ABSTRACT Introduction: Daratumumab is a CD38-targeting monoclonal antibody with established efficacy and safety in patients with relapsed or refractory multiple myeloma (RRMM). We report results of an early access protocol (EAP) of daratumumab monotherapy for RRMM in a cohort of Brazilian patients. Methods: Patients with RRMM and ≥3 prior lines of therapy, including a proteasome inhibitor (PI) and an immunomodulatory drug (IMiD), or who were double refractory to both a PI and IMiD received daratumumab, 16 mg/kg, intravenously weekly for 8 weeks, biweekly for 16 weeks, and every 4 weeks thereafter until disease progression, unacceptable toxicity, loss of clinical benefit, or study conclusion or if daratumumab became available with reimbursement. Results: Forty-nine patients received ≥1 dose of daratumumab. The median (range) duration of treatment was 6.4 (0.3-11.8) months, with a median (range) of 8 (1-13) treatment cycles. Grade 3/4 treatment-emergent adverse events (TEAEs) were reported in 38.8% of patients, most frequently neutropenia and pneumonia (10.2% each). Seven (14.3%) patients discontinued treatment due to TEAEs; 3 patients discontinued due to daratumumab-related TEAEs. Serious TEAEs occurred in 38.8% of patients. Infusion-related reactions were reported in 25 (51.0%) patients, were primarily grade 1/2, and the majority (23 patients) occurred during the first infusion. Twenty (40.8%) patients achieved a partial response or better; median progression-free survival was 8.25 (95% confidence interval, 5.55-17.54) months. Conclusion: In this EAP, daratumumab monotherapy in Brazilian patients showed a safety and efficacy profile consistent with clinical studies of daratumumab monotherapy in patients with heavily pretreated RRMM. ClinicalTrials.gov identifier: NCT02477891.

ABSTRACT Introduction: Burns are a type of injury that is among the leading causes of mortality. The use of epidemiology helps in providing subsidies for evaluation and organization of treatment and prevention, aiming at the improvement of public health. The objective is to describe the epidemiological profile of the patients treated at the Queimados Nelson Picollo unit of the Governador Otávio Lages de Siqueira Emergency Hospital (HUGOL). Method: This study analyzed the epidemiological profile of patients, aged more than 12 years, treated by plastic surgery at the burn treatment unit, Nelson Picollo, from July 2015 to June 2017. The patients who were not admitted to the burn unit were excluded from the study. Data were collected from the MVSoul R. program. Results: A total of 375 patients visited the hospital; of these, 50% of the patients needed intensive care unit treatments. The mean duration of hospital stay was 23.08 days. The majority of the patients were males, with a mean age of 39.17 years, and the main etiological agents were inflammable liquids, mainly alcohol and gasoline. The mean burned body surface area was 24.67%. A total of 1490 surgical interventions were performed, with an average of 3.97 surgeries per patient. Forty patients died; of these, 29 had airway burns. The total number of patients with airway burns was 73. Conclusion: This study provides a profile of burns and hospitalizations in the HUGOL burns unit, which corresponds with those from other centers specialized for this type of treatment.

RESUMO Introdução: Queimadura é um tipo de lesão que está entre as principais causas de mortalidade. A utilização da epidemiologia ajuda no fornecimento de subsídios para avaliação e organização de tratamento e prevenção, visando à melhora da saúde pública. O objetivo é descrever o perfil epidemiológico dos pacientes atendidos no Hospital de Urgências Governador Otávio Lages de Siqueira (HUGOL) na unidade de Queimados Nelson Picollo. Método: Este estudo analisou o perfil epidemiológico dos pacientes atendidos pela equipe de cirurgia plástica da unidade de tratamento de queimados Nelson Picollo, no período de julho 2015 até junho 2017, com idade superior a 12 anos. Critérios de exclusão: pacientes que não foram internados na unidade de queimados. Os dados foram colhidos do programa MVSoul R. Resultados: O total de atendimentos foi de 375 pacientes, dos quais 50% necessitaram de tratamentos unidade de terapia intensiva. O tempo médio de internação foi de 23,08 dias. A maioria do sexo masculino, com média de idade de 39,17 anos, com agente etiológico principal as chamas por álcool + gasolina. A média de superfície corporal queimada foi de 24,67%. Foram realizados 1490 intervenções cirúrgicas, média de 3,97 cirurgias por paciente. O total de óbitos foi de 40 pacientes, dos quais 29 apresentaram queimadura de via aérea. O total de pacientes com queimadura de via aérea foi de 73 casos. Conclusão: Este estudo demonstrou um perfil de queimaduras e internações na unidade de Queimados do HUGOL compatível com outros centros especializados neste tipo de tratamento.

Abstract Background Despite all the scientific progress that has been made on understanding the disease, prognosis for patients with relapsed and refractory Hodgkin's lymphoma remains poor and the treatment is palliative in the majority of the cases. Thus, the aim of this study was to present the results on the compassionate use of everolimus in a group of patients who were monitored at nine different centers in Brazil. Methods A 10-mg oral dose of everolimus was given to each patient daily. Response time was evaluated from the beginning of medication use until loss of response, toxicity or medical decision to cease treatment. Results Thirty-three patients were evaluated. The median age at the beginning of medication administration was 29 years. Patients had received a median of five prior therapies. Overall response rate was 45.4%, with 13 patients achieving partial response, two achieved clinical response, 14 remained with stable disease, two had disease progression, and two were not evaluated. Patients received a median of 14 cycles. Progression-free survival was nine months, and overall survival was estimated to be 36 months. Three patients used the medication for more than four years. The most frequently reported adverse events were thrombocytopenia and hypercholesterolemia. Three patients had pulmonary toxicity. Grade III and IV adverse events occurred in 39% of the patients. Conclusion Everolimus was found to provide a response in a group of patients with refractory or relapsed Hodgkin's lymphoma who had adequate tolerability to the drug.

INTRODUÇÃO: as principais utilizações do laser argônio na Ortodontia são a redução do tempo de polimerização durante a colagem ortodôntica e o aumento da resistência à cárie do esmalte dentário. OBJETIVO: o objetivo deste trabalho foi avaliar as alterações químicas e morfológicas do esmalte dentário humano tratado com laser argônio nos parâmetros da colagem ortodôntica. MÉTODOS: quinze primeiros pré-molares hígidos, extraídos por indicação ortodôntica, foram selecionados e seccionados no sentido do longo eixo em dois segmentos iguais. Uma metade de cada elemento dentário foi tratada e a outra permaneceu sem tratamento. Um total de 30 amostras foi analisado, criando o grupo laser (n = 15) e o grupo controle (n = 15). O tratamento foi feito com laser argônio com 250mW de potência por 5 segundos, com densidade de energia de 8J/cm². RESULTADOS: a análise de difração de raios X demonstrou duas fases em ambos os grupos, as fases apatita e monetita. A redução da fase monetita foi significativa após o tratamento com laser, sugerindo maior cristalinidade. A análise de Espectroscopia de Energia Dispersiva (EDS) indicou aumento na razão cálcio-fósforo no grupo laser, compatível com a diminuição da fase monetita. A morfologia superficial do esmalte dentário apresentou-se mais lisa após o tratamento com laser argônio. CONCLUSÕES: o aumento de cristalinidade e a lisura superficial do esmalte no grupo laser são fatores sugestivos de aumento de resistência à cárie no esmalte dentário.

INTRODUCTION: The main utilities of the argon laser in orthodontics are the high speed curing process in orthodontic bonding and the caries resistance promotion of the tooth enamel. OBJECTIVE: The objective of this study was to evaluate the chemical and morphological changes in the tooth enamel treated with the argon laser in the orthodontic bonding parameters. METHODS: Fifteen sound human first premolars, removed for orthodontic reason, were selected and sectioned across the long axis in two equal segments. One section of each tooth was treated and the other remained untreated. A total of thirty samples was analyzed, creating the laser group (n =15) and the control group (n =15). The treatment was done with 250 mW argon laser beam for 5 seconds, with energy density of 8 J/cm². RESULTS: The X-ray analysis demonstrated two different phases in both groups, the apatite and the monetite phases. The reduction of the monetite phase was significant following laser treatment, suggesting higher crystallinity. The EDS analysis showed an increase in the calcium-phosphorus ratio in the laser group, linked with the decrease of the monetite phase. CONCLUSIONS: The surface morphology was smoother after the laser exposure. The results of high crystallinity and superficial enamel smoothness in the laser group are suggestive of the caries resistance increase of the tooth enamel.