SHORT-TERM EFFECT OF WHEY PROTEIN SUPPLEMENTATION ON THE QUALITY OF LIFE OF PATIENTS WAITING FOR LIVER TRANSPLANTATION: A DOUBLE BLINDED RANDOMIZED CLINICAL TRIAL

Michelle Carvalho de Oliveira D’ALESSANDRO Amanda Dias GOMES Jéssica França MORAIS Yani Glaúcia Gomide MIZUBUTI Thales Antônio da SILVA Silvia Mauricio FERNANDES Larissa Loures MENDES Maria Isabel Toulson Davisson CORREIA Simone de Vasconcelos GENEROSO About the authors

ABSTRACT

Background:

Chronic liver disease is associated with malnutrition that negatively impacts a patient’s health-related quality of life (HRQoL).

Aim:

To evaluate the short-term effect of whey protein supplementation on the HRQoL and nutritional and functional status of patients waiting for liver transplantation.

Methods:

This was a double-blind randomized clinical trial with patients waiting for liver transplantation who were randomized into two groups: WP (whey protein supplementation) and the control (casein supplementation). Both groups received 40 g (20 g in the morning and 20 g in the evening) for 15 days. Nutritional and functional status were evaluated. Energy balance was calculated as the difference between energy intake (24-hour recall) and total energy expenditure (assessed by indirect calorimetry). The chronic liver disease questionnaire was used to assess HRQoL. All measurements were performed before and after the intervention.

Results:

Fifty-six patients were evaluated. Malnutrition was present in 56.9%, and it was directly associated with a poor HRQoL (p<0.05). No improvement on the nutritional and functional status was observed, in either group after protein supplementation. HRQoL improved after WP and casein supplementation, with no differences between groups (p>0.05). Patients who met protein requirements and had a positive energy balance demonstrated a higher HRQoL score (4.9, p<0.05), without between-group differences.

Conclusion:

Malnutrition substantially reduces HRQoL. Short-term WP or casein supplementation improved similarly the HRQoL.

HEADINGS:
Quality of life; Whey protein; Nutritional status; Liver transplantation

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