Solar keratitis (1919. Cullen AP. Photokeratitis and other phototoxic effects on the cornea
and conjunctiva. Int J Toxicol. 2002;21(6):455-4.)
|
UV exposure |
Keratosis of exposed skin, burning sensation, redness, punctate
keratitis |
Allergic keratoconjunctivitis(1010. Friedlaender MH. Ocular allergy. Curr Opin Allergy Clin Immunol.
2011;11(5): 477-82.)(2020. Utine CA, Bicakcigil M, Yavuz S, Ciftci F. Tear osmolarity
measurements in dry eye related to primary Sjogren's syndrome. Curr Eye Res.
2011;36(8):683-90.)
|
Allergy |
History of allergy, redness, itching, swelling |
Floppy eyelid syndrome(2121. De PK, Banerjee R. Identification, properties and effect of hormones
on rat preputial gland peroxidase. J Endocrinol. 1987;112(2):239-45.)
|
Rubbery, redundant upper tarsus |
Lid eversion with minimal pressure. Redness, papillary conjunctivitis |
Corneal hiperalgesia(2222. Derocq JM, Jbilo O, Bouaboula M, Ségui M, Clère C, Casellas P.
Genomic and functional changes induced by the activation of the peripheral
cannabinoid receptor CB2 in the promyelocytic cells HL-60. Possible involvement of
the CB2 receptor in cell differentiation. J Biol Chem.
2000;275(21):15621-8.)
|
Up regulated nocioreception triggered by corneal damage |
Disparity between signs and symptoms, corneal sensory deficit and decreased
sensory nerve population |
Ligneous conjunctivitis(2323. Deshmukh PK, Gattani SG. In vitro and in vivo consideration of novel
environmentally responsive ophthalmic drug delivery system. Pharm Dev Technol.
2013;18(4):950-6.)
|
Impaired mucosal wound healing and fibrosis due to plasminogen
deficiency |
Chronic membranous conjunctivitis triggered by local trauma |
Mucous fishing syndrome(2424. Ding CH, Wang XH, Zou LP, Lü JL, Wu HS, Wu Y, et al. [Clinical
characteristics and diagnosis of acute pandysautonomia in childhood]. Zhonghua Er Ke
Za Zhi. 2010;48(6): 454-9. Chinese.)
|
Excess of mucous manipulation |
Secretion, redness, and foreign body sensation along with signs of
epithelial trauma due to discharge of mucus |
Pseudopemphigoid(2525. Doerge D. Mechanism-based inhibition of lactoperoxidase by
thiocarbamide goitrogens. Biochemistry. 1986;25(16):4724-8.)
|
History of topical drug exposure. |
Redness, tearing, itching, and progressive fibrosis of conjunctiva |
Chronic blepharitis(2626. Dolgin E. In Brazil, basic stem cell research lags behind clinical
trials. Nat Med. 2011; 17(10):1172.)
|
Dysfunction of lipid production and secretion and epithelial
metaplasia |
Lid erythema, greasy crusting secretion. Redness and irritation of the eye
Seborrhea in other sites of the body |
Stevens-Johnsons Syndrome(2727. Drouault-Holowacz S, Bieuvelet S, Burckel A, Rigal D, Dubray C,
Lichon J, et al. Antioxidants intake and dry eye syndrome: a crossover,
placebo-controlled, randomized trial. Eur J Ophthalmol.
2009;19(3):337-42.)
|
Autoimmune disease triggered by drug or microorganism |
Acute: systemic epithelial bullous swelling. Chronic: ocular surface
fibrosis, corneal vascularization, and recurrent epithelial defect |
Toxic keratoconjunctivitis(2828. Dvorscak L, Marfurt CF. Age-related changes in rat corneal
epithelial nerve density. Invest Ophthalmol Vis Sci.
2008;49(3):910-6.)
|
Toxic agent traumatic, iatrogenic or factitious contact with ocular
surface |
Variable, depending on agent and time. Commonly, acute epithelial swelling,
redness, and tearing |