Resumo em Português:

Oito espécies novas de Flebotomus do Vale Amazônico são descritas e os princiapis caracteres ilustrados dem 8 estampas com quarenta e sete figuras no total. As descrições são baseadas em exemplares machos.

Resumo em Inglês:

This report belongs to the series of works carried out Oswaldo Cruz Ins¬titute, on the treatment of treponematosis with penicillin. The present report deals with investigations performed in order to ascer¬tain the following points: 1) the mininal curative dosis for the initial lesions of yaws; 2) the effect of reduction of the number of injections each day, to verifie the possibility of application of penicillin in the prophylaxis of yaws in rural zones; 3) reduction of the time of treatment by application of high dosis. 1) With dosis of 150 and 100 Oxford units each four hours, clinical reco¬very was obtained after 17 days of treatment. With 50 O.u. during 40 days clinical recovery was not obtained. 2) a) With 3 injections of 400 O.u. each day (6,12 and 18 hoórs clocks) clinical recovery was obtained after 14 to 16 days; b) with 2 injections of 400 O.u. each day (6 and 18 hoors clocks), clinical recovery was obtained after 16 to 23 days; c) with 1 injection of 1.600 and 3.200 each day, clinical recovery was obtained after 30 and 20 days. 3) With dosis of 33.3 and 46.7 O.u. by each kilo of weight each four hours, during 15 days, clinical recovery was obtained more or less in 25 days. The same result was obtained with the dosis of 61.5 and 166.7 O.u. by each kilo of weight, each four hours, during 4 days. But with 100.000 O.u. in fine dosis of 20.000 in a day ou by, clinical recovery was not obtained.

Resumo em Português:

Em revisão de conhecimentos sobre doenças hereditárias foi verificada em várias dessas heredopatias (anemia de hemátias em alvo, icterícia hemolítica heredo-familiar. anemia ovalocítica, anemia perniciosa de BIERMER, trombopatia constitucional, distrofia miotônica — compreendendo a doença de TNOMSEN e paramiotonia -, doença de FRIEDREICH, doença de CHARCOT-MARIE, epilepsia, keratosis follicularis ou doença de DARIER. braquidactilia, e câncer gástrico) a existência de indivíduos de comportamento semelhante ao siclêmico na anemia drepanocítica. Tais indivíduos são identificáveis por apresentarem precocemente algum dos sinais clínicos da doença. Provas especiais para cada entidade mórbida são necessárias para essa identificação.Essas verificações indicam a possibilidade de se identificarem os portadores de caráter patogênico hereditário na fase de latência (indivíduos “aparentemente sãos" ou "carrier") e que a existência de tais indivíduos é uma das características das doenças hereditárias, talvez excetuadas, as deformidades congênitas. Sugerem também que se deve relacionar o fenômeno de salteamento de gerações (skipping) na incidência das heredopatias com êsses portadores. E' sugerido o recenseamento e exames periódicos dêsses indivíduos no sentido da aquisição de dados sôbre os fatores responsáveis pela passagem da condição de "latente" para a de doente. Possivelmente, êsses conhecimentos forneceriam as bases de eventual profilaxia das doenças acima mencionadas. Na anemia perniciosa a hepatoterapia, como aconselha ASKEY, deve ser aplicada aos acloridricos, como medida preventiva.

Resumo em Inglês:

The author has reviewd papers about heredity diseases and verified that in some of them (target-cell anemia, hereditary hemolytic jaundice, ovalocytic anemia, Biermer's pernicious anemia, constitutional thrombopathia, dystrophia myotcnica (Thomsen's disease and paramyotonia), Friedreich's disease, Charcot-Marie's disease, epilepsy, keratosis follicularis or Darier's disease, brachy-dactyly and gastric cancer) have been described individuals whose behavior with reference to heredity is very similar to the siclemic in sicle cell anemia. These individuals by means of special proofs are identified because they present very early (in some cases congenital) some of the clinical signs of the disease. These observations shows: a) that it is possible to identify the heirs of a pathological condition before the development of the disease and consequently, also the carriers; b) that the presence of identificable carriers is a characteristic of hereditary diseases, perhaps excepting congenital anomalies. They also suggest that the skipping phenomenon should be related with the carriers. It is suggested a census and periodical examinations of these individuals with a view to get some data about the factors responsible for the development of the disease. Perhaps these data might contribute to establish the basis of eventual prophylactic measures against the above mentioned diseases. In Biermer's pernicious anemia the hepathotherapy should be applied to the individuals with gastric achlorhydria, as it it was advised by Askey, as a preventive.

Resumo em Português:

Os AA. iniciam com o presente trabalho uma série de publicações com o fim de rever as espécies neotropicais da família Simuliidae. Fazem a revisão bibliográfica, a redescrição do macho, fêmea, pupa, larva, e elegem os neótipos de S. (E) orbitale LUTZ, 1910. Descrevem S. (E.) pintoi n. sp. de macho, fêmea, pupa e larva; consideram S. nigrimanum MACQ., 1837 como sp. inquirendae.

Resumo em Inglês:

The present paper initiates a serial, in which the authors propose revising the neotropical species of Simuliidae. In this first contribution, a bibliographical survey, and redescriptions of the male, female, pupa and larva of S. (E.) orbitale LUTZ, 1910, are presented; a full description of S. (E.) pintoi n. sp. based on male, female, pupa and larva is given; S. nigrimanum MACQ. 1837 is considered a sp. inquirendae.

Resumo em Inglês:

It is described in this papaer the pilot-plant, for the production of Penicillin, with a capacity of, aproximately, sixty million Oxford units per month, used at the Oswaldo Cruz Institute. With this plant it has been possible to produce the active material for several clinical observations and the treatment of more than thousand pacients during the war time. Particularly, this refers to the results obtained in the treatmetne of the desease Framboesis pian, Yaws (4,5) and in others deseases, by the use of very small dosis of Penicillin.

Resumo em Inglês:

A technics for prefreezing of blood plasma and serum is described in this paper. The method indicated by Strumia et al. (2), uses a rapid local freezing to obtain the shell-freezing, with refigerated alcohol bath, at temperatures around minus 35ºC. On our work, it has been found that normal horse blood plasma fulfils the instructions given by Strumia, although normal human blood plasma, very often, fails to give the expected results. This is very disadvantageous at the routine work. With the use of small amounts of solid carbon dioxide, spread over the flasks, in the refrigerated bath, it has been possible to start the chrystallization. The technics prescribes a rapid cooling, like the one used by Strumia, to bring the temperature down, to about plus 10ºC. and, with rotating device stopped, the solid carbon dioxide is applied for one minute simultaneously on each flask. Starting rotation again, it begins to form a very uniform shell around the walls of the flasks.