C.B. Sacramento, J.Z. Moraes, P.M.A. Denapolis and S.W. Han. Gene expression promoted by the SV40 DNA targeting sequence and the hypoxia-responsive element under normoxia and hypoxia.
Figure 1. Schematic diagram of the plasmid. An SpeI restriction site was used to replace the CMV minimal promoter from pVAX-hVEGF with CMV-A. An EcoRV restriction site was used to insert the S or H sequence in the uP-vascular endothelial growth factor 165 (uP-VEGF165) gene vector. S = SV40-DTS (SV40-DNA-targeting sequence); H = HRE (hypoxia-responsive element); A = CMV (cytomegalovirus) intron A.