Normal skin and hypertrophic scar fibroblasts differentially regulate collagen and fibronectin expression as well as mitochondrial membrane potential in response to basic fibroblast growth factor. Rui Song, Hui-Ning Bian, Wen Lai, Hua-De Chen and Ke-Seng Zhao.
Figure 1. Ultrastructure of normal skin and hypertrophic scar (HS) fibroblasts. A, The normal fibroblast showed the absence of myofibroblast-like features (arrowhead). B, Transmission electron micrograph of a cross-section of HS fibroblasts showed fibroblast-to-myofibroblast transdifferentiation according to features that are similar to myofibroblasts, with the external lamina (arrowhead) and with hemidesmosome-like structure corresponding to the so-called fibronexus (arrows). C, The characteristics of actin microfilament bundles and the subplasmalemmal dense plaque (arrow) in another transformed HS fibroblast. Bars: A and B = 1 μm; C = 0.5 μm.