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Figure 1. Effect of sirolimus on isolated proximal tubules submitted to 15 min of hypoxia (H) alone or followed by 45 min of reoxygenation, as assessed by release of lactate dehydrogenase (LDH). V = vehicle. Data are reported as mean ± SD. *P < 0.05 vs control at both 15 and 60 min (ANOVA followed by the Student-Newman-Keuls post-test).