Acessibilidade / Reportar erro

Emerging Topics in Heart Failure: COVID-19 and Heart Failure

Keywords
COVID-19; Heart Failure; Myocarditis; Takotsubo Cardiomyopathy, Myocardial Infarction

Introduction

Acute COVID-19 cardiovascular syndrome has been the term proposed to describe changes in the cardiovascular system associated with SARS-CoV-2 infection.11. Hendren NS, Drazner MH, Bozkurt B, Cooper LT. Description and Proposed Management of the Acute COVID-19 Cardiovascular Syndrome. Circulation. 2020;141:1903–1914. The most common manifestations of cardiovascular involvement are myocardial injury, myocarditis, myocardial infarction with nonobstructive coronary arteries (MINOCA), arrhythmias, Takotsubo syndrome, pericardial effusion, heart failure (HF), and thromboembolic phenomena (Table 1).22. Costa IBSS, Bittar CS, Rizk SI, Araújo Filho AE, Santos KAQ, Machado TIV, et al. O Coração e a COVID-19: O que o Cardiologista Precisa Saber. Arq. Bras. Cardiol, 2020 114: 805-816.,33. Figueiredo Neto JA, Marcondes-Braga FG, Moura LZ, Figueiredo AMS, Figueiredo VMS, Mourilhe-Rocha R, et al. Coronavirus Disease 2019 and the Myocardium. Arq Bras Cardiol. 2020;114(6):1051-1057. Here, we emphasize myocardial injury, myocarditis, Takotsubo syndrome and the occurrence of COVID-19 in patients with preexisting HF.

Table 1
Spectrum of cardiovascular manifestations associated with COVID-19

Myocardial Injury

The impact of myocardial injury associated with SARS-CoV-2 infection was recognized early in the pandemic, when data from China and, subsequently, from multiple cohorts in different countries invariably showed an increase in mortality associated with elevated serum troponin levels.22. Costa IBSS, Bittar CS, Rizk SI, Araújo Filho AE, Santos KAQ, Machado TIV, et al. O Coração e a COVID-19: O que o Cardiologista Precisa Saber. Arq. Bras. Cardiol, 2020 114: 805-816.,44. Shi S, Qin M, Shen B, Cai Y, Liu T, Yang F, et al. Association of Cardiac Injury With Mortality in Hospitalized Patients With COVID-19 in Wuhan, China. JAMA Cardiol. 2020 Jul1;5(7):802-810. The mechanisms of cardiac involvement in patients with COVID-19 are multiple and include factors directly related to viral infection and, mainly, indirectly related to myocardial damage. The presence of the angiotensin-2 converting enzyme receptor on the surface of cardiomyocyte and vascular endothelial cells suggested that SARS-CoV-2 could cause toxic damage and, consequently, myocarditis.55. Inciardi RM, Lupi L, Zaccone G, Italia L, Raffo M, Tomasoni D, et al. Cardiac involvement in a patient with coronavirus disease 2019 (COVID-19). JAMA Cardiol 2020 Jul 1;5(7):819-824. However, a German study based on autopsy cases detected copies of the virus in interstitial cells and macrophages invading the myocardium, but not in cardiomyocytes.66. Lindner D, Fitzek A, Bräuninger H, Aleshcheva G, Edler C, Meissner K, et al. Association of Cardiac Infection With SARS-CoV-2 in Confirmed COVID-19 Autopsy Cases. JAMA Cardiol 2020;e203551. In addition, the presence of viral genome in the heart was not associated with inflammatory infiltrates typical of myocarditis, suggesting that SARS-CoV-2 may not cause a classic cell-mediated inflammatory condition. It is possible that other inflammatory injury pathways may play a role in myocardial damage by the virus, involving, in particular, vasculitis and systemic activation of cytokine release.

Myocarditis

Despite the uncertainty surrounding the pathophysiology of myocardial injury caused by SARS-CoV-2 infection, several cases of fulminant myocarditis have been reported.55. Inciardi RM, Lupi L, Zaccone G, Italia L, Raffo M, Tomasoni D, et al. Cardiac involvement in a patient with coronavirus disease 2019 (COVID-19). JAMA Cardiol 2020 Jul 1;5(7):819-824.,77. Hu H, Ma F, Wei X, Fang Y. Coronavirus fulminant myocarditis treated with glucocorticoid and human immunoglobulin. Eur Heart J 2020 Mar 16;ehaa190. Clinical manifestations appear to be similar to those of myocarditis caused by other viruses and include chest pain, dyspnea, arrhythmia, fever, and ventricular dysfunction. The electrocardiogram (ECG) shows diffuse ST-segment abnormalities and depression or elevation of the PR and ST segments; at times, it can mimic pathologic changes compatible with ST-segment elevation myocardial infarction.22. Costa IBSS, Bittar CS, Rizk SI, Araújo Filho AE, Santos KAQ, Machado TIV, et al. O Coração e a COVID-19: O que o Cardiologista Precisa Saber. Arq. Bras. Cardiol, 2020 114: 805-816.,33. Figueiredo Neto JA, Marcondes-Braga FG, Moura LZ, Figueiredo AMS, Figueiredo VMS, Mourilhe-Rocha R, et al. Coronavirus Disease 2019 and the Myocardium. Arq Bras Cardiol. 2020;114(6):1051-1057. Troponin is usually elevated, but at lower levels than those observed in acute coronary syndromes. Natriuretic peptides can contribute to the diagnostic confirmation of myocarditis, especially when troponin levels are only slightly increased. Diffuse changes in myocardial wall motion on echocardiography are more common in myocarditis than in acute ischemic syndromes, in which segmental changes are usually observed. Magnetic resonance imaging can be useful for diagnostic confirmation by revealing a typical pattern of inflammatory involvement. A high proportion of patients with elevated troponin and/or ECG changes appear to have persistent inflammatory abnormalities compatible with subclinical myocarditis on cardiac magnetic resonance, even after clinical recovery from COVID-19.88. Ng M-Y, Ferreira VM, Leung ST, Lee JCY, Fong AHT, Liu RWT, et al. Recovered COVID-19 Patients Show Ongoing Subclinical Myocarditis as Revealed by Cardiac Magnetic Resonance Imaging. JACC: Cardiovasc Imaging 2020, doi: https://doi.org/10.1016/j.jcmg.2020.08.012
https://doi.org/10.1016/j.jcmg.2020.08.0...

The concomitant occurrence of elevated troponin, ECG changes, and left ventricular dysfunction is associated with a worse prognosis in SARS-CoV-2 myocarditis, although any evidence of myocardial injury should be considered a risk marker for patients with COVID-19, regardless of suspected myocarditis. Similar to the management of COVID-19 and its multiple systemic repercussions, specific therapeutic strategies for SARS-CoV-2 myocarditis are based mainly on systemic support. The use of immunomodulators, such as corticosteroids and interleukin-6 receptor antagonists (e.g. tocilizumab), has been described in case reports and in a recent systematic review.99. Siripanthong B, Nazarian S, Muser D, Deo R, Santangeli P, Khanji MY, et al. Recognizing COVID-19-related myocarditis: The possible pathophysiology and proposed guideline for diagnosis and management. Heart Rhythm 2020;17:1463–1471.,1010. Coyle J, Igbinomwanhia E, Sanchez-Nadales A, Danciu S, Chu C, Shah N, et al. A recovered case of COVID-19 myocarditis and ARDS treated with corticosteroids, tocilizumab, and experimental AT-001. JACC Case Rep 2020 Jul 15;2(9):1331-1336. Their effects on COVID-19 are still under investigation. Although arrhythmias require some degree of monitoring, no specific antiarrhythmic treatment is currently recommended in the setting of SARS-CoV-2 infection.1111. Kariyanna PT, Sutarjono B, Grewal E, Singh KP, Aurora L, Smith L, et al. A Systematic Review of COVID-19 and Myocarditis. Am J Med Case Rep. 2020; 8(9):299–305.

Takotsubo Syndrome

The incidence of Takotsubo syndrome had a 5-fold increase during the COVID-19 pandemic, whereas acute coronary syndromes showed a decrease in the number of cases during the same period. A Cleveland Clinic cohort study showed that, during the pandemic, about 8% of the cases that presented as acute coronary syndrome were diagnosed as Takotsubo syndrome, different from the 1% incidence reported before the pandemic.1212. Jabri A, Kalra A, Kumar A, Alameh A, Adroja S, Bashir H, et al. Incidence of Stress Cardiomyopathy During the Coronavirus Disease 2019 Pandemic. JAMA Network Open. 2020;3(7):e2014780. Possible pathophysiologic mechanisms associated with this increase include a direct effect of the virus itself, causing myocarditis mimicking Takotsubo syndrome (Takotsubo-like cardiomyopathy), and, more likely, the effects of psychologic stress imposed by quarantine, risk of infection, reduced social interaction caused by social distancing, and socioeconomic consequences of the pandemic. Clinical presentation resembles that of other triggers, and mortality is similar to that reported in the prepandemic period.

COVID-19 in Patients with HF

HF identifies a subgroup of patients with complex management issues and greater morbidity and mortality in the setting of COVID-19. HF represents both a risk factor for worse infectious outcomes and a serious cardiovascular complication of SARS-CoV-2 infection.1313. Yonas E, Alwi I, Pranata R, Huang I, Lim MA, Gutierrez EJ, et al. Effect of heart failure on the outcome of COVID-19 — A meta analysis and systematic review. Am J Emerg Med. 2020;doi:10.1016/j.ajem.2020.07.009.
https://doi.org/10.1016/j.ajem.2020.07.0...
Activation of the inflammatory cascade, hyperstimulation of the neurohumoral system, and direct viral toxicity are some of the possible pathophysiologic mechanisms for new-onset acute or decompensated HF in this scenario.

Patients hospitalized for HF should be tested for SARS-CoV-2 infection, due to overlapping signs and symptoms, and undergo a thorough assessment of volume status, in addition to laboratory, echocardiographic, and radiographic assessment. COVID-19 can manifest as a systemic inflammatory syndrome, and this feature should be considered when prescribing vasodilators for patients with acute HF. During hospitalization, the use of guideline-recommended medications should be maintained in patients with preserved hemodynamics and blood pressure. Other strategies, such as telemedicine, including telemonitoring and virtual consultations, have been important in the management of chronic HF and in infection prevention. In addition to reducing the risk of exposure to the virus, these strategies have helped to provide preventive counseling regarding COVID-19 and to identify patients at risk of decompensation.1414. Salzano A, D’Assante R, Stagnaro FM, Valente V, Crisci G, Giardino F, et al. Heart failure management during the COVID-19 outbreak in Italy: a telemedicine experience from a heart failure university tertiary referral centre. Eur J Heart Fail. 2020;22(6):1048-1050. doi:10.1002/ejhf.1911
https://doi.org/10.1002/ejhf.1911...

Final Considerations

The spectrum of cardiac involvement in COVID-19, in patients with or without previous HF, is currently an evolving knowledge. Likewise, medium- and long-term consequences of the effects of SARS-CoV-2 infection on the heart may carry important clinical and epidemiological ramifications, but poorly predictable as yet. It is provocative to consider that we may be facing a potential new etiology of cardiomyopathy, which may contribute to an increase in the incidence of HF in the coming years.

List of participants of the Heart Failure Summit Brazil 2020 / Heart Failure Department - Brazilian Society of Cardiology

Aguinaldo Freitas Junior, Andréia Biolo, Antonio Carlos Pereira Barretto, Antônio Lagoeiro Jorge, Bruno Biselli, Carlos Eduardo Montenegro, Denilson Campos de Albuquerque, Dirceu Rodrigues de Almeida, Edimar Alcides Bocchi, Edval Gomes dos Santos Júnior, Estêvão Lanna Figueiredo, Evandro Tinoco Mesquita, Fabiana G. Marcondes-Braga, Fábio Fernandes, Fabio Serra Silveira, Felix José Alvarez Ramires, Fernando Atik, Fernando Bacal, Flávio de Souza Brito, Germano Emilio Conceição Souza, Gustavo Calado de Aguiar Ribeiro, Humberto Villacorta Jr., Jefferson Luis Vieira, João David de Souza Neto, João Manoel Rossi Neto, José Albuquerque de Figueiredo Neto, Lídia Ana Zytynski Moura, Livia Adams Goldraich, Luís Beck-da-Silva Neto, Luís Eduardo Paim Rohde, Luiz Claudio Danzmann, Manoel Fernandes Canesin, Marcelo Bittencourt, Marcelo Westerlund Montera, Marcely Gimenes Bonatto, Marcus Vinicius Simões, Maria da Consolação Vieira Moreira, Miguel Morita Fernandes da Silva, Monica Samuel Avila, Mucio Tavares de Oliveira Junior, Nadine Clausell, Odilson Marcos Silvestre, Otavio Rizzi Coelho Filho, Pedro Vellosa Schwartzmann, Reinaldo Bulgarelli Bestetti, Ricardo Mourilhe Rocha, Sabrina Bernadez Pereira, Salvador Rassi, Sandrigo Mangini, Silvia Marinho Martins, Silvia Moreira Ayub Ferreira, Victor Sarli Issa.

  • Research letter related to Heart Failure Summit Brazil / Heart Failure Department - Brazilian Society of Cardiology
  • Sources of Funding
    There were no external funding sources for this study.
  • Study Association
    This study is not associated with any thesis or dissertation work.

Referências

  • 1
    Hendren NS, Drazner MH, Bozkurt B, Cooper LT. Description and Proposed Management of the Acute COVID-19 Cardiovascular Syndrome. Circulation. 2020;141:1903–1914.
  • 2
    Costa IBSS, Bittar CS, Rizk SI, Araújo Filho AE, Santos KAQ, Machado TIV, et al. O Coração e a COVID-19: O que o Cardiologista Precisa Saber. Arq. Bras. Cardiol, 2020 114: 805-816.
  • 3
    Figueiredo Neto JA, Marcondes-Braga FG, Moura LZ, Figueiredo AMS, Figueiredo VMS, Mourilhe-Rocha R, et al. Coronavirus Disease 2019 and the Myocardium. Arq Bras Cardiol. 2020;114(6):1051-1057.
  • 4
    Shi S, Qin M, Shen B, Cai Y, Liu T, Yang F, et al. Association of Cardiac Injury With Mortality in Hospitalized Patients With COVID-19 in Wuhan, China. JAMA Cardiol. 2020 Jul1;5(7):802-810.
  • 5
    Inciardi RM, Lupi L, Zaccone G, Italia L, Raffo M, Tomasoni D, et al. Cardiac involvement in a patient with coronavirus disease 2019 (COVID-19). JAMA Cardiol 2020 Jul 1;5(7):819-824.
  • 6
    Lindner D, Fitzek A, Bräuninger H, Aleshcheva G, Edler C, Meissner K, et al. Association of Cardiac Infection With SARS-CoV-2 in Confirmed COVID-19 Autopsy Cases. JAMA Cardiol 2020;e203551.
  • 7
    Hu H, Ma F, Wei X, Fang Y. Coronavirus fulminant myocarditis treated with glucocorticoid and human immunoglobulin. Eur Heart J 2020 Mar 16;ehaa190.
  • 8
    Ng M-Y, Ferreira VM, Leung ST, Lee JCY, Fong AHT, Liu RWT, et al. Recovered COVID-19 Patients Show Ongoing Subclinical Myocarditis as Revealed by Cardiac Magnetic Resonance Imaging. JACC: Cardiovasc Imaging 2020, doi: https://doi.org/10.1016/j.jcmg.2020.08.012
    » https://doi.org/10.1016/j.jcmg.2020.08.012
  • 9
    Siripanthong B, Nazarian S, Muser D, Deo R, Santangeli P, Khanji MY, et al. Recognizing COVID-19-related myocarditis: The possible pathophysiology and proposed guideline for diagnosis and management. Heart Rhythm 2020;17:1463–1471.
  • 10
    Coyle J, Igbinomwanhia E, Sanchez-Nadales A, Danciu S, Chu C, Shah N, et al. A recovered case of COVID-19 myocarditis and ARDS treated with corticosteroids, tocilizumab, and experimental AT-001. JACC Case Rep 2020 Jul 15;2(9):1331-1336.
  • 11
    Kariyanna PT, Sutarjono B, Grewal E, Singh KP, Aurora L, Smith L, et al. A Systematic Review of COVID-19 and Myocarditis. Am J Med Case Rep. 2020; 8(9):299–305.
  • 12
    Jabri A, Kalra A, Kumar A, Alameh A, Adroja S, Bashir H, et al. Incidence of Stress Cardiomyopathy During the Coronavirus Disease 2019 Pandemic. JAMA Network Open. 2020;3(7):e2014780.
  • 13
    Yonas E, Alwi I, Pranata R, Huang I, Lim MA, Gutierrez EJ, et al. Effect of heart failure on the outcome of COVID-19 — A meta analysis and systematic review. Am J Emerg Med. 2020;doi:10.1016/j.ajem.2020.07.009.
    » https://doi.org/10.1016/j.ajem.2020.07.009
  • 14
    Salzano A, D’Assante R, Stagnaro FM, Valente V, Crisci G, Giardino F, et al. Heart failure management during the COVID-19 outbreak in Italy: a telemedicine experience from a heart failure university tertiary referral centre. Eur J Heart Fail. 2020;22(6):1048-1050. doi:10.1002/ejhf.1911
    » https://doi.org/10.1002/ejhf.1911

Publication Dates

  • Publication in this collection
    07 Dec 2020
  • Date of issue
    Nov 2020

History

  • Received
    06 Oct 2020
  • Reviewed
    06 Oct 2020
  • Accepted
    06 Oct 2020
Sociedade Brasileira de Cardiologia - SBC Avenida Marechal Câmara, 160, sala: 330, Centro, CEP: 20020-907, (21) 3478-2700 - Rio de Janeiro - RJ - Brazil, Fax: +55 21 3478-2770 - São Paulo - SP - Brazil
E-mail: revista@cardiol.br