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LACTATE CAN BE A MARKER OF METABOLIC SYNDROME IN SEVERE OBESITY?

Roberto DE-CLEVA Lilian CARDIA Alexandre VIEIRA-GADDUCCI Julia Maria GREVE Marco Aurelio SANTO About the authors

ABSTRACT

Background:

In the last decades, numerous studies have confirmed the importance of lactate - by-product to the nutrient signal of the intracellular redox state - to regulatory functions in energy metabolism.

Aim:

To evaluate changes in blood lactate in patients with severe obesity and its correlation with body composition and metabolic profile.

Methods:

Twenty-four people with severe obesity (BMI=40 kg/m2) were evaluated in a prospective case-control study before and six months after Roux-in-Y gastric bypass. The blood lactate, total cholesterol, and fractions, C-reactive protein and HOMA-IR were analyzed after 12 h fasting. Body mass composition was evaluated by bioelectrical impedance and respiratory quotient was measured by indirect calorimetry.

Results:

The initial lactate level was 2.5±1.1 mmol/l and returned to normal level (1.9±3.6 mmol/l, p=0.0018) after surgery. This reduction was positively correlated with a decrease in BMI (p=0.0001), % free fat mass (p=0,001), % fat mass (p=0.001) and HOMA-IR (p=0.01). There was normalization of lactatemia in 70% of patients. There was no correlation between lactatemia and C-reactive protein.

Conclusions:

There was a significant improvement of metabolic parameters, normalization of blood lactate, fat mass loss, although these individuals remained with a high BMI.

HEADINGS:
Obesity; Bariatric surgery; Lactic acid; Metabolic syndrome; Body composition

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