We report the case of a 47-year-old male patient with S100 negative granular cell tumor of the oral cavity, focusing on dermoscopic features as well as surgical approach, not previously reported in the literature. The study contributes to the literature on dermoscopy and surgical treatment for this tumor and provides a practical approach to differentiating non-neural granular cell tumors and granular cell tumors.
Keywords:
Dermoscopy; Granular cell tumor; Surgery, oral
| Characteristic | GCT | NN-GCT |
|---|---|---|
| Clinical examination | ||
| Location | Head and Neck | Entire body |
| Oral cavity | Common | Uncommon |
| Number | Solitary | Solitary |
| Histology | ||
| Architecture | Polypoid | Polypoid |
| Level of involvement | Dermis, adipose tissue, muscle | Papillary dermis |
| Pseudoepitheliomatous hyperplasia | +++ | + |
| Delimitation | +/- | + |
| Cytologic atypia | +/- | +/++ |
| Mitotic activity | - | ++ |
| Pustulo-ovoid bodies of Milian | + | ? |
| IHC reactivity | ||
| S-100 | + | - |
| Vimentin | + | + |
| CD68 | - (71%) | + |
| Calretinin | + | -* * however positive in the present case |
