Figure 2. *A* and *B*, Scatter plots of the relationship between the best-estimated AUC_{0-}_{¥} (µg h

ml^{-1}) of 4-methylaminoantipyrine (MAA; abscissa) and the AUC_{0-}_{¥} derived from the 2-point limited-sampling strategy (LSS) models for each volunteer (ordinate), using the jack-knife approach (Methods). *Panel A*, Formulation A, data for 5 and 24 h. *Panel B*, Formulation B, data for 4 and 24 h. *C*, Scatter plot of the relationship between the best-estimated AUC_{0-}_{¥} (µg h ml^{-1}) of MAA for dipyrone formulation A (abscissa) and the AUC_{0-}_{¥} derived using the 2-point LSS model developed for formulation B and the concentrations observed at the same respective times, but after administration of formulation A (ordinate). The continuous line in each plot represents the line of identity between the LSS-derived and the best-estimated AUC_{0-}_{¥}. AUC_{0-}_{¥}_{ }= area under the plasma drug concentration versus time curve from 0 to infinity.