Scalp cooling to prevent chemotherapy-induced alopecia<sup>,</sup>

Silva, Giselle de Barros; Ciccolini, Kathryn; Donati, Aline; Hurk, Corina van den

doi:10.1016/j.abd.2020.03.005

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Sumário

Review • An. Bras. Dermatol. 95 (5) • Sep-Oct 2020 • https://doi.org/10.1016/j.abd.2020.03.005 linkcopy

Scalp cooling to prevent chemotherapy-induced alopecia^☆^,^☆☆

Authorship SCIMAGO INSTITUTIONS RANKINGS

Chemotherapy-induced alopecia causes an important impact on cancer patients and its risk of persistence is currently a considerable issue in cancer survivors. Of the various interventions proposed for the prevention of chemotherapy-induced alopecia, scalp cooling has emerged as an effective and safe strategy. This paper aims to provide an overview on scalp cooling and chemotherapy-induced alopecia prevention.

KEYWORDS
Alopecia; Antineoplastic combined chemotherapy protocols; Cooling; Drug therapy; Prevention and mitigation

Studied in animal models	Studied in human trials: not effective	Studied in human trials: effective
Anti-doxorubicin²⁹	Topical minoxidil²³	AS101a³⁰
Topical epinephrine and norepinephrine³¹	Parathyroid hormone receptor (PPR) ligands³²	Scalp cooling⁹^,³³^,³⁴
Topical n-acetyl cysteine³⁵	Scalp tourniquet³⁶
Topical antioxidants (resveratrol, aminothiol)³¹	Topical calcitriol³⁷
Topical cyclosporine A³⁸	DHL-HisZnNA³⁹
Immunomodulators (Il-1,⁴⁰ imuvert⁴¹)
Acid FGF, EGF⁴⁰
CDK2 inhibitors⁴²
Caspase-3 inhibitors⁴³
Multi-target iron chelator M30⁴⁴

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[TFN1] ^a
More evidence needed.

Scalp cooling to prevent chemotherapy-induced alopecia☆,☆☆

Scalp cooling to prevent chemotherapy-induced alopecia^☆^,^☆☆