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O voo das graúnas: estudantes negras/os como intelectuais graúnas negrasos negras os
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Alves, Sirlene

; Silva, Alexandra Lima da

Revista Brasileira de História da Educação

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2022, Volume 22 elocation e221

Abstract: Pt Es En | Text: Pt Es En | PDF: Pt | PDF: Es | PDF: En

Resumo: Analisar os percursos de estudantes negros e negras na segunda metade do século XIX é o horizonte deste trabalho. Qual é o lugar dos estudantes negros na História da Educação? Que pegadas deixaram? Que instituições frequentaram? De que forma se posicionaram sobre os principais debates sociais de sua época? Por que é importante dar visibilidade às trajetórias desses sujeitos? A partir de conversas com a bibliografia e do cruzamento de fontes, tais como memórias e notas publicadas na imprensa, tendo como base a conjugação da História Social da Educação e a Micro-história, o artigo procura indicar o engajamento de estudantes negros e negras na luta pela emancipação e pela ampliação dos direitos de cidadania. Resumo trabalho deixaram frequentaram época sujeitos fontes imprensa Microhistória, Microhistória Micro história, história Micro-história cidadania

Resumen: Este artículo analiza las trayectorias de los estudiantes negros en la segunda mitad del siglo XIX en Brasil. ¿Dónde encajan los estudiantes negros en la historia de la educación? ¿Qué huellas han dejado? ¿A qué instituciones asistieron? ¿Cuál era su posición con respecto a los principales problemas sociales de su época? ¿Por qué es importante hacer visibles sus trayectorias? Examinando lo que se ha publicado sobre el tema, cotejando información biográfica y notas publicadas en la prensa de la época, y combinando la microhistoria y la historia social de la educación, nuestro objetivo es arrojar luz sobre el compromiso de los estudiantes negros en la lucha. por la emancipación y la expansión de los derechos civiles en el Brasil del siglo XIX. Resumen Dónde educación Qué dejado A asistieron Cuál época Por tema lucha

Abstract: Analyzing the paths of black students in the second half of the 19th century is the horizon of this work. What is the place of black students in the History of Education? What footprints did they leave? What institutions did you attend? How did they position themselves on the main social debates of their time? Why is it important to give visibility to the trajectories of these subjects? From conversations with the bibliography and the crossing of sources, such as memories and notes published in the press, based on the combination of the Social History of Education and Micro-history, the article seeks to indicate the engagement of black students in the struggle for emancipation and for the expansion of citizenship rights. Abstract th work leave attend time subjects sources press Microhistory, Microhistory Micro history, history Micro-history rights

https://doi.org/10.4025/rbhe.v22.2022.e221

A Theoretical Antioxidant Mechanism for Cytoprotective Effect of p-Acetamide-Salicylate Derivatives against Free Radical Initiator AAPH in Human Erythrocytes
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Barros, Valéria A.

; Pereira, Glaécia A. N.

; Ota, Sirlene S. B.

; Melo, Fernanda P. A.

; Jesus, Ana Carolina S. P. S. de

; Lima, Anderson B.

; Silva, Albérico B. F. da

; Borges, Rosivaldo S.

Journal of the Brazilian Chemical Society

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jul 2021, Volume 32 N. 7 Pages 1354 - 1360

Abstract: En | Text: En | PDF: En

The molecular mechanism of cytoprotective effect on human erythrocytes of aminophenol and salicylates associated derivatives was related to their antioxidant capacity. The oxidative hemolysis induced by water-soluble free-radical initiator 2,2’-azobis-(2-amidine-propane)-dihydrochloride (AAPH) was inhibited by drug candidates named benzaminophen (BZL), salicytamide or 5-acetamide-salicylic acid (ASL), and salibenzamide or 5-benzamide-salicylic acid (BSL) when compared to their parents salicylic acid (SAC) and acetaminophen (ACP). Trolox (TLX) was the most powerful compound and used as positive control. BZL showed a potent effect followed by ACP > BSL > ASL. SAC did not show protective effect in any evaluated concentrations. These results are in accordance with the molecular mechanism by using theoretical calculation of single electron transfers (SET), hydrogen atom transfers (HAT), and sequential proton loss electron transfer (SPLET) by means of DFT/B3LYP/6-31++G(d,p) level of theory. [1,5] Hydrogen shift between carboxyl and phenol moieties and electronic properties related to pKa and other physical-chemical properties can be involved. The molecular association approach provides protective compounds more effective than SAC.

https://doi.org/10.21577/0103-5053.20210033 53 downloads

The QualiRede intervention: improving the performance of care continuum in HIV, congenital syphilis, and hepatitis C in health regions
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Nemes, Maria Ines Battistella

; Castanheira, Elen Rose Lodeiro

; Alves, Ana Maroso

; Adania, Carolina Simone Souza

; Loch, Ana Paula

; Monroe, Aline Aparecida

; Souza, Rosa Alencar

; Gianna, Maria Clara

; Caminada, Sirlene

; Farias, Norma Suely de Oliveira

; Sousa, Paula de Oliveira e

; Domingues, Carmen Silva Bruniera

; Silva, Mariliza Henrique da

; Cervantes, Vilma

; Yamashiro, Juliana

; Caraciolo, Joselita Maria de Magalhães

; Silva, Fabiano Lima da

; Nemes Filho, Alexandre

; Jesus, Gabriel Lima de

; Helena, Ernani Tiaraju de Santa

; Albiero, José Francisco Gontan

; Lima, Marcela Soares Silveira

; Bellenzani, Renata

; Kehrig, Ruth Terezinha

; Vale, Felipe Campos do

; Nunes, Luceime Olivia

; Mendonça, Carolina Siqueira

; Zarili, Thais Fernanda Tortorelli

; Vilela, Mara Cristina

; Dantas, Jean Carlos de Oliveira

; Paula, Ivone de

; Tayra, Ângela

; Coelho, Débora Moraes

; Santos, Glauber Palha dos

; Quevedo, Dulce Castro

; Silva, Marcia Aparecida da

; Silva, Iraci Batista da

; Nasser, Mariana Arantes

; Andrade, Marta Campagnoni

; Santos, Maria Altenfelder

; Mercuri, Juliana

; Trindade, Katia Valeska

; Neves, Maria Aparecida Teixeira das

; Toledo, Renata Villanueva Alves de

; Almeida, Maria Cecília Rossi de

; Lima, Iraty Nunes

Revista Brasileira de Epidemiologia

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2019, Volume 22 Suppl. 1 elocation e190010

Abstract: Pt En | Text: Pt En | PDF: Pt | PDF: En

RESUMO Introdução: Modelos de cuidado contínuo baseiam recentes estratégias em HIV, infecções sexualmente transmissíveis e hepatite C (HCV). Métodos: Desenvolveram-se modelos de contínuo do cuidado em HIV, HCV e sífilis congênita incluindo todas as etapas da atenção, desde a promoção e a prevenção até o controle clínico/cura. O modelo baseou a intervenção QualiRede, desenvolvida em parceria entre universidade e Sistema Único de Saúde (SUS), direcionada a gestores e demais profissionais de 6 regiões de saúde prioritárias em São Paulo e Santa Catarina. Selecionaram-se indicadores para cada etapa do contínuo do cuidado, provenientes dos sistemas de informação do SUS e dos questionários de avaliação de processo Qualiaids e QualiAB. Os indicadores formaram a base técnica de duas oficinas com profissionais e gestores de cada região: a primeira para identificar problemas e formar um Grupo Técnico Regional; e a segunda para construir planos de ação e metas a fim de melhorar o desempenho regional. Resultados: Os indicadores estão disponíveis no website www.qualirede.org. As oficinas ocorreram em quatro regiões de São Paulo (Alto Tietê, Baixada Santista, Grande ABC e Registro) e uma região de Santa Catarina (Foz do Rio Itajaí), resultando em planos regionais em São Paulo, mas não em Santa Catarina. Observou-se domínio limitado dos novos protocolos para HIV e HCV e uso incipiente de indicadores na rotina dos serviços. Conclusão: Melhorar o desempenho do contínuo do cuidado exige apropriação dos indicadores de desempenho e coordenação integrada dos fluxos de atenção em todos os níveis de gestão.

ABSTRACT Introduction: Care continuum models have supported recent strategies against sexually transmitted diseases, such as HIV and Hepatitis C (HCV). Methods: HIV, HCV, and congenital syphilis care continuum models were developed, including all stages of care, from promotion/prevention to clinical control/cure. The models supported the intervention QualiRede, developed by a University-Brazilian National Health System (SUS) partnership focused on managers and other professionals from six priority health regions in São Paulo and Santa Catarina. Indicators were selected for each stage of the care continuum from the SUS information systems and from the Qualiaids and QualiAB facility’s process evaluation questionnaires. The indicators acted as the technical basis of two workshops with professionals and managers in each region: the first one to identify problems and to create a Regional Technical Group; and the second one to design action plans for improving regional performance. Results: The indicators are available at www.qualirede.org. The workshops took place in the regions of Alto Tietê, Baixada Santista, Grande ABC, and Registro (São Paulo) and of Foz do Rio Itajaí (Santa Catarina), which resulted in regional action plans in São Paulo, but not in Santa Catarina. A lack of awareness was observed regarding the new HIV and HCV protocols, as well as an incipient use of indicators in routine practices. Conclusion: Improving the performance of the care continuum requires appropriation of performance indicators and coordination of care flows at local, regional, and state levels of management.

https://doi.org/10.1590/1980-549720190010.supl.1

The QualiRede intervention: improving the performance of care continuum in HIV, congenital syphilis, and hepatitis C in health regions
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Nemes, Maria Ines Battistella

; Castanheira, Elen Rose Lodeiro

; Alves, Ana Maroso

; Adania, Carolina Simone Souza

; Loch, Ana Paula

; Monroe, Aline Aparecida

; Souza, Rosa Alencar

; Gianna, Maria Clara

; Caminada, Sirlene

; Farias, Norma Suely de Oliveira

; Sousa, Paula de Oliveira e

; Domingues, Carmen Silva Bruniera

; Silva, Mariliza Henrique da

; Cervantes, Vilma

; Yamashiro, Juliana

; Caraciolo, Joselita Maria de Magalhães

; Silva, Fabiano Lima da

; Nemes Filho, Alexandre

; Jesus, Gabriel Lima de

; Helena, Ernani Tiaraju de Santa

; Albiero, José Francisco Gontan

; Lima, Marcela Soares Silveira

; Bellenzani, Renata

; Kehrig, Ruth Terezinha

; Vale, Felipe Campos do

; Nunes, Luceime Olivia

; Mendonça, Carolina Siqueira

; Zarili, Thais Fernanda Tortorelli

; Vilela, Mara Cristina

; Dantas, Jean Carlos de Oliveira

; Paula, Ivone de

; Tayra, Ângela

; Coelho, Débora Moraes

; Santos, Glauber Palha dos

; Quevedo, Dulce Castro

; Silva, Marcia Aparecida da

; Silva, Iraci Batista da

; Nasser, Mariana Arantes

; Andrade, Marta Campagnoni

; Santos, Maria Altenfelder

; Mercuri, Juliana

; Trindade, Katia Valeska

; Neves, Maria Aparecida Teixeira das

; Toledo, Renata Villanueva Alves de

; Almeida, Maria Cecília Rossi de

; Lima, Iraty Nunes

Revista Brasileira de Epidemiologia

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2019, Volume 22 Suppl. 1 elocation e190010

Abstract: Pt En | Text: Pt En | PDF: Pt | PDF: En

https://doi.org/10.1590/1980-549720190010.supl.1 2475 downloads

Provenance of the Ediacaran Salinas Formation (Araçuaí Orogen, Brazil): Clues from lithochemical data and zircon U-Pb (SHRIMP) ages of volcanic clasts
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Deluca, Carolina

; Pedrosa-Soares, Antonio

; Lima, Sirlene

; Cordani, Umberto

; Sato, Kei

Brazilian Journal of Geology

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2019, Volume 49 N. 2 elocation e20190017

Abstract: En | Text: En | PDF: En

Abstract Salinas Formation occurs in a large region of the Northern Araçuaí orogen, Southeastern Brazil. It includes turbiditic wackes (> 10% matrix) to arenites (< 10% matrix), pelites and clast-supported conglomerates, metamorphosed from the biotite zone of the greenschist facies to the sillimanite zone of the amphibolite facies. Salinas Formation lies unconformably on the top of or in tectonic contact with the Macaúbas Group, and hosts Cambrian granitic intrusions dated between 540 and 500 Ma. Aiming to unravel sediment provenances for the Salinas basin, we present a detailed lithochemical (45 samples) study on low-grade rocks preserved from the regional deformation, which are found in the type area of the Salinas Formation. In addition, we compare them with deformed and more metamorphic rocks of similar composition but located in other basin sectors. The lithochemical data indicate limited chemical weathering in the sediment sources, good correlations with the mineralogical compositions in respect to the variable amounts of metamorphic minerals typical of pelitic (micas, garnet, and other peraluminous silicates) and psammitic (feldspars, quartz) fractions. The main provenances of sedimentary protoliths are clearly related to continental magmatic arc and active continental margin environments. U-Pb (SHRIMP) analyses performed on zircon grains from clasts of intermediate to felsic volcanic rocks, extracted from a clast-supported metaconglomerate, yield concordant zircon Pb 206 /U 238 ages from ca. 579 Ma to ca. 697 Ma, with most of the ages in the interval of 587 to 630 Ma. This indicates that the main primary sediment source is the Rio Doce magmatic arc (630-580 Ma), in very good agreement with the arc-related lithochemical signature. Eleven zircon crystals yield a Concordia age of 620 ± 10 Ma, representing an important Ediacaran volcanic episode in the tectonic evolution of the Araçuaí orogen.

https://doi.org/10.1590/2317-4889201920190017 1043 downloads

Using allogeneic cortical graft preserved in glycerin as spacer in the advancement of tibial tuberosity in 34 dogs
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Gomes Junior, Deusdete C.

; Oriá, Arianne P.

; Vieira, João Victor R.

; Barbosa, Sirlene F.

; Estrela-Lima, Alessandra

; Dórea Neto, Francisco A.

Pesquisa Veterinária Brasileira

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dec 2018, Volume 38 N. 12 Pages 2246 - 2253

Abstract: Pt En | Text: Pt En | PDF: Pt | PDF: En

RESUMO: O ligamento cruzado cranial é o principal responsável pela estabilidade do joelho, impedindo o deslocamento da tíbia cranial em relação ao fêmur. A deficiência neste ligamento (CCLD) pode causar subluxação da tíbia e disfunção do membro pélvico devido à sobrecarga. As osteotomias tibiais estão entre as técnicas cirúrgicas mais atuais para o tratamento de CCLD em cães e proporcionam a estabilidade dinâmica por meio da modificação da geometria óssea da distribuição das forças que atuam sobre a articulação. O objetivo desse estudo é descrever o uso do enxerto ósseo cortical alogênico conservado em glicerina como espaçador no avanço da tuberosidade tibial (TTA) para o tratamento do CCLD. Para isso, 34 cães submetidos à cirurgia de TTA foram avaliados, sendo 23 machos (67,35%) e 11 fêmeas (32,35%). Os procedimentos curúrgicos aconteceram entre maio de 2011 e outubro de 2015. Com relação ao procedimento cirúrgico após a osteotomia da tuberosidade tibial, um disco alogênico cortical, em forma de cunha serrada, conservado em glicerina com proporções de 2 x 1mm foi aplicado como espaçador possibilitando a TTA. Avanços de 3 a 12mm foram executados, dependendo da necessidade do paciente. Para animais com luxação da patela, realizou-se a trocleoplastia e a TTA para a correção do desvio. A idade média dos animais foi de 6,67±3,58 anos e pesos médios de 15,16±12,97kg. Cães sem raça definida, Poodles e Yorkshire Terriers foram os mais afetados. Dos 36 joelhos avaliados, 11 (30,56%) foram associados a algum processo traumático e em 25 (69,44%) não havia nenhuma relação com um trauma prévio. Dos ferimentos, 20 (55,56%) aconteceram no membro direito e 16 (44,44%) no esquerdo, sendo que dois animais apresentavam CCLD bilateralmente. Os animais tiveram suporte contínuo, discreto movimento de gaveta e compressão tibial negativa 15 dias após a cirurgia. Aos 30 dias, 26 casos tinham suporte firme (FS); aos 45 dias, 24 casos tinham FS e oito casos sem claudicação (WC). Durante avaliações radiográficas subsequentes, observou-se a incorporação progressiva da união do enxerto e da osteotomia. Neste estudo, a maior parte do CCLD diagnosticado ocorreu em machos, divergindo dos resultados obtidos por outros autores que encontraram maior frequência em fêmeas. Suporte sem claudicação foi observado na maioria dos casos de implantes aos 60 dias. Foi concluído que o enxerto ósseo cortical alogênico conservado foi capaz de promover a união óssea na TTA de cães com CCLD. Nenhum dos animais apresentou sinais de contaminação, infecção da ferida cirúrgica ou rejeição relacionada à presença do enxerto, demonstrada pela incorporação completa do enxerto ósseo observada precocemente aos 45 dias em alguns animais. A glicerina foi um bom meio de conservação para os fragmentos destinados à enxertia porque, além do menor custo, manteve os fragmentos ósseos livres de contaminação, reduzindo a antigenicidade e preservando as funções de osteoindução e osteocondução. A possibilidade de moldagem do enxerto à necessidade do animal é uma característica favorável à execução da técnica modificada que pode ser moldada de acordo com o tamanho do animal, possibilitando perfeita adaptação ao local osteotomizado em diferentes raças. Intercorrências comumente observadas na TTA com luxação patelar, lesões meniscais, fratura da crista tibial e deslocamento não foram encontradas nos animais deste estudo, provavelmente devido à melhor distribuição de forças entre a passagem do parafuso no TT e a placa do TTA, confirmando que tem boa adaptação à técnica conferindo às vantagens da TTA modificada em relação à TTA convencional.

ABSTRACT: Cranial cruciate ligament is the main responsible for knee stability by preventing cranial tibial displacement regarding the femur. Deficiency in this ligament (CCLD) may cause subluxation of the tibia and dysfunction of the pelvic member due to overloading. Tibial osteotomies are among the more current surgical techniques for treating CCLD in dogs and they proportionate the dynamic stability by means of modifying bone geometry and the distribution of forces acting on the articulation. The objective of this work is to describe the use of the allogeneic cortical bone graft conserved in glycerin as a spacer on the tibial tuberosity advancement (TTA) for treating the CCLD. In order to do that, 34 dogs submitted to TTA surgery correction were evaluated, being 23 males (67.35%) and 11 females (32.35%). Surgical procedures happened from May 2011 to October 2015. Regarding the surgical procedure after osteotomy of the tibial tuberosity, a disk of allogeneic cortical disk, sawn wedge-hapsed, conserved in glycerin, proportions of 2x1mm was applied as spacer, enabling TTA. Advancements from 3 to 12 mm were executed, depending on the need of the patient. For animals with patella dislocation, trochleoplasty and TTA were executed in order to correct the deviation. The mean ± SD age of animals was 6.67±3.58 and weight was 15.16±12.97 kg. Mongrel dogs, Poodles and Yorkshire terriers were the most affected ones. From the 36 evaluated knees, 11 (30.56%) were associated with some traumatic process and in 25 (69.44%) there was no relation with previous trauma. From those wounds, 20 (55.56%) happened in the right limb and 16 (44.44%) in the left limb and two animals had CCLD bilaterally. Animals had continuous support, discreet drawer movement and negative tibial compression 15 days after surgery. At 30 days, 26 cases (72.22%) had firm support (FS); at 45 days, 24 cases (66 test at 7 and 67%) had FS and eight cases (22.22%) without claudication (WC). During subsequent radiographic evaluations the progressive incorporation of the graft and osteotomy union were observed. In this study, most of the diagnosed CCLD occurred in males diverging from results obtained by other authors that found greater frequency in females. Support without claudication it was observed in most of the cases of implants at 60 days. We concluded that the conserved allogeneic cortical bone graft was able to promote bone union in TTA of dogs with CCLD. None of the animals had signs of contamination, infection of the surgical wound or rejection related with the presence of the graft, demonstrated by the complete graft-bone incorporation observed early at 45 days in some animals. The glycerin was a good conservation medium for those fragments intended for grafting because, besides being of low cost, it kept bone fragments free of contamination, reducing antigenicity and preserving the functions of osteoinduction and osteoconduction. The possibility of molding the graft to the animal need is a characteristic favorable to executing the modified technique that could be molded according to the size of the animal, allowing perfect adaptation to the osteotomized local in different breeds. Intercurrences commonly observed in TTA with patellar dislocation, meniscal lesions, tibial crest fracture and displacement were not found in the animals of this study, probably due to the better distribution of forces between the pass screw in TT and the TTA plate confirming that it has good adaptation to the technique conferring to the modified TTA advantages regarding the conventional TTA.

https://doi.org/10.1590/1678-5150-pvb-5968 773 downloads

Pterodon pubescens oil nanoemulsions: physiochemical and microbiological characterization and in vivo anti-inflammatory efficacy studies
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Hoscheid, Jaqueline

; Outuki, Priscila M.

; Kleinubing, Sirlene A.

; Goes, Paulo R.N. de

; Lima, Marli M.S.

; Cuman, Roberto K.N.

; Cardoso, Mara L.C.

Revista Brasileira de Farmacognosia

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jun 2017, Volume 27 N. 3 Pages 375 - 383

Abstract: En | Text: En | PDF: En

Abstract Pterodon pubescens (Benth.) Benth., Fabaceae, fruits have been investigated for their anti-inflammatory and antinociceptive activities, and have demonstrated effectiveness in inflammatory conditions. A physiochemical and microbiological stability study was conducted to investigate two nanoemulsion-based delivery systems of two different hydrophilic surfactants (polyethylene glycol-40H castor oil or polyethylene glycol-40 castor oil). The nanoemulsions, containing P. pubescens oil, lecithin, hydrophilic surfactant and water, were analyzed for droplet size distribution, polydispersity index, pH, consistency index, stability against centrifugal force, and active content/vouacapan derivatives. The physicochemical characteristics were followed for 365 days. The nanoemulsion system was evaluated for anti-inflammatory activity by using with a peritonitis model, immediately after preparation and after 365 days of storage at 25 °C. The stability study demonstrated that proper storage (25 °C) preserved the characteristics of the nanoemulsion containing 7.5% polyethylene glycol-40H castor oil, 5% lecithin, and 5% P. pubescens oil. Further, it ensured a shelf life of 365 days as a phytotherapeutic formulation. In the peritonitis assay induced by carrageenan, nanoemulsion prepared with polyethylene glycol-40H castor oil (125 mg/kg) reduced leukocyte migration, even after 365 days of storage (25 °C), highlighting its potential for the treatment of inflammatory diseases. However, further studies are needed to confirm its clinical effectiveness.

https://doi.org/10.1016/j.bjp.2016.08.012 999 downloads

Effect of iron content on the catalytic properties of activated carbon-supported magnetite derived from biomass
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Lima, Sirlene B.

; Borges, Sarah Maria S.

; Rangel, Maria do Carmo

; Marchetti, Sergio G.

Journal of the Brazilian Chemical Society

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feb 2013, Volume 24 N. 2 Pages 344 - 354

Abstract: Pt En | Text: Pt En | PDF: Pt | PDF: En

Nos últimos tempos, a intensa atividade humana levou a um aumento de resíduos agrícolas no meio ambiente. Visando a encontrar novas aplicações para estes materiais estudou-se, neste trabalho, o efeito do teor de ferro (2.5, 5, 10 e 15%) sobre as propriedades catalíticas de óxido de ferro suportado em carvão ativado, preparado a partir de cascas de coco. O teor de ferro afetou as propriedades texturais e redutoras dos sólidos. Detectou-se hematita na amostra mais pobre em ferro e magnetita com um núcleo de hematita nas demais. Estes catalisadores foram eficazes na remoção do azul de metileno em soluções aquosas por adsorção e pela reação de Fenton. O sólido com 15% de ferro foi o mais ativo, provavelmente devido à maior quantidade de sítios ativos na superfície. Estes catalisadores são ambientalmente amigáveis, contribuindo para a redução de resíduos sólidos no meio ambiente e purificação de efluentes têxteis, preservando os recursos hídricos.

In recent times, the intense human activity has led to an increase of the agriculture wastes in the environment. "In order to find new applications for these materials, the effect of iron content (2.5, 5, 10 and 15%) on the catalytic properties of activated carbon-supported iron oxide, prepared from coconut shells, was studied. The iron amount affected the textural and reducing properties of the solids and particle sizes. Hematite was found for the most iron-poor sample, while particles of magnetite with a core of hematite were found for the others. These catalysts were effective in the methylene blue removal from aqueous solutions by adsorption and Fenton reaction. The solid with 15% of iron was the most active one probably due to the highest iron amount on the surface. These catalysts are environmentally friendly, contributing to the decrease of the solid wastes in the environment as well as to purify textile effluents, preserving water resources.

https://doi.org/10.5935/0103-5053.20130044 4152 downloads

Anti-inflammatory and analgesic potential of Caesalpinia ferrea
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Lima, Sandrine Maria A.

; Araújo, Larissa Cardoso C.

; Sitônio, Marília Maria

; Freitas, Ana Carina C.

; Moura, Sirlene L.

; Correia, Maria Tereza S.

; Malta, Diana Jussara N.

; Gonçalves-Silva, Teresinha

Revista Brasileira de Farmacognosia

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- Sobre o periódico
- SciELO Analytics

feb 2012, Volume 22 N. 1 Pages 169 - 175

Abstract: En | Text: En | PDF: En

Caesalpinia ferrea Mart. belongs to the family Fabaceae. Known as pau-ferro and jucá, it is used in folk medicine to treat diabetes, as antipyretic and antirheumatic. This study aimed to evaluate the anti-inflammatory and antinociceptive activities of the ethanol extract of the fruits of C. ferrea (EECf). In the evaluation of anti-inflammatory activity, EECf (50 mg/kg) produced significantly inhibition of ear edema by 66.6% compared to control. Indomethacin (10 mg/kg) showed inhibition of 83.9% compared to control. EECf (50 mg/kg) inhibited of vascular permeability induced by acetic acid and was also able to reduce of cell migration to the peritoneal cavity induced by thioglycolate. In the writhing test induced by acid acetic, EECf (12.5, 25 and 50 mg/kg) significantly reduced the number of contortions by 24.9, 46.9 and 74.2%, respectively. In the formalin test, EECf presented effects only in the second phase. The results provided experimental evidence for the effectiveness of the traditional use of C. ferrea in treating various diseases associated with inflammation and pain.

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