Figure 4. A, B, Scatter plots of the relationship between the best-estimated AUC0-¥ (µg h
ml-1) or Cmax (µg/ml) of MAA (abscissa) and the corresponding parameter values derived from the 3-point limited-sampling strategy (LSS) models (see equations in Table 5) for each volunteer (ordinate), using the jack-knife approach (Methods). The continuous line in each plot represents the line of identity between the LSS-derived and the best-estimated AUC0-¥ (A) or Cmax (B). AUC0-¥ = area under the plasma drug concentration versus time curve from 0 to infinity; Cmax = peak plasma concentration.