considered; Equal over-written letters indicate statistical difference in the inter-group post hoc analysis.
Comparison of hemodynamic variables and hematological data in the preoperative period between the groups evaluated
Heart rate (bpm)	76 (52–92)	73 (54–95)	72 (55–114)	0.792^a a Kruskal-Wallis;
Systolic BP (mmHg)	120 (80–158)	108 (90–160)	113 (84–160)	0.097^a a Kruskal-Wallis;
Diastolic BP (mmHg)	74 (40–99)	70 (43–100)	80 (50–94)	0.577^a a Kruskal-Wallis;
Mean BP (mmHg)	88 ± 16	85 ± 13	87 ± 11	0.550^c c ANOVA; For statistical significance the value of p < 0.05 was considered; Equal over-written letters indicate statistical difference in the inter-group post hoc analysis.
Hemoglobin (g.dL⁻¹)	12.3 ± 1.3	12.65 ± 1.2	12.20 ± 1.0	0.076^c c ANOVA; For statistical significance the value of p < 0.05 was considered; Equal over-written letters indicate statistical difference in the inter-group post hoc analysis.
Hematocrit (V/V) %	36.7 ± 3.7	38.1 ± 3.5	37.3 ± 2.8	0.263^c c ANOVA; For statistical significance the value of p < 0.05 was considered; Equal over-written letters indicate statistical difference in the inter-group post hoc analysis.
Platelets	252 ± 43	251 ± 55	236 ± 37	0.327^c c ANOVA; For statistical significance the value of p < 0.05 was considered; Equal over-written letters indicate statistical difference in the inter-group post hoc analysis.
Prothrombin Time (s)	14.4 (13.3–15.4)	14.3 (13.4–16.5)	14.2 (13–15.2)	0.134^a a Kruskal-Wallis;
Prothrombin Activity (%)	84 ± 5	84 ± 8	85 ± 5	0.690^c c ANOVA; For statistical significance the value of p < 0.05 was considered; Equal over-written letters indicate statistical difference in the inter-group post hoc analysis.
TTPa (s)	31.1 (21.3–39.2)	31.6 (21.5–39.9)	31.4 (24.5–39.1)	0.567^a a Kruskal-Wallis;
RTTPa	1.05 (0.72–1.33)	1.06 (0–1.22)	1.05 (0.83–1.33)	0.088^a a Kruskal-Wallis;
INR	1.12 (1–1.21)	1.11 (1–1.32)	1.11 (1.04–1.22)	0.615^a a Kruskal-Wallis;
Fibrinogen (mg.dL⁻¹)	289 ± 59	298 ± 41	310 ± 46	0.244^c c ANOVA; For statistical significance the value of p < 0.05 was considered; Equal over-written letters indicate statistical difference in the inter-group post hoc analysis.
Comparison of interventions to control bleeding and intraoperative bleeding between the groups evaluated
Nº of interventions for bleeding control (Suture or Clips)	8 (4–24)	11 (6–18)	9 (6‒16)	0.469^a a Kruskal-Wallis;
Nº Clips for hemostasis	2 (0‒18)	5 (0‒12)	3 (0‒10)	0.483^a a Kruskal-Wallis;
Gauze Weight (g)	15 (10‒50)	20 (10‒50)	20 (10‒65)	0.580^a a Kruskal-Wallis;
Nº Staples	6 (5‒8)^a a Kruskal-Wallis;	6 (6‒7)^a a Kruskal-Wallis;	6 (5‒7)	0.005^a a Kruskal-Wallis;
Vol. of blood on pump (mL)	80 (30‒300)^a a Kruskal-Wallis; , ^b b Chi-Square;	50 (20‒110)^a a Kruskal-Wallis;	100 (50‒120)^b b Chi-Square;	0.013^a a Kruskal-Wallis;
Comparison of hematological data in the postoperative period between the groups evaluated
Hemoglobin (g.dL⁻¹)	12.3 ± 1.4^a a Kruskal-Wallis;	13.2 ± 1.4^a a Kruskal-Wallis;	12.8 ± 0.9	0.023^c c ANOVA; For statistical significance the value of p < 0.05 was considered; Equal over-written letters indicate statistical difference in the inter-group post hoc analysis.
Hematocrit (V/V) %	36.4 ± 4.2^a a Kruskal-Wallis; , ^b b Chi-Square;	38.7 ± 3.6^a a Kruskal-Wallis;	38.8 ± 2.8^b b Chi-Square;	0.000^c c ANOVA; For statistical significance the value of p < 0.05 was considered; Equal over-written letters indicate statistical difference in the inter-group post hoc analysis.
Platelets	266 (196‒408)	251 (116‒382)	274 (173‒378)	0.463^a a Kruskal-Wallis;
Prothrombin Time (s)	14.6 (11.9‒15.7)	14.6 (13.4‒29.2)	14.6 (13.5‒15.7)	0.905^a a Kruskal-Wallis;
Prothrombin Activity (%)	80 (71‒96)^a a Kruskal-Wallis; , ^b b Chi-Square;	82.5 (62‒99)^a a Kruskal-Wallis;	85 (69‒93)^b b Chi-Square;	0.004^a a Kruskal-Wallis;
TTPa(s)	29.1 ± 1.8^a a Kruskal-Wallis;	30.3 ± 2.7	30.7 ± 2.3^a a Kruskal-Wallis;	0.032^c c ANOVA; For statistical significance the value of p < 0.05 was considered; Equal over-written letters indicate statistical difference in the inter-group post hoc analysis.
RTTPa	1.02 ± 0.11	1.04 ± 0.07	1.04 ± 0.08	0.547^c c ANOVA; For statistical significance the value of p < 0.05 was considered; Equal over-written letters indicate statistical difference in the inter-group post hoc analysis.
INR	1.16 (1.06‒1.9)^a a Kruskal-Wallis;	1.11 (1‒1.35)^a a Kruskal-Wallis;	1.13 (1.05‒1.27)	0.013^a a Kruskal-Wallis;
Fibrinogen (mg.dL⁻¹)	309 (205‒481)	329 (234‒477)	341 (252‒492)	0.208^a a Kruskal-Wallis;

Sociedade Brasileira de Anestesiologia (SBA) Rua Professor Alfredo Gomes, 36, Botafogo , cep: 22251-080 - Rio de Janeiro - RJ / Brasil , tel: +55 (21) 97977-0024 - Rio de Janeiro - RJ - Brazil
E-mail: editor.bjan@sbahq.org

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[1] Ethical approval statement

Institutional Research Ethics Committee (CAAE 95198518. 9.0000.5085/Number 4.058.659) and registered in the Brazilian Registry of Clinical Trials (REBEC RBR-4w39gz).

All procedures performed in the study involving human participants were in accordance with the ethical standards of the institutional and/or national research committee and with the 1964 Helsinki declaration and its later amendments or comparable ethical standards.

[2] Informed consent statement

Informed consent was obtained from all individual participants included in the study.