Normal skin and hypertrophic scar fibroblasts differentially regulate collagen and fibronectin expression as well as mitochondrial membrane potential in response to basic fibroblast growth factor. Rui Song, Hui-Ning Bian, Wen Lai, Hua-De Chen and Ke-Seng Zhao.
Figure 2. Effect of basic fibroblast growth factor (bFGF) on proliferation and death of normal skin and hypertrophic scar (HS) fibroblasts. A, The proliferation of HS fibroblasts was reduced compared to that of normal fibroblasts following treatment with bFGF at concentrations of 0.1 to 1000 ng/mL for 72 h. B, bFGF treatment did not affect the mortality of normal fibroblasts. C, bFGF treatment resulted in an increase of HS fibroblast mortality. Data are reported as means ± SEM. The experiments were performed in triplicate and repeated at least once. **P < 0.01 vs untreated fibroblasts; #P < 0.05, ##P < 0.01 vs normal skin fibroblasts (paired t-test and one-way randomized ANOVA).