The authors present two cases of PTU-associated hepatotoxicity which had different outcome. One patient developed jaundice and altered transaminases, that disappeared after the discontinuation of PTU. The other patient presented with upper gastrointestinal bleeding, hepatic failure and died soon after the admission. Laboratory evaluation showed negative sorology for viral hepatitis in both cases. The authors highlight the importance of the orientation of the patient about the possibility of developing jaundice during the use of PTU and in cases of hepatotoxicity they orient the immediate withdraw of the drug and clinical follow-up.
Hepatitis; Hepatotoxicity; Propylthiouracil; Anti-thyroid drugs