Figure 4. *A*, *B*, Scatter plots of the relationship between the best-estimated AUC_{0-}_{¥} (µg h

ml^{-1}) or C_{max} (µg/ml) of MAA (abscissa) and the corresponding parameter values derived from the 3-point limited-sampling strategy (LSS) models (see equations in Table 5) for each volunteer (ordinate), using the jack-knife approach (Methods). The continuous line in each plot represents the line of identity between the LSS-derived and the best-estimated AUC_{0-}_{¥}_{ }(A) or C_{max} (B). AUC_{0-}_{¥}_{ }= area under the plasma drug concentration versus time curve from 0 to infinity; C_{max }= peak plasma concentration.