Effect of treatment with sitagliptin on somatosensory-evoked potentials and metabolic control in patients with type 2 diabetes mellitus

Efeito do tratamento com sitagliptina sobre os potenciais evocados somatossensoriais e controle metabólico de pacientes com diabetes melito tipo 2

Joelma Ines Tagliapietra Barros Francisco Vagnaldo Fechine Renan Magalhães Montenegro Júnior Otoni Cardoso do Vale Virgínia Oliveira Fernandes Marcellus Henrique Loiola Ponte de Souza Gilmara Holanda da Cunha Manoel Odorico de Moraes Catarina Brasil d’Alva Maria Elisabete Amaral de Moraes About the authors

Objective:

To evaluate the effect of sitagliptin on somatosensory-evoked potentials (SEPs) and metabolic control in patients with type 2 diabetes mellitus without clinical diabetic neuropathy.

Materials and methods:

Interventional, prospective, and open study. Patients with less than six months from the diagnosis were included. Examinations of SEPs and laboratory tests at fasting and after food stimulation were performed before and after three months of treatment with sitagliptin (100 mg/day).

Results:

There was a reduction in the mean levels of HbA1c (P < 0.0001), fasting glucose (P = 0.001), total cholesterol (P = 0.019), and ALT (P = 0.022). An increase in active GLP-1 was found at the end of the study (P = 0.0025). Several SEPs showed statistically significant differences when analyzed before and after treatment with sitagliptin.

Conclusion:

The results give a glimpse of the possible use of sitagliptin in the treatment of some neurodegenerative conditions of the peripheral nervous system, in addition to its already established role in glycemic control.

Diabetes mellitus; type 2; dipeptidyl-peptidase IV inhibitors; incretins; diabetes complications


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