Figure 2. A and B, Scatter plots of the relationship between the best-estimated AUC0-¥ (µg h
ml-1) of 4-methylaminoantipyrine (MAA; abscissa) and the AUC0-¥ derived from the 2-point limited-sampling strategy (LSS) models for each volunteer (ordinate), using the jack-knife approach (Methods). Panel A, Formulation A, data for 5 and 24 h. Panel B, Formulation B, data for 4 and 24 h. C, Scatter plot of the relationship between the best-estimated AUC0-¥ (µg h ml-1) of MAA for dipyrone formulation A (abscissa) and the AUC0-¥ derived using the 2-point LSS model developed for formulation B and the concentrations observed at the same respective times, but after administration of formulation A (ordinate). The continuous line in each plot represents the line of identity between the LSS-derived and the best-estimated AUC0-¥. AUC0-¥ = area under the plasma drug concentration versus time curve from 0 to infinity.