The value of red blood cell distribution width in subclinical hypothyroidism

Yu, Hea Min; Park, Kang Seo; Lee, Jae Min

doi:10.1590/0004-2730000002836

Acessibilidade / Reportar erro

Brasil

Arquivos Brasileiros de Endocrinologia & Metabologia

Español English

Brasil

Español English

sumário « anterior atual seguinte »

Sumário

Artigos Originais • Arq Bras Endocrinol Metab 58 (1) • Feb 2014 • https://doi.org/10.1590/0004-2730000002836 copy

The value of red blood cell distribution width in subclinical hypothyroidism

O valor da amplitude de distribuição de eritrócitos no hipotireoidismo subclínico

Authorship SCIMAGO INSTITUTIONS RANKINGS

Objective

: Therefore, we evaluated the relationship between the subclinical hypothyroidism and red cell distribution width (RDW) levels in a healthy population.

Subjects and methods

: The medical records of 23,343 consecutive health subjects were reviewed. Subjects were classified into four thyroid stimulating hormone (TSH) groups to determine the correlation between TSH and other variables in detail (0.3 to < 2.5 mU/L, 2.5 to < 5 mU/L, 5 to < 7.5 mU/L, and ≥ 7.5 mU/L).

Results

: In the multivariate linear regression analysis, RDW was associated with TSH levels, and e-GFR was inversely associated with TSH levels, respectively (standardized beta coefficient = 0.102, -0.019; p < 0.001, p < 0.001). After adjusting for age and sex, in the four groups, TSH levels were significantly correlated with RDW, estimated glomerular filtration rate (e-GFR), and free thyroxine (fT4) levels in all groups. Furthermore in the 4 ^th group, RDW levels were more strongly associated with TSH levels than in the other groups (p = 0.006).

Conclusions

: RDW levels are correlated with euthyroid and subclinical thyroid status. Notably, RDW is more correlated with subclinical hypothyroidism than the euthyroid status. This study presents the relationship between the RDW levels and thyroid function using TSH level in a large healthy population.

Red blood cell distribution width; subclinical hypothyroidism; thyroid stimulating hormone

Patient	Symptoms	Age at onset of crisis
1	Tonic-clonic crisis	17
2	Absence	10
3	Complex partial crisis	6
4	Tonic-clonic crisis	12
5	Tonic crisis, absence	28
6	Nocturnal epilepsy	9
7	Absence, tonic-clonic crisis	11
8	*Oral automatisms, tonic-clonic crisis*	19
9	Oral automatisms, absence	4
10	Tonic crises	13
11	Nocturnal epilepsy, myoclonia	6
12	Myoclonia, tonic-clonic crisis	13
13	Tonic crises	2
14	Complex partial crisis	12
15	Oral automatisms, myoclonia	7
16	Absence	21
17	Tonic crises	24
18	Complex partial crisis	8
19	Absence	15
20	Tonic crisis, absence	5

	1% increase in TSH	95% CI	P value
RBC	-0.343	-0.493 to -0.193	< 0.001*
Hb	-0.187	-0.212 to -0.109	< 0.001*
Hct	-0.175	-0.247 to -0.092	< 0.001*
RDW	0.102	0.049 to 0.154	< 0.001*
ESR	-0.009	-0.015 to -0.002	0.007*
T. protein	0.576	0.441 to 0.711	< 0.001*
e-GFR	-0.019	-0.024 to -0.014	< 0.001*
UA	0.001	-0.044 to 0.046	0.964
TC	0.002	0.001 to 0.003	0.006*
HDL	-0.003	-0.007 to 0.002	0.236
LDL	-0.001	-0.004 to 0.003	0.710
fT4	-0.088	-0.125 to -0.032	< 0.001*

Variables	All (n = 23,343)		1 ^st (n = 16,896)		2 ^nd (n = 5,079)		3 ^rd (n = 645)		4 ^th (n = 283)
			Euthyroid				Subclinical hypothyroidism
	r	P value	r	P value	r	P value	r	P value	r	P value
RBC	-0.013	0.058	0.008	0.319	-0.012	0.409	-0.049	0.211	-0.123	0.039*
Hb	-0.003	0.688	-0.010	0.207	0.000	0.972	-0.012	0.752	-0.039	0.515
Hct	-0.009	0.188	-0.011	0.159	-0.003	0.840	-0.027	0.496	-0.094	0.115
RDW	0.024	< 0.001*	0.019	0.014*	0.028	0.045*	0.082	0.038*	0.166	0.006*
ESR	0.018	0.010*	0.012	0.158	0.027	0.069	-0.016	0.705	-0.063	0.324
T. protein	0.058	< 0.001*	0.042	< 0.001*	0.029	0.04*	0.003	0.938	0.124	0.039*
e-GFR	-0.063	< 0.001*	-0.054	< 0.001*	-0.039	0.006*	-0.087	0.027*	-0.144	0.017*
UA	0.019	0.005*	0.026	0.001*	0.015	0.273	-0.071	0.073	0.038	0.532
TC	0.03	< 0.001*	0.010	0.194	-0.02	0.149	0.052	0.192	0.144	0.017*
HDL	-0.004	0.595	-0.002	0.792	0.017	0.239	0.089	0.024*	-0.003	0.966
LDL	0.024	< 0.001*	-0.007	0.372	-0.03	0.041*	0.042	0.3	0.198	0.001*
fT4	-0.076	< 0.001*	-0.074	< 0.001*	-0.053	< 0.001*	-0.89	0.031*	-0.477	< 0.001*

Sociedade Brasileira de Endocrinologia e Metabologia Rua Botucatu, 572 - conjunto 83, 04023-062 São Paulo, SP, Tel./Fax: (011) 5575-0311 - São Paulo - SP - Brazil
E-mail: abem-editoria@endocrino.org.br

Acompanhe os números deste periódico no seu leitor de RSS

[1] Correspondence to
: Kang Seo Park. Division of Endocrinology and Metabolism, Department of Internal Medicine, Research Institute of Clinical Medicine of Eulji University Hospital, Republic of Korea. 302-799 – Dunsan-dong 1306, Seo-gu, Daejeon, Republic of Korea. htoonfire@daum.net