Exuberant tufted folliculitis^*

Dear editor,

A 40-year-old African-American man reported a 5-year history of pustules and crusts on the scalp. Physical examination revealed extensive atrophic patches of cicatricial alopecia and polytrichia (Figure 1). Dermatoscopy of a single tuft showed more than 30 hairs emerging from one follicular orifice (Figure 2). Dermatoscopic imaging of a tuft removed via punch reveals the hairs retained within the involved follicular units (Figure 3). Histopathological examination showed polytrichia, peri- and intrafollicular infiltrate with neutrophils, lymphocytes, and histiocytes, which were most intense in the upper half of the dermis. Therefore, we reached the diagnosis of folliculitis decalvans.

Figure 1
Extensive areas of cicatricial alopecia with polytrichia

Figure 2
Dermoscopy shows multiple hairs emerging from the same follicular orifice

Figure 3
Dermatoscopic image of a tuft showing retained hairs within the involved follicular units

There is a controversy concerning whether tufted folliculitis (TF) is a specific disease, a subset of folliculitis decalvans, or a common manifestation of different causes of alopecia. The term was first used by Smith in 1978 to describe a case of a patient with cicatricial alopecia who presented with hair tufts associated with intense inflammatory signs and follicular pustules. Culture from scalp biopsy revealed growth of S. aureus.¹ In this first article, the author already pointed out many similarities between that case and the one described by Brocq in 1888 as folliculitis decalvans.

TF is caused by clustering of adjacent follicular units due to a fibrosing process that happens when the infundibular epithelia of damaged follicles heal leading to the formation of a common infundibulum. Telogen hairs can not detach and stay retained within the involved follicular units.² Several diseases have been described as cause of TF: folliculitis decalvans, central centrifugal cicatricial alopecia (CCCA), pemphigus vulgaris, folliculitis keloidalis, dissecting cellulitis, lichen planopilaris, discoid lupus, and tinea capitis.³ TF has already been described in a patient treated with cyclosporine and in two women having chemotherapy to treat breast cancer, one using lapatinib and the other, trastuzumab.

One cause of confusion is that most authors use the terms TF and polytrichia as synonyms.³ Polytrichia is defined as multiple (5 or more) hairs emerging from the same follicular opening. By defining TF only according to this pattern, it is easy to understand it just as a final stage of different diseases. Under this perspective, the use of the two terms for the same condition is a cause for confusion. The term TF could be abolished from the medical vocabulary in favor of polytrichia, which is semantically more appropriate.

However, the authors who see TF as a specific diagnosis understand that the term could not be used for all the patients with polytrichia, but should be reserved just for those cases of inflamed hair scalp with pustules that grow S. aureus (as in Smith’s original description). As such, TF would be a subset of folliculitis decalvans.⁴

Despite this controversy, TF is frequently observed in patients with folliculitis decalvans. In a retrospective multicenter review study with 82 patients with folliculitis decalvans, 88% of them presented with TF.⁵ Huge tufts with more than 10 hairs are characteristic of this condition.

• *
  Work conducted at the Department of Dermatology, Faculdade de Medicina, Universidade Estadual Paulista, Botucatu (SP), Brazil.
• Financial support: None.

REFERENCES

• ¹
  Smith NP. Tufted folliculitis of the scalp. J R Soc Med. 1978;71:606-8.
• ²
  Annessi G. Tufted folliculitis of the scalp: a distinctive clinicohistological variant of folliculitis decalvans. Br J Dermatol. 1998;138:799-805.
• ³
  Sperling LC, Cowper S, Knopp EA. An Atlas of Hair Pathology with Clinical Correlations. 2nd ed. Boca Raton: CRC Press; 2012.
• ⁴
  Powell J, Dawber RP. Folliculitis decalvans and tufted folliculitis are specific infective diseases that may lead to scarring, but are not a subset of central centrifugal scarring alopecia. Arch Dermatol. 2001;137:373-4.
• ⁵
  Vañó-Galván S, Molina-Ruiz AM, Fernández-Crehuet P, Rodrigues-Barata AR, Arias-Santiago S, Serrano-Falcón C, et al. Folliculitis decalvans: a multicentre review of 82 patients. J Eur Acad Dermatol Venereol 2015; 29:1750-7.

Publication Dates

• Publication in this collection
  Jan-Feb 2019

History

• Received
  10 Dec 2017
• Accepted
  12 Apr 2018