Ceyhan et al. 2018CEYHAN D, KOCMAN AE, YILDIRIM E, OZATIK O, AYDIN S & KOSE A. 2018. Comparison of the effects of curcumin, tramadol and surgical treatments on neuropathic pain induced by chronic constriction injury in rats. Turk Neurosurg 28: 288-95. doi:10.5137/1019-5149.JTN.19824-17.0.
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There was no significant difference between IG and CG for PT, VFFS and CPT. |
Daugherty et al. 2018DAUGHERTY DJ, MARQUEZ A, CALCUTT NA & SCHUBERT D. 2018. A novel curcumin derivative for the treatment of diabetic neuropathy. Neuropharmacology 129: 26-35. doi:10.1016/j.neuropharm.2017.11.007.
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GI presented increased hind paw withdrawal latency for HPT (p <0.0001) and increased tactile withdrawal threshold for VFFS compared to CG (p <0.0001) (rat with neuropathy had mechanical hyperalgesia and no change was observed regarding thermal sensitivity). There was no significant difference between IG and CG for MNCV. |
Jia et al. 2018JIA T ET AL. 2018. Nanoparticle-encapsulated curcumin inhibits diabetic neuropathic pain involving the P2Y12 receptor in the dorsal root ganglia. Front Neurosci 11. doi:10.3389/fnins.2017.00755.
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GI showcased increased hindpaw withdrawal latency for PT (p <0.01) and increased tactile withdrawal threshold for VFFS compared to CG (p <0.01) (rat with neuropathy had both mechanical and thermal hyperalgesia). |
Pierreti et al. 2017 |
IG showed a decrease in paw withdrawal time in FT (p <0.01), decreased tactile withdrawal threshold for VFFS (p <0.01) and decreased hind paw withdrawal latency in PT + zymosan (p <0.05) (thermal and mechanical sensitivity between rats with neuropathy and rats without neuropathy were not compared). |
Liu et al. 2016aLIU GM, XU K, LI J & LUO YG. 2016a. Curcumin upregulates S100 expression and improves regeneration of the sciatic nerve following its complete amputation in mice. Neural Regen Res 11: 1304-1311. doi:10.4103/1673-5374.189196.
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IG showed an increase in MNCV (p <0.05) compared to CG. |
Liu et al. 2016bLIU S, LI Q, ZHANG MT, MAO-YING QL, HU LY, WU GC, MI WL & WANG YQ. 2016b. Curcumin ameliorates neuropathic pain by down-regulating spinal IL-1β via suppressing astroglial NALP1 inflammasome and JAK2-STAT3 signalling. Sci Rep 6: 1-14. doi:10.1038/srep28956.
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IG showed decreased paw withdrawal latency in CAT (p <0.01) and increased tactile withdrawal threshold for VFFS compared to CG (p <0.01) (rat with neuropathy had mechanical hyperalgesia and thermal hypoalgesia). |
Ma et al. 2016MA J, LIU J, YU H, WANG Q, CHEN Y & XIANG L. 2016. Curcumin promotes nerve regeneration and functional recovery after sciatic nerve crush injury in diabetic rats. Neurosci Lett 610: 139-43. doi:10.1016/j.neulet.11.005.
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IG presented decreased hind paw withdrawal latency for HPT (p <0.05) and decreased tactile withdrawal threshold for VFFS compared with CG (p <0.05) and increased MNCV (p <0.05) and increased SFI (p < 0.05) (rat with neuropathy had mechanical and thermal hypoalgesia). |
Abd Allah & Gomaa 2015ABD ALLAH ESH & GOMAA AMS. 2015. Effects of curcumin and captopril on the functions of kidney and nerve in streptozotocin-induced diabetic rats: Role of angiotensin converting enzyme 1. Appl Physiol Nutr Metab 40: 1061-7. doi:10.1139/apnm-2015-0145.
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IG had increased reaction time for HPT (p <0.05), increased latency response for TFT (p <0.05), increased tactile withdrawal threshold for VFFS (p <0.05) compared with CG (mouse with neuropathy had hyperalgesia thermal). |
Adhikari et al. 2015ADHIKARI R, JYOTHI Y, BORA D & VAMSEE VA. 2015. Combined effect of aqueous extract of curcuma longa linn. With metformin in diabetes induced neuroptahic pain in rats. Asian J Pharm Clin Res 8: 166-70.
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IG showed increased reaction time for HPT (p <0.001) and increased latency response for TFT (p <0.001) compared to CG (rat with neuropathy had thermal hyperalgesia). |
Agthong et al. 2015AGTHONG S, KAEWSEMA A & CHAROENSUB T. 2015. Curcumin ameliorates functional and structural abnormalities in cisplatin-induced neuropathy. Exp Neurobiol 24: 139-45. doi:10.5607/en.2015.24.2.139.
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IG showed decreased reaction time for HPT (p <0.05) and increased MNCV (p <0.05) compared CG (rat with neuropathy had thermal hypoalgesia). |
Babu et al. 2015BABU A, PRASANTH KG & BALAJI B. 2015. Effect of curcumin in mice model of vincristine-induced neuropathy. Pharm Biol 53: 838-48. doi:10.3109/13880209.2014.943247.
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IG showed increased reaction time for HPT (p <0.001) and CPT (p <0.001), decreased tail peeling time in TBT (p <0.001), decreased paw lift time (p <0.001 ) and paw licking (p <0.01) in the FT, and increase in SFI (p <0.001) compared to CG. There was no significant difference between GI and CG in the RRT (rat with neuropathy had thermal hyperalgesia and mechanical hypoalgesia). |
Greeshma et al. 2015GREESHMA N, PRASANTH KG & BALAJI B. 2015. Tetrahydrocurcumin exerts protective effect on vincristine induced neuropathy: Behavioral, biochemical, neurophysiological and histological evidence. Chem Biol Interact 238: 118-128. doi:10.1016/j.cbi.2015.06.025.
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IG presented increased tactile withdrawal latency for HPT (p <0.001) and CPT (p <0.001), increased mechanical threshold for RST (p <0.001), increased SFI (p <0.001) and decreased paw elevation time (p <0.001) and paw licking (p <0.01) in the FT compared to CG (rat with neuropathy had thermal and mechanical hyperalgesia). There was no significant difference between the groups in the RRT. |
Meng et al. 2015MENG B, SHEN LL, SHI XT GONG YS, FAN XF, LI J & CAO H. 2015. Effects of curcumin on TTX-R sodium currents of dorsal root ganglion neurons in type 2 diabetic rats with diabetic neuropathic pain. Neurosci Lett 605: 59-64. doi:10.1016/j.neulet.2015.08.011.
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IG presented increased hind paw withdrawal latency for PT (p <0.05) and increased tactile withdrawal threshold in the TBT compared to CG (p <0.05) (rat with neuropathy had mechanical and thermal hyperalgesia). |
Yuce et al. 2015 |
IG presented increase of SFI (p < 0.05) compared to CG. |
Cao et al. 2014CAO H, ZHENG JW, LI JJ, MENG B, LI J & GE RS. 2014.Effects of curcumin on pain threshold and on the expression of nuclear factor κ B and CX3C receptor 1 after sciatic nerve chronic constrictive injury in rats. Chin J Integr Med 20: 850-6. doi:10.1007/s11655-013-1549-9.
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IG presented increased hind paw withdrawal latency for PT (p <0.05) and increased tactile withdrawal threshold for VFFS compared to CG (p <0.05) (rat with neuropathy had thermal and mechanical hyperalgesia). |
Zhao et al. 2014a |
IG presented increased hind paw withdrawal latency for PT (p <0.01) compared to CG (rat with neuropathy had thermal hyperalgesia). There was no significant difference between IG and CG in the RRT and the locomotor activity test. |
Zhu et al. 2014ZHU X, LI Q, CHANG R, YANG D, SONG Z, GUO Q & HUAN C. 2014. Curcumin alleviates neuropathic pain by inhibiting p300/CBP histone acetyltransferase activity-regulated expression of BDNF and Cox-2 in a rat model. PLoS One 9: 35-39. doi:10.1371/journal.pone.0091303.
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IG presented increased hind paw withdrawal latency for PT (p <0.05) and VFFS (p <0.05) compared to CG (rat with neuropathy had thermal and mechanical hyperalgesia). |
Zanjani et al. 2014ZANJANI TM, AMELI H, LABIBI F, SEDAGHAT K & SABETKASAEI M. 2014.The attenuation of pain behavior and serum COX-2 concentration by curcumin in a rat model of neuropathic pain. Korean J Pain 27: 246-252. doi:10.3344/kjp.2014.27.3.246.
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IG presented increased paw withdrawal latency for VFFS (p <0.001) and decreased paw withdrawal frequency in the CAT (p <0.001) (rat with neuropathy had mechanical and thermal hyperalgesia compared to rat without neuropathy). |
Zhao et al. 2014b |
IG presented increased paw withdrawal latency for VFFS (p <0.05) compared to CG (rat with neuropathy had mechanical hyperalgesia). |
Nagilla et al. 2014 |
IG presented decreased hindpaw withdrawal latency for HPT (p <0.05) and increased tactile withdrawal threshold for VFFS (p <0.001) compared to CG (rat with neuropathy had mechanical hyperalgesia and thermal hypoalgesia). |
Banafshe et al. 2014BANAFSHE HR, HAMIDI GA, NOUREDDINI M, MIRHASHEMI SM, MOKHTARI R & SHOFERPOUR M. 2014. Effect of curcumin on diabetic peripheral neuropathic pain: Possible involvement of opioid system. Eur J Pharmacol 723: 202-6. doi:10.1016/j.ejphar.2013.11.033.
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IG presented lowering in hind paw withdrawal latency for PT (p <0.05) and increased tactile withdrawal threshold for VFFS compared to CG (rat with neuropathy had thermal hypoalgesia and mechanical hyperalgesia). |
Jeon et al. 2013JEON Y, KIM CE, JUNG D, KWAK K, PARK S, LIM D, KIM S & BAEK W. 2013. Curcumin Could Prevent the Development of Chronic Neuropathic Pain in Rats with Peripheral Nerve Injury. Curr Ther Res - Clin Exp 74: 1-4. doi:10.1016/j.curtheres.2012.10.001.
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IG presented increased tactile withdrawal threshold for VFFS compared to CG (p <0.05) (rat with neuropathy had mechanical hyperalgesia). |
Joshi et al. 2013JOSHI RP, NEGI G, KUMAR A, PAWAR YB, MUNJAL B, BANSAL AK & SHARMA SS. 2013. SNEDDS curcumin formulation leads to enhanced protection from pain and functional deficits associated with diabetic neuropathy: An insight into its mechanism for neuroprotection. Nanomedicine Nanotechnology. Biol Med 9: 776-85. doi:10.1016/j.nano.2013.01.001.
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IG presented increased tail withdrawal latency for TFT (hot) (p <0.01) and TFT (cold) (p <0.01) and increased tactile withdrawal threshold for VFFS (p <0.01) and RST (p <0.01) and increased MNCV (p <0.01) compared to CG (rat with neuropathy had mechanical and thermal hyperalgesia). |
Li et al. 2013LI Y, ZHANG Y, LIU DB, LIU HY, HOU WG & DONG YS. 2013.Curcumin attenuates diabetic neuropathic pain by downregulating TNF-α in a rat model. Int J Med Sci 10: 377-381. doi:10.7150/ijms.5224.
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IG presented increased hindpaw withdrawal latency for PT (p <0.04) and increased tactile withdrawal threshold for VFFS compared to CG (p <0.03) (rat with neuropathy had mechanical and thermal hyperalgesia). |
Ma et al. 2013MA J, LIU J, YU H, CHEN Y, WANG Q & XIANG L. 2013.Curcumin promotes nerve regeneration and functional recovery in rat model of nerve crush injury. Neurosci Lett 547: 26-31. doi:10.1016/j.neulet.2013.04.054.
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IG presented decreased hindpaw withdrawal latency for HPT (p <0.01), decreased tactile withdrawal threshold for VFFS (p <0.01), increased MNCV (p <0.01) and increased SFI (p <0.01) compared with CG (rat with neuropathy had mechanical and thermal hypoalgesia). |
Mohammadi et al. 2013 |
IG presented greater SNFR (p <0.05), increase in SFI (p <0.05) and SNSI (p <0.05) compared to CG. |
Kandhare et al. 2012KANDHARE AD, RAYGUDE KS, GHOSH P, GHULE AE & BODHANKAR SL. 2012. Therapeutic role of curcumin in prevention of biochemical and behavioral aberration induced by alcoholic neuropathy in laboratory animals. Neurosci Lett 511: 18-22. doi:10.1016/j.neulet.2012.01.019.
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IG showed increased tail-lift latency for TFT (p <0.001), increased tactile withdrawal threshold for VFFS (p <0.001) and RST (p <0.001) and increased MNCV (p <0.001) compared with CG (rat with neuropathy had mechanical and thermal hyperalgesia). |
Patzkó et al. 2012PATZKÓ Á ET AL. 2012. Curcumin derivatives promote Schwann cell differentiation and improve neuropathy in R98C CMT1B mice. Brain 135: 3551-3566. doi:10.1093/brain/aws299.
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There was no significant difference between IG and CG in the rota-rod test. |
Zhao et al. 2012ZHAO X, XU Y, ZHAO Q, CHEN CR, LIU AM & HUANG ZL. 2012. Curcumin exerts antinociceptive effects in a mouse model of neuropathic pain: Descending monoamine system and opioid receptors are differentially involved. Neuropharmacol 62: 843-854. doi:10.1016/j.neuropharm.08.050.
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IG presented increased paw withdrawal latency for VFFS (p <0.01) and increased hind paw withdrawal latency for HPT (p <0.01) compared to CG (rat with neuropathy had mechanical and thermal hyperalgesia). |
Sharma et al. 2007SHARMA S, CHOPRA K & KULKARNI SK. 2007. Effect of Insulin and its Combination with Resveratrol or Curcumin in Attenuation of Diabetic Neuropathic Pain: Participation of Nitric Oxide and TNF-alpha. Phytother Res 21: 278-283.
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IG presented increased hind paw withdrawal latency for HPT (p <0.05) and increased latency response for TFT (p <0.05) (rat with neuropathy had thermal hyperalgesia). |