C.K.L.P. Batista, G.A.C. Brito, M.L.P. Souza, B.T.A. Leitão, F.Q. Cunha and R.A. Ribeiro. A model of hemorrhagic cystitis induced with acrolein in mice. Braz J Med Biol Res 2006; 39: 1475-1481.
Figure 4. Effect of different routes of administration of mesna on bladder wet weight (A) and Evans blue extravasation (B) in acrolein-induced hemorrhagic cystitis. Acrolein (ACR) (75 µg/bladder)-induced increase in bladder wet weight and Evans blue extravasation were measured 3 h after the induction of cystitis in mice treated with vehicle (saline, S). Mesna-treated animals received 2 mg/bladder mesna injected intravesically (ive) simultaneously with ACR or 80 mg/kg of mesna injected intraperitoneally (ip) 1 h before ACR injection. Data are reported as means ± SEM (N = 6). *P < 0.05 compared to saline control group (S, treated with acrolein and saline) (ANOVA and Bonferroni test).