Brazilian Dental Journalhttps://www.scielo.br/feed/bdj/2020.v31n1/2024-03-19T20:31:31.592000ZVol. 31 No. 1 - 2020WerkzeugThe Contribution of the Brazilian Dental Journal to the Brazilian Scientific Research over 30 Years10.1590/0103-64402020045512024-03-19T20:31:31.592000Z2020-08-09T06:48:16.145000ZEstrela, CarlosPécora, Jesus DjalmaSousa-Neto, Manoel Damião
<em>Estrela, Carlos</em>;
<em>Pécora, Jesus Djalma</em>;
<em>Sousa-Neto, Manoel Damião</em>;
<br/><br/>
Abstract The Brazilian Dental Journal (BDJ) was officially launched in 1990, stimulated by the courage and boldness of researchers dedicated to teaching and research in dentistry. The journal was conceived in a worldwide coverage and universal language to allow publication of the results of Brazilian studies, which otherwise would not be accessible to the scientific dental community. In the year we celebrate the thirtieth anniversary of BDJ, this article presents a brief overview of Brazilian dental research and a bibliometric analysis of the articles published in this journal as a contribution to our readers and fellow researchers. The purpose was to identify the mot frequent categories of study, the most published areas of dentistry and BDJ’s top 50 most-cited articles in the Scopus and Google Scholar databases. A search was performed on all BDJ online issues published from 1990 to 2019. In this period, BDJ published 1,710 articles. Based on their distribution by category of study, 557 articles were in the basic research/dental materials area, 527 in the basic research/biology area and 280 in the clinical research area. Eight articles were cited more than 100 times in the Scopus database and 266 times in the Google Scholar database. Endodontics was the most published area. This overview of BDJ production over those 30 years allows establishing a profile of the characteristics, impact and trends of the published studies, as well as the journal’s contribution to the top 50 most-cited articles in the Scopus and Google Scholar databases.A Bibliometric Analysis of Articles Published in Brazilian Dental Journal over 30 years10.1590/0103-64402020045502024-03-19T20:31:31.592000Z2020-08-09T06:48:16.145000ZMoraes, Rafael Ratto deMorel, Laura LourençoCorrea, Marcos BrittoLima, Giana da Silveira
<em>Moraes, Rafael Ratto De</em>;
<em>Morel, Laura Lourenço</em>;
<em>Correa, Marcos Britto</em>;
<em>Lima, Giana Da Silveira</em>;
<br/><br/>
Abstract This study assessed bibliometric characteristics of all articles published in Brazilian Dental Journal (BDJ) in its 30 years of existence (1990-2019) and factors associated with citation rates. A document search was carried out in Scopus in December, 2019 and information about the articles were exported, including citations. Type of study and main subject in each article were categorized. Number of citations was categorized in tertiles. Logistic regression models were used to assess the association between variables related to articles’ characteristics and number of citations. In 30 years, 1705 articles were published and 18507 citations received, with average 57 articles and 334 pages published yearly and 10.9 cites/doc. The most frequent types of study were laboratorial (63%), clinical (18.5%), and case reports (11%); the main subjects were dental materials (21.6%), endodontics (19.3%), and oral pathology/stomatology (13.1%). Most articles had origin in Brazil (90%), followed by USA (4.6%) and UK (1.5%). Aside from BDJ, Journal of Endodontics (3.5%) and International Endodontic Journal (2.2%) were journals that most often cited BDJ. Main origins of citations were Brazil (36.7%), USA (10.6%), and India (9%). Older articles had higher odds to be highly cited (12% increase/year), longer articles had lower odds (9% decrease/page). Narrative reviews and epidemiological studies were associated with more citations and systematic reviews with less citations. In conclusion, BDJ covered many subjects and study types in 30 years, showing increased growth in international audience. The journal may be regarded as one of the leading Brazilian journals in dentistry published in English.Association between Estrogen, Vitamin D and Microrna17 Gene Polymorphisms and Periapical Lesions10.1590/0103-6440202002024-03-19T20:31:31.592000Z2020-08-09T06:48:16.145000ZSilva-Sousa, Alice CorrêaMazzi-Chaves, Jardel FranciscoFreitas, Jessica VavassoriSalles, Alessandro GuimarãesSegato, Raquel Assed Bezerra da SilvaSilva, Léa Assed Bezerra daAntunes, Lívia Azeredo AlvesAntunes, Leonardo SantosBaratto-Filho, FlaresSousa-Neto, Manoel DamiãoKüchler, Erika Calvano
<em>Silva-Sousa, Alice Corrêa</em>;
<em>Mazzi-Chaves, Jardel Francisco</em>;
<em>Freitas, Jessica Vavassori</em>;
<em>Salles, Alessandro Guimarães</em>;
<em>Segato, Raquel Assed Bezerra Da Silva</em>;
<em>Silva, Léa Assed Bezerra Da</em>;
<em>Antunes, Lívia Azeredo Alves</em>;
<em>Antunes, Leonardo Santos</em>;
<em>Baratto-Filho, Flares</em>;
<em>Sousa-Neto, Manoel Damião</em>;
<em>Küchler, Erika Calvano</em>;
<br/><br/>
Abstract This study evaluated the association between polymorphisms in genes encoding estrogen receptors 1 (ESR1) and 2 (ESR2), vitamin D receptor (VDR) and in microRNA17 (which binds to ESR1 and VDR) with persistent apical periodontitis (PAP) after the endodontic treatment. We included 162 patients who completed endodontic treatment at least one year ago and presented apical periodontitis at the beginning of the root canal therapy. Clinical and radiographic exams were performed to evaluate the presence of PAP or healthy periradicular tissues (healed). Saliva samples were collected as a genomic DNA. The genotyping of ESR1 (rs2234693 and rs9340799), ESR2 (rs1256049 and rs4986938), VDR (rs739837 and rs2228570) and miRNA17 (rs4284505) were performed by real-time PCR. Chi-square test was used to the distribution of genotype and allele frequencies. Haplotype analysis was also performed. Eighty-nine patients were included in the “healed” group and 73 in the “PAP” group. No association was found between the allelic and genotypic polymorphisms studied and PAP (p>0.05). Haplotype analysis also did not demonstrated an association (p>0.05). In conclusion, the genetic polymorphisms in ESR1, ESR2, VDR and miRNA17 are not associated with PAP.Apical Displacement and Residual Root Canal Filling with Single-Cone After Post Space Preparation: A Micro-CT Analysis10.1590/0103-64402020025972024-03-19T20:31:31.592000Z2020-08-09T06:48:16.145000ZRosatto, Camila Maria Peres deOliveira, Lilian VieiraFerraz, Danilo CassianoSoares, Priscilla Barbosa FerreiraSoares, Carlos JoséMoura, Camilla Christian Gomes
<em>Rosatto, Camila Maria Peres De</em>;
<em>Oliveira, Lilian Vieira</em>;
<em>Ferraz, Danilo Cassiano</em>;
<em>Soares, Priscilla Barbosa Ferreira</em>;
<em>Soares, Carlos José</em>;
<em>Moura, Camilla Christian Gomes</em>;
<br/><br/>
Abstract The purpose of this study was to evaluate the presence of residues after post space preparation (PSP) and establish whether the apical displacement of the gutta-percha was affected by the moments and methods of PSP in teeth filled by the single-cone technique. The root canals of 20 bovine incisor teeth were instrumented with Reciproc and filled with single-cone and AH Plus. The specimens were divided into 4 groups according to the moment and method of PSP (n=5): immediate with drill, immediate with thermoplasticizer, delayed with drill and delayed with thermoplasticizer. Micro-CT scans were performed before and after the PSP for residues of the root canal filling (1) and analysis of apical displacement (2). Data were analyzed by using 2-way repeated measurement ANOVA (1) and 2-way ANOVA (2) followed by the Tukey’s test (a=0.05). Significance effect on the residues percentage remaining for methods (p=0.044), for moments (p=0.006), for thirds repetition (p<0.001), and for interaction between methods and thirds (p<0.001), and moments and thirds (p=0.044). Significance effect on the apical displacement of root canal filing was detected for methods (p=0.008), however no difference was found between moments (p=0.617). In general, PSP using drill resulted in more homogeneous root canal preparation, mainly when made immediately. For all other combinations between methods and moments for PSP, the middle and apical thirds presented significant higher residues remaining. Thermo method performed in both moments and the drill method performed immediately had displacement in the apical direction, representing extrusion of the root filling material.Cytotoxicity of Chelating Agents Used In Endodontics and Their Influence on MMPs of Cell Membranes10.1590/0103-64402020028122024-03-19T20:31:31.592000Z2020-08-09T06:48:16.145000ZPivatto, KellinPedro, Fabio Luis MirandaGuedes, Orlando AguirreSilva, Adriana Fernandes daPiva, EvandroPereira, Thiago MachadoRosa, Welligton Luiz de Oliveira daBorges, Alvaro Henrique
<em>Pivatto, Kellin</em>;
<em>Pedro, Fabio Luis Miranda</em>;
<em>Guedes, Orlando Aguirre</em>;
<em>Silva, Adriana Fernandes Da</em>;
<em>Piva, Evandro</em>;
<em>Pereira, Thiago Machado</em>;
<em>Rosa, Welligton Luiz De Oliveira Da</em>;
<em>Borges, Alvaro Henrique</em>;
<br/><br/>
Abstract This study evaluated the cytotoxic effect and the ability to inhibit matrix metalloproteinases (MMP-2 and MMP-9) of 0.2% chitosan (CH) and 1% acetic acid (AA) compared with 17% ethylenediaminetetraacetic acid (EDTA). Cell viability assay was performed according to ISO 10993-5 with mouse fibroblasts (L929). The culture was exposed to 0.2% CH, 1% AA, and 17% EDTA. The chelating agents were evaluated immediately after contact with the cells and after 6 h, 12 h, and 24 h of incubation. Cell viability was analyzed using the 3-(4,5-dimethythiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) assay. Inhibition of the gelatinolytic activity of MMP-2 and MMP-9 was evaluated by gelatin zymography. Different concentrations of CH were evaluated: 50 mM, 5 mM, 0.5 mM, and 0.05 mM. EDTA (0.5 mM) was used as a positive control. The results demonstrated that CH and AA had an initial cytotoxic effect, which decreased after 6 h, 12 h, and 24 h, being statistically similar to EDTA (P > 0.05). Additionally, CH at concentrations of 50 mM, 5 mM, and 0.5 mM had an inhibitory effect on MMP-2 and MMP-9, similar to that of the control with EDTA. The chelating agents had no cytotoxic effects after 24 h. MMP-2 and MMP-9 were inhibited by the experimental solutions.Negative Pressure Irrigation Presents Mineralizing Potential in Dogs’ Immature Teeth with Periapical Lesion10.1590/0103-64402018027642024-03-19T20:31:31.592000Z2020-08-09T06:48:16.145000ZSilva, Léa Assed Bezerra daLinhares, Marcela LopesSilva, Raquel Assed Bezerra daNelson-Filho, PauloLucisano, Marília PacíficoPucinelli, Carolina MaschiettoCarvalho, Fabrício Kitazono deCohenca, Nestor
<em>Silva, Léa Assed Bezerra Da</em>;
<em>Linhares, Marcela Lopes</em>;
<em>Silva, Raquel Assed Bezerra Da</em>;
<em>Nelson-Filho, Paulo</em>;
<em>Lucisano, Marília Pacífico</em>;
<em>Pucinelli, Carolina Maschietto</em>;
<em>Carvalho, Fabrício Kitazono De</em>;
<em>Cohenca, Nestor</em>;
<br/><br/>
Abstract The objective of this in vivo study was to assess the effect of the root canal irrigation by negative and positive apical pressure on the expression of molecules that are an indicative of cell differentiation with mineralizing phenotype in teeth of dogs with incomplete rhizogenesis and induced periapical lesion. A total of 30 teeth (60 roots) were distributed into 3 groups (n=20): EndoVac®, Conventional and Control. After 90 days, the routine histotechnical procedures were performed and the sections were submitted to immunohistochemical technique for the staining of osteopontin (OPN), alkaline phosphatase (ALP) and the RUNX2 transcription factor in the apical and periapical regions of the roots. A semi-quantitative analysis of the positive immunostaining was performed and the intensity of the expression was classified in absent (0), mild (1), moderate (2), or intense (3). Scores data were statistically analyzed by the Kruskal-Wallis non-parametric test and Dunn post-test, and the significance level was set at 5%. RUNX2 immunostaining revealed that in the negative pressure group there was a significantly stronger (p<0.05) immunostaining in comparison to the control group. Regarding the OPN expression, it was not possible to detect a statistically significant difference between the groups (p>0.05). After analyzing ALP immunostaining, a statistically significant difference was observed between the groups (p<0.05), and the negative pressure group showed a markedly stronger mark immunostaining than the control group. The results of the present in vivo study allowed concluding that negative apical pressure irrigation presents mineralizing potential in immature teeth with apical periodontitis.Effect of Using Biomimetic Analogs on Dentin Remineralization with Bioactive Cements10.1590/0103-64402020030832024-03-19T20:31:31.592000Z2020-08-09T06:48:16.145000ZSadoon, Noha YFathy, Salma MOsman, Manal F
<em>Sadoon, Noha Y</em>;
<em>Fathy, Salma M</em>;
<em>Osman, Manal F</em>;
<br/><br/>
Abstract This study evaluated the impact of using biomimetic analogs (poly-acrylic acid and sodium tri-meta-phosphate) on dentin remineralization using two cement materials, the first is calcium silicate based and the second is calcium hydroxide based materials. Two standardized occlusal cavities (mesial and distal) were prepared within dentin after removal of occlusal enamel. Artificial demineralized dentin was induced through pH cycling (8 h in demineralizing and 16 h in remineralizing solutions). Demineralized cavities were divided into four groups; two groups received cement materials. The other groups were first treated with biomimetic analogs then restored with pulp cement materials. Teeth were sectioned buccolingually into two halves. Treated cavities with analogs were stored in simulated body fluid containing poly-acrylic acid. Untreated cavities were stored in simulated body fluid only. Ground unstained sections of demineralized dentin were examined using light microscope. Specimens were examined after 1, 6 and 12 weeks of storage using energy dispersive X-ray Spectroscopy (EDX) and Vickers microhardness was evaluated. Two-way ANOVA was used to analyze data statistically. Calcium silicate-based cement group with biomimetic analogs showed the highest statistically significant calcium and phosphorous wt% in addition to highest surface hardness values after 12 weeks of storage. Demineralized dentin ground sections showed increase in light zones after total period of storage. Calcium silicate-based cement showed the best ability to enrich the artificial carious dentin with ions for remineralization. Using biomimetic analogs had a significant impact on demineralized dentin surface hardness improvement.Light Activation and Thermocycling Methods on the Shear Bond Strength of Brackets Bonded to Porcelain Surfaces10.1590/0103-64402020031012024-03-19T20:31:31.592000Z2020-08-09T06:48:16.145000ZLopes, Gustavo VallandroCorrer-Sobrinho, LourençoCorrer, Américo BortolazzoGodoi, Ana Paula Terossi deVedovello, Silvia Amélia ScudelerMenezes, Carolina Carmo de
<em>Lopes, Gustavo Vallandro</em>;
<em>Correr-Sobrinho, Lourenço</em>;
<em>Correr, Américo Bortolazzo</em>;
<em>Godoi, Ana Paula Terossi De</em>;
<em>Vedovello, Silvia Amélia Scudeler</em>;
<em>Menezes, Carolina Carmo De</em>;
<br/><br/>
Abstract The present study was evaluated the effect of different light activation and thermocycling methods on the shear bond strength (SBS) and on the adhesive remnant index (ARI) of metal brackets bonded to feldspathic ceramic. Hundred metal brackets were bonded to 20 porcelain cylinders, divided into four groups (n=25) based on light activation and thermocycling processes. The cylinders were etched with 10% hydrofluoric acid for 60 s and coated with two layers of silane. The brackets were bonded with Transbond XT composite resin. Light activation in Groups 1 and 3 was performed during 3 s using the VALO Ortho Cordless appliance with irradiance 3,200 mW/cm2 and in Groups 2 and 4 for 40 s using Optilight Max appliance with irradiance 1,200 mW/cm². The samples were stored in deionized water at 37°C for 24 h and the samples from Groups 1 and 2 were submitted to the SBS test at a rate of 1 mm/min, whereas the samples from Groups 3 and 4 were submitted to 7,000 thermal cycles (5°/55°C) before to the SBS test. The data were assessed by two-way analysis of variance and by Tukey’s test (a=0.05). No significant difference was observed between SBS means in the different light activation devices used. The samples subjected to thermocycling revealed lower SBS values (p≤0.05). There was predominance of score 0 for ARI in all groups. Therefore, the different light activation methods did not interfere in SBS, but thermocycling reduced SBS.The Effect of Cigarette Smoking And Low-Level Laser Irradiation in RANK/RANKL/OPG Expression10.1590/0103-64402020025192024-03-19T20:31:31.592000Z2020-08-09T06:48:16.145000ZRibeiro, Larissa Nogueira SoaresMonteiro, Patrícia MariaBarretto, Gabriel DessottiLuiz, Kelly GalisteuAlves, Sandra Yasuyo FukadaStuani, Maria Bernadete Sasso
<em>Ribeiro, Larissa Nogueira Soares</em>;
<em>Monteiro, Patrícia Maria</em>;
<em>Barretto, Gabriel Dessotti</em>;
<em>Luiz, Kelly Galisteu</em>;
<em>Alves, Sandra Yasuyo Fukada</em>;
<em>Stuani, Maria Bernadete Sasso</em>;
<br/><br/>
Abstract The objective of this study was to investigate the effects of low-level laser therapy (LLLT) and cigarette smoke on alveolar socket osteoclastogenesis signaling after tooth extraction, in rats. Sixty male Wistar rats were randomly assigned to four groups with 15 animals each: Control Group (with right maxillary molar extraction - ME), Experimental I (with ME and LLLT), Experimental II (with ME and cigarette smoke) and Experimental III group (with ME, LLLT and cigarette smoke). Euthanasia was performed at 3, 7 and 14 days postoperative. qRT-PCR was used to evaluate expression of Tnfrsf11a (RANK), Tnfsf11 (Rankl) and Tnfrsf11b (OPG). Data were submitted to statistical analysis using two-way ANOVA followed by Bonferroni test (α=0.05). There was an upregulation of RANK, RANKL and OPG genes over all the time of healing in Exp I group compared to control group. Exp II group showed a decreased expression of all genes over time, whereas Exp III genes expression were higher than Exp II values but lower than Control and Exp I values over time. The results of this study concluded that the LLLT had a positive effect, whereas cigarette smoke had a negative effect on RANK, RANKL and OPG gene expression in bone remodeling process.Association between Genetic Polymorphisms in RANK, RANKL and OPG and Peri-Implant Diseases in Patients from the Amazon Region10.1590/0103-64402020030022024-03-19T20:31:31.592000Z2020-08-09T06:48:16.145000ZSilva, Raphael Carvalho eReis, Marilia Bianchini LemosArid, JulianaFlores, Elvira Katherine BarrigaCruz, Giuseppe ValdugaMarañón-Vásquez, Guido A.Souza, Lizete Karla Filgueiras deNovaes Jr, Arthur BelémQueiroz, Alexandra Mussolino deKüchler, Erika Calvano
<em>Silva, Raphael Carvalho E</em>;
<em>Reis, Marilia Bianchini Lemos</em>;
<em>Arid, Juliana</em>;
<em>Flores, Elvira Katherine Barriga</em>;
<em>Cruz, Giuseppe Valduga</em>;
<em>Marañón-Vásquez, Guido A.</em>;
<em>Souza, Lizete Karla Filgueiras De</em>;
<em>Novaes Jr, Arthur Belém</em>;
<em>Queiroz, Alexandra Mussolino De</em>;
<em>Küchler, Erika Calvano</em>;
<br/><br/>
Abstract The present study evaluated polymorphisms in RANK, RANKL and OPG-encoding genes to assess whether they are associated with mucositis and peri-implantitis in a population from the Brazilian Amazon region. One hundred and fourteen patients with dental implants were included in the study. After clinical and radiographic examination, the sample was categorized into 4 groups, according to the peri-implant status: Healthy (n=71), Mucositis (n=30), Peri-implantitis (n=13) and Diseased (Mucositis + Peri-implantitis, n=43). Genomic DNA was extracted from buccal cells from saliva, and the genetic polymorphism in osteoprotegerin (OPG), Kappa nuclear factor activator receptor (RANKL) and nuclear kappa factor activator receptor (RANK) were genotyped by the real time PCR. Univariate and multivariate statistical analyses were performed to compare clinical variables among groups and to evaluate genotypes and alleles distributions and the established alpha was 5%. Age, peri-implant biotype, diabetes and presence of peri-implant biofilm were associated with mucositis (p<0.05) and peri-implantitis (p<0.05). Smoking, alcoholism, and periodontal biofilms were also associated with the presence of peri-implantitis (p<0.05). Univariate and multivariate analysis did not demonstrate an association of peri-implantitis or mucositis with any genetic polymorphism in RANK (rs3826620), RANKL (rs9594738) and OPG (rs2073618) (p>0.05). The studied genetic polymorphism in RANK, RANKL and OPG were not associated with mucositis and peri-implantitis in a Brazilian population from the Amazon region.Color Stability of Ceramic Veneers Luted With Resin Cements and Pre-Heated Composites: 12 Months Follow-Up10.1590/0103-64402020028422024-03-19T20:31:31.592000Z2020-08-09T06:48:16.145000ZGugelmin, Brenda ProcopiakMiguel, Luiz Carlos MachadoBaratto Filho, FlaresCunha, Leonardo Fernandes daCorrer, Gisele MariaGonzaga, Carla Castiglia
<em>Gugelmin, Brenda Procopiak</em>;
<em>Miguel, Luiz Carlos Machado</em>;
<em>Baratto Filho, Flares</em>;
<em>Cunha, Leonardo Fernandes Da</em>;
<em>Correr, Gisele Maria</em>;
<em>Gonzaga, Carla Castiglia</em>;
<br/><br/>
Abstract The objective was to evaluate the color stability of ceramic veneers luted with resin cements and pre-heated composite resins (60oC) for 12 months, and determine the degree of conversion (DC) of the luting agents. Two resin cements (AllCem Veneer, light-cured (LRC) and AllCem, dual-cured (DRC)] and three composite resins [Z100 (MNCR-minifilled), Herculite Classic (MHCR-micro-hybrid) and Durafill (MCCR-microfilled)] were used for cementing 0.8-mm-thick lithium-silicate glass-ceramic laminates (Suprinity, shade B2-HT, Vita) on bovine enamel (n=10). The specimens were stored at 37oC in distilled water. CIELab parameters were determined at 24h after luting (baseline), 7, 30, 90, 180 days and 12 months. Three specimens were prepared for DC evaluation, performed by micro-Raman spectroscopy. Data were analyzed by ANOVA and Tukey’s test (a=5%). For ΔEab and ΔE00, there were significant differences for luting material (p<0.001), time (p<0.001), and double interaction (p<0.001). The groups cemented with MHCR (1 year), MCCR (90 days and 1 year) and MCCR-PH (1 year) were the ones with ΔE values greater than the acceptability threshold. All other groups maintained their ΔE lower than the acceptability threshold after 1 year in distilled water. Regarding DC, there were no significant differences (p=0.127) among the materials. Non-significant negative correlations were observed between the mean ΔEab and DC (R=-0.65) and ΔE00 and DC (R=-0.64). A significant positive correlation was observed mean ΔEab and ΔE00 (R=0.99). It was concluded that the different luting agents influenced the final color of the restorations. The heating of the composite resins did not affect their DC.Oral Mucositis in Pediatric Oncology Patients: A Nested Case-Control to a Prospective Cohort10.1590/0103-64402018028812024-03-19T20:31:31.592000Z2020-08-09T06:48:16.145000ZRibeiro, Isabella Lima ArraisMelo, Ana Carolina Rodrigues deLimão, Nayara PereiraBonan, Paulo Rogério FerretiLima Neto, Eufrásio de AndradeValença, Ana Maria Gondim
<em>Ribeiro, Isabella Lima Arrais</em>;
<em>Melo, Ana Carolina Rodrigues De</em>;
<em>Limão, Nayara Pereira</em>;
<em>Bonan, Paulo Rogério Ferreti</em>;
<em>Lima Neto, Eufrásio De Andrade</em>;
<em>Valença, Ana Maria Gondim</em>;
<br/><br/>
Abstract This study aimed to evaluate the factors associated with the occurrence of severe oral mucositis (SOM) in pediatric oncology patients during the chemotherapeutic treatment. This is a nested case-control to a prospective cohort that monitored 105 patients for 10 consecutive weeks after the beginning of the chemotherapy treatment. Logistic regression was used to identify the factors associated with SOM, by group of malignancy (hematologic or solid tumors) (Sig.=5%). To patients with hematologic tumors were found factors associated with SOM in two weeks of treatment: in the 6th week (increase in frequency of chemotherapy doses (OR=3.02)) and in the 7th week (female sex (OR=21.28); and increase in frequency of chemotherapy doses (OR=2.51)); and to patients with solid tumors were found factors associated with SOM in five weeks of treatment: in the 1st week (female sex (OR=14.43); age increase (OR=1.24)); in the 2nd week (Miscellany (OR=6.39)); in the 5th week (Antimetabolites (OR=17.44); Miscellany (OR=45.42); and platelets reduction (OR=1.12)); in the 6th week (creatinine increase (OR=1.63)); and in the 7th week (creatinine increase (OR=2.39)). For patients with hematologic tumors, to be female, and the increase in the frequency of chemotherapy doses increased the risk for SOM and for patients with solid tumors, to be female, the increase in age and in level blood concentration of creatinine, the reduction in number of platelets and the use of chemotherapy with miscellany and antimetabolites agents were associated with an increase in risk for occurrence of SOM.