Biological agents: investigation into leprosy and other infectious diseases before indication* * Study carried out at the Outpatient Service of the Dermatology Department of the Base Hospital at the State Medical School of São José do Rio Preto, São Paulo.

Agentes biológicos: pesquisa de hanseníase e outras doenças infecciosas antes da indicação

João Roberto Antônio Rosa Maria Cordeiro Soubhia Vania Del Arco Paschoal Carolina Forte Amarante Ana Regina Franchi Travolo About the authors

Biological agents are widely used for various immune-mediated diseases, with remarkable effectiveness in the treatment of rheumatoid arthritis (RA), psoriasis, psoriatic arthritis, ankylosing spondylitis and Crohn's disease. However, attention needs to be drawn to the adverse effects of these therapies and the risk of reactivating underlying granulomatous infectious diseases such as tuberculosis, leprosy, syphilis, leishmaniasis, among others. The objective of this paper is to describe a case of leprosy in a patient with RA using anti-TNF alfa, demonstrating the need for systematic investigation of skin lesions suggestive of leprosy in patients who require rheumatoid arthritis therapeutic treatment, especially in endemic regions like Brazil.

Rheumatoid arthritis; Exposure to biological agents; Leprosy; Tumor necrosis factor-alpha


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