Logomarca do periódico: Anais Brasileiros de Dermatologia

Open-access Anais Brasileiros de Dermatologia

Publication of: Sociedade Brasileira de Dermatologia
Area: Health Sciences ISSN printed version: 0365-0596
ISSN online version: 1806-4841
Previous title Anais Brasileiros De Dermatologia E Sifilografia

Table of contents

Anais Brasileiros de Dermatologia, Volume: 99, Issue: 6, Published: 2024

Anais Brasileiros de Dermatologia, Volume: 99, Issue: 6, Published: 2024

Document list
Editorial
Anais Brasileiros de Dermatologia - Impact Factor and CiteScore for 2023 Marques, Silvio Alencar Roselino, Ana Maria Ferreira Almeida Jr, Hiram Larangeira de Abbade, Luciana Patrícia Fernandes
Continuing Medical Education
Differential diagnosis of pigmented nail lesions Bertanha, Laura Noriega, Leandro Fonseca Chiacchio, Nilton Gióia Di Matter, Adriana Chiacchio, Nilton Di

Abstract in English:

Abstract The diagnosis of pigmented nail lesions is a concern for both general practitioners and dermatologists, due to the possibility of indicating nail melanoma. The origin of the dark pigmentation can be either melanocytic or non-melanocytic (fungi, bacteria, or blood), and clinical evaluation alone may not be sufficient for differentiation, requiring additional exams. Onychoscopy provides valuable information prior to biopsy. The causes of nail pigmentation will be described to aid in the differential diagnosis.
Original Article
Analysis of clinical characteristics and factors affecting treatment responses in patients with pyoderma gangrenosum: a multicenter study of 239 patients Erduran, Funda Adışen, Esra Hayran, Yıldız Aksoy, Güneş Gür Alpsoy, Erkan Selçuk, Leyla Baykal Günaydın, Sibel Doğan Yazıcı, Ayça Cordan Öktem, Ayşe Güngör, Malik Afacan, Elif Kuşçu, Deniz Devrim Elmas, Leyla Aydoğan, Kübra Bayramgürler, Dilek Demirsoy, Evren Odyakmaz Akyol, Melih Güner, Rukiye Yasak Erdoğan, Hilal Kaya Acer, Ersoy Ergun, Tulin Yaylı, Savaş Bulut, Ferhan Saraç, Esra Aktaş, Akın

Abstract in English:

Abstract Background Pyoderma Gangrenosum (PG) is a chronic disease characterized by recalcitrant skin ulcers. Objective We aimed to evaluate the demographic, clinical characteristics, treatments and factors affecting the treatment responses of patients with PG. Methods We performed a multicenter study of 12 tertiary care centers. We analyzed the data of the patients who were followed up with a diagnosis of PG between the years 2012‒2022 retrospectively. Results We included a total of 239 patients of whom 143 were female and 96 were male, with an average age of 54.2 ± 17.4 years. The most common treatment was systemic steroids (n = 181, 75.7%). Among these patients, 50.8% (n = 92) used systemic steroids as the sole systemic agent, while 49.2% (n = 89) used at least one adjuvant immunosuppressive agent. The independent factors determined in regression analysis to influence response to systemic steroids positively were disease onset age ≥ 30-years, negative pathergy, absence of leukocytosis, negative wound culture, presence of a single lesion, and absence of upper extremity involvement. Biological agents were used in 18.4% (n = 44) of the patients in the present study. We also analyzed pathergy positive PG and early onset (onset age < 30) PG separately due to their distinct clinical features which were revealed during statistical analysis. Study limitations Retrospective nature of the present study. Conclusions Analyses of the factors influencing treatment responses are addressed in this study. Also, we concluded that investigation for accompanying autoinflammatory diseases of pathergy positive PG and early onset PG is necessary and the patients in these two groups are more resistant to treatment, necessitating more complicated treatments.
Original Article
Association of psoriasis with geographic and fissured tongue in the Han population in southwestern China Hu, Yuting Li, Ying Yan, Wei Zhou, Yu

Abstract in English:

Abstract Background Psoriasis is a common immune-mediated skin disease that can involve other organs and tissues, including the oral mucosa. Some studies have found an increased proportion of geographic tongue (GT) and fissured tongue (FT) in patients with psoriasis, which appears to be region-specific. Objectives The association of psoriasis with GT/FT in Eastern Asian populations remains unknown. Thus, the authors aimed to investigate the association of psoriasis with GT/FT in the Han population in southwestern China. Methods This study was conducted on 230 psoriatics and 230 healthy controls at West China Hospital. The authors compared the proportion of subjects with GT/FT in the two groups and compared age, gender, smoking, alcohol consumption, age at onset of psoriasis, duration of psoriasis, nail and joint involvement, Psoriasis Area and Severity Index, Body Surface Area, Dermatology Life Quality Index, and proportion using biologics in psoriatics with or without GT /FT. Results The authors have found a strong association between psoriasis and FT (p < 0.001), and a non-significant association between psoriasis and GT (p = 0.760). Compared to psoriasis patients without FT, the authors found that psoriasis patients with FT were older (p = 0.021) and had an increased frequency of late-onset psoriasis (p = 0.014); they also had more severe psoriasis (p = 0.047) and poorer quality of life (p = 0.045). Study limitations GT has periods of exacerbation and remission, so the authors cannot avoid a deviation of the prevalence of GT in this study from the true prevalence rate. Also, biologics have been found to lead to remission of GT and FT, which may have influenced the GT/FT ratio in the case group in this study. Conclusions Psoriasis was associated with FT in the Han population in southwestern China, attention must be paid to the treatment of psoriatics with FT and skin diseases in patients with FT.
Original Article
Dermoscopic monitoring of pediatric melanocytic nevi regarding pattern and diameter changes Erdil, Dilara İlhan Aksu, Ayşe Esra Koku Erdemir, Vefa Aslı Turgut Erdil, Duygu Leblebici, Cem Polat, Asude Kara

Abstract in English:

Abstract Background Childhood and adolescence are dynamic period in terms of nevogenesis, and the development and growth of new melanocytic nevus are frequently observed. In this study, the aim was to examine the pattern and diameter changes seen in the follow-up of pediatric melanocytic nevus. Objectives To describe the pattern and diameter changes seen in the follow-up of pediatric melanocytic. Methods Our study involved the assessment of 301 pediatric melanocytic nevi in 50 patients attended at the Dermatology Clinic of Istanbul Training and Research Hospital between January 2008 and 2022. The pediatric melanocytic nevi were diagnosed clinically and dermoscopically. Subsequently, we conducted video-dermoscopic monitoring of these nevi over a span of 3 months to 3 years. Results 46% of our patients were female (n = 23), with a mean age of 11.5 years. While the pattern of nevi was globular in 40% patients, the rate of globular pattern decreased to 30% in the follow-up. The basal homogeneous nevus pattern was seen in 10% patients, but was detected in 13.9% in the follow-up. Peripheral globules were observed in 19.3% of the cases, but in the follow-up, 61.1% of the globules regressed completely. Nevus excision was indicated in only 11 of 301 nevi. Study limitations Single-center study and a small of studies available on this subject. Conclusions Pediatric melanocytic nevi can show dynamic changes compared to nevi in adults. In this study, growth rates, dermoscopic features, and pattern changes seen in the follow-up of melanocytic nevi were evaluated. The globular pattern was observed most frequently. The presence of peripheral globules is frequently observed in pediatric melanocytic nevi with regression during the follow-up period.
Original Article
Efficacy and safety of secukinumab in psoriasis: five-year real life experience Acer, Ersoy Erdoğan, Hilal Kaya Ağaoğlu, Esra Baştürk, Hatice Bilgin, Muzaffer Saraçoğlu, Zeynep Nurhan

Abstract in English:

Abstract Background The efficacy and safety of secukinumab in psoriasis patients has been demonstrated in randomized controlled clinical trials. Objectives The authors aimed to evaluate the efficacy and safety of secukinumab in plaque psoriasis patients followed in our clinic. Methods Data from 101 plaque psoriasis patients who received at least 16 weeks of secukinumab treatment between June 2018 and June 2023 were retrospectively analyzed. Results Fifty-three (53%) of the patients were bionaive. PASI-75, -90, -100 response rates were 72%, 50%, 30% respectively at week 16 in all patients. PASI-75 and -90 responses were higher in naive patients at weeks 16 and 28 (p < 0.001, p < 0.001, p < 0.01, p = 0.01, respectively). The percentage of patients with PASI ≤ 1, ≤ 3, ≤ 5 were 50%, 77%, and 92%, respectively at week 16. They were higher in the naive group than in nonnaive group at weeks 16 and 28 (p = 0.02, p < 0.01, p = 0.05, p = 0.07, p < 0.01, p = 0.03, respectively). At week 52, PASI-75, -90, -100 responses were significantly lower in smoking patients (p = 0.04, p = 0.03, p < 0.01, respectively). The mean duration of secukinumab treatment was 19.80 ± 12.76 months. Secukinumab was discontinued 14 (26.4%) naive patients and 28 (58.3%) nonnaive patients at one occasion during treatment (p < 0.001). The most common adverse event in patients was mucocutaneous candida infection (8%). No hepatitis B or C reactivation and no active or reactivation tuberculosis were observed in any of the patients during the follow-up period. Study limitations This is a single-center retrospective study with relatively few patients including only the Turkish population. Conclusion Secukinumab seems to be effective in plaque psoriasis, particularly in bionaive and non-smokers. Moreover, it is safe in patients with inactive hepatitis or tuberculosis.
Original Article
Is autologous platelet-rich plasma capable of increasing hair density in patients with androgenic alopecia? A systematic review and meta-analysis of randomized clinical trials Kieling, Lucas Konzen, Ana Terezinha Zanella, Rafaela Koehler Valente, Denis Souto

Abstract in English:

Abstract Fundamentals Platelet-rich plasma (PRP) has been progressively more used in androgenetic alopecia (AGA). Objectives The authors aimed to evaluate PRP efficacy compared to placebo in AGA. Methods A comprehensive search was conducted across seven databases, until 01/04/2023. Randomized clinical trials focusing on AGA and PRP use to increase hair density were included. Patients aged between 15 and 63 years, diagnosed with AGA characterized by Norwood I‒VII and Ludwig I‒III scales, were included. Studies with a sample size <10, lacking PRP processing method, focusing on complementary therapies or other alopecias, were excluded. The authors conducted subgroup analysis for activator, spin method, study design, risk of bias, and gender. Meta-regression was conducted for activator, spin method, design, and gender. The authors used GRADEpro to assess evidence certainty and the RoB-2 tool for risk of bias. Asymmetry was measured through a Funnel plot followed by Egger’s test. The protocol was registered at PROSPERO (CRD42023407334). Results The authors screened 555 registers and included fourteen studies involving 431 patients for qualitative synthesis, with 13 studies included in the meta-analysis. Meta-analysis demonstrated a mean difference of 27.55 hairs/cm2 and 95% CI (14.04; 41.06), I2= 95.99%, p < 0.05. Hair diameter meta-analysis presented a mean difference of 2.02 μm, 95% CI (−0.85 μm; 4.88 μm), and I2= 77.11% (p = 0.02). That is, low quality evidence. Study limitations Studies were highly heterogeneous, of low quality, and presented evident publication bias. Conclusions Highly heterogeneous studies with publication bias suggest PRP effectively increases hair density in AGA, so further high-quality randomized clinical trials are recommended to strengthen the evidence.
Original Article
Piedraia hortae: biofilm formation and its importance in the pathogenesis of Piedra nigra (black piedra) Almeida Junior, Hiram Larangeira de Assis, Thales Moura de Faria, Eduardo Camargo Costa, Luiz Roberto Kramer Ibaldo, Berenice Marques

Abstract in English:

Abstract Background Little is known about the ultrastructure of Piedraia hortae. Objective To examine a P. hortae colony with scanning electron microscopy and investigate possible contributions to its the pathogenesis of black piedra. Results On low magnifications, two distinct aspects of the colony are identified, a compact area and a filamentous area. Analysis of the filamentous area demonstrates hyphae adhered by a thin reticular substance. A recurring finding is the adhesion between the fungal filaments in parallel. On high magnifications, the microfibrillar substance adhering the hyphae to each other becomes very evident. Examination of the compact area shows the hyphae embedded in the reticular matrix forming a biofilm and the colony well adhered. On high magnification, it can be observed that the hyphae are within this fibrillar matrix, which has the same appearance as the filamentous substance that adheres the hyphae to each other. Study limitations Only one strain was examined. Conclusions The formation of biofilm with fungal structures and reticulated extracellular substance is important in the pathogenesis of black piedra.
Original Article
Two years of innovative dermatological care: the first public health consultation service for the transgender and gender diverse community in Argentina Wilder, Lola Kuperman Orsi, Valeria Chebi, Gonzalo Balague, Maria Agustina Campana, Luciana Cabral

Abstract in English:

Abstract Background The LGBTQI + community encounters distinct healthcare challenges due to discrimination and inadequate understanding of their needs. Dermatologists play a crucial role in addressing this by fostering inclusiveness, recognizing individual concerns, and adopting tailored approaches, thereby promoting a more equitable healthcare system. Objective To address the need for an inclusive healthcare space, the authors established the first dermatological practice exclusively for transgender and non-binary patients. This article presents a comprehensive two-year experience in a public hospital. Methods The authors conducted a retrospective and descriptive study, analyzing the medical records of 114 patients evaluated at a specialized dermatological practice between June 2021 and May 2023. Key variables assessed included self-identified gender, age, residence, access to private healthcare, human immunodeficiency virus status, hormonal treatment, surgical interventions, consultation motives, employment stability, and family support during gender expression transition. Results The present study included 114 patients, 49.1% trans men, 39.5% trans women, and 8.8% non-binary individuals. Trans men, on average younger than trans women (p < 0.001), predominantly sought care for body modification-related concerns, particularly acne and androgenetic alopecia. In contrast, trans women exhibited a more diverse range of consultation motives typically unrelated to hormonal or surgical procedures. Study limitations This study is retrospective and limited in geographic scope. Additionally, the patient population lacked diversity in terms of Black ethnicity. Conclusions The pioneering dermatological practice for transgender and non-binary patients exemplifies healthcare equity and cultural competence. Effective LGBTQI + healthcare requires addressing unique dermatological concerns while fostering inclusiveness and continuous learning within the medical community.
Review
Extra-follicular cutaneous manifestations of frontal fibrosing alopecia Donati, Aline Wu, Isabelle I. Hue

Abstract in English:

Abstract Frontal fibrosing alopecia (FFA) is an inflammatory cicatricial alopecia, which is considered to be a variant of lichen planopilaris. In addition to follicular changes, FFA often presents with associated cutaneous manifestations in most patients, including lichen planus pigmentosus, implantation line hypochromia and facial papules. The objective of the present article is to provide a detailed overview of the non-follicular cutaneous clinical manifestations of FFA and discuss their impact on the diagnosis and treatment of patients with this condition.
Review
The role of excimer light in dermatology: a review Schatloff, Dan Hartmann Altbir, Catalina Retamal Valenzuela, Fernando

Abstract in English:

Abstract Excimer light is a subtype of NB-UVB that emits a 308 nm wavelength, and can provide targeted phototherapy treatment. The absorption of 308 nm light by skin cells leads to therapeutic response in various common and ultraviolet-responsive skin diseases, such as psoriasis and vitiligo, and photo-resistant skin diseases such as prurigo nodularis, localized scleroderma, genital lichen sclerosis, and granuloma annulare, cutaneous T-cell lymphomas, among others. Excimer light has few adverse reactions and overall is well tolerated by patients, furthermore, it can be performed in places that are difficult to access. This article aims to explain the therapeutic bases and applications of excimer light in current dermatology.
Review
Update on the pathogenesis of atopic dermatitis Criado, Paulo Ricardo Miot, Hélio Amante Bueno-Filho, Roberto Ianhez, Mayra Criado, Roberta Fachini Jardim Castro, Caio César Silva de

Abstract in English:

Abstract Atopic dermatitis is a chronic, recurrent, and multifactorial skin-mucosal manifestation resulting from the interaction between elements mainly associated with the skin barrier deficit, the homeostasis of the immune response, neurological aspects, and patterns of reactivity to environmental antigens, which are established in genetically predisposed individuals. In addition to the skin, atopic diathesis involves other organs such as the airways (upper and lower), eyes, digestive tract, and neuropsychiatric aspects, which inflict additional morbidity on the dermatological patient. The different phenotypes of the disease fundamentally depend on the participation of each of these factors, in different life circumstances, such as age groups, occupational exposure patterns, physical activity, pollution, genetic load, and climatic factors. A better understanding of the complexity of its pathogenesis allows not only the understanding of therapeutic targets but also how to identify preponderant elements that mediate disease activity in each circumstance, for selecting the best treatment strategies and mitigation of triggering factors. This narrative review presents an update on the pathogenesis of atopic dermatitis, especially aimed at understanding the clinical manifestations, the main disease phenotypes and the context of available therapeutic strategies.
Letter - Research
Evaluation of the efficacy and safety of hydrogen peroxide in the treatment of molluscum contagiosum in children compared to potassium hydroxide: a pilot study Inoue, Elinah Narumi Saboia, Felipe de Paula Hertz, Amanda Olandoski, Marcia Arida, Dâmia Kuster Kaminski
Letter - Research
Factors associated with facial melasma severity in Brazilian women: an internet-based survey Abreu, Ana Flávia Teixeira de Dias, Marina Oliveira Barbosa, Mayla Martins Conti Amorim, Rebecca Perez de Miot, Hélio Amante Espósito, Ana Cláudia Cavalcante
Letter - Research
Guselkumab, Risankizumab, and Tildrakizumab demonstrate parallel effectiveness and safety in psoriasis treatment: a head-to-head comparative study in real clinical practice Mansilla-Polo, Miguel Sahuquillo-Torralba, Antonio Pujol-Marco, Conrad Bargues-Navarro, Guillermo Botella-Estrada, Rafael
Letter - Research
Lack of efficacy of oral N-acetylcysteine ​​in the treatment of facial melasma in women: a randomized, double-blind, placebo-controlled clinical trial Alfredo, Melissa de Almeida Corrêa Holanda, Ingrid Rocha Meireles Cassiano, Daniel Pinho Espósito, Ana Cláudia Cavalcante Lima, Paula Basso Miot, Hélio Amante
Letter - Research
Melanocytic nevi and melanomas of the oral mucosa: detailed description of a case series Costa, Izadora Fernanda Veiga de Jesus Vilela, Deyla Duarte Carneiro Pires, Bruno Cunha Farias, Jener Gonçalves de Freitas, Valéria Souza Santos, Jean Nunes dos
Letter - Research
Squamoid eccrine ductal carcinoma: series of five cases of a rare tumor Honorato, Cecília Mirelle Almeida Carrascoza, Giovanna Gelli Abed, Nubia Marrer Moya, Fernanda Gonçalves
Letter - Research
Translation, cultural adaptation, and validation of the Family Dermatology Life Quality Index instrument into the Brazilian Portuguese language (FDLQI-BRA) Souza, Maria Laura Malzoni Miot, Hélio Amante Martinez, José Eduardo
Letter - Research
Treatment of capillary and venous cutaneous vascular malformations using long pulse 1,064-nm neodymium:yttrium-aluminum-garnet laser and intense pulsed light Gomes, Ludmilla Cardoso Careta, Mariana Figueiroa Wu, Isabelle I. Hue Loureiro, Vivian Barzi Torezan, Luís Antonio Ribeiro
Letter - Research
Trends on detecting malignant skin neoplasms during the National Campaigns of Skin Cancer Prevention (2000‒2023) Grana, Aline Guimarães Gonçalves, Heitor de Sá Barcaui, Carlos Baptista Talhari, Carolina Miot, Hélio Amante
Letter - Clinical
A case of eosinophilic annular erythema as a presenting sign for primary biliary cholangitis Sanz, Pablo López Rivera, Noelia de Sande Ramírez, Claudia Guerrero Córdoba, Silvia Manso Guardiola, Carlota Rodríguez de Vera Travesedo, Eduardo Escario
Letter - Clinical
A case of psoriasiform eruption developed during imatinib therapy Watanabe, Yukina Hiraiwa, Tomoko Ohtsuka, Mikio Yamamoto, Toshiyuki
Letter - Clinical
Acquired ichthyosis as a messenger to gastric diffuse large B-cell lymphoma Yavaşoğlu, İrfan Turgutkaya, Atakan Tataroğlu, Canten Bolaman, Ali Zahit
Letter - Clinical
Confocal reflectance microscopy in basal cell carcinoma associated with nevus sebaceous: case report Ferraz, Ingrid Priscila Ribeiro Paes Carvalho, Gustavo Braga, Juliana Casagrande Tavoloni Paula, Rafaela Brito de Molina, André
Letter - Clinical
Diagnosis of glomus tumor and preoperative mapping with ultrasonography Martini, Athos Paulo Santos Rosa, Ariel Córdova Rigatti, Marcelo Funchal, Gabriella Di Giunta Torres, Matheus Hariel Colin Pacheco, Matheus Alves
Letter - Clinical
Hay-Wells syndrome: the challenges of a nine-year follow-up Amorim, Rebecca Perez de Nakata, Maria Vitória Yuka Messias Gonçalves, Vitória Gabrielle De Paula Castro, Ivanka Miranda de Haddad, Gabriela Roncada Abbade, Luciana Patrícia Fernandes
Letter - Clinical
Mimicking urticaria: a Schnitzler syndrome case Cruz, Kelielson Cardoso de Macêdo Martinez, Daniela de Abreu e Silva Quintella, Danielle Carvalho Cuzzi, Tullia Dortas Junior, Sergio Duarte Valle, Solange Oliveira Rodrigues
Letter - Clinical
Pyoderma gangrenosum triggered by secukinumab in a patient with palmoplantar pustulosis Wang, Huizhong Sun, Jingru
Letter - Clinical
Squamous cell carcinoma of the nail unit after repeated UV nail lamp exposure. A call for action? Ordoñez, Tatiana Ruf, Marina Angles, Valeria Brau, Gabriel Ferrario, Damián Mazzuoccolo, Luis
Letter - Clinical
Vascularized parallel-ridge pattern: dermoscopic sign in acral melanoma with anatomopathological correlation Maciel, Elisa Scandiuzzi Fernandez, Masiel Garcia Enokihara, Milvia Maria Simões e Silva Hirata, Sérgio Henrique
Letter - Dermatopathology
Apocrine poroma: a case with multiple lesions Alves, Natalia Scardua Mariano Dantas, Bianca Cristina Castro, Luana Rytholz Swiczar, Bethânia Cabral Cavalli Valente, Neusa Yuriko Sakai
Letter - Tropical/Infectious and Parasitic Dermatology
Lobomycosis: single lesion on the lip Nunes, Kananda Kesye Sousa Rodrigues, Carlos Alberto Chirano Schettini, Antonio Pedro Mendes Talhari, Sinésio
Letter - Tropical/Infectious and parasitic dermatology
Treatment of eumycetoma with terbinafine alone and in combination with salvage therapy Bonifaz, Alexandro Tirado-Sánchez, Andrés Vázquez-González, Denisse Araiza, Javier Moreno-López, Luis Miguel González, Gloria M. Chandler, David
Letter - Therapy
Abemaciclib-induced lichen planus pigmentosus inversus improving after switching to ribociclib Communie, Antoine Valo, Isabelle Soulié, Patrick Grimaux, Xavier
Letter - Therapy
Nodular scleroderma partially controlled with tofacitinib Zhou, Kai-Yi Ye, Qian Fang, Sheng
Retraction
RETRACTION: Notice of withdrawal of the article “Pediatric case of trichilemmal cyst arising on the face”
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