Figure 3. *A* and *B*, Scatter plots of the relationship between the best-estimated C_{max} (µg/ml) of 4-methylaminoantipyrine (MAA; abscissa) and the C_{max} derived from the 2-point limited-sampling strategy (LSS) models for each volunteer (ordinate), using the jack-knife approach (Methods). *Panel A*, Formulation A, data for 2 and 3 h. *Panel B*, Formulation B, data for 1.5 and 2 h. *C*, Scatter plot of the relationship between the best-estimated C_{max} (µg/ml) of MAA for dipyrone formulation A (abscissa) and the C_{max} derived using the 2-point LSS model developed for formulation B and the concentrations observed at the same respective times, but after administration of formulation A (ordinate). The continuous line in each plot represents the line of identity between the LSS-derived and the best-estimated C_{max}._{ }C_{max} = peak plasma concentration.