Abstract Introduction: recent studies have suggested the use of neck circumference as a parameter capable of identifying risks of cardiometabolic complications and the accumulation of truncal fat caused by both antiretroviral therapy and the lifestyle of people with the human immunodeficiency virus (HIV). Objective: to investigate the relationship between neck circumference and anthropometric indicators and to assess cardiometabolic risk and truncal obesity through proposed cut-off points. Methods: cross-sectional study including 233 people with HIV. Demographic, socioeconomic, lifestyle and clinical data were collected using a structured questionnaire. The anthropometric evaluation included: weight, height, body mass index (BMI) measurements; waist (WC), neck (NC), arm and arm muscle circumferences; triceps and subscapular skinfolds and their sum. ROC curves were constructed to determine the accuracy of NC in predicting cardiometabolic risk in people living with HIV. Results: the sample was 57.5 % male, with a mean age of 38.4 years (95 % CI: 37.2-39.7 years). NC showed a positive and significant correlation with all anthropometric variables analyzed (p < 0.05), and a higher correlation strength with WC and BMI. The NC cut-off point selected as a predictor of risk of cardiac metabolic complications and truncal obesity in women was ≥ 32.4 cm, considering both WC and BMI. For men, the NC cut-off points were different when considering WC (≥ 39.6 cm) and BMI (≥ 38.1 cm) as a reference. It is worth noting that NC performed well in ROC curve analysis for men, while in women it was a poor performance. Conclusion: NC proved to be a promising indicator in the assessment of nutrition and health of people living with HIV, especially in men.

Resumen Introducción: estudios recientes han sugerido el uso de la circunferencia del cuello como parámetro capaz de identificar los riesgos de complicaciones cardiometabólicas y la acumulación de grasa troncal causados tanto por la terapia antirretroviral como por el estilo de vida de las personas con el virus de la inmunodeficiencia humana (VIH). Objetivo: investigar la relación entre la circunferencia del cuello y los indicadores antropométricos y evaluar el riesgo cardiometabólico y la obesidad troncal a través de los puntos de corte propuestos. Métodos: estudio transversal que incluyó a 233 personas con VIH. Se recogieron datos demográficos, socioeconómicos, de estilo de vida y clínicos mediante un cuestionario estructurado. La evaluación antropométrica incluyó: medidas de peso, altura, índice de masa corporal (IMC); circunferencias de cintura (CC), cuello (CN), brazo (CA) y músculo del brazo (MCB); pliegues cutáneos del tríceps y subescapular y su suma. Se construyeron curvas ROC para determinar la precisión de la CN en la predicción del riesgo cardiometabólico en personas que viven con el VIH. Resultados: el 57,5 % de la muestra eran varones, con una edad media de 38,4 años (IC 95 %: 37,2-39,7 años). La CN mostró una correlación positiva y significativa (p < 0,05) con todas las variables antropométricas analizadas, y una mayor fuerza de correlación con la CC y el IMC. El punto de corte de la CN seleccionado como predictor de riesgo de complicaciones metabólicas cardiacas y obesidad troncular en mujeres fue ≥ 32,4 cm, considerando tanto la CC como el IMC. En el caso de los hombres, los puntos de corte de la CN fueron diferentes al considerar como referencia la CC (≥ 39,6 cm) y el IMC (≥ 38,1 cm). Cabe destacar que la CN obtuvo buenos resultados en el análisis de la curva ROC en el caso de los hombres, mientras que en el de las mujeres fue deficiente. Conclusión: la CN demostró ser un indicador prometedor en la evaluación de la nutrición y la salud de las personas que viven con el VIH, especialmente en los hombres.

ABSTRACT Identifying Coffea arabica cultivars that are more efficient in the use of nitrogen is an important strategy and a necessity in the context of environmental and economic impacts attributed to excessive nitrogen fertilization. Although Coffea arabica breeding data have a multi-trait structure, they are often analyzed under a single trait structure. Thus, the objectives of this study were to use a Bayesian multitrait model, to estimate heritability in the broad sense, and to select arabica coffee cultivars with better genetic potential (desirable agronomic traits) in nitrogen-restricted cultivation. The experiment was carried out in a greenhouse with 20 arabica coffee cultivars grown in a nutrient solution with low-nitrogen content (1.5 mM). The experimental design used was in randomized blocks with three replications. Six agromorphological traits of the arabica coffee breeding program and five nutritional efficiency indices were used. The Markov Chain Monte Carlo algorithm was used to estimate genetic parameters and genetic values. The agromorphological traits were considered highly heritable, with a credibility interval (95% probability): H2 = 0.9538 – 5.89E-01. The Bayesian multitrait model presents an adequate strategy for the genetic improvement of arabica coffee grown in low-nitrogen concentrations. Coffee arabica cultivars Icatu Precoce 3282, Icatu Vermelho IAC 4045, Acaiá Cerrado MG 1474, Tupi IAC 1669-33, Catucaí 785/15, Caturra Vermelho and Obatã IAC 1669/20 demonstrated greater potential for cultivation in low-nitrogen concentration.

Abstract Lower lip squamous cell carcinomas (LLSCC) could be associated with a previous history of potentially malignant oral diseases (PMOD), especially actinic cheilitis (AC), with high sun exposure being a well-described risk factor. Immune evasion mechanisms, such as the PD-1/PD-L1 (programmed cell death protein 1/programmed death-ligand 1) pathway has been gaining prominence since immunotherapy with immune checkpoint inhibitors showed a positive effect on the survival of patients with different types of neoplasms. Concomitant with the characterization of the tumor microenvironment, the expression of either or both PD-1 and PD-L1 molecules may estimate mutual relations of progression or regression of the carcinoma and prognostic values of the patient. Objective: Considering the importance of tumor microenvironment characterization, this study aims to determine the immunoexpression of PD-L1 and correlate with the frequency of CD4+ and CD8+ cells in AC and LLSCC lesions and with tumor-infiltrating lymphocytes (TILs) in LLSCC and its relationship with histopathological characteristics. Methodology: This sample includes 33 cases of AC and 17 cases of LLSCC. The cases were submitted to histopathological analysis and to CD4+, CD8+, and PD-L1+ cell determination by immunohistochemistry. Results: There was a significant difference among the frequencies of CD4+, CD8+, and PD-L1+ cells between AC and LSCC cases, higher in the last group. Moreover, histopathological and atypical changes in AC and LLSCC were correlated with the frequencies of PD-L1+, CD4+, and CD8+ cells. In AC, PD-L1+ cases had a low frequency of CD4+ cells, but on the other hand, PD-L1+ cases of LLSCC had a higher frequency of CD4+ and CD8+ cells. Conclusion: Therefore, the PD-L1 molecule may be a potential escape route for the immune response in oral lesions, but the mechanisms differ between AC and LLSCC. Future studies related to immune evasion and immunotherapy in oral lesions should consider the analysis of inflammatory infiltrate and TILs.

ABSTRACT. The importance of rice (Oryza sativa) is indisputable this cereal is the staple food for half of the global population. Genetic progress estimation allows evaluation of the effectiveness of genetic improvement of crops and helps in the planning of breeding programs. This paper aims to estimate the genetic yield progress made by the program in the state of Minas Gerais, Brazil, which is run by the Epamig/UFV/Embrapa consortium. A total of 210 lines were evaluated by value for cultivation and use testing that was conducted in the municipalities of Janaúba, Leopoldina, and Lambari, from 1993 to 2016. Based on Vencovsky’s (1986) method, the genetic gains in Lambari, Janaúba, and Leopoldina were 1.46, 0.14, and 0.11%, respectively. The gain in Leopoldina was considered very low during the evaluated period. According to Breseghello’s (1998) method, the annual average genetic gain was 0.23 and 0.04% in Lambari and Janaúba, respectively. In Leopoldina, a yield gain of - 2.37% per year was observed for the evaluation period from 1994 to 1999, and a yield gain of 0.1% per year was observed from 2000 to 2016. These results can be explained by the focus on quality as a strategy for the breeding program in Minas Gerais State in the 1990s. Vencovsky’s (1986) and Breseghello’s (1998) methods were able to quantify yield gains and demonstrate the dynamics of the irrigated rice genetic improvement program in Minas Gerais State.

Abstract: The aim of this study was to obtain estimates of genetic parameters via meta-analysis and mixed models to evaluate the potential of the germplasm from Embrapa Pecuaria Sudeste for integration in breeding programs. Data on the dry matter yield of 77 accessions evaluated in 24 harvests were used. Descriptive analysis was performed for mixed model and meta-analytical estimates. The variances for each parameter were estimated. For the meta-analysis, variances were used as weighting measures, and the fixed and random models were tested. A diagonal structure was considered for the residual variance matrix. Mean dry matter yield ranged from 1019.5 to 2684 kg ha-1. The phenotypic, permanent environmental, and genotypic variances oscillated widely throughout the harvests, as well as heritability. Meta-analytical estimates proved to be an accurate and complementary approach to the mixed model analysis. Both mixed model and meta-analytical estimates indicated the breeding potential of the alfalfa germplasm.

RESUMO Esse trabalho mostra uma rota sintética mediada por tetraetilenoglicol (P. E. 325°C) em que utiliza o ácido túngstico, como material de partida. A formação de uma suspensão estável de cor azul foi observada durante o curso da reação. O tamanho das partículas depende do tempo de síntese, sendo que partículas de tamanho em torno de 400 nm foram obtidas após 15 minutos de reação em tetraetilenoglicol. Os materiais particulados foram então recozidos em diferentes temperaturas: 150°, 350°C, 500°C e 800°C, e caracterizados por TGA / DSC, DRX, FT-RAMAN, MEV, Espectroscopia óptica UV-VIS e adsorção de N2 a 77K. Observou-se que a síntese proporcionou WO3 sob fase ortorrômbica que evoluiu para monoclínica após tratamento térmico na temperatura igual ou superior a 350°C. A caracterização morfológica indicou a formação de partículas ovoides quando tratadas em temperaturas em torno de 500°C, temperatura a partir da qual a área superficial diminui drasticamente. A atividade fotocatalítica para a degradação de rodamina B (rhB, 10 mg.L-1) foi avaliada sob irradiação ultravioleta (6 Watts). Maior atividade foi encontrada para o material tratado a 500°C, sendo que descoramento foi total após 180 minutos na presença de 10 mg desse catalisador.

ABSTRACT This work shows a synthetic route mediated by tetraethylene glycol (P. E. 325 ° C) in which tungstic acid is used as the starting material. The formation of a stable blue suspension was observed during the course of the reaction. The size of the particles depends on the synthesis time, and particles of size around 400 nm were obtained after 15 minutes of reaction in tetraethylene glycol. The particulate materials were then annealed at different temperatures: 150 °, 350 ° C, 500 ° C and 800 ° C, and characterized by TGA / DSC, DRX, FT-RAMAN, MEV, UV-VIS optical spectroscopy and N2 adsorption at 77K. It was observed that the synthesis provided WO3 under orthorhombic phase that evolved to monoclinic after heat treatment at a temperature equal to or greater than 350 ° C. The morphological characterization indicated the formation of ovoids particles when treated at temperatures around 500 ° C, a temperature from which the surface area decreases dramatically. The photocatalytic activity for the degradation of rhodamine B (rhB, 10 mg.L-1) was evaluated under ultraviolet irradiation (6 Watts). Greater activity was found for the material treated at 500 ° C, with total discoloration after 180 minutes in the presence of 10 mg of this catalyst.

RESUMO Filmes constituídos por amido de mandioca, álcool polivinílico (PVA) e argila Bentonita (BNT) e glicerol como plastificante foram obtidos utilizando o método casting. A fim de aumentar a compatibilidade dos polímeros ao mineral e sua hidrofobicidade, estes foram posteriormente modificados quimicamente utilizando metacrilato de glicidila (GMA) para a substituição dos grupamentos hidroxilas por vinílicos. Este procedimento gerou filmes com excelente estabilidade a sorção de água e permeabilidade ao vapor de água 15% menor quando comparados coms os filmes sem modificação química. Adicionalmente, esta estratégia também resultou na melhora de 25% na resistência a tração, mantendo o mesmo módulo de Young mas, com uma leve diminuição na estabilidade térmica (início de degradação 14ºC menor). A adição da argila BNT gera filmes compósitos com propriedades, mecânicas, térmicas e físicas diferenciadas, contudo há uma dependência entre a quantidade de reforço e a distribuição estrutural das lamelas de argila na matriz. As modificações químicas foram comprovadas por RMN H1, FTIR, DRX e os filmes foram caracterizados por DRX, sorção e permeabilidade a água, ensaios mecânicos (tração, alongamento e módulo de Young) e TGA. A utilização de 1% m/m deste reforço gera compósitos com BNT estruturalmente esfoliado, independentemente da prévia modificação com metacrilato de glicidila. Já a formulação com 5% m/m gerou filmes compósitos intercalados. Qualquer outro teor de reforço exibe estruturas lamelares aglomeradas (empacotadas). Destaca-se que nas formulações reforçadas com 1% de argila, houve melhora em cerca 30% na resistência a tração com permeabilidade a água 60% menor, para cargas maiores de argila. Estes fatos apontam que as modificações propostas neste trabalho geraram propriedades promissoras para a produção de materiais de embalagem biodegradáveis.

ABSTRACT Films constituted by cassava starch, polyvinyl alcohol (PVA) and Bentonite clay (BNT) and glycerol as plasticizer were obtained using the casting method. In order to increase the compatibility of the polymers with the mineral and its hydrophobicity, they were subsequently chemically modified by replacing the hydroxyl groups with vinyls using glycidyl methacrylate (GMA). This procedure generated films with excellent water sorption stability and 15% lower water vapor permeability. This strategy also resulted in a 25% improvement in tensile strength, maintaining the same Young’s modulus and slight decrease in thermal stability (onset of degradation 14 ° C lower). The addition of BNT clay generates composite films with different mechanical, thermal and physical properties, however, there is a dependence between the amount of reinforcement and the structural distribution of the clay lamellae in the matrix. The chemical modifications were confirmed by H 1 NMR, FTIR, XRD and the films were characterized by XRD, sorption and water permeability, mechanical tests (traction, stretching and Young’s modulus) and TGA. The use of 1% w / w of this reinforcement generates composites with structurally exfoliated BNT, independently of the previous modification with glycidyl methacrylate. The formulation with 5% m / m generated intercalated composite films. Any other reinforcing content exhibits agglomerated (packaged) lamellar structures. It is noteworthy that in the formulations reinforced with 1% clay, there was an improvement of about 30% in tensile strength with 60% lower water permeability, for higher clayey loads. These facts indicate that the modifications proposed in this work have generated promising properties for the production of biodegradable packaging materials.

ABSTRACT. This work aimed to present the optimum environment number methodology and propose the optimization of the National Sunflower Trials Network, by means of the environments exclusion that do not provide loss of the environmental variability already established. Grain and oil yield data of 16 genotypes evaluated at 16 environments of the National Sunflower Trials Network, obtained from trials conducted out-of-season in 2012 and 2013 were used. An analysis was proposed to establish the optimum environment number for genotypes evaluation, based on genotype performance in the various environmental combinations. The removal or maintenance of environments in the experimental network was dynamic, since different environmental combinations impacted the representativeness of the complete network in a different way. This analysis also provides a graphical view of the impact of the environment removal from the network. Once detected points below the established correlation, the researcher could infer about the network minimum environment number and, suggest through consistent information of several testing years, the environment exclusion.

RESUMO Objetivo: Avaliar os impactos clínico e cirúrgico dos fenômenos que podem ocorrer na exotropia intermitente. Métodos: Os prontuários de casos de exotropia intermitente de 1991 a 2014 foram revisados retrospectivamente. Todos os pacientes foram submetidos a uma serie de medidas incluindo o protocolo com oclusão monocular com base na propedêutica proposta por Kushner. Resultados: Outdoor sensitivity foi observada em 31% dos pacientes com taxa de subcorreção de 44% vs. 18% dos casos sem outdoor sensitivity. Após 1 hora de oclusão monocular, 41% de todos os pacientes apresentaram um aumento no desvio com uma taxa de subcorreção 40%, enquanto 25% não. Conclusão: Os resultados demonstram a importância da propedêutica completa, uma vez que há maior taxa de subcorreção tardia nos casos de outdoor sensitivity e maior desvio após a oclusão.

ABSTRACT Purpose: To evaluate the clinical and surgical impacts of phenomena that could occur in intermittent exotropia. Methods: The medical records of intermittent exotropia cases from 1991 to 2014 were retrospectively reviewed. All patients underwent a series of measures, including a protocol to assess monocular occlusion based on the propedeutics proposed by Kushner. Results: Outdoor sensitivity was observed in 31% of patients with an undercorrection rate of 44% vs. 18% of cases with no outdoor sensitivity. After 1 h of monocular occlusion, 41% of all patients achieved an increase in deviation with an undercorrection rate of 40%, whereas 25% did not. Conclusion: The results show the importance of complete propedeutics, since there is a higher rate of late undercorrection in cases with outdoor sensitivity and increased deviation after occlusion.

ABSTRACT. This study presents self-organizing maps (SOM) as an alternative method to evaluate genetic diversity in plant breeding programs. Twenty-five genotypes were evaluated in two environments for 11 phenotypic traits. The genotypes were clustered according to the SOM technique, with variable topology and numbers of neurons. In addition to the SOM analysis, unweighted pair group method with arithmetic mean clustering (UPGMA) was performed to observe the behavior of the clustering when submitted to these techniques and to evaluate their complementarities. Genotype ordering according to SOM was consistent with UPGMA results, evidenced by the basic structure of UPGMA groups being preserved in each group of the maps. Regarding genotype arrangement and the group neighbors, maps involving five neurons presented inferior organization efficiency compared to the six-map arrangements in both environments. It was observed that the organization pattern among the rice genotypes evaluated by the maps was complementary to the UPGMA approach, as observed in all scenarios. It can be concluded that self-organizing maps have the potential to be useful for genetic diversity studies in breeding programs.

RESUMO Objetivo: avaliar a eficácia da estratégia adotada e a qualidade do atendimento em trauma pediátrico na sobrevivência dos pacientes atendidos após desastre em uma cidade do interior de Minas Gerais, em comparação a resultados esperados por estudos sobre mortalidade infantil em grandes queimados. Métodos: análise retrospectiva observacional de dez pacientes que sofreram queimaduras e foram transferidos para um centro de referência de trauma. Utilizou-se o escore de R-Baux modificado para estimar a mortalidade esperada. Comparou-se a mortalidade esperada a partir do escore de R-Baux e a mortalidade real, a partir do teste de uma proporção. Comparou-se, também, tempo de admissão pós-trauma com mortalidade e grau de superfície corporal queimada com mortalidade. Resultados: o R-Baux médio foi de 75,2, o que significa uma mortalidade esperada para grandes queimados de 5%. No entanto, a mortalidade do grupo com grande área de superfície corporal queimada desse estudo foi de 60%, valor p=0,001. Observou-se neste caso uma mortalidade muito além da esperada pela literatura. Conclusão: apesar das inúmeras variáveis, aventa-se a hipótese de infraestrutura de atendimento em trauma pediátrico aquém da necessária no Estado. Este estudo sugere maior incentivo à políticas públicas para atendimento de trauma pediátrico, centro de referência preparado, acordos de transferência bem estabelecidos e otimização de planos de catástrofe para diminuição da morbimortalidade para os pacientes que sobrevivem à primeira hora após o trauma.

ABSTRACT Objective: to evaluate the effectiveness of the adopted strategy and the care quality for pediatric trauma in the survival of patients attended after a disaster in a city in the interior of Minas Gerais state, compared to the expected results of studies on infant mortality in major burns. Methods: retrospective observational analysis of ten patients who were burned and transferred to a trauma reference center. We used the modified R-Baux score to estimate the expected mortality. We compared the expected mortality predicted by R-Baux score and the actual mortality determined from one-ratio test. We also compared time of post-trauma admission with mortality and burned body surface area with mortality. Results: mean R-Baux score was 75.2, which means an expected mortality of 5% among major burn patients. However, in this study, mortality in the group of children with large burned body surface area was of 60%, p=0.001, a rate far beyond that expected in literature. Conclusion: despite the innumerable variables, we consider the hypothesis of the pediatric trauma care infrastructure being inferior than the one needed in the state. This study suggests a greater incentive for public policies concerning pediatric trauma care, prepared referral center, well-established transfer agreements, and optimization of catastrophe plans, in order to reduce morbimortality of patients who survive the first hour after trauma.

RESUMO O objetivo deste trabalho foi avaliar a influência dos fatores ambientais sobre o desempenho das progénies de diferentes touros da raça Nelore no semiárido brasileiro. Informações de 741 animais foram coletadas de uma fazenda comercial localizada no municipio de Varzelândia-MG. Os animais eram filhos de 27 touros da raça Nelore e eram categorizados como LA (livro aberto) ou PO (puros de origem). Foram avaliados os dados de peso, ganho de peso médio diário e perímetro escrotal. As avaliações foram realizadas aos 12 (ano) e 18 (sobreano) meses de idade. Os dados foram analisados pelo método dos quadrados mínimos, utilizando um modelo que considerou efeito de categoria (LA ou PO), touro, anos, mês de nascimento e sexo dos bezerros. Houve influência significativa da categoria, sexo, mês de nascimento e touro sobre o desempenho dos animais até o ano, enquanto as características de desempenho ao sobreano foram influenciadas somente pelo mês de nascimento e touro (P<0,05). Sendo assim, os fatores do meio como ano e mês de nascimento e sexo do bezerro são importantes fontes de variação sobre o desempenho dos bezerros do nascimento até o sobreano, devendo, portanto, ser consideradas na comparação e seleção de animais com base nestas características.

SUMMARY The aim of this study was to evaluate the influence of environmental factors on the performance of progeny from different Nellore sires in Brazilian semiarid region. Data on live weight, average daily gain and scrotal circumference of 741 animals categorized as OR (open registry) or PB (purebred) and born from 27 sires were collected from a commercial farm located in Varzelândia-MG. Evaluations were taken at 12 (yearling) and 18months of age. Data were analyzed using the least-squares method, considering the effect of pedigree (OR or PB), sire, year of birth, month of birth and calf sex in the model. There was a significant influence of the pedigree, sex, month of birth and sire on animal's performance until yearling age, whereas the performance traits at 18months were influenced only by the month of birth and sire (P<0.05). Therefore, environmental factors such as year, month of birth and calf sex are important sources of variation on calf performance from birth to18 months and it should be considered when comparing and selecting animals based on these traits.

RESUMO O melhoramento genético da alfafa para alimentação animal leva mais tempo do que para muitas outras culturas. Por isso, definir melhores métodos de seleção é importante para o sucesso do melhoramento da cultura. Objetivou-se utilizar métodos de seleção direta, indireta e simultânea, para a seleção de cultivares de alfafa, com base em características de produção e valor nutritivo. As características avaliadas foram subdivididas em dois grupos: produção e valor nutritivo. Os ganhos de seleção foram estimados por seleção direta, indireta e simultânea para cada grupo, considerando-se a seleção das 25 % melhores cultivares. As seleções direta e indireta entre as médias dos genótipos não são eficientes para fornecer as respostas desejáveis para todo o conjunto de características. Os resultados da seleção simultânea, utilizando-se o índice de Tai, forneceram uma distribuição de ganhos mais equilibrada para os conjuntos de características em todos os cortes. A seleção simultânea permitiu a identificação das cultivares 5681 e Verdor no primeiro corte, bem como a ProINTA Patricia no segundo corte, como superiores, nos dois grupos de características avaliadas.

ABSTRACT Alfalfa breeding aimed at trait improvement for livestock feed takes longer periods of time, if compared to many other crops. Therefore, better selection methods are necessary for the success of alfalfa breeding programs. Although knowing about selection methods is quite important, there is a notable lack of information, as regards successful solutions. This study aimed to use direct, indirect and simultaneous selection methods for selecting alfalfa cultivars, based on yield traits and nutritive value. The evaluated traits were subdivided into two groups: forage yield and nutritive value. Selection gains were estimated by direct, indirect and simultaneous selection for each group, considering the selection of the 25 % best cultivars. Direct and indirect selections among genotype averages are not efficient to provide the desirable responses to the whole set of traits. The results for simultaneous selection, using the Tai index, provided a more balanced gain distribution to the set of traits in all cuts. The simultaneous selection allowed the identification of the 5681 and Verdor cultivars in the first cut, as well as ProINTA Patricia in the second cut, as superior in the two groups of evaluated traits.

Resumo Estudos que utilizam métricas baseadas em céu dinâmico para abordagem de desempenho de iluminação natural em recintos são raros em cidades de latitudes tropicais. Este estudo aplicou a métrica Autonomia Espacial de Luz Natural (sDA 300,50% ≥75%, IES LM 83-12) para Cuiabá (15ºS, 56ºW, Brasil), uma cidade de savana com predominância de céus parcialmente nublados. Simulações paramétricas foram utilizadas para investigar a disponibilidade de iluminação natural em contexto urbano adensado. As condições de iluminação natural dentro de um recinto de profundidade variada localizado em um cânion urbano foram simuladas com Radiance/Daysim no Grasshopper/Honeybee. Dimensões da via e de altura dos edifícios frontais foram variadas com o objetivo de observar a relação entre o ângulo de céu e o sDA para as quarto orientações solares principais. Os resultados deste estudo de caso mostraram que a profundidade do recinto tende a ser o parâmetro mais relevante entre os analisados para a otimização de iluminação natural interna. Finalmente, as limitações dessa abordagem e oportunidades de futuras pesquisas foram discutidas.

Abstract Studies using metrics related to dynamic sky conditions for indoor daylight performance assessment in urban environment are rare in tropical latitudes. This study applied one of these metrics, the spatial Daylight Autonomy (sDA 300,50% ≥75%, IES LM 83-12) for Cuiabá (15ºS, 56ºW, Brazil), a savanna climate city with a high frequency of partly cloudy skies. Parametric simulations were used to investigate the availability of daylight in dense urban areas. So daylight conditions inside a reference room with varied depths located within a continuous urban canyon were simulated with Radiance/Daysim in Grasshopper/Honeybee. Dimensions of the street and heights of front buildings (obstructions) are also varied in order to observe the relation between the sky angle and the sDA, for the four main cardinal directions. The results of regression analysis for this case study showed that among all evaluated parameters, room depth tended to be the most relevant for the optimization of indoor daylight. Finally, limitations of this approach and opportunities for further investigations were discussed.

O planejamento de pesquisas com adolescentes privados de liberdade deve envolver escolhas éticas e bioéticas com o objetivo de atender a vulnerabilidade desses casos. O maior desafio encontra-se no fato de se buscar garantir o exercício da autonomia e da voluntariedade. Neste trabalho, apresentamos e discutimos as escolhas éticas e bioéticas efetuadas no planejamento de pesquisa que envolve adolescentes privados de liberdade, assim como as medidas especiais adotadas com vistas a garantir a autonomia e a voluntariedade dos participantes. Foram realizadas oficinas prévias que tiveram o objetivo de trabalhar os temas da autonomia e da voluntariedade com todos os adolescentes institucionalizados que tivessem a oportunidade de participar da pesquisa. Com isso, pretendeu-se que os adolescentes se tornassem mais fortalecidos e pudessem utilizar o exercício da autonomia como uma habilidade protetiva. De modo geral, avaliamos que a experiência de realização das oficinas foi bastante enriquecedora tanto para os adolescentes como para as pesquisadoras, e também que as oficinas atingiram os objetivos propostos, de forma que o planejamento resultou bem-sucedido. Os adolescentes iniciaram a participação nas oficinas com uma postura passiva e acrítica, e finalizaram-na com uma postura mais participativa, buscando discutir e esclarecer dúvidas. Sugere-se que essas questões sejam consideradas em estudos com essa população.

The planning of research with adolescents deprived of freedom should consider bioethical and ethical choices aiming at dealing with the vulnerability of these cases. The biggest challenge is the fact that they seek to ensure the exercise of autonomy and willingness. In this paper we present and discuss the ethical and bioethical choices made in the planning of research involving adolescents deprived of freedom, as well as the special procedures adopted to guarantee the autonomy and the willingness of the participants. Previous workshops were held with the aim at dealing with the issues of autonomy and willingness to all institutionalized adolescents who could participate of the research. Thus, the objective was that the adolescents became more empowered and could use the exercise of autonomy as a protective ability. We came to the conclusion that the experience of conducting the workshops was very enriching for both adolescents and for researchers, and also that the workshops were successful, for a successful planning resulted from it. The adolescents started their participation in the workshops with a passive and uncritical attitude, and ended with a more participatory attitude, seeking to discuss and answer the questions. It was suggested that these issues should be considered in studies with this population.

La planificación de investigación con adolescentes privados de libertad debe involucrar elecciones éticas y bioéticas con el objetivo de atender la vulnerabilidad de esos casos. El mayor desafío se encuentra en el hecho de buscar garantizar el ejercicio de la autonomía y de la voluntariedad. En este trabajo, presentamos y discutimos las elecciones éticas y bioéticas efectuadas en la planificación de investigación que involucra adolescentes privados de libertad, así como las medidas especiales adoptadas con vistas a garantizar la autonomía y la voluntariedad de los participantes. Fueron realizados talleres previos que tuvieron el objetivo de trabajar los temas de la autonomía y de la voluntariedad con todos los adolescentes institucionalizados que tuviesen la oportunidad de participar de la investigación. Con eso, se buscó que los adolescentes se fortalecieran más y pudiesen utilizar el ejercicio de la autonomía como una habilidad protectiva. De modo general, evaluamos que la experiencia de realización de los talleres fue bastante enriquecedora tanto para los adolescentes como para las investigadoras, y también que las oficinas alcanzaron los objetivos propuestos, de forma que la planificación resultó exitosa. Los adolescentes iniciaron la participación en los talleres con una postura pasiva y acrítica, y la finalizaron con una postura más participativa, buscando discutir y aclarar dudas. Se sugiere que esas cuestiones sean consideradas en estudios con esa población.