Search | SciELO

BACKGROUND Eosinophils are granulocytes that rapidly increase frequency in the bloodstream during helminthic infections and allergic responses. They are found in tissue infected by Leishmania during early disease, but their role during infection is not entirely understood. OBJECTIVES We aim to compare the disease due to Leishmania amazonensis in BALB/c and Δdbl-GATA1 mice, which lack eosinophils. METHODS BALB/c and Δdbl-GATA1 mice infected with L. amazonensis were observed for several weeks. The parasite load and dissemination pattern were assessed. FINDINGS The Δdbl-GATA1 mice developed an anticipated dissemination of L. amazonensis and a worsening disease. No differences were found in the lesion development or the parasite load in the footpad among Δdbl-GATA1 mice and BALB/c eight weeks after infection. However, nine weeks after infection, massive growth of metastatic lesions appeared in several parts of the skin in Δdbl-GATA1 mice, weeks earlier than BALB/c. We observed increased parasites in the bloodstream, probably an essential dissemination route. Thirteen weeks after infection, metastatic lesions were found in all Δdbl-GATA1 mice. MAIN CONCLUSION These results suggest a protective role of eosinophils in delaying the disease caused by L. amazonensis, although several limitations of this mice strain must be considered.

https://doi.org/10.1590/0074-02760220242

Biogran Grafting in Rat Tibia Defects - A Model of High Bone Metabolism Site
Facebook Twitter

Other social networks
Google+
LinkedIn
Reddit
StambleUpon
CiteULike
Mendeley
Other networks

Metrics
- SciELO Analytics
- Dimensions
- PlumX
- Altmetric

Ferreira, Luiza de Almeida Queiroz

; Lehman, Luiz Felipe Cardoso

; Diniz, Marina Gonçalves

; Ferreira, Anderson José

; Silva, Rosangela Maria Ferreira da Costa e

; Silva, Tarcília Aparecida

; Mesquita, Ricardo Alves

; Oliveira, Rafaela Férrer de

; Noronha, Mariana Saturnino

; Leão, Daniel Marques

; Andrade, Ângela Leão

; Domingues, Rosana Zacarias

; Diniz, Ivana Márcia Alves

Brazilian Archives of Biology and Technology

Journal Metrics
- Sobre o periódico
- SciELO Analytics

2024, Volume 67 elocation e24230003

Abstract: En | Text: En | PDF: En

Abstract We investigated the Biogran on bone repair and metabolism at several time-intervals upon grafting into rat tibia artificial defects. The biomaterial was thoroughly characterized in vitro, and its dissolution behavior upon immersion was assessed in simulated body fluid (SBF) solution for 1, 3, 7, 14, and 30 days. Biogran was also assessed by in vitro hydroxyapatite formation in SBF solution, which is a marker for bioactive behavior. In vivo, distal and proximal bone defects were performed in the Wistar rat's right tibia and filled according to the experimental groups: I) negative control, no filling; II) positive control, 10 mg of autogenous bone; and III) 10 mg of Biogran. Animals were euthanized at 1, 2, 3, 4, 7, and 10 weeks. Bone neoformation was analyzed using histomorphometry (proximal defect), and local levels of bone morphogenetic protein 2 (BMP-2) were measured using the ELISA assay (distal defect). In vitro, the Biogran sample showed a fast dissolution rate within the first 7 days, parallel to the formation of the hydroxyapatite layer. In vivo, the sample was progressively resorbed at a higher rate within the first month until it became almost absent at week 10th. The sample presented similar or higher bone neoformation concerning the autogenous bone. BMP-2 levels were sustained in the Biogran group (around 200 pg/mg) and detected until the last experimental time with a significant difference compared with the controls. Results suggest Biogran is a candidate for hard tissue engineering even in highly active bone remodeling sites.

https://doi.org/10.1590/1678-4324-2024230003

Noteworthy records of the ticks Ornithodoros rostratus and Amblyomma sculptum parasitizing Pteronura brasiliensis in the central-western region of Brazil, with pathogen investigation notes
Facebook Twitter

Other social networks
Google+
LinkedIn
Reddit
StambleUpon
CiteULike
Mendeley
Other networks

Metrics
- SciELO Analytics
- Dimensions
- PlumX
- Altmetric

Barros-Battesti, Darci Moraes

; André, Marcos Rogério

; Hoppe, Estevam Guilherme Lux

; Seron, Gustavo

; Bassini-Silva, Ricardo

; Calchi, Ana Claúdia

; Andrade, Lívia Oliveira

; Perin, Patrícia Parreira

; Martins, Thiago Fernandes

; Castro-Santiago, Ana Carolina

; Leuchtenberger, Caroline

; Almeida, Samara

; Foerster, Nathalie

; Furtado, Mariana

; de Castro Jacinavicius, Fernando

Revista Brasileira de Parasitologia Veterinária

Journal Metrics
- Sobre o periódico
- SciELO Analytics

2024, Volume 33 N. 1 elocation e014523

Abstract: Pt En | Text: Pt En | PDF: Pt | PDF: En

Resumo Um macho de Pteronura brasiliensis (Carnivora: Mustelidae) foi encontrado morto às margens do Rio Negro, no Pantanal do estado de Mato Grosso do Sul, município de Aquidauana. Dois carrapatos encontrados aderidos à sua pele foram identificados, morfologicamente, como uma ninfa de segundo ínstar de Ornithodoros rostratus (Argasidae) e um macho de Amblyomma sculptum (Ixodidae). Para complementar a identificação morfológica, esses espécimes de carrapatos foram submetidos à extração de DNA e testados por meio de ensaios de PCR, para confirmar a identidade molecular dos espécimes. Além disso, os extraídos dos carrapatos foram testados e revelaram-se negativos nos ensaios de PCR para todos os patógenos testados. Também foram examinados 30 lotes, compostos por 174 indivíduos de O. rostratus, depositados na Coleção Acari do Instituto Butantan, e encontramos material de quatro estados brasileiros, incluindo-se um lote contendo 2 machos e 2 fêmeas de Aquidauana, estado de Mato Grosso do Sul (MS), coletado do solo. Este foi, portanto, o primeiro registro de O. rostratus parasitando P. brasiliensis e o primeiro registro de localidade (Aquidauana). Da mesma forma, A. sculptum é comumente encontrado no Pantanal e relatado aqui, pela segunda vez, parasitando a ariranha, hospedeiro pouco estudado em relação a ectoparasitas.

Abstract A male of Pteronura brasiliensis (Carnivora: Mustelidae) was found dead on the banks of the Rio Negro, in the Pantanal wetlands of Mato Grosso do Sul state, Aquidauana municipality. Two ticks found attached to its skin were morphologically identified as a second-instar nymph of Ornithodoros rostratus (Argasidae) and a male of Amblyomma sculptum (Ixodidae). In order to complement the morphological identification, these tick specimens were subjected to DNA extraction, and tested using PCR assays to confirm the molecular identity the specimens. Also, the tick DNA samples were tested and were negative in the PCR assays for all the pathogens tested. We also examined 30 batches, consisting of 174 individuals of O. rostratus deposited in the Acari Collection of the Butantan Institute, and we found material from four Brazilian states, including one batch containing 2 males and 2 females from Aquidauana, of Mato Grosso do Sul state, collected from the soil. This was therefore the first record of O. rostratus parasitizing P. brasiliensis and the first locality record (Aquidauana). Likewise, A. sculptum is commonly found in the Pantanal and is reported here for the second time parasitizing the giant otter, which is a host little studied regarding the ectoparasites.

https://doi.org/10.1590/s1984-29612024003

Prevalence of trachoma in indigenous and non-indigenous areas, Northeastern Brazil, 2019–2021
Facebook Twitter

Other social networks
Google+
LinkedIn
Reddit
StambleUpon
CiteULike
Mendeley
Other networks

Metrics
- SciELO Analytics
- Dimensions
- PlumX
- Altmetric

Gomez, Daniela Vaz Ferreira

; Almeida, Wanessa da Silva de

; Souza Junior, Paulo Roberto Borges de

; Lopes, Maria de Fátima Costa

; Luna, Expedito José de Albuquerque

; Zimmermann, Ivan Ricardo

; Tavares, Noemia Urruth Leão

; Gutierrez, Maria Margarita Urdaneta

; Szwarcwald, Célia Landmann

Revista Panamericana de Salud Pública

Journal Metrics
- Sobre o periódico
- SciELO Analytics

2024, Volume 48 elocation e19

Abstract: Es En Pt | Text: Es En Pt | PDF: Es | PDF: En | PDF: Pt

RESUMEN Objetivo. Estimar la prevalencia del tracoma en poblaciones indígenas y no indígenas en determinadas zonas del estado de Maranhão, en el nordeste de Brasil. Métodos. Se trató de una encuesta de ámbito poblacional con muestreo probabilístico. Para el diagnóstico del tracoma, se realizó un examen ocular externo con una lupa frontal de 2,5X aumentos. Se estimó la prevalencia de la inflamación tracomatosa folicular (TF) en la población infantil de 1 a 9 años y la prevalencia de la triquiasis tracomatosa (TT) en la población de 15 años o más. Se obtuvieron las frecuencias relativas de las características sociodemográficas y ambientales. Resultados. En el estudio participaron 7 971 personas, 3 429 de poblaciones no indígenas y 4 542 de poblaciones indígenas. La prevalencia de la TF en las poblaciones no indígenas e indígenas fue de 0,1% y 2,9%, respectivamente, en tanto que la de la TT en las poblaciones indígenas fue de 0,1%. Conclusiones. La prevalencia de la TF y la TT en las dos unidades de evaluación del estado de Maranhão estuvo dentro de los límites recomendados para la eliminación del tracoma como problema de salud pública. Sin embargo, la prevalencia de la TF fue mayor en la unidad de evaluación indígena, lo que indica una mayor vulnerabilidad de esta población a la enfermedad. La prevalencia de la TF inferior al 5,0% implica una reducción de la transmisión, que puede haber sido consecuencia tanto de la mejora de las condiciones socioeconómicas como de la aplicación de la estrategia SAFE de la Organización Mundial de la Salud.

ABSTRACT Objective. To estimate the prevalence of trachoma in indigenous and non-indigenous populations in selected areas of the state of Maranhão, in northeastern Brazil. Methods. This was a population-based survey with probabilistic sampling. For the diagnosis of trachoma, external ocular examination was performed using head magnifying loupes, at 2.5X magnification. The prevalence of trachomatous inflammation – follicular (TF) in children aged 1–9 years and the prevalence of trachomatous trichiasis (TT) in the population aged ≥15 years were estimated. Relative frequencies of sociodemographic and environmental characteristics were obtained. Results. The study included 7 971 individuals, 3 429 from non-indigenous populations and 4 542 from indigenous populations. The prevalence of TF in non-indigenous and indigenous populations was 0.1% and 2.9%, respectively, and the prevalence of TT among indigenous populations was 0.1%. Conclusions. The prevalence of TF and TT in the two evaluation units in the state of Maranhão were within the limits recommended for the elimination of trachoma as a public health problem. However, the prevalence of TF was higher in the indigenous evaluation unit, indicating a greater vulnerability of this population to the disease. The prevalence of TF of below 5.0% implies a reduction in transmission, which may have resulted from improved socioeconomic conditions and/or the implementation of the World Health Organization SAFE strategy.

RESUMO Objetivo. Estimar a prevalência do tracoma em populações indígenas e não indígenas em áreas selecionadas do estado do Maranhão, na região Nordeste do Brasil. Métodos. Inquérito de base populacional com amostragem probabilística. Para o diagnóstico de tracoma, foi realizado exame ocular externo com o auxílio de lupas binoculares com ampliação de 2,5×. Foram estimadas a prevalência de inflamação tracomatosa folicular (TF) em crianças de 1 a 9 anos de idade e a prevalência de triquíase tracomatosa (TT) na população com idade ≥15 anos. Foram obtidas as frequências relativas das características sociodemográficas e ambientais. Resultados. O estudo incluiu 7 971 indivíduos (3 429 de populações não indígenas e 4 542 de populações indígenas). A prevalência de TF nas populações não indígenas e indígenas foi de 0,1% e 2,9%, respectivamente, e a prevalência de TT entre as populações indígenas foi de 0,1%. Conclusões. A prevalência de TF e TT nas duas unidades de avaliação no estado do Maranhão ficou dentro dos limites recomendados para a eliminação do tracoma como problema de saúde pública. No entanto, a prevalência de TF foi maior na unidade de avaliação indígena, indicando uma maior vulnerabilidade dessa população à doença. A prevalência de TF abaixo de 5,0% implica uma redução na transmissão, que pode ter sido resultado de melhores condições socioeconômicas e da implementação da estratégia SAFE da Organização Mundial da Saúde.

https://doi.org/10.26633/rpsp.2024.19

Itinerários terapêuticos para cuidados em saúde bucal de adultos quilombolas de um distrito rural da Bahia, Brasil
Facebook Twitter

Other social networks
Google+
LinkedIn
Reddit
StambleUpon
CiteULike
Mendeley
Other networks

Metrics
- SciELO Analytics
- Dimensions
- PlumX
- Altmetric

Souto, Ricardo de Almeida

; Souzas, Raquel

; Silva, Etna Kaliane Pereira da

; Pereira, Lucelia Luiz

; Nery, Joilda Silva

Ciência & Saúde Coletiva

Journal Metrics
- Sobre o periódico
- SciELO Analytics

2024, Volume 29 N. 3 elocation e04302023

Abstract: En Pt | Text: En Pt | PDF: En | PDF: Pt

Abstract This study examined the oral health-related therapeutic itineraries of quilombola adults in a rural district of Vitória da Conquista, Bahia. This qualitative study involved ten semi-structured interviews of adult members of the quilombola community, in May 2021, which were then transcribed and analysed using content analysis. The results showed little or poor oral hygiene at some stage of life, especially in childhood and adolescence, the use of popular oral health care practices, and experiences of professional care featuring tooth extraction. Use of health services was mostly reported only in the period prior to the COVID-19 pandemic. Responses as to perceived ease of access to health services in the community varied. One common complaint as to satisfaction with oral health was the need to use or replace dental prostheses. This study concluded that oral health must be promoted jointly with disease prevention, dental rehabilitation and recognition for the knowledge and worldview of the quilombola population.

Resumo O estudo analisou os itinerários terapêuticos relacionados à saúde bucal de adultos quilombolas de um distrito rural de Vitória da Conquista, Bahia. Trata-se de uma pesquisa qualitativa, na qual foram realizadas dez entrevistas semiestruturadas com adultos quilombolas em maio de 2021, transcritas e analisadas por meio da análise de conteúdo. Os resultados evidenciaram ausência e/ou precariedade na higiene bucal em alguma fase da vida, especialmente infância e adolescência; utilização de práticas populares para cuidado a saúde bucal e experiências de cuidado profissional marcados pela exodontia. A utilização de serviços de saúde foi relatada, em sua maioria, apenas no período anterior à pandemia de COVID-19, os entrevistados divergiram quanto à percepção de facilidade do acesso aos serviços de saúde em sua comunidade. Os relatos sobre a satisfação da saúde bucal destacaram a necessidade de uso ou substituição de próteses dentárias. À guisa de conclusão, entende-se que é necessária a promoção de saúde bucal de forma articulada com ações que possibilitem a prevenção de agravos, a reabilitação odontológica e a valorização do conhecimento e da visão de mundo da população quilombola.

https://doi.org/10.1590/1413-81232024293.04302023

Pneumomediastino como Complicação de Infeção SARS-CoV-2: Série de Casos
Facebook Twitter

Other social networks
Google+
LinkedIn
Reddit
StambleUpon
CiteULike
Mendeley
Other networks

Metrics
- SciELO Analytics
- Dimensions
- PlumX
- Altmetric

Cunha, Joana Gomes da

; Lopes, Andreia

; Almeida, Rita dos Santos

; Pereira, Sofia Santos

; Veiga, Ricardo

; Quental, Bárbara

; Romão, Vera

Medicina Interna

Journal Metrics
- Sobre o periódico
- SciELO Analytics

dec 2023, Volume 30 N. 4 Pages 15 - 22

Abstract: En Pt | Text: En Pt | PDF: En | PDF: Pt

Abstract Introduction: Even though pneumomediastinum cases are t frequent, it has been described as a non-negligible complication in patients with SARS-CoV-2 infection. According to the available literature at this moment, development of pneumomediastinum in patients with SARS-CoV-2 infection does not seem to be related to the classic mechanism of pulmonary barotrauma. This work aims to raise awareness of this nosological entity and its pathophysiology. Methods: The authors conducted a retrospective study of all COVID-19 cases with pneumomediastinum between January and February 2021 in an Internal Medicine ward at a Central Hospital - analysis of their comorbidities, disease evolution, complications, and a review of the available literature. Results: From 400 patients admitted with COVID-19, in 2 months under study, 4 developed pneumomediastinum: all male, aged between 68 and 81 years, with various comorbidities, mainly cardiovascular. All were subjected to non-invasive mechanical ventilation, with three of them additionally subjected to invasive mechanical ventilation. They evolved unfavorably and ended up dying. Conclusion: Pneumomediastinum, as a complication of SARS-CoV-2 infection, proved to be very serious, with a negative outcome in all the identified patients. It is important to be aware of predisposing factors, for early diagnosis and timely intervention.

Resumo Introdução: Apesar de raro, o pneumomediastino tem sido descrito como uma complicação não desprezível nos doentes com infeção SARS-CoV-2, o que, segundo a literatura, não parece estar relacionado com o mecanismo clássico de barotrauma pulmonar. Pretende-se, com este trabalho, alertar para esta entidade nosológica e potencial fisiopatologia, através da descrição de casos de pneumomediastino em doentes com COVID-19 e revisão dos dados disponíveis até ao momento atual. Métodos: Análise retrospetiva e descritiva dos casos de pneumomediastino ocorridos em doentes com COVID-19, entre janeiro e fevereiro de 2021, no serviço de Medicina Interna, de um hospital central - avaliação epidemiológica e das comorbilidades de cada doente, evolução da doença, complicações e revisão da literatura disponível até ao momento. Resultados: Dos 400 doentes admitidos com COVID-19 ao longo dos 2 meses em estudo, 4 desenvolveram pneumomediastino: todos do género masculino, idade entre os 68 e 81 anos, com várias comorbilidades, predominantemente cardiovasculares. Todos foram submetidos a ventilação mecânica não invasiva, sendo que três deles foram adicionalmente sujeitos a ventilação mecânica invasiva. Evoluíram desfavoravelmente, acabando por falecer. Conclusão: O pneumomediastino, como complicação da infeção SARS-CoV-2, revelou-se de grande gravidade, com desfecho negativo em todos os doentes identificados, importando estar atento aos fatores predisponentes, para um diagnóstico precoce e uma atuação atempada.

https://doi.org/10.24950/rspmi.2062

Training on the Impact of Climate Change on Public Health: Reflections and Lessons Learnt
Facebook Twitter

Other social networks
Google+
LinkedIn
Reddit
StambleUpon
CiteULike
Mendeley
Other networks

Metrics
- SciELO Analytics
- Dimensions
- PlumX
- Altmetric

Viegas, Susana

; Santos, João Almeida

; Kazmierczak, Aleksandra

; Assunção, Ricardo

; Viegas, Carla

; Martins, Carla

Portuguese Journal of Public Health

Journal Metrics
- Sobre o periódico
- SciELO Analytics

dec 2023, Volume 41 N. 3 Pages 230 - 234

Abstract: En | Text: En | PDF: En

https://doi.org/10.1159/000533973

Geophysical key indicators for tailings dam physical integrity monitoring - Brazil
Facebook Twitter

Other social networks
Google+
LinkedIn
Reddit
StambleUpon
CiteULike
Mendeley
Other networks

Metrics
- SciELO Analytics
- Dimensions
- PlumX
- Altmetric

Sá, Gilvan

; Braga, Marco Antonio

; Almeida, Luiz Antonio Pinto e

; Dias, Leonardo Santana de Oliveira

; Cunha, Alan de Souza

; Rocha, Demetrius Cunha Gonçalves da

; Telles, Ricardo Luiz Teixeira

REM - International Engineering Journal

Journal Metrics
- Sobre o periódico
- SciELO Analytics

dec 2023, Volume 76 N. 4 Pages 363 - 370

Abstract: En | Text: En | PDF: En

Abstract The geotechnical monitoring of tailings dams combined with a suitable application of geophysical electrical methods can improve their structure evaluation, allowing several correlations between direct analyses and the resistivity anomaly pattern. Considering this synergy, twenty-three electrical resistivity sections (ERT) were acquired along the beach, abutments, and central part of a dam, totalizing 10,776 m of dataset. After the interpretation of each ERT section, comparing the anomaly ranges with the water level meters measurements, three resistivity zones were defined: Zones of low resistivity (<64 ohm-m), correlated to regions of high humidity; zones of high resistivity (> 357 ohm-m), interpreted as dry zones, and regions with intermediate resistivity values, located between these limits. The groundwater surface generated from the interpretation of the electrical resistivity dataset and the groundwater surface acquired from the water level gauges were almost coincident. On the right abutment, the conductive anomalies showed remarkable continuity, suggesting a high moisture content in this region with strong gradients (200 mV) directed towards the zone of low resistivity values identified in the sections. The analysis showed a robust correlation of the ERT data with localized physical geotechnical measurements, valuable for monitoring dam integrity, overseeing the structure's response to climate and operational changes, and ultimately mitigating the risks of failure. The results of this study support the adoption of a seasonal 4D electrical resistivity survey as an effective tool to monitor and manage surface and high humidity zones, key indicators of dam integrity throughout the entire structure.

https://doi.org/10.1590/0370-44672022760030

Long-term oncological and surgical outcomes after Video Endoscopic Inguinal Lymphadenectomy (VEIL) in patients with penile cancer
Facebook Twitter

Other social networks
Google+
LinkedIn
Reddit
StambleUpon
CiteULike
Mendeley
Other networks

Metrics
- SciELO Analytics
- Dimensions
- PlumX
- Altmetric

Tobias-Machado, Marcos

; Ornellas, Antonio A.

; Hidaka, Alexandre K.

; Medina, Luis G.

; Mattos, Pablo A. L.

; Besio, Ruben S.

; Abreu, Diego

; Castro, Pedro R.

; Nishimoto, Ricardo H.

; Astigueta, Juan

; Dourado, Aurus

; Machado, Roberto D.

; Magnabosco, Wesley J.

; Corona-Montes, Victor

; Villoldo, Gustavo M.

; Zampolli, Hamilton C.

; Taha, Anis

; Auad, Pericles R.

; Faria, Eliney F.

; Arantes, Paulo B. O.

; Tavares, Alessandro

; Nascimento, Francisco S. M. S.

; Brazão Jr., Eder S.

; Rocha, Maurício M.

; Costa, Walter H.

; Panico, Vinicius

; Reis, Leonardo O.

; Almeida-Carrera, Roberto J.

; Silva, Rafael C.

; Zequi, Stênio C.

; Calixto, José R. R.

; Sotelo, Rene

International braz j urol

Journal Metrics
- Sobre o periódico
- SciELO Analytics

oct 2023, Volume 49 N. 5 Pages 580 - 589

Abstract: En | Text: En | PDF: En

ABSTRACT Objective: To report outcomes from the largest multicenter series of penile cancer patients undergoing video endoscopic inguinal lymphadenectomy (VEIL). Materials and Methods: Retrospective multicenter analysis. Authors of 21 centers from the Penile Cancer Collaborative Coalition-Latin America (PeC-LA) were included. All centers performed the procedure following the same previously described standardized technique. Inclusion criteria included penile cancer patients with no palpable lymph nodes and intermediate/high-risk disease and those with non-fixed palpable lymph nodes less than 4 cm in diameter. Categorical variables are shown as percentages and frequencies whereas continuous variables as mean and range. Results: From 2006 to 2020, 210 VEIL procedures were performed in 105 patients. Mean age was 58 (45-68) years old. Mean operative time was 90 minutes (60-120). Mean lymph node yield was 10 nodes (6-16). Complication rate was 15.7%, including severe complications in 1.9% of procedures. Lymphatic and skin complications were noted in 8.6 and 4.8% of patients, respectively. Histopathological analysis revealed lymph node involvement in 26.7% of patients with non-palpable nodes. Inguinal recurrence was observed in 2.8% of patients. 10y- overall survival was 74.2% and 10-y cancer specific survival was 84.8%. CSS for pN0, pN1, pN2 and pN3 were 100%, 82.4%, 72.7% and 9.1%, respectively. Conclusion: VEIL seems to offer appropriate long term oncological control with minimal morbidity. In the absence of non-invasive stratification measures such as dynamic sentinel node biopsy, VEIL emerged as the alternative for the management of non-bulky lymph nodes in penile cancer.

https://doi.org/10.1590/s1677-5538.ibju.2023.0065

10.

Calidad de la información de los promocionales de la industria farmacéutica y la educación médica
Facebook Twitter

Other social networks
Google+
LinkedIn
Reddit
StambleUpon
CiteULike
Mendeley
Other networks

Metrics
- SciELO Analytics
- Dimensions
- PlumX
- Altmetric

Peredo-Silva, Luis

; Reyes-Morales, Hortensia

; Guizar-García, Luis Alberto

; Almeida-Gutiérrez, Eduardo

; Páez- Moreno, Ricardo

; Lifshitz, Alberto

; Mino-León, Dolores

Investigación en educación médica

Journal Metrics
- Sobre o periódico
- SciELO Analytics

sep 2023, Volume 12 N. 47 Pages 58 - 66

Abstract: Es En | Text: Es En | PDF: Es | PDF: En

Resumen Introducción: El 15% de los promocionales de la industria farmacéutica (IF) incluyen información que no se fundamenta con los resultados del artículo original. Objetivo: Evaluar la validez de los artículos científicos originales que sustentan la información de los promocionales de la IF dirigidos a internistas y cardiólogos y conciliar la información del artículo científico original con la del promocional. Método: Los promocionales se obtuvieron en los congresos nacionales de Medicina Interna (MI) y Cardiología (C) realizados en México; aleatoriamente se seleccionaron 10 de cada especialidad; tres investigadores evaluaron la calidad de las referencias bibliográficas, la validez de los artículos originales y realizaron la conciliación de la información. Se realizó análisis descriptivo. Resultados: Se recolectaron 57 promocionales de MI y 16 de C; la calidad de las referencias bibliográficas de 4 promocionales de MI se evaluaron como evidencia “moderada” y las referencias de 4 promocionales de C como evidencia “no científica”. Los ensayos clínicos controlados de MI y C fueron válidos, un estudio observacional de C se catalogó sin validez. La conciliación de la información del promocional con la del artículo original reveló diferencias en cuatro promocionales de cada especialidad y de acuerdo con los criterios éticos para la promoción de medicamentos de la Organización Mundial de la Salud (OMS) predominó la falta de exactitud, en algunos casos la información no fue fidedigna y/o verdadera. Conclusiones: Es importante capacitar al médico en lectura crítica, para que evalúe objetivamente la información e identifique la promoción de medicamentos inefectivos y/o inseguros.

Abstract Introduction: It has been reported that 15% of the promotional products from the pharmaceutical industry (PI) include information not supported by the results of the original research. Objective: Evaluate the validity of the scientific information that supports the data included in the pharmaceutical industry promotional brochures for internists and cardiologists and reconcile the information. Method: Promotional brochures were collected during national conferences of Internal Medicine (IM) and Cardiology (C), and 10 promotional brochures of each medical specialty were randomly selected. Three researchers evaluated the quality of the references, and the validity of the original research and compared the information from the promotional brochure and the original publication. Descriptive statistical analysis was performed. Results: 57 IM and 16 C promotional brochures were collected; the quality of the references of 4 promotional brochures from IM was classified as “moderate” evidence and the references of 4 promotional from C were identified as “non-scientific” evidence. Clinical trials of IM and C were evaluated as valid and an observational study of C was classified as invalid. Comparison between promotional information and the original study detected differences in four IM and four C promotions, according to the ethical criteria for the promotion of medicines by the World Health Organization (WHO) the lack of accuracy predominated, and in some cases, the information was not reliable and/or true. Conclusions: Training in critical lectures is crucial for medical doctors. This will allow them a critical review of promotional information from PI, to identify the ones that may lead to inappropriate prescription.

https://doi.org/10.22201/fm.20075057e.2023.47.23507

11.

Dapagliflozin in patients with critical illness: rationale and design of the DEFENDER study
Facebook Twitter

Other social networks
Google+
LinkedIn
Reddit
StambleUpon
CiteULike
Mendeley
Other networks

Metrics
- SciELO Analytics
- Dimensions
- PlumX
- Altmetric

Tavares, Caio de Assis Moura

; Azevedo, Luciano César Pontes de

; Rea-Neto, Álvaro

; Campos, Niklas Söderberg

; Amendola, Cristina Prata

; Bergo, Ricardo Reinaldo

; Kozesinski-Nakatani, Amanda Christina

; David-João, Paula Geraldes

; Westphal, Glauco Adrieno

; Guimarães Júnior, Mário Roberto Rezende

; Lobo, Suzana Margareth Ajeje

; Tavares, Marcos Soares

; Dracoulakis, Marianna Deway Andrade

; Souza, Guilherme Martins de

; Almeida, Guacyra Margarita Batista de

; Gebara, Otavio Celso Eluf

; Tomba, Pablo Oscar

; Albuquerque, Camila Santos N

; Silva, Mariana Castaldi Ramalho

; Pereira, Adriano José

; Damiani, Lucas Petri

; Corrêa, Thiago Domingos

; Serpa-Neto, Ary

; Berwanger, Otavio

; Zampieri, Fernando Godinho

Critical Care Science

Journal Metrics
- Sobre o periódico
- SciELO Analytics

sep 2023, Volume 35 N. 3 Pages 256 - 265

Abstract: En Pt | Text: En Pt | PDF: En | PDF: Pt

ABSTRACT Background: Critical illness is a major ongoing health care burden worldwide and is associated with high mortality rates. Sodium-glucose cotransporter-2 inhibitors have consistently shown benefits in cardiovascular and renal outcomes. The effects of sodium-glucose cotransporter-2 inhibitors in acute illness have not been properly investigated. Methods: DEFENDER is an investigator-initiated, multicenter, randomized, open-label trial designed to evaluate the efficacy and safety of dapagliflozin in 500 adult participants with acute organ dysfunction who are hospitalized in the intensive care unit. Eligible participants will be randomized 1:1 to receive dapagliflozin 10mg plus standard of care for up to 14 days or standard of care alone. The primary outcome is a hierarchical composite of hospital mortality, initiation of kidney replacement therapy, and intensive care unit length of stay, up to 28 days. Safety will be strictly monitored throughout the study. Conclusion: DEFENDER is the first study designed to investigate the use of a sodium-glucose cotransporter-2 inhibitor in general intensive care unit patients with acute organ dysfunction. It will provide relevant information on the use of drugs of this promising class in critically ill patients. ClinicalTrials.gov registry: NCT05558098

RESUMO Antecedentes: A doença crítica é um importante ônus permanente da assistência médica em todo o mundo e está associada a altas taxas de mortalidade. Os inibidores do cotransportador de sódio-glicose do tipo 2 têm demonstrado consistentemente benefícios nos desfechos cardiovasculares e renais. Os efeitos dos inibidores do cotransportador de sódio-glicose do tipo 2 em doenças agudas ainda não foram devidamente investigados. Métodos: O DEFENDER é um estudo de iniciativa do investigador, multicêntrico, randomizado, aberto, desenhado para avaliar a eficácia e a segurança da dapagliflozina em 500 participantes adultos com disfunção orgânica aguda hospitalizados na unidade de terapia intensiva. Os participantes aptos serão randomizados 1:1 para receber 10mg de dapagliflozina e o tratamento padrão por até 14 dias ou apenas o tratamento padrão. O desfecho primário é um composto hierárquico de mortalidade hospitalar, início de terapia renal substitutiva e tempo de internação na unidade de terapia intensiva, até 28 dias. O monitoramento da segurança será rigoroso durante todo o estudo. Conclusão: O DEFENDER é o primeiro estudo desenvolvido para investigar o uso de um inibidor do cotransportador de sódio-glicose do tipo 2 em pacientes de unidade de terapia intensiva geral com disfunção orgânica aguda. O estudo fornecerá informações relevantes sobre o uso de medicamentos dessa classe promissora em pacientes críticos. Registro ClincalTrials.gov: NCT05558098

https://doi.org/10.5935/2965-2774.20230129-en

12.

Physical rehabilitation in Brazilian pediatric intensive care units: a multicenter point prevalence study
Facebook Twitter

Other social networks
Google+
LinkedIn
Reddit
StambleUpon
CiteULike
Mendeley
Other networks

Metrics
- SciELO Analytics
- Dimensions
- PlumX
- Altmetric

Redivo, Juliana

; Kannan, Harini

; Souza, Andreia Aparecida Freitas

; Colleti Junior, José

; Kudchadkar, Sapna Ravi

; Horigoshi, Nelson Kazunobu

; Costa, Graziela de Araújo

; Castilho, Taísa Roberta Ramos de

; Peron, Paula Peres Domingues

; Scaranto, Walter Perez

; Medeiros, Daniela Nasu Monteiro

; Matsumoto, Toshio

; Almeida, Carlos Gustavo de

; Oliveira, Felipe Rezende Caino de

; Brandão, Marcelo Barciela

; Lima-Setta, Fernanda

; Prata-Barbosa, Arnaldo

; Xavier, Glaciele Nascimento

; Andrade, Livia Barbosa de

; Aguiar, Agda Ultra de

; Coutinho, Marcos Paulo Galdino

; Castro, Roberta Esteves Viera de

; Landy, Glazia André

; Balaniuc, Suzana Lopes Bonfim

; Yamaguchi, Ricardo Silveira

Critical Care Science

Journal Metrics
- Sobre o periódico
- SciELO Analytics

sep 2023, Volume 35 N. 3 Pages 290 - 301

Abstract: En Pt | Text: En Pt | PDF: En | PDF: Pt

ABSTRACT Objective: To determine the prevalence and factors associated with the physical rehabilitation of critically ill children in Brazilian pediatric intensive care units. Methods: A 2-day, cross-sectional, multicenter point prevalence study comprising 27 pediatric intensive care units (out of 738) was conducted in Brazil in April and June 2019. This Brazilian study was part of a large multinational study called Prevalence of Acute Rehabilitation for Kids in the PICU (PARK-PICU). The primary outcome was the prevalence of mobility provided by physical therapy or occupational therapy. Clinical data on patient mobility, potential mobility safety events, and mobilization barriers were prospectively collected in patients admitted for ≥ 72 hours. Results: Children under the age of 3 years comprised 68% of the patient population. The prevalence of therapist-provided mobility was 74%, or 277 out of the 375 patient-days. Out-of-bed mobility was most positively associated with family presence (adjusted odds ratios 3.31;95%CI 1.70 - 6.43) and most negatively associated with arterial lines (adjusted odds ratios 0.16; 95%CI 0.05 - 0.57). Barriers to mobilization were reported on 27% of patient-days, the most common being lack of physician order (n = 18). Potential safety events occurred in 3% of all mobilization events. Conclusion: Therapist-provided mobility in Brazilian pediatric intensive care units is frequent. Family presence was high and positively associated with out-of-bed mobility. The presence of physiotherapists 24 hours a day in Brazilian pediatric intensive care units may have a substantial impact on the mobilization of critically ill children.

RESUMO Objetivo: Determinar a prevalência e os fatores associados à reabilitação física de crianças em estado grave em unidades de terapia intensiva pediátrica brasileiras. Métodos: Realizou-se um estudo de prevalência pontual multicêntrico, transversal, de 2 dias, abrangendo 27 unidades de terapia intensiva pediátrica (do total de 738) no Brasil em abril e junho de 2019. Este estudo brasileiro fez parte de um grande estudo multinacional chamado Prevalence of Acute Rehabilitation for Kids in the PICU (PARK-PICU). O desfecho primário foi a prevalência de mobilidade proporcionada pela fisioterapia ou pela terapia ocupacional. Foram coletados prospectivamente dados clínicos sobre a mobilidade do paciente, possíveis eventos de segurança de mobilidade e barreiras de mobilização em pacientes admitidos por ≥ 72 horas. Resultados: As crianças com idade inferior a 3 anos eram 68% da população de pacientes. A prevalência de mobilidade fornecida pelo terapeuta foi de 74%, ou 277 dos 375 pacientes-dia. A mobilidade para fora do leito foi mais positivamente associada à presença de familiares (razão de chance ajustada de 3,31; IC95% 1,70 - 6,43) e mais negativamente associada às linhas arteriais (razão de chance ajustada de 0,16; IC95% 0,05 - 0,57). Foram relatadas barreiras à mobilização em 27% dos pacientes-dia, sendo a mais comum a falta de prescrição médica (n = 18). Registaram-se eventuais eventos de segurança em 3% de todos os eventos de mobilização. Conclusão: A mobilidade proporcionada pelo terapeuta nas unidades de terapia intensiva pediátrica brasileiras é frequente. A presença de familiares foi alta e positivamente associada à mobilidade para fora do leito. A presença de fisioterapeutas 24 horas por dia nas unidades de terapia intensiva pediátrica brasileiras pode exercer papel importante na mobilização de crianças em estado grave.

https://doi.org/10.5935/2965-2774.20230388-en

13.

Total Arthroplasty in Complex Elbow Injury
Facebook Twitter

Other social networks
Google+
LinkedIn
Reddit
StambleUpon
CiteULike
Mendeley
Other networks

Metrics
- SciELO Analytics
- Dimensions
- PlumX
- Altmetric

Rezende, Ricardo Fernandes

; Gajo, Marcela de Melo

; Costa, Sérgio Moreira da

; Lazarini, Rafael Fuchs

; Carvalho Junior, Antonio Enéas Rangel de

; Almeida Filho, Ildeu Afonso de

Revista Brasileira de Ortopedia

Journal Metrics
- Sobre o periódico
- SciELO Analytics

sep 2023, Volume 58 N. 5 Pages 813 - 817

Abstract: Pt En | Text: Pt En | PDF: Pt | PDF: En

Resumo Os autores apresentam um caso atípico de fratura complexa do cotovelo esquerdo com perda extensa de tecido ósseo e muscular. O paciente foi submetido a diversos procedimentos cirúrgicos, que resultaram em uma artroplastia total do cotovelo esquerdo associada à reconstrução do tríceps com enxerto do tendão do músculo semitendíneo. muscular cirúrgicos semitendíneo

Abstract The authors present an atypical case of a left elbow complex fracture with extensive loss of bone and muscle tissue. The patient was submitted to several surgical procedures, which resulted in a total arthroplasty of the left elbow with triceps reconstruction using a semitendinosus muscle tendon graft. tissue procedures graft

https://doi.org/10.1055/s-0040-1722574

14.

A Study of the Current Scenario of the Obstetrics and Gynecology Residency during the COVID-19 Pandemic
Facebook Twitter

Other social networks
Google+
LinkedIn
Reddit
StambleUpon
CiteULike
Mendeley
Other networks

Metrics
- SciELO Analytics
- Dimensions
- PlumX
- Altmetric

Sonnenfeld, Marina Martinelli

; Nozaki, Alexandre Massao

; Genova, Anelise Silva de

; Ristow, José Ricardo Weitz

; Moura, Tamiris Ferreira de

; Cabral, Rayanne Pereira

; Garcia, João Victor Almeida

; Guimarães, Camila Abdias

; Oliveira, André Luiz Malavasi Longo de

; Francisco, Rossana Pulcineli Vieira

Revista Brasileira de Ginecologia e Obstetrícia

Journal Metrics
- Sobre o periódico
- SciELO Analytics

jul 2023, Volume 45 N. 7 Pages 377 - 383

Abstract: En Pt | Text: En Pt | PDF: En | PDF: Pt

Abstract Objective To analyze the impact of the COVID-19 pandemic on the residency of gynecology and obstetrics in São Paulo. Methods Cross-sectional study developed by representatives of residents of the Association of Gynecology and Obstetrics of the State of São Paulo (SOGESP, in the Portuguese acronym). Data were collected from questionnaires applied to gynecology and obstetrics residents registered on the SOGESP website in February 2022. The interviewees answered about the repercussions of the pandemic on medical residency and whether they had technical and psychological support during the period. Results A total of 247 questionnaires were collected from residents of gynecology and obstetrics. The residents had an age of 28.3 ± 3 years old, and most of them were female (88.4%). The displacement to COVID care was reported by 62.34% of the students, but only 35.6% reported completely adequate personal protective equipment and only 7.7% reported complete theoretical and technical instruction to support these patients. Almost all of the interviewees stated that the gynecology sector was the most affected. The majority of the interviewees considered that the second-year residents had the greatest loss, and more than half of the residents in the 1st and 2nd year said they wished to give up their residency during the pandemic. More than 80% of the residents reported online theoretical classes and/or presentation of articles, reinforcing the fact that virtual activities gained a greater space within the medical residency. Conclusion The pandemic impacted the residency in greater proportion in outpatient clinics and gynecological surgeries, also interfering with the physician's desire to continue with the program.

Resumo Objetivo Analisar o impacto pandemia de COVID-19 sobre a residência de ginecologia e obstetrícia do Estado de São Paulo. Métodos Estudo transversal desenvolvido por representantes dos residentes da Associação de Ginecologia e Obstetrícia do Estado de São Paulo (SOGESP). Foram coletados dados de questionários aplicados aos residentes de ginecologia e obstetrícia cadastrados no site da SOGESP em fevereiro de 2022. Os entrevistados responderam sobre repercussões da pandemia sobre a residência médica e se tiveram suporte técnico e psicológico durante o período. Resultados Foram levantados 247 questionários de residentes de ginecologia e obstetrícia. Os residentes apresentaram idade de 28,3 ± 3 anos, sendo a maioria do sexo feminino (88,4%). O deslocamento para “covidários” foi referido por 62,34% dos avaliados, porém somente 35,6% referiram equipamento de proteção individual completamente adequado e apenas 7,7% referiram instrução completa teórica e técnica para o suporte destes pacientes. Quase a totalidade dos entrevistados afirmou que o setor de ginecologia foi o mais afetado. A maioria dos entrevistados considerou que o os residentes do segundo ano foram os que tiveram maior prejuízo, sendo que mais da metade dos residentes do 1° e 2° ano afirmou ter desejado desistir da residência durante a pandemia. Mais de 80% dos residentes referiram aulas teóricas e/ou apresentação de artigos online, reforçando o fato de que as atividades virtuais ganharam um espaço maior dentro da residência médica. Conclusão A pandemia impactou nas residências em maior proporção nos ambulatórios e cirurgias ginecológicas, interferindo também sobre o desejo do médico de seguir com o programa.

https://doi.org/10.1055/s-0043-1772181

15.

Retinopathy of prematurity: Eight-year outcomes of a Portuguese neonatal intensive care unit
Facebook Twitter

Other social networks
Google+
LinkedIn
Reddit
StambleUpon
CiteULike
Mendeley
Other networks

Metrics
- SciELO Analytics
- Dimensions
- PlumX
- Altmetric

Almeida, Ricardo Liz

; Costa, Raquel Monteiro

; Bennett, Monica

; Alfaiate, Mário

; Basto, Lígia

Nascer e Crescer

Journal Metrics
- Sobre o periódico
- SciELO Analytics

jun 2023, Volume 32 N. 2 Pages 82 - 88

Abstract: En Pt | Text: En Pt | PDF: En | PDF: Pt

Abstract Introduction: Retinopathy of prematurity (ROP) is a vasoproliferative disorder of the retina in preterm newborns and is an important and preventable cause of visual impairment in children. The aim of this study was to investigate the incidence of ROP in a sample of preterm infants with ophthalmologic observation criteria and its association with specific major risk factors. Methods: Retrospective study of clinical records of premature infants with criteria for ROP screening in a Portuguese neonatal intensive care unit between January 2011 and December 2018. Results: Three hundred thirty-five infants met the criteria for ROP screening. The incidence of ROP and severe ROP requiring treatment was 9.0% and 1.8%, respectively. No infants with gestational age (GA) > 30 weeks or birth weight (BW) > 1500 g developed ROP. Neonatal comorbidities such as respiratory distress syndrome and intraventricular hemorrhage were not significantly associated with the development of ROP. GA, BW, supplemental oxygen therapy, and surfactant administration were independent predictors for the development of ROP. Discussion: Compared to neighboring countries with similar human development indexes, the incidence of ROP found in this study was relatively low. Implementation of the American Academy of Pediatrics/American Academy of Ophthalmology (AAO/AAP) guidelines in daily practice would potentially reduce the number of infants screened and allow diagnosis of most ROP cases. Conclusion: Statistically significant risk factors should be considered when evaluating preterm infants. Modification of current screening guidelines may be useful and cost-effective, and result in less stressful experiences for infants undergoing unnecessary ophthalmologic examinations.

Resumo Introdução: A retinopatia da prematuridade (ROP) é uma doença vasoproliferativa que ocorre na retina do recém-nascido prematuro, sendo uma importante e prevenível causa de baixa acuidade visual na infância. O objetivo deste estudo foi investigar a incidência desta patologia numa amostra de RN prematuros com critérios para observação oftalmológica, bem como a sua associação a determinados fatores de risco. Métodos: Estudo retrospetivo de rastreios realizados numa unidade de cuidados intensivos neonatais portuguesa a recém-nascidos com critérios para rastreio de ROP entre janeiro de 2011 e dezembro de 2018. Resultados: Trezentos e trinta e cinco recém-nascidos apresentaram critérios para rastreio de ROP. A incidência de ROP e ROP grave foi 9,0% e 1,8%, respetivamente. Nenhum recém-nascido com idade gestacional > 30 semanas ou peso à nascença > 1500 g desenvolveu ROP. Certas comorbilidades, como síndrome de dificuldade respiratória ou hemorragia peri-intraventricular, foram significativamente associadas ao desenvolvimento desta patologia. A idade gestacional, peso à nascença, terapia com oxigénio suplementar e administração de surfactante foram preditores independentes do desenvolvimento de ROP. Discussão: Comparativamente a países vizinhos com índices de desenvolvimento humano semelhantes, a incidência de ROP neste estudo foi relativamente baixa. A implementação das orientações da American Academy of Pediatrics/American Academy of Ophtalmology reduziria potencialmente o número de RN rastreados e não deixaria casos de ROP por diagnosticar. Conclusão: É importante que o clínico tenha em conta os fatores de risco significativos para esta patologia quando aborda um recém-nascido prematuro. A alteração das atuais recomendações de rastreio poderia ser útil e custo-efetiva e poupar o recém-nascido a stress associado exames oftalmológicos desnecessários.

https://doi.org/10.25753/birthgrowthmj.v32.i2.25870

Showing

itens per page

Page of 82 Next

Select one or more results

All Alphabetic

Results

Comparative chart Download CSV

Statistics of

Send result

To*

Use ; (semicolon) to insert more emails.

Send to email

This page

Selected records

All references (max. 300)

Your email

Subject

Comments

Export format:

RIS (for EndNote, ProCite, Reference Manager, RefWorks, Citavi, etc.)

BibTeX

Citation

CSV (for Excel, etc)

Export:

This page

Selected itens

All references (max. 2000)

Sem resultados

No documents were found for your search

Glossary and search help

You can enrich your search in a very simple way. Use the search indexes combined with the connectors (AND or OR) and specify more your search.

For example, if you want to search for articles about
cases of dengue in Brasil in 2015, use:
ti:dengue and publication_year:2015 and aff_country:Brasil

See below the complete list of search indexes that can be used:

Index code	Element
ti	article title
au	author
kw	article keywords
subject	subject (title words, abstract and keywords)
ab	abstract
ta	journal short title (e.g. Cad. Saúde Pública)
journal_title	journal full title (e.g. Cadernos de Saúde Pública)
la	publication language code (e.g. pt - Portuguese, es - Spanish)
type	document type
pid	publication identifier
publication_year	publication year of publication
sponsor	sponsor
aff_country	country code of the author's affiliation
aff_institution	author affiliation institution
volume	article volume
issue	article issue
elocation	elocation
doi	DOI number
issn	journal ISSN
in	SciELO colection code (e.g. scl - Brasil, col - Colômbia)
use_license	article usage license code

SciELO - Scientific Electronic Library Online
Rua Dr. Diogo de Faria, 1087 – 9º andar – Vila Clementino 04037-003 São Paulo/SP - Brasil
Email: scielo@scielo.org

All the contents of this site www.scielo.br, except where otherwise noted, is licensed under a Creative Commons Attribution License.
more »