Figure 6 - Internalization of fluo-SRIF in COS-7 cells transfected with cDNA encoding the sst5 SRIF receptor. After 20 min of incubation, the bulk of the ligand is still confined to a sub-plasmalemmal zone. Compare the distribution of the acid-washable fraction of the ligand, as seen here, with that evident at the same time point in sst2A-transfected cells. Scale bar: 10 Ám