Normal skin and hypertrophic scar fibroblasts differentially regulate collagen and fibronectin expression as well as mitochondrial membrane potential in response to basic fibroblast growth factor. Rui Song, Hui-Ning Bian, Wen Lai, Hua-De Chen and Ke-Seng Zhao.
Figure 6. Effect of basic fibroblast growth factor (bFGF) on the regulation of cellular ATP levels in normal and hypertrophic scar (HS) fibroblasts. Cells were grown and treated with bFGF at concentrations of 0.1 to 1000 ng/mL for 72 h and then subjected to the luciferin-luciferase assay. bFGF decreased the intracellular ATP levels in HS fibroblasts and increased the ATP levels in the normal fibroblasts. Data are reported as means ± SEM. *P < 0.05, **P < 0.01 vs untreated fibroblasts (paired t-test and one-way randomized ANOVA).