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Figure 1. Schematic diagram of the plasmid. An SpeI restriction site was used to replace the CMV minimal promoter from pVAX-hVEGF with CMV-A. An EcoRV restriction site was used to insert the S or H sequence in the uP-vascular endothelial growth factor 165 (uP-VEGF165) gene vector. S = SV40-DTS (SV40-DNA-targeting sequence); H = HRE (hypoxia-responsive element); A = CMV (cytomegalovirus) intron A.