Short Editorial Legumain – Another Piece in the Complex Puzzle of Atherosclerotic Plaque Formation and Vulnerability Timóteo, Ana Teresa |
Short Editorial Role of Omega-3 and Omega-6 on Cardiovascular Risk Factors: Importance of Dietary Sources and Lipid Structure Soares, Victória Moralez Silva, Thais Caroline da Santos, Priscila Portugal dos |
Short Editorial Blood Pressure Response and Exercise Stress Echocardiography: New Perspectives on a Contemporary Challenge Vilela, Eduardo M. Fontes-Carvalho, Ricardo |
Short Editorial Post-COVID Syndrome or Long COVID: A New Challenge for the Healthcare System Mill, José Geraldo Polese, Jéssica |
Short Editorial Risk Assessment in Heart Failure: Comprehensive is Always Better! Mendes, Miguel |
Short Editorial Mortality Risk Stratification in Heart Failure. The Search for the Holy Grail Continues! Autonomic Nervous System Analysis is Back! Rocha, Eduardo Arrais Cunha, Bianca Lopes Brasil, Helena Nogueira Pereira, Francisca Tatiana Moreira Pires Neto, Roberto da Justa |
Short Editorial Acute Myocardial Infarction: Do We Need Markers for Microcirculation Injury? Moreover, Would the Fibrinogen/Albumin Ratio Be the Answer? |
Short Editorial Pericoronary Fat Attenuation on Computed Tomography Unveils a Guilty Factor of Coronary Artery Disease Associated with Anabolic–Androgenic Steroids |
Short Editorial Ischemic Heart Disease and Income Level – A Thinking on Social and Structural Determinants |
ORIGINAL ARTICLE Relationship between the Fibrinogen/Albumin Ratio and Microvascular Perfusion in Patients Undergoing Primary Percutaneous Coronary Intervention for ST-Elevated Myocardial Infarction: A Prospective Study Kaplangoray, Mustafa Toprak, Kenan Cicek, Omer Faruk Deveci, Edhem Abstract in Portuguese: Resumo Fundamento A contagem corrigida de quadros TIMI (CTFC), o grau de blush miocárdico (MBG) e a resolução do segmento ST (STR) são parâmetros utilizados para avaliar a reperfusão em nível microvascular em pacientes submetidos à intervenção coronária percutânea primária (ICPp). A relação fibrinogênio/albumina (FAR) tem sido associada a eventos trombóticos em pacientes com infarto do miocárdio com elevação do segmento ST (IAMCSST) e insuficiência venosa crônica. Objetivos Investigar a relação do FAR com CTFC, MBG e STR.Métodos: O estudo incluiu 167 pacientes consecutivos que foram submetidos a ICPp com sucesso para IAMCSST e alcançaram fluxo TIMI-3. Os casos foram divididos em dois grupos, FAR alto (> 0,0765) e FAR baixo (≤ 0,0765), de acordo com o valor de corte desse parâmetro na análise característica do operador do receptor (ROC). STR, CTFC e MBG foram utilizados para avaliar a reperfusão miocárdica. Valores de p<0,05 foram considerados estatisticamente significativos. Resultados O valor CTFC, escore SYNTAX, relação neutrófilos/linfócitos, lipoproteína de baixa densidade, glicose e pico de cTnT foram significativamente maiores, enquanto STR, MBG e FEVE foram menores no grupo FAR alto. A análise de correlação de Spearman revelou relação significativa entre FAR e STR (r=-0,666, p<0,001), MBG (-0,523, p<0,001) e CTFC (r=0,731, p≤0,001). De acordo com a análise de regressão logística, FAR, glicose, pico de cTnT e dor até o tempo de Balão foram os preditores independentes mais importantes de MBG 0/1, CTFC>28 e STR<50%). A análise ROC revelou que o ponto de corte o valor de FAR≥0,0765 foi preditor de STR incompleto com sensibilidade de 71,9% e especificidade de 69,8%, MBG0/1 com sensibilidade de 72,6% e especificidade de 68,6%, e CTFC>28 com sensibilidade de 76% e uma especificidade de 65,8%. Conclusões A FAR é um importante preditor independente de perfusão microvascular em pacientes submetidos a ICPp por IAMCSST.Abstract in English: Abstract Background Correct TIMI frame count (CTFC), myocardial blush grade (MBG), and ST-segment resolution (STR) are parameters used to evaluate reperfusion at the microvascular level in patients that have undergone primary percutaneous coronary intervention (pPCI). Fibrinogen-to-albumin ratio (FAR) has been associated with thrombotic events in patients with ST-elevation myocardial infarction (STEMI) and chronic venous insufficiency. Objectives To investigate the relationship of FAR with CTFC, MBG, and STR. Methods: The study included 167 consecutive patients who underwent successful pPCI for STEMI and achieved TIMI-3 flow. The cases were divided into two groups, high (>0.0765) and low FAR (≤0.0765), according to the cut-off value of this parameter in the receiver operator characteristic analysis (ROC). STR, CTFC, and MBG were used to evaluate myocardial reperfusion. P values<0.05 were considered statistically significant. Results CTFC value, SYNTAX score, neutrophil/lymphocyte ratio, low-density lipoprotein, glucose, and peak cTnT were significantly higher, whereas STR, MBG, and LVEF were lower in the high FAR group. Spearman’s correlation analysis revealed a significant relationship between the FAR and STR (r=-0.666, p<0.001), MBG (-0.523, p<0.001), and CTFC (r=0.731, p≤0.001). According to the logistic regression analysis, FAR, glucose, peak cTnT, and pain to balloon time were the most important independent predictors of MBG 0/1, CTFC>28, and STR<50%).ROC analysis revealed that the cut-off value of FAR≥0.0765 was a predictor of incomplete STR with a sensitivity of 71.9 % and a specificity of 69.8 %, MBG0/1 with a sensitivity of 72.6 % and a specificity of 68.6 %, and CTFC >28 with a sensitivity of 76 % and a specificity of 65.8 %. Conclusions FAR is an important independent predictor of microvascular perfusion in patients undergoing pPCI for STEMI. |
Original Article Relationship between Increased Plasma Levels of Legumain and Properties of Coronary Atherosclerotic Plaque Deng, Yunpeng Fan, Yudong Wu, Di Zhang, Zilong Zhang, Miaomiao Huang, Zhiping Gao, Yuxia Abstract in Portuguese: Figura Central : Relação entre Níveis Plasmáticos Aumentados de Legumain e Propriedades da Placa Aterosclerótica CoronáriaAbstract in English: Central Illustration : Relationship between Increased Plasma Levels of Legumain and Properties of Coronary Atherosclerotic Plaque |
Original Article Hematological Changes during Seven Days of Hospitalization in Patients with Acute Myocardial Infarction Martins, Cyntia Maria de Holanda Monteiro Júnior, José Gildo de Moura Torres, Dilênia de Oliveira Cipriano Sobral Filho, Dario Celestino Morais, Maria Clara Santos Montarroyos, Ulisses Ramos Silva, Izadora Karina da Santos, Ana Célia Oliveira dos Abstract in Portuguese: Resumo Fundamento O infarto agudo do miocárdio é uma das principais causas de mortalidade em todo o mundo e a formação de placa aterosclerótica é o principal mecanismo fisiopatológico, que resulta em inflamação crônica e induz a maturação eritrocitária, podendo causar aumento no índice de amplitude de distribuição dos glóbulos vermelhos (RDW). Objetivo Avaliar o papel do índice de anisocitose em pacientes com infarto agudo do miocárdio em ambos os tipos de infarto como preditor de gravidade. Métodos Os pacientes foram incluídos no estudo de acordo com os critérios de inclusão e exclusão, seguindo a rotina hospitalar baseada na história clínica e laboratorial. As análises estatísticas foram realizadas de acordo com cada variável. Chegou-se a todas as conclusões considerando o nível de significância de 5%. Resultados Durante o período de acompanhamento, nos 349 pacientes analisados, a taxa de mortalidade esteve associada às variáveis RDW (CV) e RDW (SD). Nos pacientes que foram a óbito, notou-se aumento, conforme demonstrado no modelo multivariado, nos efeitos de um infarto agudo do miocárdio com supradesnivelamento do segmento ST e RDW, ajustado para fatores de confusão (valor-p = 0,03 e 0,04). Em contrapartida, o número total de eritrócitos (valor-p = 0,00) e hemoglobina (valor-p = 0,03) apresentou diminuição durante a internação de pacientes graves. Conclusão O índice de anisocitose foi fator preditivo de mortalidade e pode ser utilizado como indicador de pior prognóstico em pacientes com infarto agudo do miocárdio.Abstract in English: Abstract Background Acute myocardial infarction is a major cause of mortality worldwide, and atherosclerotic plaque formation is the main pathophysiological mechanism, which results in chronic inflammation that induces erythrocyte maturation and may cause an increase in the red cell distribution width (RDW) index. Objective Evaluate the role of the anisocytosis index in patients with acute myocardial infarction in both types of infarctions as a predictor of severity. Methods Patients were included in the study according to the inclusion/exclusion criteria, following the hospital routine based on their clinical and laboratory history. Statistical analyzes were performed according to each variable. All conclusions were drawn considering the significance level of 5%. Results During the follow-up period, in the 349 patients analyzed, the mortality rate was associated with the variables RDW (CV) and RDW (SD), in those patients who died, an increase was noted, as demonstrated in the multivariate model, for the effects of an acute ST elevation myocardial infarction and the RDW, adjusted for confounding factors (p-value = 0.03 and 0.04). In contrast, the total number of erythrocytes (p-value = 0.00) and hemoglobin (p-value = 0.03) showed a decrease during severe patients’ hospitalization. Conclusion The anisocytosis index was a predictive factor of mortality and can be used as an indicator of worse prognosis in patients with acute myocardial infarction. |
Original Article Coronary Inflammation by Computed Tomography Pericoronary Fat Attenuation and Increased Cytokines in Young Male Anabolic Androgenic Steroid Users Souza, Francis Ribeiro de Rochitte, Carlos E. Silva, Douglas Carli Sampaio, Barbara Passarelli, Marisa Santos, Marcelo R. dos Fonseca, Guilherme W. Battaglia Filho, Antonio Carlos Correa, Kelly do Val, Renata Margarida Yonamine, Maurício Pereira, Rosa Maria R. Negrão, Carlos Eduardo Kalil-Filho, Roberto Alves, Maria Janieire de Nazaré Nunes Abstract in Portuguese: Figura Central : Inflamação Coronária Avaliada pela Atenuação de Gordura Pericoronária na Tomografia Computadorizada e Elevação de Citocinas em Usuários Jovens de Esteroides Anabólicos AndrogênicosAbstract in English: Central Illustration : Coronary Inflammation by Computed Tomography Pericoronary Fat Attenuation and Increased Cytokines in Young Male Anabolic Androgenic Steroid Users |
Original Article Red Blood Cells’ Omega-6 and Omega-3 Polyunsaturated Fatty Acids Have a Distinct Influence on LDL Particle Size and its Structural Modifications Gonçalinho, Gustavo Henrique Ferreira Sampaio, Geni Rodrigues Soares-Freitas, Rosana Aparecida Manólio Damasceno, Nágila Raquel Teixeira Abstract in Portuguese: Figura Central : Os Ácidos Graxos Poli-insaturados Ômega-6 e Ômega-3 Presentes nas Hemácias Exercem uma Influência Distinta sobre o Tamanho das Partículas de LDL e suas Alterações EstruturaisAbstract in English: Central Illustration : Red Blood Cells’ Omega-6 and Omega-3 Polyunsaturated Fatty Acids Have a Distinct Influence on LDL Particle Size and its Structural Modifications |
Original Article Long-term Health-Related Quality of Life and Outcomes after Hospitalization for COVID-19 in Brazil: Post-COVID Brazil 1 Study Protocol Trott, Geraldine Scolari, Fernando Luis Rover, Marciane Maria Silva, Mariana Motta Dias da Souza, Denise de Santos, Rosa da Rosa Minho dos Schardosim, Raíne Fogliati de Carli Rech, Gabriela Soares Mesquita Neto, Juliana de Estivalete, Gabriel Pozza Freitas, Hellen Jordan Martins Itaqui, Carolina Rothmann Kozesinski-Nakatani, Amanda Christina Biolo, Andreia Marcolino, Milena Soriano Barreto, Bruna Brandão Schvartzman, Paulo Roberto Antonio, Ana Carolina Peçanha Robinson, Caroline Cabral Falavigna, Maicon Polanczyk, Carisi Anne Rosa, Regis Goulart Abstract in Portuguese: Figura Central : Qualidade de Vida em Longo Prazo e Desfechos após Internação por COVID-19 no Brasil: Protocolo do Estudo Pós-COVID Brasil 1 Delineamento do estudo pós-COVID Brasil.Abstract in English: Central Illustration : Long-term Health-Related Quality of Life and Outcomes after Hospitalization for COVID-19 in Brazil: Post-COVID Brazil 1 Study Protocol Post-COVID Brazil study design. |
Original Article Association of Income Level and Ischemic Heart Disease: Potential Role of Walkability Cerci, Rodrigo Julio Fernandes-Silva, Miguel Morita Vitola, João Vicente Cerci, Juliano Julio Pereira Neto, Carlos Cunha Masukawa, Margaret Gracia, Ana Paula Weller Silvello, Lara Luiza Prado, Pedro Guedes, Murilo Hino, Adriano Akira Ferreira Baena, Cristina Pellegrino Abstract in Portuguese: Visual Abstract : Associação de Nível de Renda e Doença Isquêmica do Coração: Papel Potencial da Caminhabilidade Associação entre doença isquêmica do coração (ajustada por fatores de risco tradicionais e variáveis socioeconômicas) e nível de renda (A), e escore z de caminhabilidade (B), e associação de escore z de caminhabilidade e nível de renda (C).Abstract in English: Central Illustration Association of Income Level and Ischemic Heart Disease: Potential Role of Walkability Association of ischemic heart disease (adjusted for traditional risk factors and socioeconomics variables) and income level (A), and walkability z-score (B), and association of walkability z-score and income level (C). |
Original Article Exaggerated Systolic Blood Pressure Increase with Exercise and Myocardial Ischemia on Exercise Stress Echocardiography Martins-Santos, Cláudia Bispo Duarte, Lara Teles Alencar Ferreira-Junior, Cleovaldo Ribeiro Feitosa, Allexa Gabriele Teixeira Oliveira, Edvaldo Victor Gois Campos, Iana Carine Machado Bispo Melo, Enaldo Vieira de Andrade, Stephanie Macedo Sousa, Antônio Carlos Sobral Oliveira, Joselina Luzia Menezes Abstract in Portuguese: Figura Central : Resposta Exagerada da Pressão Arterial Sistólica ao Exercício e Isquemia Miocárdica à Ecocardiografia sob Estresse FísicoAbstract in English: Central Illustration : Exaggerated Systolic Blood Pressure Increase with Exercise and Myocardial Ischemia on Exercise Stress Echocardiography ESBPRE: exaggerated systolic blood pressure response to exercise; HR: heart rate; SBP: systolic blood pressure. |
Original Article Incremental Role of New York Heart Association Class and Cardiopulmonary Exercise Test Indices for Prognostication in Heart Failure: A Cohort Study Engster, Pedro Henrique de Borba Zimerman, André Schaan, Thomas Borges, Marina S. Souza, Gabriel Costa, Giovanni Donelli Rohde, Luis Eduardo Silveira, Anderson Donelli da Abstract in Portuguese: Figura Central : Papel Incremental da Classificação da New York Heart Association e dos Índices do Teste de Exercício Cardiopulmonar para Prognóstico na Insuficiência Cardíaca: um Estudo de Coorte FEVE: fração de ejeção do ventrículo esquerdo; HR: hazard ratio; IC: intervalo de confiança; NYHA: New York Heart Association; VO 2: consumo de oxigênio.Abstract in English: Central Illustration : Incremental Role of New York Heart Association Class and Cardiopulmonary Exercise Test Indices for Prognostication in Heart Failure: A Cohort Study LVEF: left ventricular ejection fraction; HR: hazard ratio; CI: confidence interval; NYHA: New York Heart Association; VO 2: oxygen consumption. |
Original Article Predictive Model of All-Cause Death in Patients with Heart Failure using Heart Rate Variability Gomes, Bruno Ferraz de Oliveira Benchimol-Barbosa, Paulo Roberto Nadal, Jurandir Abstract in Portuguese: Figura Central : Modelo Preditivo de Mortalidade por Todas as Causas em Pacientes com Insuficiência Cardíaca Usando a Variabilidade da Frequência CardíacaAbstract in English: Central Illustration : Predictive Model of All-Cause Death in Patients with Heart Failure using Heart Rate Variability |
Review Article Percutaneous Strategies in Structural Heart Diseases: Focus on Chronic Heart Failure Filippini, Filippe Barcellos Ribeiro, Henrique Barbosa Bocchi, Edimar Bacal, Fernando Marcondes-Braga, Fabiana G. Avila, Monica S. Sturmer, Janine Daiana Marchi, Mauricio Felippi de Sá Kanhouche, Gabriel Freire, Antônio Fernando Cassar, Renata Abizaid, Alexandre A. Brito Jr, Fábio Sândoli de Abstract in Portuguese: Figura Central : Estratégias Percutâneas em Doenças Estruturais: Foco em Insuficiência Cardíaca Crônica Principais dispositivos transcateter para monitorização e tratamento de pacientes com insuficiência cardíaca avançada. AP: artéria pulmonar; AE: átrio esquerdo; ENV: estimulação de nervo vago; TEB: terapia estimuladora de barorreceptor; DSR: denervação simpática renal; F: aprovação pelo agência reguladora americana (FDA); E: aprovação pelo agência reguladora europeia (CE Mark).Abstract in English: Central Illustration : Percutaneous Strategies in Structural Heart Diseases: Focus on Chronic Heart Failure Transcatheter devices for monitoring and treating advanced chronic heart failure patients. PA: pulmonary artery; LA: left atrium; AFR: atrial flow regulator; TASS: Transcatheter Atrial Shunt System; VNS: vagus nerve stimulation; BAT: baroreceptor activation therapy; RDN: renal sympathetic denervation; F: approval by the American regulatory agency (FDA); E: approval by the European regulatory agency (CE Mark). |
Research Letter Left Anterior Fascicular Block Associated with Atrioventricular Block during Exercise Stress Test Falcão, Andréa Marinho Suares, Vagner L. Chalela, William A. |
Research Letter Excess Systolic Blood Pressure Associated with Fine Particulate Matter Air Pollution above the WHO Guidelines in Brazil Salerno, Pedro Rafael Vieira de Oliveira Motairek, Issam Dallan, Luis Augusto Palma Bourges-Sevenier, Brendan Rajagopalan, Sanjay Al-Kindi, Sadeer G. |
Case Report Left Atrial Appendage Occlusion and Implantation of a Bicaval System: Report of a Simultaneous Transcatheter Procedure in a Critically Ill Elderly Patient Cherem, Marcos Bernini, Carlos Eduardo Saad, Jamil Abdalla Dias Sobrinho, Dirceu Barbosa Silva, Marcio Sérgio Carvalho Muzzi, Ruthnea Aparecida Lazaro |
Letter to the Editor Cost-Effectiveness of the Use of the Coronary Calcium Score in Primary Prevention as a Guide for the Therapeutic Decision Nascimento, Cristian Rodrigues do Santos, Júlio Martinez Mendes, Rodrigo Lopes, Johnnatas Mikael Tenório, Pedro Pereira |
Erratum Erratum |