Etiological investigation of patients with sex ambiguity and XY karyotype is a complex matter. Traditionally, testicular function has been assessed only by examining the steroidogenic capacity of Leydig cells and spermatogenesis. Recently, it has been shown that measurement of the serum antimüllerian hormone (AMH), as a marker of Sertoli cell function, may also help clinicians. The aim of this review is to show historic and physiological aspects of the AMH, and its utility to establish the diagnosis in patients with intersexual states. The authors experience in intersex evaluation combining the measurement of androgens, AMH and gonadotropins is also showed.
Antimüllerian hormone; Intersex; 5a-reductase deficiency; Sertoli cell; Testis; Testosterone
