TY  - JOUR 
T1  - Non-clinical studies required for new drug development - Part I: early <i>in silico</i> and <i>in vitro</i> studies, new target discovery and validation, proof of principles and robustness of animal studies
JO  - Brazilian Journal of Medical and Biological Research
A1  - Andrade, E.L.
A1  - Bento, A.F.
A1  - Cavalli, J.
A1  - Oliveira, S.K.
A1  - Freitas, C.S.
A1  - Marcon, R.
A1  - Schwanke, R.C.
A1  - Siqueira, J.M.
A1  - Calixto, J.B.
SN  - 0100-879X
UL  - 10.1590/1414-431X20165644
VL  - 49 
Y1  - 2016
PB  - Brasil 
ER  -