@article{andrade_bento_cavalli_oliveira_freitas_marcon_schwanke_siqueira_calixto_2016,  title={Non-clinical studies required for new drug development - Part I: early <i>in silico</i> and <i>in vitro</i> studies, new target discovery and validation, proof of principles and robustness of animal studies},  volume={49},  ISSN={0100-879X},  url={https://doi.org/10.1590/1414-431X20165644},  DOI={10.1590/1414-431X20165644},  number={11},  journal={Brazilian Journal of Medical and Biological Research},  publisher={Associação Brasileira de Divulgação Científica},  author={Andrade, E.L. and Bento, A.F. and Cavalli, J. and Oliveira, S.K. and Freitas, C.S. and Marcon, R. and Schwanke, R.C. and Siqueira, J.M. and Calixto, J.B.},  year={2016},  pages={e5644} }