Link between immunoexpression of hMLH1 and hMSH2 proteins and clinical-epidemiological aspects of actinic cheilitis

Sarmento, Dmitry José de Santana; Godoy, Gustavo Pina; Miguel, Márcia Cristina da Costa; Silveira, Éricka Janine Dantas da

doi:10.1590/abd1806-4841.20164800

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Investigation • An. Bras. Dermatol. 91 (4) • Jul-Aug 2016 • https://doi.org/10.1590/abd1806-4841.20164800 copy

Link between immunoexpression of hMLH1 and hMSH2 proteins and clinical-epidemiological aspects of actinic cheilitis^* * Work performed at the Universidade Estadual da Paraíba (UEPB) e Universidade Federal do Rio Grande do Norte (UFRN) - Natal (RN), Brazil.

Authorship SCIMAGO INSTITUTIONS RANKINGS

Abstract:

Background:

The studies found in the literature associate the immunoexpression of hMLH1 and hMSH2 proteins with histologic aspects, but do not correlate it with clinical and epidemiological data.

Objective:

To evaluate the immunoexpression of hMLH1 and hMSH2 in actinic cheilitis, correlating it with clinical characteristics.

Methods:

We analyzed 40 cases. Histological and immunohistochemical analyses were performed. The following clinical variables were evaluated: gender, age range, ethnicity, clinical aspect and occupational sunlight exposure. Statistical evaluation included the Student t-test, while the significance level was set at 5%.

Results:

Greater immunoexpression of hMLH1 and hMSH2 was observed in females, individuals aged over 40, and mixed-race/black patients. Furthermore, the immunoexpression of these proteins was greater in actinic cheilitis with a white-colored appearance and in patients without occupational sunlight exposure. No statistical differences were observed for the variables studied.

Conclusion:

This study uncovered variations of hMLH1 and hMSH2 protein expression upon evaluation of clinical aspects in actinic cheilitis.

Keywords:
Cheilitis; Clinical diagnosis; Immunohistochemistry

VARIABLE		n	IMMUNOEXPRESSION
VARIABLE		hMLH1			hMSH2
			mean+SD^(a) (a) The data presented comprise the number of positive cells per 1,000 lesional cells;	p^(b) (b) T-student test.	mean+SD ^(a) (a) The data presented comprise the number of positive cells per 1,000 lesional cells;	p^(b) (b) T-student test.
Gender	Male	30	640,93+163,13	0.338	714,47+187,97	0.658
	Female	10	698,40+159,41		744,10+161,68
Age range	≥ 40 years	32	655,53+171,09	0.986	728,16+177,48	0.665
	< 40 years	8	654,38+129,67		696,75+201,33
Ethnicity^* * The variables have missing data;	White	26	659,73+150,14	0.459	711,69+190,78	0.371
	Mixed-race/black	9	705,00+173,88		775,67+153,49
Clinical aspect^* * The variables have missing data;	White lesion	20	706,75+139,74	0.166	753,00+163,34	0.615
	Red lesion	14	634,07+157,32		720,57+209,11
Occupational sunlight exposure^* * The variables have missing data;	Yes	24	663,88+142,09	0.372	702,58+202,60	0.524
	No	11	712,36+159,97		746,64+149,09

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E-mail: revista@sbd.org.br

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[1] Mailing address: Dmitry José de Santana Sarmento, Avenida Coronel Pedro Targino, s/n, Centro, 58233-000 - Araruna - PB, Brazil. E-mail: dmitry_sarmento@hotmail.com

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Link between immunoexpression of hMLH1 and hMSH2 proteins and clinical-epidemiological aspects of actinic cheilitis* * Work performed at the Universidade Estadual da Paraíba (UEPB) e Universidade Federal do Rio Grande do Norte (UFRN) - Natal (RN), Brazil.

Abstract:

Background:

Objective:

Methods:

Results:

Conclusion:

Link between immunoexpression of hMLH1 and hMSH2 proteins and clinical-epidemiological aspects of actinic cheilitis^* * Work performed at the Universidade Estadual da Paraíba (UEPB) e Universidade Federal do Rio Grande do Norte (UFRN) - Natal (RN), Brazil.