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ABSTRACT BACKGROUND: Weight regain in the postoperative period after bariatric surgery is directly related to the relapse of preoperative comorbidities and a negative impact on the patients’ biochemical profile. AIMS: To assess the metabolic impact of weight regain on preoperative comorbidities and on patients’ biochemical profiles, in order to show the impact of the complications on the metabolic outcomes of bariatric surgery. METHODS: A retrospective study was carried out with 75 women in the late postoperative period of bariatric surgery who presented pathological weight regain (≥20% of the maximum weight loss). Data of interest consisted of glycemic, lipid, and inflammatory profile measurements at three different moments of evaluation: preoperative period, at the weight nadir (minimum weight), and after weight regain. A multivariate analysis was performed. RESULTS: The mean age was 46.39±12.09 years. Preoperative body mass index was 40.10±4.11 kg/m2. There was an overall increase of 3.36 points in the mean body mass index between the nadir and after regain: from 26.30±3.9 kg/m2 to 29.66±4.66 kg/m2. The mean time to reach the nadir was 18±7.6 months, with an average percentage of excess weight loss of 91.08±11.8%. The median time for pathological weight regain was 48 months, and the mean regain amongst the sample was 8.85±5.65 kg. There was a significant correlation between pathological weight regain and levels of insulin (r=0.351; p<0.011), C-peptide (r=0.303; p<0.011), C-reactive protein (r=0.402; p<0.001), and vitamin D (r=-0.435; p<0.001), the last two being the most influenced by the percentage of weight regained. CONCLUSIONS: The pathological weight regain in the postoperative period of bariatric surgery results in losses in the patients’ metabolic and inflammatory profiles. However, the biochemical benefits are sustained up to the preoperative levels of the parameters analyzed.

RESUMO RACIONAL: Reganho de peso no pós-operatório de cirurgia bariátrica está diretamente relacionado à recidiva das comorbidades pré-operatórias e a um impacto negativo no perfil bioquímico desses pacientes. OBJETIVOS: avaliar o impacto metabólico do reganho de peso nas comorbidades pré-operatórias e no perfil bioquímico desses pacientes, a fim de mostrar o impacto das complicações nos desfechos metabólicos finais da cirurgia bariátrica. MÉTODOS: Estudo retrospectivo que analisou 75 mulheres no pós-operatório tardio de cirurgia bariátrica que apresentaram reganho patológico de peso (=20% do máximo de peso perdido). Foram coletados dados referentes às medidas dos perfis glicêmico, lipídico e inflamatório em três momentos distintos de avaliação: no pré-operatório, no nadir de peso (menor peso) e após o reganho ponderal. Foi realizada uma análise multivariada. RESULTADOS: A idade média foi 46.39±12.09 anos. IMC médio pré-operatório foi 40.10±4.11 kg/m2. Houve um aumento de 3,36 pontos no IMC médio entre o nadir e após reganho: de 26.30±3.9 Kg/m2 para 29.66±4.66 Kg/m2. O tempo médio para atingir o nadir foi de 18±7.6 meses, com uma %PEP de 91.08±11.8%. O tempo médio para o reganho patológico foi de 48 meses, e a média de reganho foi 8.85±5.65 kg. Houve correlação significativa entre o reganho patológico e os níveis de insulina (r=0.351; p<0.011), peptídeo C (r=0.303; p<0.011), proteína C reativa (r=0.402; p<0.001) e vitamina D (r=-0.435; p<0.001), sendo os dois últimos os mais influenciados pela porcentagem de reganho de peso. CONCLUSÕES: O reganho de peso patológico no pós-operatório de cirurgia bariátrica resulta em prejuízos ao perfil metabólico e inflamatório dos pacientes. No entanto, os benefícios bioquímicos perduram em relação aos níveis pré-operatórios dos parâmetros analisados

https://doi.org/10.1590/0102-672020230037e1755

Long COVID-19 syndrome associated with Omicron XBB.1.5 infection: a case report
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Espíndola, Otávio

; Resende, Paola C

; Guaraldo, Lusiele

; Calvet, Guilherme Amaral

; Fuller, Trevon L

; Penetra, Stephanie Lema Suarez

; Santos, Heloisa Ferreira Pinto

; Pina-Costa, Anielle

; da Silva, Michele Fernanda Borges

; Moraes, Isabella Campos Vargas

; Medeiros, Fernando

; Whitworth, Jimmy

; Smith, Christopher

; Nielsen-Saines, Karin

; Siqueira, Marilda M

; Brasil, Patrícia

Memórias do Instituto Oswaldo Cruz

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2023, Volume 118 elocation e230069

Abstract: En | Text: En | PDF: En

BACKGROUND There is interest in lingering non-specific symptoms after severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection, referred to as Long coronavirus disease 2019 (Long COVID-19). It remains unknown whether the risk of Long COVID-19 is associated with pre-existing comorbidities or initial COVID-19 severity, including infections due to new Omicron lineages which predominated in 2023. OBJECTIVES The aim of this case report was to characterize the clinical features of acute XBB.1.5 infection followed by Long COVID-19. METHODS We followed a 73-year old female resident of Rio de Janeiro with laboratory-confirmed SARS-CoV-2 during acute infection and subsequent months. The SARS-CoV-2 lineage was determined by genome sequencing. FINDINGS The participant denied comorbidities and had completed a two-dose vaccination schedule followed by two booster doses eight months prior to SARS-CoV-2 infection. Primary infection by viral lineage XBB.1.5. was clinically mild, but the participant subsequently reported persistent fatigue. MAIN CONCLUSIONS This case demonstrates that Long COVID-19 may develop even after mild disease due to SARS-CoV-2 in fully vaccinated and boosted individuals without comorbidities. Continued monitoring of new SARS-CoV-2 lineages and associated clinical outcomes is warranted. Measures to prevent infection should continue to be implemented including development of new vaccines and antivirals effective against novel variants.

https://doi.org/10.1590/0074-02760230069

Leishmanicidal and Antimicrobial Activities of 4-Quinolone Alkaloids from Stems of the Medicinal Plant Waltheria indica (Malvaceae) and Their Chemotaxonomic Significance
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Silva, Raquel M.

; Domingos, Levy T. S.

; Castro, Gabriellen M. M. de

; Laport, Marinella S.

; Ferreira-Pereira, Antônio

; Lima, Murilo M. C.

; Cotinguiba, Fernando

Journal of the Brazilian Chemical Society

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nov 2022, Volume 33 N. 11 Pages 1291 - 1298

Abstract: En | Text: En | PDF: En

A chemical investigation of the stem of Waltheria indica (Malvaceae) yielded twelve 4-quinolone alkaloids, which were primarily waltheriones. These were waltherione A (1), waltherione B (2), waltherione C (3), waltherione G (4), waltherione H (5), waltherione J (6), waltherione L (7), waltherione P (8), chamaedrone (9), 8-deoxy-antidesmone (10), antidesmone (11), and the previously unreported alkaloid N-methoxy-waltherione A (12). These alkaloids belong to an unusual class of 4-quinolones and therefore, have chemosystematic significance for distinguishing the Waltheria and Melochia genera from the rest of the Malvaceae family. The ability of the alkaloid isolates to reverse the phenotypic expression of fluconazole-resistance was tested by using a mutant strain of Saccharomyces cerevisiae that expressed a Candida albicans transporter. Of the isolates tested, waltherione G afforded a positive result. Leishmanicidal activity and bactericidal tests were also performed using the isolated alkaloids, which showed promising results.

https://doi.org/10.21577/0103-5053.20220060

Caracterización de DELUX: Dispositivo de esterilización por luz ultravioleta para máscaras PFF2/N95 contra COVID-19
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Lombello, Christiane Bertachini

; Daghastanli, Nasser Ali

; Neto, Hermann Windisch

; Affonso Fonseca, Fernando Luiz

; Ambrosio, Felipe Nogueira

; Arbex, Raquel

; Fernando, Isabella Kobb

; da Silva, Victor Allisson

; dos Santos, Luisa Pataquini

; da Ana, Patricia Aparecida

Ingenius. Revista de Ciencia y Tecnología

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jun 2022, N. 27 Pages 23 - 31

Abstract: En Es | Text: En Es | PDF: En | PDF: Es

Abstract The World Health Organization (WHO) has declared a public health pandemic state due to the transmission of the new coronavirus on March 11th, 2020. COVID-19, that is caused by SARS-CoV-2, has a very broad clinical spectrum, with predominantly respiratory symptoms developments. The role of the health professionals in fighting the pandemic requires the use of Personal Protective Equipment (PPE). PFF2 / N95 masks are suitable PPEs for this purpose. Due to the high demand for PFF2 / N95 masks to fight the pandemic, there was a shortage of this PPE worldwide. This work aims to present a characterization of the device called DELUX, utilized for UVC (ultraviolet C light spectra) sterilization of PFF2 / N95 masks, and allowing to extend the time of safe use of this PPE in emergency conditions. The photometric validation of the device resulted in the verification of the emission spectrum of the lamps used in the device, and the measurement of the optical power, demonstrating the adequacy of irradiation with UVC light, with a 15-minute cycle, and safely. Biological validation showed that DELUX is capable of inactivating SARS-CoV-2 present on the surface of PFF2 / N95 masks, thus being efficient for their sterilization. The safety offered by the sterilization cycle allows to extend the safe use of those masks.

Resumen La Organización Mundial de la Salud (OMS) declaró un estado pandémico de salud pública debido a la transmisión del nuevo coronavirus el 11 de marzo de 2020. La COVID-19, causada por el SARS-CoV-2, tiene un espectro clínico muy amplio, con predominio de desarrollos sintomáticos respiratorios. El papel de los profesionales de salud en la lucha contra la pandemia requiere un equipo de protección personal (EPP). Las máscaras PFF2 / N95 son EPP adecuados para este propósito. Debido a la gran demanda de máscaras PFF2 / N95 para combatir la pandemia, hubo escasez en el mercado. Este trabajo tiene como objetivo caracterizar un dispositivo denominado DELUX para la esterilización por UVC (espectros de luz ultravioleta C) de mascarillas PFF2 / N95, ampliando su tiempo de uso seguro en condiciones de emergencia. La validación fotométrica del dispositivo permitió la verificación del espectro de emisión de las lámparas empleadas en el dispositivo y la medición de la potencia óptica, demostrando la idoneidad de la irradiación con luz UVC, en ciclos de 15 minutos, de forma segura. La validación biológica mostró que DELUX es capaz de desactivar el SARS-CoV-2 presente en la superficie de las mascarillas PFF2 / N95, siendo así eficiente para su esterilización extendiendo el tiempo de utilización de estas mascarillas.

https://doi.org/10.17163/ings.n27.2022.03 25 downloads

Fatores associados à adesão ao tratamento da hepatite C: revisão integrativa
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Côco, Layla Tatiane

; Silva, Giovanni Faria

; Romeiro, Fernando Gomes

; Cerqueira, Ana Teresa de Abreu Ramos

Ciência & Saúde Coletiva

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apr 2022, Volume 27 N. 4 Pages 1359 - 1376

Abstract: Pt En | Text: Pt En | PDF: Pt | PDF: En

Resumo Esta revisão integrativa propôs-se a analisar na literatura da área estudos sobre fatores associados à adesão ao tratamento da hepatite C. Foram pesquisados artigos, publicados em inglês, espanhol e português, nas bases de dados Lilacs, Medline, PsycINFO, Web of Science, Scopus e CINAHL, entre os anos 2000 a 2019. Foram obtidas, inicialmente, 540 publicações e, posteriormente, aplicando-se os critérios de inclusão estabelecidos, foram selecionados 22 artigos. Constatou-se nos artigos analisados que a porcentagem de não adesão ao tratamento variou de 12% a 32%. Foram identificados como facilitadores da adesão: receber tratamento para transtornos psiquiátricos identificados durante o tratamento, ter conhecimento sobre os medicamentos e doença, receber tratamento menos complexo e com maior possibilidade de cura, apresentar menor número de eventos adversos, ter apoio social e bom vínculo com o médico. Foram identificadas como barreiras à adesão: presença de sintomas depressivos e de outros transtornos mentais, uso abusivo de álcool e substâncias psicoativas, baixa escolaridade, idade (ser mais jovem); etnia (afro-americanos), desemprego, não ter parceiro fixo, relatar estigma, distância do serviço de saúde, complexidade e eventos adversos do tratamento. Foram também identificadas lacunas nas pesquisas sobre adesão.

Abstract This integrative review examined factors associated with hepatitis C treatment adherence. The articles included were published in English, Spanish and Portuguese in the Lilacs, Medline, PsycINFO, Web of Science, Scopus and CINAHL databases, between 2000 and 2019. Initially, 540 publications were found and, after applying the study inclusion criteria, 22 articles were selected. Percentage non-adherence to treatment ranged from 12% to 32%. The variables identified as facilitating adherence were: receiving treatment for psychiatric disorders identified during treatment; knowing about medications and disease; receiving less complex treatment with greater likelihood of cure; fewer adverse events; social support; doctor-patient communication; and/or being in relationships. Barriers to adherence identified were: presence of depressive symptoms and other mental disorders; abuse of alcohol and psychoactive substances; education; age; ethnicity; unemployment; not having a steady partner; stigma; distance from health services; and the complexity and adverse effects of treatment. This review identified gaps in research on adherence.

https://doi.org/10.1590/1413-81232022274.06942021

Fatores associados à adesão ao tratamento da hepatite C: revisão integrativa
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Côco, Layla Tatiane

; Silva, Giovanni Faria

; Romeiro, Fernando Gomes

; Cerqueira, Ana Teresa de Abreu Ramos

Ciência & Saúde Coletiva

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apr 2022, Volume 27 N. 4 Pages 1359 - 1376

Abstract: Pt En | Text: Pt En | PDF: Pt | PDF: En

https://doi.org/10.1590/1413-81232022274.06942021

Tandem Synthesis of Furanaphthoquinones via Enamines and Evaluation of Their Antiparasitic Effects against Trypanosoma cruzi
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Cardoso, Mariana F. C

; Forezi, Luana S. M

; Souza, Acácio S. de

; Faria, Ana F. M

; Galvão, Raissa M. S

; Bello, Murilo L

; Silva, Fernando C. da

; Faria, Robson X

; Ferreira, Vitor F

Journal of the Brazilian Chemical Society

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mar 2022, Volume 33 N. 3 Pages 238 - 250

Abstract: En | Text: En | PDF: En

Furanaphthoquinones are well known in medicinal chemistry for exhibiting relevant structural heterogeneity and bioactivities. In this work, it was synthesized a series of furanaphthoquinones through a tandem reaction between lawsone (8) and cyclic ketones in the presence of morpholine. This strategy provides an efficient and general method for synthesizing furanaphthoquinones with activity against the epimastigote form of Trypanosoma cruzi (T. cruzi), the parasite that causes Chagas disease. Compound 9b was the better prototype, and it exhibited high potency for causing parasite death, showed reduced acute toxicity towards mammalian cells, and was capable of rupturing the epimastigote plasma membrane and acting on sterol 14α-demethylase (CYP51). Additionally, 9b reduced trypomastigote viability by 99% after 24 h. Candidate 9b demonstrated the best and most promising profile when bound to CYP51.

https://doi.org/10.21577/0103-5053.20210142

Antivirais para pacientes adultos hospitalizados com infecção por SARS-CoV-2: Um estudo de Fase II/III, randomizado, multicêntrico, controlado por placebo, adaptativo, com múltiplos braços e estágios. COALITION COVID-19 BRAZIL IX - REVOLUTIOn: protocolo e plano de análise estatística
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Maia, Israel Silva

; Marcadenti, Aline

; Zampieri, Fernando Godinho

; Damiani, Lucas Petri

; Santos, Renato Hideo Nakagawa

; Negrelli, Karina Leal

; Gomes, Samara Pinheiro do Carmo

; Gomes, Jaqueline Oliveira

; Carollo, Mariana Barbosa dos Santos

; Miranda, Tamiris Abait

; Santucci, Eliana

; Valeis, Nanci

; Laranjeira, Ligia Nasi

; Westphal, Glauco Adrieno

; Horta, Jacques Gabriel Alvares

; Flato, Uri Adrian Prync

; Fernandes, Camilo

; Barros, Waldemar Carlos

; Bolan, Renata S

; Gebara, Otávio Celso Eluf

; Alencar Filho, Meton Soares de

; Hamamoto, Victor Augusto

; Hernandes, Mauro Esteves

; Golin, Nicole Alberti

; Olinda, Ronald Torres de

; Machado, Flávia Ribeiro

; Rosa, Régis Goulart

; Veiga, Viviane Cordeiro

; Azevedo, Luciano César Pontes de

; Avezum, Alvaro

; Lopes, Renato Delascio

; Souza, Tiago Moreno L

; Berwanger, Otávio

; Cavalcanti, Alexandre Biasi

Revista Brasileira de Terapia Intensiva

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mar 2022, Volume 34 N. 1 Pages 44 - 55

Abstract: Pt En | Text: Pt En | PDF: Pt | PDF: En

RESUMO Os medicamentos reaproveitados são importantes em contextos de recursos limitados porque as intervenções estão mais rapidamente disponíveis, já foram testadas com segurança em outras populações e são, em geral, mais baratas. Os medicamentos reaproveitados são uma solução eficaz, especialmente para doenças emergentes, como a COVID-19. O estudo REVOLUTIOn visa avaliar três medicamentos antivirais reaproveitados: atazanavir, daclatasvir e sofosbuvir, já utilizados em pacientes infectados pelo HIV ou pelo vírus da hepatite C, em um estudo randomizado, controlado por placebo, adaptativo, multibraço e em múltiplos estágios. Os medicamentos serão testados simultaneamente em um ensaio de Fase II para primeiro identificar se algum deles, isoladamente ou em combinação, reduz a carga viral. Se reduzirem, será iniciado um estudo de Fase III para investigar se tais medicamentos são capazes de aumentar o número de dias sem suporte respiratório. Os participantes devem ser adultos hospitalizados com idade ≥ 18 anos com início dos sintomas ≤ 9 dias e saturação de oxigênio ≤ 94% em ar ambiente ou necessidade de oxigênio suplementar para manter saturação de oxigênio > 94%. O tamanho total esperado da amostra varia entre 252 e 1.005 participantes, dependendo do número de estágios que serão concluídos no estudo. Assim, o protocolo é aqui descrito em detalhes, juntamente do plano de análise estatística. Em conclusão, o estudo REVOLUTIOn foi concebido para fornecer evidências se o atazanavir, o daclatasvir ou o sofosbuvir reduzem a carga viral de SARS-CoV-2 em pacientes com COVID-19 e aumentam o número de dias em que os pacientes ficam sem suporte respiratório. Neste artigo de protocolo, descrevem-se a fundamentação, o desenho e a situação do ensaio. Identificador do ClinicalTrials.gov:NCT04468087

ABSTRACT Repurposed drugs are important in resource-limited settings because the interventions are more rapidly available, have already been tested safely in other populations and are inexpensive. Repurposed drugs are an effective solution, especially for emerging diseases such as COVID-19. The REVOLUTIOn trial has the objective of evaluating three repurposed antiviral drugs, atazanavir, daclatasvir and sofosbuvir, already used for HIV- and hepatitis C virus-infected patients in a randomized, placebo-controlled, adaptive, multiarm, multistage study. The drugs will be tested simultaneously in a Phase II trial to first identify whether any of these drugs alone or in combination reduce the viral load. If they do, a Phase III trial will be initiated to investigate if these medications are capable of increasing the number of days free respiratory support. Participants must be hospitalized adults aged ≥ 18 years with initiation of symptoms ≤ 9 days and SpO2 ≤ 94% in room air or a need for supplemental oxygen to maintain an SpO2 > 94%. The expected total sample size ranges from 252 to 1,005 participants, depending on the number of stages that will be completed in the study. Hence, the protocol is described here in detail together with the statistical analysis plan. In conclusion, the REVOLUTIOn trial is designed to provide evidence on whether atazanavir, daclatasvir or sofosbuvir decrease the SARS-CoV-2 load in patients with COVID-19 and increase the number of days patients are free of respiratory support. In this protocol paper, we describe the rationale, design, and status of the trial. ClinicalTrials.gov identifier:NCT04468087

https://doi.org/10.5935/0103-507x.20220002-pt

Teores de carbono em espécies florestais da Caatinga
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Silva, Ane Cristine Fortes da

; Freire, Fernando José

; Borges, César Henrique Alves

; Araujo, Emmanoella Costa Guaraná

; Santana, Gabriel Mendes

; Cunha Neto, Ernandes Macedo da

; Sanquetta, Carlos Roberto

Ciência Florestal

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mar 2022, Volume 32 N. 1 Pages 71 - 85

Abstract: Pt En | Text: Pt En | PDF: Pt | PDF: En

RESUMO Objetivou-se quantificar os teores de C nos reservatórios da biomassa vegetal de diferentes espécies da Caatinga, floresta tropical seca do Nordeste do Brasil. Foi realizado um estudo florístico e fitossociológico prévio e selecionadas nove espécies de maior densidade absoluta, que representou 87% do fragmento. Foram amostradas biomassa dos compartimentos folhas e lenho de cada uma das espécies para determinação do teor de C. Como resultado, houve diferença nos teores foliares de C entre as espécies. O teor de C foliar das espécies variou entre 448,0 e 454,3 g C por kg de biomassa seca e o teor de C do lenho das espécies variou entre 451,4 e 453,1 g C por kg de biomassa seca. Esses resultados sugerem a utilização de fator de conversão de biomassa para carbono específico por espécie em Caatinga, como alternativa ao fator genérico de 50% recomendado pelo IPCC. Esta pesquisa revela que o uso do fator recomendado pelo IPCC superestima estoques de C em Caatinga. Mais estudos são encorajados para confirmar esse resultado.

ABSTRACT This study aimed to quantify the carbon contents in biomass reservoirs of different species in a Tropical Dry Forest located in Northeast, Brazil. We developed a previous floristic and phytosociological study and selected the nine highest absolute density (AD) species of the fragment, representing 87% of the fragment AD. We sampled the leaves and stem tissues of each species for carbon content determination. As result, the leaf C content differed between the species. The C leaf content ranged between 448.0 and 454.3 g C per kg of dry biomass. The C stem content varied between the species from 451.4 to 453.1 g C per kg of dry biomass. Our results suggest the use of a species-specific biomass-carbon conversion factor in Caatinga, as an alternative to the 50% factor recommended by the IPCC. This research reveals that the use of the factor recommended by the IPCC overestimates C stocks in Caatinga. Further studies are encouraged to confirm this result.

https://doi.org/10.5902/1980509842456

10.

Inhibition of tuber sprouting in potato cultivars Asterix and Challenger by 1.4-dimethylnaphthalene
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Mendonça Neto, Abelardo Barreto de

; Pereira, Ariana Mota

; Guimarães, Maria Eduarda da Silva

; Gonçalves, Dreice Nascimento

; Soares, Luciana Gomes

; Cruz, Renata Ranielly Pedroza

; Freire, Ana Izabella

; Finger, Fernando Luiz

; Cecon, Paulo Roberto

Ciência Rural

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2022, Volume 52 N. 8 elocation e20210131

Abstract: Pt En | Text: Pt En | PDF: Pt | PDF: En

RESUMO: Objetivou-se com este estudo verificar a eficiência do 1,4-dimetilnaftaleno na supressão da brotação e a consequente manutenção da qualidade de tubérculos de batata das cultivares Asterix e Challenger, em diferentes temperaturas e tempos de armazenamento. Foram testados seis tratamentos, com e sem 1,4-DNM, nas temperaturas de 8 °C e 20 °C. As avaliações foram feitas aos 0, 45, 90, 135 e 180 dias após a aplicação. Os parâmetros avaliados foram: número de brotos, teores de açúcares solúveis totais, teores de açúcares redutores, e não redutores, e coloração dos palitos de batata após a fritura. Os efeitos do 1,4-DMN no controle da qualidade das batatas resultaram no controle da brotação e em menores teores de açúcares solúveis totais e de açúcares redutores, sobretudo na cultivar Challenger e à temperatura de 20 ºC.

ABSTRACT: The aim of this study was to verify the efficiency of 1,4-dimethylnapthalene in suppressing sprouting and the consequent maintenance of the quality of potato tubers of Asterix and Challenger cultivars, at different temperatures and storage regimes. Six treatments were tested, with and without 1.4-DNM, at temperatures of 8 ° C and 20 ° C. Assessments were made at 0, 45, 90, 135 and 180 days after application. The parameters evaluated were: number of sprouts, levels of total soluble sugars, levels of reducing and non-reducing sugars and coloration of potato strips after frying. The effects of 1.4-DMN on the quality control of potatoes resulted in sprout control and lower levels of total soluble sugars and reducing sugars, especially in the Challenger cultivar and at a temperature of 20 ºC.

https://doi.org/10.1590/0103-8478cr20210131

11.

Sleep quality in COPD patients: correlation with disease severity and health status
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Clímaco, Danielle Cristina Silva

; Lustosa, Thais C

; Silva, Marcus Vinícius de França Pereira

; Lins-Filho, Ozeas L

; Rodrigues, Valesca Kehrle

; Oliveira-Neto, Luiz de Albuquerque P de

; Feitosa, Audes Diógenes Magalhães

; Queiroga Jr, Fernando José Pinho

; Cabral, Marília Montenegro

; Pedrosa, Rodrigo P

Jornal Brasileiro de Pneumologia

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2022, Volume 48 N. 3 elocation e20210340

Abstract: Pt En | Text: Pt En | PDF: Pt | PDF: En

RESUMO Objetivo: Avaliar os preditores clínicos de má qualidade do sono em pacientes com DPOC, com e sem apneia obstrutiva do sono (AOS). Métodos: Pacientes estáveis consecutivos com DPOC foram avaliados quanto à AOS por meio de polissonografia noturna; quanto à qualidade do sono por meio do Índice de Qualidade do Sono de Pittsburgh (IQSP) e quanto ao impacto da doença por meio do Teste de Avaliação da DPOC. A gravidade da DPOC foi classificada conforme as diretrizes de 2020 da GOLD. Os preditores de má qualidade do sono foram avaliados por meio de análise de regressão logística multivariada. Resultados: Foram estudados 51 pacientes com DPOC apenas e 51 pacientes com DPOC e AOS. Ambos os grupos eram semelhantes quanto à idade (66,2 ± 9,2 anos vs. 69,6 ± 10,7, p = 0,09) e limitação do fluxo aéreo (p = 0,37). Sono de má qualidade esteve presente em 74,8% dos participantes, sem diferença significativa entre os pacientes com DPOC, com e sem AOS, quanto à pontuação no IQSP (p = 0,73). A polissonografia mostrou aumento do estágio 1 do sono non-rapid eye movement e do índice de despertares, bem como redução da eficiência do sono e do estágio 3 do sono non-rapid eye movement nos pacientes com DPOC e AOS (p < 0,05). Os preditores independentes de má qualidade do sono foram DPOC grau C/D da GOLD (OR = 6,4; IC95%: 1,79-23,3; p < 0,01), pontuação ≥ 10 no Teste de Avaliação da DPOC (OR = 12,3; IC95%: 4,1-36,5; p < 0,01) e menor SaO2 < 80% (p < 0,0001). Conclusões: O sono de má qualidade é bastante comum em pacientes com DPOC e apresenta relação com DPOC grave e estado de saúde ruim, além de ter impacto negativo na qualidade de vida global. Não obstante as alterações na polissonografia, a AOS aparentemente não tem impacto na qualidade do sono referida por pacientes com DPOC.

ABSTRACT Objective: To evaluate clinical predictors of poor sleep quality in COPD patients with and without obstructive sleep apnea (OSA). Methods: Consecutive stable patients with COPD were evaluated for OSA by means of overnight polysomnography; for sleep quality by means of the Pittsburgh Sleep Quality Index (PSQI); and for disease impact by means of the COPD Assessment Test. COPD severity was graded in accordance with the 2020 GOLD guidelines. Predictors of poor sleep quality were evaluated by multivariate logistic regression analysis. Results: We studied 51 patients with COPD alone and 51 patients with COPD and OSA. Both groups had similar age (66.2 ± 9.2 years vs. 69.6 ± 10.7, p = 0.09) and airflow limitation (p = 0.37). Poor sleep quality was present in 74.8% of the study participants, with no significant difference between COPD patients with and without OSA regarding PSQI scores (p = 0.73). Polysomnography showed increased stage 1 non-rapid eye movement sleep and arousal index, as well as reduced sleep efficiency and stage 3 non-rapid eye movement sleep, in the group of patients with COPD and OSA (p < 0.05). Independent predictors of poor sleep quality were GOLD grade C/D COPD (OR = 6.4; 95% CI, 1.79-23.3; p < 0.01), a COPD Assessment Test score ≥ 10 (OR = 12.3; 95% CI, 4.1-36.5; p < 0.01), and lowest SaO2 < 80% (p < 0.0001). Conclusions: Poor sleep quality is quite common in patients with COPD and is associated with severe COPD and poor health status, having a negative impact on overall quality of life. Despite changes in polysomnography, OSA appears to have no impact on subjective sleep quality in COPD patients.

https://doi.org/10.36416/1806-3756/e20210340

12.

Production of healthy mixed vegetable beverage: antioxidant capacity, physicochemical and sensorial properties
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PINTO, Daiane dos Santos

; SILVA, Sandra dos Santos

; FIGUEIREDO, Raimundo Wilane de

; MENEZES, Fernando Lima de

; CASTRO, Janevane Silva de

; PIMENTA, Antônia Torres Ávila

; SANTOS, João Evangelista de Ávila dos

; NASCIMENTO, Ronaldo Ferreira do

; GABAN, Socorro Vanesca Frota

Food Science and Technology

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2022, Volume 42 elocation e28121

Abstract: En | Text: En | PDF: En

Abstract The present study aimed to develop and perform physicochemical and sensory analyses of new vegetable beverage with cashew nuts (C), brown rice, and prunes (P). Four formulations (F) were developed: F1: 3% C + 9% P; F2: 6% C + 9% P; F3: 3% C + 12% P; F4: 6% C + 12% P. All formulations had good acceptance with grades ranging from 6.14 to 7.23. Among formulations, F3 showed more promising from a functional and sensory point of view, since presented a higher content of oleic acid and antioxidant activity, and showed lower values for calories, lipids and viscosity compared to all other formulations. It was concluded that it was technically possible to develop an alternative vegetable beverage for those allergic to cow's milk, those with lactose intolerance, and people with obesity or cardiovascular and digestive problems.

https://doi.org/10.1590/fst.28121

13.

Characterization of primary direct-acting antiviral (DAA) drugs resistance mutations in NS5A/NS5B regions of hepatitis C virus with genotype 1a and 1b from patients with chronic hepatitis
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Santos, Ana Paula de Torres

; Silva, Vanessa Cristina Martins

; Mendes-Corrêa, Maria Cássia

; Lemos, Marcilio Figueiredo

; Malta, Fernanda de Mello

; Santana, Rúbia Anita Ferraz

; Dastoli, Gregório Tadeu Fernando

; Castro, Vanessa Fusco Duarte de

; Pinho, João Renato Rebello

; Moreira, Regina Célia

Revista do Instituto de Medicina Tropical de São Paulo

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2022, Volume 64 elocation e61

Abstract: En | Text: En | PDF: En

ABSTRACT The Hepatitis C virus (HCV) infection is a public health problem. The high level of HCV replication and its lack of post-transcriptional correction mechanisms results in the emergence of viral variants and the difficulty in determining polymorphisms and variants that contain the substitutions associated with resistance towards new antivirals. The main focus of this study was to map the NS5A and NS5B polymorphisms and resistance mutations to new antiviral drugs in HCV strains genotype 1 from patients with chronic hepatitis C infection. Serum samples were collected from patients who underwent routine viral load tests at the Instituto Adolfo Lutz, Sao Paulo city, Brazil. A total of 698 and 853 samples were used for the characterization of NS5A and NS5B regions, respectively, which comprise the HCV genotypes 1a and 1b. The prevalence of resistance mutations found in the NS5A region was 6.4%, with Y93H, L31M, Q30R, and Y93N as the main resistance-associated substitutions (RAS). No NS5B-associated RAS was observed for any of the analyzed drugs. These findings support that the RAS test should be offered to individuals with poor response to double combination regimens prior to treatment initiation, thereby assisting strain vigilance and selection of effective treatment or retreatment options using DAA regimens.

https://doi.org/10.1590/s1678-9946202264061

14.

Increased yield and nutrient content of Tropaeolum majus L. with use of chicken manure 1
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Silva, Orivaldo Benedito da

; Goelzer, Ademir

; Santos, Fernando Henrique Moreira dos

; Carnevali, Thiago de Oliveira

; Vieira, Maria do Carmo

; Zárate, Néstor Antonio Heredia

Revista Ceres

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oct 2021, Volume 68 N. 5 Pages 379 - 389

Abstract: En | Text: En | PDF: En

ABSTRACT Nasturtium (Tropaeolum majus L.) is an unconventional plant or vegetable grown for ornamental, food and medicinal purposes. However, information on cultivation of the species involving organic residue is incipient. Therefore, aimed to evaluate plant growth, flower yield, and nutrient contents of leaves and flowers of Nasturtium cultivated with addition of chicken manure. Five doses of chicken manure were studied, applied in the soil incorporated (I) (1, 6, 10, 14 and 19 t ha-1) and cover (C) (1, 6, 10, 14 and 19 t ha-1) forms, using the experimental array Plan Puebla III, leading to nine combinations of doses and forms of adding the chicken manure, in randomized blocks with four replicates. The greatest plant height (35.75 cm) was achieved at 168 days after transplanting (DAT) under 10 t ha-1 I and 10 t ha-1 C. The greatest yield terms of in number (15.4 million ha-1) and fresh (10.45 t ha-1) and dry weights (0.849 t ha-1) of flowers were found by using doses close to 10 t ha-1 I and 10 t ha-1 C. To obtain the best development and yield of Nasturtium flowers, 10 t ha-1 I and 10 t ha-1 C of chicken manure should be used.

https://doi.org/10.1590/0034-737x202168050002 28 downloads

15.

Salivary nitrite and systemic biomarkers in obese individuals with periodontitis submitted to FMD
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Cortelli, Sheila C

; Máximo, Priscila de Macedo

; Peralta, Felipe S

; Silva, Rodrigo Augusto da

; Rovai, Emanuel S

; Costa, Fernando O

; Aquino, Davi R

; Rodrigues, Edson

; Cortelli, Jose R

Brazilian Dental Journal

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apr 2021, Volume 32 N. 2 Pages 27 - 36

Abstract: Pt En | Text: Pt En | PDF: Pt | PDF: En

Resumo O objetivo deste estudo clínico, é avaliar o impacto da desinfecção bucal completa (DBC) nos níveis de nitrito salivar e biomarcadores sistêmicos e sua correlação com a carga bacteriana subgengival total em pacientes obesos e não obesos com periodontite. No total, 94 pacientes (55 obesos e 39 não obesos) foram avaliados inicialmente, sete foram perdidos durante o estudo, resultando em 87 indivíduos ao final. Os resultados foram avaliados no início do estudo, 3, 6 e 9 meses após o tratamento periodontal por DBC. Os níveis de nitrito salivar foram determinados usando o reagente de Griess. Amostras de sangue foram coletadas para determinação da Proteína C Reativa (PCR), fosfatase alcalina e glicemia de jejum. A PCR em tempo real foi usada para determinar a carga bacteriana subgengival total. O protocolo de DBC resultou em níveis aumentados de nitrito salivar em 6 e 9 meses após o tratamento no grupo de não obesos (p <0,05). Em indivíduos obesos, o tratamento da DBC levou a um aumento nos níveis de nitrito salivar em 6 meses (p <0,05); no entanto, aos 9 meses, os níveis de nitrito voltaram aos níveis basais. Para ambos os grupos, os maiores valores de nitrito foram observados aos 6 meses. Além disso, em ambos os grupos, a DBC foi associada à diminuição dos biomarcadores relacionados à inflamação sistêmica e doenças cardiovasculares, como PCR (p <0,05) e fosfatase alcalina (p <0,05), e não teve impacto na glicemia de jejum. Este estudo demonstra que pacientes obesos com periodontite apresentam níveis de nitrito salivar semelhantes quando comparados a indivíduos não obesos. O protocolo de DBC resultou em aumentos nos níveis de nitrito salivar e foi associado a um impacto positivo nos biomarcadores sistêmicos, independentemente do status de obesidade.

Abstract The objective of this 9-month clinical study is to assess the impact of one-stage full-mouth disinfection (FMD) on salivary nitrite levels and systemic biomarkers and its correlation with total subgingival bacterial load in obese and non-obese patients with periodontitis. In total, 94 patients (55 obese and 39 non-obese) were initially evaluated, seven were lost during follow-up, resulting in 87 individuals at the end of the study. Outcomes were assessed at baseline, 3, 6, and 9 months post periodontal treatment by FMD. Salivary nitrite levels were determined using Griess reagent. Blood samples were collected to determine C-Reactive Protein (CRP), alkaline phosphatase and fasting blood glucose. Real-time PCR was used to determine the total subgingival bacterial load. FMD protocol resulted in increased salivary nitrite levels at 6- and 9-months post-treatment in the non-obese group (p<0.05). In obese individuals, FMD treatment led to an increase in salivary nitrite levels at 6 months (p<0.05); however, at 9 months, the nitrite levels returned to baseline levels. For both groups, the highest nitrite values were observed at 6 months. In addition, in both groups, FMD was associated with a decrease in biomarkers related to systemic inflammation and cardiovascular diseases, such as CRP (p<0.05) and alkaline phosphatase (p<0.05), and had no impact on the fasting blood glucose. This study demonstrates that obese patients with periodontitis present similar salivary nitrite levels when compared with non-obese individuals. FMD protocol resulted in increases in salivary nitrite levels and was associated with a positive impact on systemic biomarkers, regardless of obesity status.

https://doi.org/10.1590/0103-6440202103782 228 downloads

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