Comment on: mean platelet volume in patients with retinal artery occlusion

Comentário sobre: volume médio de plaquetas em pacientes com oclusão da artéria da retina

Yakup Aksoy Abdullah Kaya About the authors

Dear Editor:

We read the article titled "Mean platelet volume in patients with retinal artery occlusion" by Şahin et al. with great interest(11 Şahin M, Şahin A, Yüksel H, Türkcü FM, Yıldırım A. Mean platelet volume in patients with retinal artery occlusion. Arq Bras Oftalmol. 2016;79(1):12-4.). The aim of this study was to investigate the mean platelet volume (MPV) of patients with retinal artery occlusion (RAO). The authors concluded that MPV values were significantly higher in patients with RAO, which suggested that larger platelets may contribute to the pathogenesis of the RAOs. We congratulate the authors on their informative study. We also would like to offer a criticism and comment on this article.

It is known that platelets are involved in the homeostatic process and have an important role in atherosclerosis and arterial thrombosis and that MPV is a marker of platelet function and activation(22 Hekimsoy Z, Payzin B, Ornek T, Kandogan G. Mean platelet volume in Type 2 diabetic patients. J Diabetes Complications 2004;18(3):173-6.). The relationships between MPV and many systemic diseases, various pathologies, and various drugs have been investigated by researchers, particularly over the last two decades. It has been reported that increased MPV is associated with myocardial infarction, thromboembolism, stroke, obesity, metabolic syndrome, and hypercholesterolemia. In addition, external factors, including smoking and drugs, such as metformin and rosuvastatin, may also alter MPV value(11 Şahin M, Şahin A, Yüksel H, Türkcü FM, Yıldırım A. Mean platelet volume in patients with retinal artery occlusion. Arq Bras Oftalmol. 2016;79(1):12-4.

2 Hekimsoy Z, Payzin B, Ornek T, Kandogan G. Mean platelet volume in Type 2 diabetic patients. J Diabetes Complications 2004;18(3):173-6.

3 Dolasık I, Sener SY, Celebı K, Aydın ZM, Korkmaz U, Canturk Z. The effect of metformin on mean platelet volume in dıabetıc patients. Platelets. 2013;24(2):118-21.

4 Akyüz A, Akkoyun DÇ, Değirmenci H, Oran M. Rosuvastatin Decreases mean platelet volume in patients with diabetes mellitus. Angiology. 2016;67(2):116-20.
-55 Varol E, Akcay S, Icli A, Yucel H, Ozkan E, Erdogan D, et al. Mean platelet volume in patients with prehypertension and hypertension. Clin Hemorheol Microcirc. 2010;45(1):67-72.).

The authors stated that patients with systemic diseases other than hypertension (HT) and diabetes mellitus (DM) were excluded from the study and patients with HT or DM were included. However, it has been reported that both DM and HT are associated with increased MPV, and hyperglycemia results in the formation of larger platelets(22 Hekimsoy Z, Payzin B, Ornek T, Kandogan G. Mean platelet volume in Type 2 diabetic patients. J Diabetes Complications 2004;18(3):173-6.

3 Dolasık I, Sener SY, Celebı K, Aydın ZM, Korkmaz U, Canturk Z. The effect of metformin on mean platelet volume in dıabetıc patients. Platelets. 2013;24(2):118-21.

4 Akyüz A, Akkoyun DÇ, Değirmenci H, Oran M. Rosuvastatin Decreases mean platelet volume in patients with diabetes mellitus. Angiology. 2016;67(2):116-20.
-55 Varol E, Akcay S, Icli A, Yucel H, Ozkan E, Erdogan D, et al. Mean platelet volume in patients with prehypertension and hypertension. Clin Hemorheol Microcirc. 2010;45(1):67-72.). The authors also stated that there were no differences in the presence of HT and DM between the control and RAO groups. The authors meant that the platelet counts of the patients in the groups were similar, but the severity of the disease and drugs used for treatments might have differed between the patient groups. Obesity is also an important factor affecting MPV, and the authors did not provide any information about the body mass indices of the patients. Therefore, we think that the inclusion of patients with HT, DM, or high BMI might have affected the results of the study.

  • Funding: No specific financial support was available for this study.

REFERENCES

  • 1
    Şahin M, Şahin A, Yüksel H, Türkcü FM, Yıldırım A. Mean platelet volume in patients with retinal artery occlusion. Arq Bras Oftalmol. 2016;79(1):12-4.
  • 2
    Hekimsoy Z, Payzin B, Ornek T, Kandogan G. Mean platelet volume in Type 2 diabetic patients. J Diabetes Complications 2004;18(3):173-6.
  • 3
    Dolasık I, Sener SY, Celebı K, Aydın ZM, Korkmaz U, Canturk Z. The effect of metformin on mean platelet volume in dıabetıc patients. Platelets. 2013;24(2):118-21.
  • 4
    Akyüz A, Akkoyun DÇ, Değirmenci H, Oran M. Rosuvastatin Decreases mean platelet volume in patients with diabetes mellitus. Angiology. 2016;67(2):116-20.
  • 5
    Varol E, Akcay S, Icli A, Yucel H, Ozkan E, Erdogan D, et al. Mean platelet volume in patients with prehypertension and hypertension. Clin Hemorheol Microcirc. 2010;45(1):67-72.

Publication Dates

  • Publication in this collection
    Jul-Aug 2016

History

  • Received
    25 Apr 2016
  • Accepted
    20 May 2016

Response: comment on: mean platelet volume in patients with retinal artery occlusion

Resposta do comentário sobre: volume médio de plaquetas em pacientes com oclusão da artéria da retina

Muhammed Şahin Alparslan Şahin Harun Yüksel Fatih Mehmet Türkcü Adnan Yıldırım About the authors Corresponding author: Muhammed Şahin. Department of Ophthalmology. School of Medicine Dicle University - Diyarbakir, Turkey.

Dear Editor:

We read with great interest the correspondence generated by our article regarding the "Mean platelet volume in patients with retinal artery occlusion." We thank the authors for their interest in our article(11 Şahin M, Şahin A, Yüksel H, Türkcü FM, Yıldırım A. Mean platelet volume in patients with retinal artery occlusion. Arq Bras Oftalmol. 2016;79(1):12-4.).

We agree with the authors that systemic disorders, such as diabetes mellitus and hypertension, and medications, such as antihypertensives and antidiabetics, may alter the laboratory parameters. Because of its retrospective nature, our study lacked information on the medications of the patients and the severity of their diseases. This issue was mentioned in the study limitations. In addition, it was not possible to perform statistical analyses because of the small number of patients with hypertension or diabetes mellitus (eight patients).

Second, we agree that obesity might affect MPV values, and the lack of data on body mass index was mentioned in the study limitations.

We again thank the authors for their valuable comments and hope that we have clarified the points related to their comment.

REFERENCES

  • 1
    Şahin M, Şahin A, Yüksel H, Türkcü FM, Yıldırım A. Mean platelet volume in patients with retinal artery occlusion. Arq Bras Oftalmol. 2016;79(1):12-4.
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