Laser therapy in wound healing associated with diabetes mellitus - Review

Sousa, Raquel Gomes de; Batista, Keila de Nazaré Madureira

doi:10.1590/abd1806-4841.20163778

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Review • An. Bras. Dermatol. 91 (4) • Jul-Aug 2016 • https://doi.org/10.1590/abd1806-4841.20163778 copy

Laser therapy in wound healing associated with diabetes mellitus - Review^* * Study performed at Department of Physiotherapy and Occupational Therapy, Universidade Federal do Pará (UFPA) - Belém (PA), Brazil.

Authorship SCIMAGO INSTITUTIONS RANKINGS

Abstract:

The article discusses the results of a literature review on the application of low intensity laser therapy on the healing of wounds associated diabetes mellitus in the last 10 years.

Objective:

To determine the most effective parameter in healing wounds related to diabetes mellitus, as well as the most widely used type of laser.

Methodology:

consisted of bibliographic searching the databases Bireme, SciELO, PubMed/Medline and Lilacs by using the keywords related to the topic. Were selected from these keywords, papers discussing the use of laser on wounds associated with diabetes, published in the period 2005-2014, in Portuguese or English.

Results:

After analyzing the research, 12 studies consistent with the theme were selected.

Conclusion:

Based on this review, the studies that showed more satisfactory results in healing diabetic wounds were those who applied energy densities in the range of 3-5 J/cm2, power densities equal to or below 0.2 W/cm2 and continuous emission. The He-Ne laser with a wavelength of 632.8 nm was used more often.

Keywords:
Diabetic foot; Foot ulcer; Laser therapy, low-level; Wound healing

Study	Author(s)/ Year	Sample	Diabetic group treated	Type of laser	Power densitiy	Energy density	Application time	Emission form	Wavelenght	Beam
1	Maiya et al., 2005¹⁵15 Maiya GA, Kumar P, Rao L. Effect of Low Intensity Helium-Neon (He-Ne) Laser Irradiation on DiabeticWound Healing Dynamics. Photomed Laser Surg. 2005;23:187-90.	Total sample: 48 male	N=24	He-Ne	______*	4.8 J/cm²	______*	Continuous	632.8 nm	Visible
1		Wistar mice
2	Carvalho et al., 2006¹⁶16 Carvalho PT, Mazzer N, dos Reis FA, Belchior AC, Silva IS. Analysis of the influence of low-power HeNe laser on the healing of skin wounds in diabetic and non-diabetic rats. Acta Cir Bras. 2006;21:177-83.	Total sample: 48 male	N=12	He-Ne	0.2 W/cm²	4 J/cm²	60s	Continuous	632.8 nm	Visible
2		Wistar mice
3	Houreld, Abrahamse, 2007¹⁷17 Houreld N, Abrahamse H. Irradiation with a 632.8 nm Helium-Neon Laser with 5 J/cm2 Stimulates Proliferation and Expression of Interleukin-6 in Diabetic Wounded Fibroblast Cells. Diabetes Technol Ther. 2007;9:451-9.	Sample: Cell culture of human skin fibroblasts	______*	He-Ne	2.206 mW/ cm²	5 J/cm²	37min	Continuous	632.8 nm	Visible
		Sample: Cell culture of human skin fibroblasts				16 J/cm²	2h
		Diabetic cells
4	Gungormus¸Akyol, 2009¹⁹19 Güngörmüs M, Akyol UK. Effect of Biostimulation on Wound Healing in Diabetic Rats. Photomed Laser Surg. 2009;27:607-10.	Total sample: 36 female	N=18	GaAlAs	0.1W/cm²	10 J/cm²	______*	Continuous	808nm	Invisible
4		Wistar mice
5	Maiya et al., 2009¹⁴14 Maiya AG, Kumar P, Nayak S. Photo-stimulatoryeffectoflowenergyhelium-neon laser irradiation on excisional diabetic wound healing dynamics in wistar rats. Indian J Dermatol. 2009;54:323-9.	Total sample: 192 male	N=168	He-Ne	0.01 W/cm²	3-9 J/cm²	3 -27 min	Continuous	632.8 nm	Visible
5		Wistar mice
6	Carvalho et al., 2010⁸8 Carvalho Pde T, Silva IS, Reis FA, Perreira DM, Aydos RD. Influence of ingaalp laser (660nm) on the healing of skin wounds in diabetic rats. Acta Cir Bras. 2010;25:71-9.	Total sample: 30 male	N=15	GaAlAs	______*	10 J/ cm²	24 s	Continuous	660 nm	Visible
6		Wistar mice
7	Noudeh et al., 2010²⁴24 JahangiriNoudeh Y, Shabani M, Vatankhah N, Hashemian SJ, Akbari K. A Combination of 670nm and 810nm Diode Lasers for Wound Healing Acceleration in Diabetic Rats. Photomed Laser Surg. 2010;28:621-7.	Total sample: 19 male	N=5	AlGaInP	______*	10 J/cm²	48 s	Continuous	670nm	Visible
7		Wistar mice		GaAlAs		1.33 J/cm²	50 s		810nm	Invisible
8	Hegde et al., 2011¹⁸18 Hegde VN, Prabhu V, Rao SB, Chandra S, Kumar P, Satyamoorthy K, et al. Effect of laser dose and treatment dchedule on excision wound healing in diabetic mice. Photo chemPhotobiol. 2011;87:1433-41.	Total sample: 105 male	N=35	He-Ne	4.02 mW/cm²	1-5 J/cm²	4-21 min	Continuous	632.8 nm	Visible
8		Swiss mice
9	Ayuk et al., 2012²²22 Ayuk SM, Houreld NN, Abrahamse H. Collagen Production in Diabetic Wounded Fibroblasts in Response to Low-Intensity Laser Irradiation at 660nm. Diabetes Technol Ther. 2012;14:1110-7.	Sample: Cell culture of human skin fibroblasts	______*	______*	10.22 mW/cm²	5 J/ cm²	8 min 9 s	Continuous	660nm	Visible
10	Rocha et al., 2012²¹21 Rocha CLJV, Rocha Júnior AM, Aarestrup BJV, Aarestrup FM. Inibição da expressão de ciclooxigenase 2 em feridas cutâneas de camundongos NOD submetidos à terapia a laser de baixa intensidade. J Vasc Bras. 2012;11:175-181.	Total sample: 30 non-obese diabetic mice (NOD)	N=7	GaAs	15mW/cm²	3.8 J/ cm²	20 s	Pulsed	780 nm	Invisible
11	Khoo et al., 2014²³23 Khoo NK, Shokrgozar MA, Kashani IR, Amanzadeh A, Mostafavi E, Sanati H, et al. In vitro Therapeutic Effects of Low Level Laser at mRNA Level on the Release of Skin Growth Factors from Fibroblasts in Diabetic Mice. Avicenna J Med Biotechnol. 2014;6:113-8.	Total sample: 14. Cell culture of the skin of diabetic and non-diabetic mice	N=7	GaAlAs	10 mW/cm²	1 J/ cm²	1 min and 40 s	Continuous	810 nm	Invisible
12	Kilík et al., 2014²⁰20 Kilík R, Lakyová L, Sabo J, Kruzliak P, Lacjaková K, Vasilenko T, et al. Effect of Equal Daily Doses Achieved by Different Power Densities of Low Level Laser Therapy at 635nm on Open Skin Wound Healing in Normal and Diabetic Rats. Biomed Res Int. 2014;2014:269253.	Total sample: 48 male mice	N=24	GaAlAs	1 mW/ cm²	5 J/cm²	83 min 20 s	Continuous	635 nm	Visible
					5mW/ cm²		16 min 40 s
					15mW/ cm²		5 min 33 s

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E-mail: revista@sbd.org.br

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[1] Mailing address: Raquel Gomes de Sousa, Augusto Corrêa St., 01 - Portão 4, Cidade Universitária José Silveira Neto, Faculdade de fisioterapia e terapia ocupacional, Setor Saúde, 66075-110 Guamá, PA. Email: raquelgomes.rg@gmail.com

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Laser therapy in wound healing associated with diabetes mellitus - Review* * Study performed at Department of Physiotherapy and Occupational Therapy, Universidade Federal do Pará (UFPA) - Belém (PA), Brazil.

Abstract:

Objective:

Methodology:

Results:

Conclusion:

Laser therapy in wound healing associated with diabetes mellitus - Review^* * Study performed at Department of Physiotherapy and Occupational Therapy, Universidade Federal do Pará (UFPA) - Belém (PA), Brazil.