Over 30 years working with the Pain Management Clinic, and after almost four years as Editor-in-Chief of a scientific journal that has been gradually improving its technical quality, I wonder how pain, as a physical symptom, changes the course of the subject’s history. Surely the patient suffers. I emphasize that pain and suffering are words that translate distinct meanings and are surrounded by an ocean of meanings. Existential suffering from what a person is, ends up creating physical pain. And physical pain causes suffering. I remember one patient I cared for earlier in my career who had her legs and two fingers amputated and lost her memory, financial status, social position, and body image. Undoubtedly, there was physical pain throughout the amputation process, and the suffering was of the order of my imagination¹. There is pain when there is empathy. Fortunately, the patient did not evolve with phantom limb pain, either on the amputation stump, which could have had more dramatic consequences. All of this after a gastrointestinal infection, followed by septicemia and systemic vasculitis. The impact of this incident, however, at the peripheral and central neuronal level, is still a major challenge for researchers^2,3. After all, any mnemic record that causes pain, suffering, and changes the natural course of the subject’s history is still hermetically treated in psychotherapy offices, and after, on average eight years comes to the care of a specialized physician⁴. Contemporary ephemerality, the reason for so many absences, including that of love and compassion for others, besides the desperate search for a position of strong social representation, move the patient away from the caregiver and health professional⁵. Perhaps, the consequences over time of the recording in the nervous system of pain and suffering in newborns and premature infants, currently reported in publications as anxiety, abdominal pain, reduction in intelligence coefficient score, among others, alert health professionals about the importance of avoiding pain and suffering at any level^6-8. I emphasize that this binomial does not make a person better but worse⁹. The burdens and aggression imposed by the modern world interfere with the course of the subject’s history, depending on individual genetics, environment, social, economic, and psychic history, and are modulated by their ability to cope. So that patient-centered pain education programs have clearly aided treatment adherence and outcome¹⁰. I conclude this reflection by emphasizing that caring for the body, soul, and spirit is fundamental to the correct flow of a full life: - without pain and suffering. Life is to be happy.