The association of fractional CO2 laser 10.600nm and photodynamic therapy in the treatment of onychomycosis* * Study carried out at the Faculdade de Medicina Estadual de São José do Rio Preto (FAMERP) - São José do Rio Preto (SP), Brazil.

Guilherme Bueno de Oliveira João Roberto Antonio Carlos Roberto Antonio Fernanda Alves Tomé About the authors



Onychomycosis is a fungal infection of the nails caused in most cases by dermatophytes Trichophyton rubrum and Trichophyton mentagrophytes. Despite numerous available antifungal drugs for therapy of this infection, the cure rate is low, with high rates of relapse after treatment and side effects.


To present a new option for the treatment of onychomycosis, in search of a more effective and rapid method than conventional ones.


Patients underwent two sessions of CO2 fractional laser 10.600nm associated with photodynamic therapy. Mycological and digital photography were performed before and after the treatment.


McNemar test with continuity correction and degrees of freedom = 1: for clinical cure rate, 13.06, with p=0.00005; for mycological cure, 17.05, with p=0.00005; 72% felt fully satisfied with the procedure.


The use of fractional CO2 laser 10.600nm associated with photodynamic therapy can be effective in the treatment of onychomycosis, decreasing the risk of systemic lesions that may be triggered with prolonged use of oral antifungals.

Nail diseases; Nails; Onychomycosis

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