Combined
Biological &
Clinical Therapy |
NK1R antagonists Lanepitant and
Befetupitant for corneal neovascularization |
Reduction of corneal hemangiogenesis, lymphangiogenesis,
and leukocyte infiltration |
Bignami et al., 2014(185)
|
Contact lenses for the culture and delivery
of corneal epithelial cells for the treatment
of limbal stem cell deficiency |
Reconstruction of the recipient corneal surface |
Brown et al., 2014(186)
|
| Topical AMA0526 after corneal trauma |
Inhibition of angiogenesis in vitro, reduction of
corneal opacity, and neovascularization |
Sijnave et al., 2015(187)
|
Topical applied cell-permeable FK506BP
on corneal alkali burn injury |
Corneal opacity and corneal
neovascularization were significantly decreased |
Kim et al., 2015(188)
|
| Topical β-1,3-glucan in corneal alkali burn |
Epithelial wound healing in vitro and
suppression of acute inflammatory reaction |
Choi et al., 2013(189)
|
Downregulation of vimentin by pharmacological
agent withaferin A in corneal alkali injury |
Vimentin deficiency alters the fibrotic response to corneal
alkali injury and instead engages a reparative healing
mechanism to restore corneal clarity |
Bargagna-Mohan
et al., 2012(190)
|
Inhibitory oligonucleotides of miR-206,
miR-206-I, intrastromally injected into alkali-burned
corneas. The possible binding of miR-206 on its
molecular target Cx43 was assessed |
Ameliorated inflammatory responses both in vivo
and in vitro. Cx43 was directly targeted by miR-206 |
Li et al., 2015(191)
|
Injection of a naked plasmid expressing green
fluorescent protein (GFP; pCMV-GFP) into an
unwounded mouse corneal stroma. Injection of
pCMV-GFP or plasmids expressing small hairpin
RNA in the corneal wound injury model |
In the corneal wound injury model, the GFP-positive
cells demonstrated extensive dendritic-like processes that
extended to adjacent cells, whereas the vimentin knockdown
model showed significantly reduced corneal opacity |
Das et al., 2014(192)
|
Application of angiogenin eye drops in
neovascularization and corneal opacity |
Reduction of the inflammatory response
induced by TNF-α or LPS |
Lee et al., 2016(193)
|
Keratocytes in culture and within intact
normal and diseased tissue were induced
to produce collagen type II upon treatment
with TGFβ3 and dexamethasone |
Collagen type II deposition and a threefold
increase in corneal hardness and elasticity |
Greene et al., 2016(194)
|
Fresh isolated omental cells were injected
subconjunctivally in limbal corneal alkali injury |
Reduction of corneal neovascularization
and neutrophil infiltration |
Bu et al., 2014(195)
|
Deep corneal neovessels treated with
intrastromal injections of bevacizumab |
Complete regression of neovessels in 16 patients, partial
regression in 6 patients, and reduced opacity and
improved visual acuity in 5 patients |
Sarah et al., 2016(196)
|
Combined
Biological &
Surgical Therapy |
Allogeneic limbal mesenchymal stem cell
therapy after severe corneal chemical burn |
Reduction of corneal opacity, neovascularization, and
corneal fluorescein staining |
Acar et al., 2015(197)
|
Autologous or allogenic cultivated limbal
stem cell transplantation using a standardized
protocol free from xenogenic products |
Reduction in corneal neovascularization |
Zakaria et al., 2014(198)
|
The transplantation of CECs in combination
with the selective ROCK inhibitor Y-27632
in corneal endothelial dysfunction |
Endothelium with a monolayer hexagonal cell
shape with a normal expression of function-related
markers; recovery of corneal transparency |
Okumura et al., 2012(199),
Kinoshita et al.,(158)
|
Autologous and allogeneic limbal epithelial cells
cultivated on amniotic membranes and transplanted
in cases of limbal stem cell deficiency |
Improvement in corneal epithelium
quality, with subsequent improvement
in symptoms, quality of life, and vision |
Ramirez et al., 2015(200)
|
Limitações e avanços em novos tratamentos e perspectivas futuras na cegueira corneal
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