Ginkgo biloba leaf extract (EGb 761) enhances catalepsy induced by haloperidol and L nitroarginine in mice. L. Fontana, A.S. Souza, E.A. Del Bel and R.M.W. de Oliveira. Brazilian Journal of Medical and Biological Research, 38 (11): 1649, 2005.
Figure 2. Effects of acute (day 1) or repeated (day 1 and day 5) Ginkgo biloba (EGb 761) administration on catalepsy induced by haloperidol (panel A) or L-NOARG (panel B). Animals (N = 8-12) received a single dose of EGb 761, 80 mg/kg (E80) by gavage, followed 30 min later by an ip injection of saline, 2 mg/kg haloperidol (H) or 40 mg/kg L-NOARG (L). Ten minutes later they were submitted to the catalepsy test (day 1). The animals were then treated twice a day for 4 days with either E80 or water. On the fifth day (day 5), they again received a single dose of saline. H or L ip injection and catalepsy were evaluated 10, 60, and 120 min. *P < 0.05 compared to water/saline and E80/saline groups, +P < 0.05 compared to water/haloperidol group (ANOVA followed by the Duncan test).