Acessibilidade / Reportar erro

Thyroid function and autoimmunity in HIV-infected women

Função tireoidiana e autoimunidade em mulheres infectadas pelo HIV

The recent report on thyroid function and autoimmunity in HIV-infected is very interesting (1. Carvalho LG , Teixeira Pde F , Panico AL , Cohen MV , Pinheiro MF , Barroso PF , et al . Evaluation of thyroid function and autoimmunity in HIV-infected women . Arq Bras Endocrinol Metabol . 2013 ; 57 ( 6 ): 450 - 6 .). Carvalho and cols. noted “an association between HAART and the development of AITD (1. Carvalho LG , Teixeira Pde F , Panico AL , Cohen MV , Pinheiro MF , Barroso PF , et al . Evaluation of thyroid function and autoimmunity in HIV-infected women . Arq Bras Endocrinol Metabol . 2013 ; 57 ( 6 ): 450 - 6 .)”. In fact, effect of HAART on thyroid function has been proposed for many years. Madeddu and cols. noted “high prevalence of subclinical hypothyroidism” in the patients receiving HAART (2. Madeddu G , Spanu A , Chessa F , Calia GM , Lovigu C , Solinas P , et al . Thyroid function in human immunodeficiency virus patients treated with highly active antiretroviral therapy (HAART): a longitudinal study . Clin Endocrinol (Oxf) . 2006 ; 64 ( 4 ): 375 - 83 .). In relation to autoimmunity, there are many autoantibodies that may be seen in HIV-infected patients including “anti-cardiolipin, anti-beta2 GPI, anti-DNA, anti-small nuclear ribonucleoproteins (snRNP), anti-thyroglobulin, anti-thyroid peroxidase, anti-myosin, and anti-erythropoietin antibodies (3. Zandman-Goddard G , Shoenfeld Y . HIV and autoimmunity . Autoimmun Rev . 2002 ; 1 ( 6 ): 329 - 37 .)”. However, the role of autoantibodies in the development of hypothyroidism in patients receiving antiretroviral drugs has not been assessed (4. Beltran S , Lescure FX , El Esper I , Schmit JL , Desailloud R . Subclinical hypothyroidism in HIV-infected patients is not an autoimmune disease . Horm Res . 2006 ; 66 ( 1 ): 21 - 6 .). The finding of autoantibodies and use of HARRT might be only an accidental concomitant occurrence. In fact, it is proven that Graves’ disease, which is a well-known AITD, has an interrelationship with HIV infection in naïve cases (5. Sheikh V , Dersimonian R , Richterman AG , Porter BO , Natarajan V , Burbelo PD , et al . Graves’ disease as immune reconstitution disease in HIV-positive patients is associated with naive and primary thymic emigrant CD4 T-cell recovery . AIDS . 2014 ; 28 ( 1 ): 31 - 9 .).

REFERENCES

  • 1
    Carvalho LG , Teixeira Pde F , Panico AL , Cohen MV , Pinheiro MF , Barroso PF , et al . Evaluation of thyroid function and autoimmunity in HIV-infected women . Arq Bras Endocrinol Metabol . 2013 ; 57 ( 6 ): 450 - 6 .
  • 2
    Madeddu G , Spanu A , Chessa F , Calia GM , Lovigu C , Solinas P , et al . Thyroid function in human immunodeficiency virus patients treated with highly active antiretroviral therapy (HAART): a longitudinal study . Clin Endocrinol (Oxf) . 2006 ; 64 ( 4 ): 375 - 83 .
  • 3
    Zandman-Goddard G , Shoenfeld Y . HIV and autoimmunity . Autoimmun Rev . 2002 ; 1 ( 6 ): 329 - 37 .
  • 4
    Beltran S , Lescure FX , El Esper I , Schmit JL , Desailloud R . Subclinical hypothyroidism in HIV-infected patients is not an autoimmune disease . Horm Res . 2006 ; 66 ( 1 ): 21 - 6 .
  • 5
    Sheikh V , Dersimonian R , Richterman AG , Porter BO , Natarajan V , Burbelo PD , et al . Graves’ disease as immune reconstitution disease in HIV-positive patients is associated with naive and primary thymic emigrant CD4 T-cell recovery . AIDS . 2014 ; 28 ( 1 ): 31 - 9 .

Publication Dates

  • Publication in this collection
    Feb 2014

History

  • Received
    12 Sept 2013
  • Accepted
    6 Dec 2013
Sociedade Brasileira de Endocrinologia e Metabologia Rua Botucatu, 572 - conjunto 83, 04023-062 São Paulo, SP, Tel./Fax: (011) 5575-0311 - São Paulo - SP - Brazil
E-mail: abem-editoria@endocrino.org.br