Effects of inspired oxygen fractions in rabbits anesthetized with isoflurane or sevoflurane, maintained on spontaneous ventilation

Horr, M.; Nunes, N.; Biteli, E.G.F.; Lopes, P.C.F.; Gering, A.P.; Moro, J.V.; Rocha, F.D.L.

doi:10.1590/1678-4162-10472

Acessibilidade / Reportar erro

Brasil

Arquivo Brasileiro de Medicina Veterinária e Zootecnia

Español English

Brasil

Español English

sumário « anterior atual seguinte »

Sumário

Veterinary Medicine • Arq. Bras. Med. Vet. Zootec. 71 (3) • May-Jun 2019 • https://doi.org/10.1590/1678-4162-10472 copy

Effects of inspired oxygen fractions in rabbits anesthetized with isoflurane or sevoflurane, maintained on spontaneous ventilation

Efeitos de frações inspiradas de oxigênio em coelhos anestesiados com isoflurano ou sevofluorano, mantidos em ventilação espontânea

Authorship SCIMAGO INSTITUTIONS RANKINGS

ABSTRACT

It is important to identify the best inspired fraction of oxygen in a variety of situations, including sevoflurane or isoflurane anesthesia, in spontaneously breathing rabbits. For this, 64 rabbits were assigned to eight groups: GI100 (FiO₂= 1,0 + isoflurane), GS100 (FiO₂= 1,0 + sevoflurane), GI80 (FiO₂= 0,8 + isoflurane), GS80 (FiO₂= 0,8 + sevoflurane), GI60 (FiO₂= 0,6 + isoflurane), GS60 (FiO₂= 0,6 + sevoflurane), GI21 (FiO₂= 0,21 + isoflurane), GS21 (FiO₂= 0,21 + sevoflurane). The induction was performed with (2.5MAC) of the anesthetic. The vaporizer was setted at 1.5 MAC and FiO₂ as attributed for each group. After the induction, the concentration was changed to 1 MAC. Measurements of parameters were performed 30 minutes after induction (T0), and then at 15 minute intervals (from T15 to T60). The arterial partial pressures of oxygen (PaO₂), alveolar oxygen partial pressure (P_AO₂) and alveolar-arterial oxygen gradient [P(A-a)O₂] were higher with the use of high FiO₂. The GI80 showed higher levels of PaO₂ FiO₂ ratio and respiratory index (RI). In conclusion, the FiO₂ of 0.21 is not indicated, because it causes hypoxemia. The isoflurane determines better ventilation when compared to sevoflurane, but isoflurane associated with 80% of oxygen promotes intrapulmonary shunt increase.

Keywords:
rabbit; inhalatory anesthesia; ventilation

Universidade Federal de Minas Gerais, Escola de Veterinária Caixa Postal 567, 30123-970 Belo Horizonte MG - Brazil, Tel.: (55 31) 3409-2041, Tel.: (55 31) 3409-2042 - Belo Horizonte - MG - Brazil
E-mail: abmvz.artigo@gmail.com

Acompanhe os números deste periódico no seu leitor de RSS

[1] E-mail: monicahorr@yahoo.com.br

Parameters	Groups	Time Points
		T0	T15	T30	T45	T60
	GI100	254±59^A	303±87^AE	297±53^A	283±82^A	331±77^A
	GS100	340±41^Db	349±30^Ab	355±35^A	376±29^Da	358±14^A
	GI80	154±61^Bb	187±73^B	212±63^BDa	217±36^BEa	229±44^Ea
PaO₂	GS80	242±59^AE	267±65^E	233±63^B	247±58^E	247±59^E
	GI60	168±27^B	178±28^B	181±50^BD	172±47^B	169 ±55^B
	GS60	185±24^BE	167±50^B	162±53^D	157±54^B	164±60^B
	GI21	67±15^C	68±21^C	64±20^C	66±14^C	64±24^C
	GS21	62±12^C	57±13^C	56±10^C	58±9^C	56±8^C
	GI100	74±14^A	68±7^AE	70±8^A	67±8^AB	68±9^A
	GS100	75±20^A	74±16^A	68±15^A	67±12^A	67±16^A
	GI80	55±12^BC	59±9^BDE	52±9^BC	55±10^B	56±11^A
PvO₂	GS80	69±12^AB	68±12^AE	68±11^A	68±13^AB	67±11^A
	GI60	59±9^B	57±10^E	56±7^AB	55±6^ABD	55±5^A
	GS60	59±4^B	57±5^E	57±4^AB	56±4^ABD	55±3^A
	GI21	45±7^C	44±9^CDE	43±11^C	44±6^CD	39±9^C
	GS21	45±8^Ca	39±11^Cb	41±11^C	39±9^Cb	39±9^Cb
	GI100	49±6	51±7	48±8	47±7	46±7^B
	GS100	43±8	45±11	44±8	47±11	44 ±12^B
	GI80	42±11	53±11	48±9	44±7	44±9^B
PaCO₂	GS80	45±14^a	54±12	54±21^A	57±17^A	61±21^Ab
	GI60	43±6	42±9	38±9^B	41±9^B	39±8^B
	GS60	44±10	43±9	44±10	44±10	44±11^B
	GI21	46±6	47±9	45±7	45±7	47±11^B
	GS21	36±7	40±6	42±6	40±9^B	42±8^B
	GI100	56±12	59±11	49±18	54±10	54±13^B
	GS100	52±8	53±8	51±10	53±12	53±14^B
	GI80	55±5	55±10	54±9	54±6	53±6^B
PvCO₂	GS80	60±16^A	61±12	64±20^A	64±19^A	70±27^A
	GI60	50±6^a	49±6	44±10^Bb	48±8^B	47±8^B
	GS60	52±9	49±8	48±11^B	47±11^B	53±16^B
	GI21	50±8	50±12	52±9	51±10	55±13
	GS21	42±7^Ba	51±7^b	50±6^b	52±8^b	51±11^Bb
	GI100	99.2±0.5^B	99.6±0.5^B	99.4±0.7^B	99.3±0.8^B	99.5±0.6^B
	GS100	99.9±0.0^B	99.9±0.0^B	99.9±0.0^B	99.9±0.0^B	99.9±0.0^B
	GI80	96.9±4.0^B	98.2±2.2^B	99.2±0.9^B	99.6±0.1^B	99.7±0.1^B
SaO₂	GS80	99.6±0.3^B	99.6±0.3^B	99.6±0.1^B	99.7±0.1^B	99.5±0.4^B
	GI60	98.9±0.6^B	98.9±0.5^B	98.3±1.5^B	98.3±1.4^B	97.8±1.6^B
	GS60	99.5±0.2^B	99.5±1.2^B	99.2±1.0^B	98.7±2.1^B	98.9±1.4^B
	GI21	88.4±6.0^A	87.2±10.0^A	85.7±9.8^A	88.3±6.1^A	83.1±12.0^A
	GS21	91.8±0.5^Aa	92.7±0.3^Cb	90.7±0.4^Ccd	90.9±0.5^Ac	89.9 ±0.6^Cde
	GI100	84.8±6.7^BC	83.2±3.8^BCD	86.4±7.7^BC	86.1±7.3^BC	88.9 ±5.9^B
	GS100	93.0±3.4^Ba	92.9±2.7^C	92.0±2.7^B	91.3±2.4^B	90.2±3.8^Bb
	GI80	84.7±11.9^BC	82.4±10.3^BD	81.9±12.0^BC	84.2±9.6^BC	84.7±10.2^B
SvO₂	GS80	90.0±2.3^BDa	88.6±3.9^BC	87.8±5.7^BC	88.2±4.8^BC	87.0±4.7^Bb
	GI60	78.3±5.8^AC	78.2±7.5^AD	79.3±7.1^C	80.8±6.8^AC	83.2±4.2^B
	GS60	86.3±3.6^BC	85.7±3.8^BCD	83.2±8.0^BC	83.0±6.6^BC	83.9±6.0^B
	GI21	73.0±7.8^A	70.9±16.9^A	68.4 ±18.2^A	72.3±8.2^A	62.3±18.5^A
	GS21	82.1±2.4^ACD	81.5±1.8^BD	82.5±2.8^BC	81.4±2.3^AB	81.5±2.6^B
	GI100	352±61^A	301±88^A	312±49^A	328±84^A	284±79^A
	GS100	277±37^Ba	265±28^ABa	261±31^AB	236±31^BCb	258±21^AB
	GI80	334±59^Aa	287±69^A	269±62^ABb	269±38^ABb	256±45^ABb
P(A-a)O₂	GS80	245±53^B	208±53^BC	242±65^BD	225± 49^BD	220±39^BD
	GI60	177±28^C	170±28^C	173±45^C	179±39^C	185± 55^C
	GS60	165±25^C	184±49^C	189±47^CD	194±56^CD	187±52^CD
	GI21	14±18^D	11±24^D	17±25^E	16±20^E	14±33^E
	GS21	31±14^D	31±14^D	30±10^E	29±09^E	29±10^E
	GI100	1.46±0.60^B	1.13±0.66	1.09±0.38	1.32±0.74^C	0.95±0.51
	GS100	0.84±0.26^BCa	0.77±0.14^BC	0.75±0.18	0.63±0.14^BCb	0.72±0.08
	GI80	2.88±2.15^Aa	2.02±1.50^AC	1.52±1.04^B	1.30±0.45	1.19±0.46^b
IR	GS80	1.12±0.56^BC	0.88±0.54^BC	1.15±0.53	0.99±0.41	0.97±0.39
	GI60	1.08±0.40^BC	0.99±0.38^BC	1.09±0.67	1.18±0.69	1.35±1.01
	GS60	0.92±0.26^BC	1.43±1.36^C	1.55±1.44^B	1.66 ±1.50^AC	1.54±1.40^A
	GI21	0.27±0.34^C	0.28±0.46^BC	0.40±0.48^A	0.31±0.34^B	0.41±0.57^B
	GS21	0.55±0.34^BC	0.65±0.56^B	0.58±0.31	0.53 ±0.23^BC	0.55±0.28
	GI100	0.42±0.09^BC	0.50±0.14^BC	0.49 ±0.08^BC	0.46 ±0.13^BC	0.53±0.12^B
	GS100	0.54±0.06^CDa	0.56±0.04^BCa	0.57 ±0.05^BC	0.61±0.04^b	0.58±0.02^B
	GI80	0.31±0.12^B	0.39±0.15^B	0.44±0.12^B	0.44±0.07^B	0.47±0.09^B
PaO₂/P_AO₂	GS80	0.49±0.12^BCD	0.55±0.12^BC	0.49 ±0.12^BC	0.52 ±0.11^BC	0.52±0.10^B
	GI60	0.49±0.08^BCD	0.51±0.08^BC	0.51 ±0.13^BC	0.49 ±0.12^BC	0.47±0.15^B
	GS60	0.52±0.06^CD	0.47±0.14^BC	0.45 ±0.14^BC	0.44±0.15^B	0.46±0.15^B
	GI21	0.83±0.22^AD	0.88±0.35^A	0.80 ±0.31^AC	0.81 ±0.24^AC	0.87±0.50^A
	GS21	0.67±0.14^D	0.64±0.14^C	0.65±0.11^C	0.66±0.09^C	0.65±0.10^B
	GI100	261.2±59.6	308.9±87.4	301.5±52.7	287.6±82.3	331.9±77.5
	GS100	339.8±40.6^Ba	349.2±29.9^Ba	355.6±35.1	376.1±29.3^Ab	357.9±14.5
	GI80	192.5±77.0^Aa	234.5±91.3^A	265.9±78.3^b	271.6±45.1^Bb	287.0±54.6^b
PaO₂/FiO₂	GS80	302.5±73.5^B	334.5±81.0^B	291.7±78.7	309.2±73.2	308.8±73.9
	GI60	288.6±46.9^B	301.7±47.4	306.0±80.9	290.8±75.4	282.4±90.1
	GS60	308.5±40.1^B	279.8±83.2	270.2±89.0	261.9 ±89.8^B	273.9±99.6
	GI21	320.5±72.2^B	323.9±99.0	306.5±98.7	315.0±68.8	307.7±117.4
	GS21	296.3±56.8^B	270.7±63.4	267.6±49.0	278.8 ±45.7^B	269.8±40.7
	GI100	20.0±10.8^A	16.6±10.1	13.7±14.1	11.4±11.2	10.0±10.0
	GS100	12.9±9.3	12.9±12.5	7.7±9.7	8.3±12.8	7.3±14.0
	GI80	11.5±17.0	23.1±18.4^A	15.3±10.7	8.7±6.9	8.2±5.4
P(a-ET)CO₂	GS80	5.2±17.9^B	10.0±14.8	7.7±13.8	7.8±7.6	8.9±8.0
	GI60	14.4±10.0	14.6±10.9	9.2±12.8	11.3±10.5	10.1±9.9
	GS60	17.5±11.2	15.5±11.1	14.9±13.8	13.1±10.0	15.4±13.0
	GI21	13.9±6.9	15.3±10.0	12.9±10.4	13.6±8.9	15.3±12.4
	GS21	4.4±4.8^B	5.6±4.1^B	4.7±5.7	2.4±9.3	2.7±6.6
	GI100	14.7±3.1^AC	14.7±2.4^BCD	15.2±1.6	14.4±1.5^AC	14.7±1.8
	GS100	16.9±2.6^C	17.0±2.5^CD	17.9±2.1^AC	17.6±1.7^BC	17.4±2.6^ACD
	GI80	15.1±1.3^AC	15.5±1.2^D	16.2±1.7^C	16.0±2.2^C	16.2±1.7^D
CaO₂	GS80	15.6±1.5	15.1±2.2	14.7±1.0^BC	15.9±2.1^C	15.9±2.0^D
	GI60	14.2±2.1^AC	14.2±1.9^BCD	13.5±3.1^BC	11.8±5.2^A	13.8±2.5^BD
	GS60	18.0±2.1^BC	17.9±2.2^ACD	17.7±2.2^AC	17.5±2.3^BC	17.7±2.1^CD
	GI21	13.1±1.5^A	13.2±1.7^BD	13.0±0.9^B	13.6±1.6^AC	12.6±1.7^B
	GS21	13.0±1.2^A	12.5±1.8^B	13.4±1.5^B	12.6±1.6^A	12.1±1.9^B